{ "uniprot_canonical_ac": "A0A0G2K5L2-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2K5L2-1|A0A0G2K5L2_RAT Isoform 1 of Mitochondrial glutamate carrier 1-like OS=Rattus norvegicus OX=10116 GN=LOC100911440 PE=1 SV=1 CANONICAL=A0A0G2K5L2-1", "length": 323, "sequence": "MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRMYASMSDCLIKTIRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLPKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKMLAAQAQLATQGGGQPSVEAPAAPRPTATQLTRDLLRNHGIAGLYKGLGATLLRDVPFSIVYFPLFANLNQLGRPSSEEKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLERGVNEDTYSGFLDCARKIWRHEGPSAFLKGAYCRALVIAPLFGIAQVVYFLGIAESLLGLLQEPQA" }, "uniprot_id": "A0A0G2K5L2_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2", "id": "A0A0G2K5L2", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [], "uniprot_ac": "A0A0G2K5L2", "site_annotation": [ { "end_pos": 74, "annotation": "n_glycosylation_sequon", "start_pos": 72 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2#A0A0G2K5L2-1", "isoform_ac": "A0A0G2K5L2-1", "locus": { "end_pos": 213974834, "strand": "+", "start_pos": 213977857, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000086238", "id": "ENSRNOT00000086238", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000073467", "id": "ENSRNOP00000073467", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K5L2-1|A0A0G2K5L2_RAT Isoform 1 of Mitochondrial glutamate carrier 1-like OS=Rattus norvegicus OX=10116 GN=LOC100911440 PE=1 SV=1 CANONICAL=A0A0G2K5L2-1", "length": 323, "sequence": "MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRMYASMSDCLIKTIRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLPKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKMLAAQAQLATQGGGQPSVEAPAAPRPTATQLTRDLLRNHGIAGLYKGLGATLLRDVPFSIVYFPLFANLNQLGRPSSEEKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLERGVNEDTYSGFLDCARKIWRHEGPSAFLKGAYCRALVIAPLFGIAQVVYFLGIAESLLGLLQEPQA" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2#Q5FVG4-1", "isoform_ac": "Q5FVG4-1", "locus": { "end_pos": 214411740, "strand": "+", "start_pos": 214414763, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000025240", "id": "ENSRNOT00000025240", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000025240", "id": "ENSRNOP00000025240", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Q5FVG4-1|A0A0G2K5L2_RAT Computationally mapped isoform of Mitochondrial glutamate carrier 1-like OS=Rattus norvegicus OX=10116 GN=LOC100911440 PE=1 SV=1 CANONICAL=A0A0G2K5L2-1", "length": 229, "sequence": "MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRMYASMSDCLIKTIRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLPKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIGCVAGSAAAVAVNPCDVVKTRLQSLERGVNEDTYSGFLDCARKIWRHEGPSAFLKGAYCRALVIAPLFGIAQVVYFLGIAESLLGLLQEPQA" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:100911440", "resource": "KEGG Pathway", "id": "rno:100911440", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-428643", "resource": "Reactome", "id": "R-RNO-428643", "name": "Organic anion transporters" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q9D6M3-1", "protein_name": "Mitochondrial glutamate carrier 1", "sequence": { "length": 323, "sequence": "MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRMYASMSDCLIKTIRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLPKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQAQLSAQGGAQPSVEAPAPPRPTATQLTRDLLRNHGIAGLYKGLGATLLRDVPFSIVYFPLFANLNQLGRPSSEEKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLERGVNEDTYSGFLDCARKIWRHEGPSAFLKGAYCRALVIAPLFGIAQVVYFLGIAESLLGLLQEPQA" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/69383", "id": "69383", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Slc25a22", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q9H936-1", "protein_name": "Mitochondrial glutamate carrier 1", "sequence": { "length": 323, "sequence": "MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFGIAQVVYFLGIAESLLGLLQDPQA" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/69383", "id": "69383", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "SLC25A22", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008772957.1", "ac": "XP_008772957.1", "name": "mitochondrial glutamate carrier 1 isoform X1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015183", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2", "id": "A0A0G2K5L2", "database": "UniProtKB" } ], "name": "L-aspartate transmembrane transporter activity", "id": "GO:0015183" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005347", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2", "id": "A0A0G2K5L2", "database": "UniProtKB" } ], "name": "ATP