{ "uniprot_canonical_ac": "A0A0G2K628-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2K628-1|A0A0G2K628_RAT Isoform 1 of Proto-oncogene c-Ski OS=Rattus norvegicus OX=10116 GN=Ski PE=1 SV=1 CANONICAL=A0A0G2K628-1", "length": 699, "sequence": "MSSLGGPAAFSARWAQEAYKKESAKEAGAATVPAPVPTAAEPPPVLHLPAIQPPPPVLPGPFFMPSDRSTERCETVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINSVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKALENRTCHWGFDSANWRAYILLSQDYTGKEEQARLGRCLDDVKEKFDYANKYKRRVPRVSEPPASIRPKTDDTSSQSPASSEKDKQSTWLRTLAGSSNKSLGCAHPRQRLSAFRPWSPAVSASEKETSPHLPALIRDSFYSYKSFETAVAPNVALAPPTQQKVVNSPPCTTVVSRAPEPLTTCIQPRKRKLTMDAPGAPDMLTPVAAAEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLSSPGMHAPPVAAPDAAAHADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLTAALQAKRSLHQELEFLRVAKKEKLREATEAKRSLRKEIERLRAENEKKMKEANESRVRLKRELEQARQVRVCDKGCEAGRLRAKYSAQIEDLQAKLQHAEADREQLRADLLREREAREHLEKVVKELQEQLWPRPRPENSGGESNAELDP" }, "uniprot_id": "A0A0G2K628_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "type": [ "PubMed" ], "id": "22673903" } ], "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012" } ], "uniprot_ac": "A0A0G2K628", "site_annotation": [ { "end_pos": 243, "annotation": "n_glycosylation_sequon", "start_pos": 241 }, { "end_pos": 337, "annotation": "n_glycosylation_sequon", "start_pos": 335 }, { "end_pos": 604, "annotation": "n_glycosylation_sequon", "start_pos": 602 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628#A0A0G2K628-1", "isoform_ac": "A0A0G2K628-1", "locus": { "end_pos": 172559337, "strand": "+", "start_pos": 172623813, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000080591", "id": "ENSRNOT00000080591", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000073651", "id": "ENSRNOP00000073651", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K628-1|A0A0G2K628_RAT Isoform 1 of Proto-oncogene c-Ski OS=Rattus norvegicus OX=10116 GN=Ski PE=1 SV=1 CANONICAL=A0A0G2K628-1", "length": 699, "sequence": "MSSLGGPAAFSARWAQEAYKKESAKEAGAATVPAPVPTAAEPPPVLHLPAIQPPPPVLPGPFFMPSDRSTERCETVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINSVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKALENRTCHWGFDSANWRAYILLSQDYTGKEEQARLGRCLDDVKEKFDYANKYKRRVPRVSEPPASIRPKTDDTSSQSPASSEKDKQSTWLRTLAGSSNKSLGCAHPRQRLSAFRPWSPAVSASEKETSPHLPALIRDSFYSYKSFETAVAPNVALAPPTQQKVVNSPPCTTVVSRAPEPLTTCIQPRKRKLTMDAPGAPDMLTPVAAAEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLSSPGMHAPPVAAPDAAAHADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLTAALQAKRSLHQELEFLRVAKKEKLREATEAKRSLRKEIERLRAENEKKMKEANESRVRLKRELEQARQVRVCDKGCEAGRLRAKYSAQIEDLQAKLQHAEADREQLRADLLREREAREHLEKVVKELQEQLWPRPRPENSGGESNAELDP" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:313757", "resource": "KEGG Pathway", "id": "rno:313757", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-201451", "resource": "Reactome", "id": "R-RNO-201451", "name": "Signaling by BMP" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2173795", "resource": "Reactome", "id": "R-RNO-2173795", "name": "Downregulation of SMAD2/3:SMAD4 transcriptional activity" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "P12755-1", "protein_name": "Ski oncogene", "sequence": { "length": 728, "sequence": "MEAAAGGRGCFQPHPGLQKTLEQFHLSSMSSLGGPAAFSARWAQEAYKKESAKEAGAAAVPAPVPAATEPPPVLHLPAIQPPPPVLPGPFFMPSDRSTERCETVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINAVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKALENRTCHWGFDSANWRAYILLSQDYTGKEEQARLGRCLDDVKEKFDYGNKYKRRVPRVSSEPPASIRPKTDDTSSQSPAPSEKDKPSSWLRTLAGSSNKSLGCVHPRQRLSAFRPWSPAVSASEKELSPHLPALIRDSFYSYKSFETAVAPNVALAPPAQQKVVSSPPCAAAVSRAPEPLATCTQPRKRKLTVDTPGAPETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQEQLWPRARPEAAGSEGAAELEP" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/31124", "id": "31124", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "SKI", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017449382.1", "ac": "XP_017449382.1", "name": "ski oncogene", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046811", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "histone deacetylase inhibitor activity", "id": "GO:0046811" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "chromatin binding", "id": "GO:0003682" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "zinc ion binding", "id": "GO:0008270" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "protein kinase binding", "id": "GO:0019901" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "protein domain specific binding", "id": "GO:0019904" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "ubiquitin protein ligase binding", "id": "GO:0031625" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046332", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "SMAD binding", "id": "GO:0046332" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070491", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "repressing transcription factor binding", "id": "GO:0070491" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "identical protein binding", "id": "GO:0042802" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227" } ], "total": 12, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "centrosome", "id": "GO:0005813" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017053", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "transcription repressor complex", "id": "GO:0017053" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "transcription regulator complex", "id": "GO:0005667" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016605", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "PML body", "id": "GO:0016605" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "pmid": "", "evidence": [ { "url": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "negative regulation of cell population proliferation", "id": "GO:0008285" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030326", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "embryonic limb morphogenesis", "id": "GO:0030326" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048741", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "skeletal muscle fiber development", "id": "GO:0048741" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001843", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "neural tube closure", "id": "GO:0001843" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030514", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "negative regulation of BMP signaling pathway", "id": "GO:0030514" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048147", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "negative regulation of fibroblast proliferation", "id": "GO:0048147" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060395", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "SMAD protein signal transduction", "id": "GO:0060395" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022011", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "myelination in peripheral nervous system", "id": "GO:0022011" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032926", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "negative regulation of activin receptor signaling pathway", "id": "GO:0032926" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030512", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "negative regulation of transforming growth factor beta receptor signaling pathway", "id": "GO:0030512" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045668", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "negative regulation of osteoblast differentiation", "id": "GO:0045668" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048593", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "camera-type eye morphogenesis", "id": "GO:0048593" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010626", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "negative regulation of Schwann cell proliferation", "id": "GO:0010626" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035019", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "somatic stem cell population maintenance", "id": "GO:0035019" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043388", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "positive regulation of DNA binding", "id": "GO:0043388" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009948", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "anterior/posterior axis specification", "id": "GO:0009948" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014902", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "myotube differentiation", "id": "GO:0014902" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043010", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K628", "id": "A0A0G2K628", "database": "UniProtKB" } ], "name": "camera-type eye development", "id": "GO:0043010" }, 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