transmembrane transporter activity", "id": "GO:0005347" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005313", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2", "id": "A0A0G2K5L2", "database": "UniProtKB" } ], "name": "L-glutamate transmembrane transporter activity", "id": "GO:0005313" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2", "id": "A0A0G2K5L2", "database": "UniProtKB" } ], "name": "mitochondrial inner membrane", "id": "GO:0005743" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2", "id": "A0A0G2K5L2", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015810", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2", "id": "A0A0G2K5L2", "database": "UniProtKB" } ], "name": "aspartate transmembrane transport", "id": "GO:0015810" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043490", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2", "id": "A0A0G2K5L2", "database": "UniProtKB" } ], "name": "malate-aspartate shuttle", "id": "GO:0043490" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015813", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2", "id": "A0A0G2K5L2", "database": "UniProtKB" } ], "name": "L-glutamate transmembrane transport", "id": "GO:0015813" } ], "total": 3, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2K5L2", "type": "synonym", "resource": "RefSeq", "name": "LOC100911440" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2", "type": "recommended", "resource": "UniProtKB", "name": "LOC100911440" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2", "type": "synonym", "resource": "UniProtKB", "name": "Slc25a22" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2", "type": "synonym", "resource": "UniProtKB", "name": "rCG_47744" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000018450", "id": "ENSRNOG00000018450", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/100911440", "id": "100911440", "database": "GeneID" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/309111", "id": "309111", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002067", "id": "IPR002067", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018108", "id": "IPR018108", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR023395", "id": "IPR023395", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:100911440", "id": "rno:100911440", "database": "KEGG Pathway" }, { "url": "https://omabrowser.org/oma/group/CTKKIWQ/", "id": "CTKKIWQ", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=945010at2759", "id": "945010at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00153", "id": "PF00153", "database": "Pfam" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-428643", "id": "R-RNO-428643", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008772957.1", "id": "XP_008772957.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1307826", "id": "1307826", "database": "RGD" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=6492572", "id": "6492572", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2", "id": "A0A0G2K5L2", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [ { "synonyms": [ { "id": "MONDO:0012245", "url": "https://monarchinitiative.org/disease/MONDO:0012245", "resource": "MONDO", "name": "epileptic encephalopathy, early infantile, 3", "description": "" }, { "id": "MONDO:0012245", "url": "https://monarchinitiative.org/disease/MONDO:0012245", "resource": "MONDO", "name": "EIEE3", "description": "" }, { "id": "MONDO:0012245", "url": "https://monarchinitiative.org/disease/MONDO:0012245", "resource": "MONDO", "name": "SLC25A22 early infantile epileptic encephalopathy", "description": "" }, { "id": "MONDO:0012245", "url": "https://monarchinitiative.org/disease/MONDO:0012245", "resource": "MONDO", "name": "epileptic encephalopathy, early infantile, 3; EIEE3", "description": "" }, { "id": "MONDO:0012245", "url": "https://monarchinitiative.org/disease/MONDO:0012245", "resource": "MONDO", "name": "epileptic encephalopathy, early infantile, type 3", "description": "" }, { "id": "MONDO:0012245", "url": "https://monarchinitiative.org/disease/MONDO:0012245", "resource": "MONDO", "name": "early infantile epileptic encephalopathy caused by mutation in SLC25A22", "description": "" } ], "recommended_name": { "id": "DOID:0080440", "url": "http://disease-ontology.org/term/DOID:0080440", "resource": "Disease Ontology", "name": "early infantile epileptic encephalopathy 3", "description": "An early infantile epileptic encephalopathy characterized by onset in the first months of life of erratic, typically myoclonic, refractory seizures that has_material_basis_in homozygous or compound heterozygous mutation in the SLC25A22 gene on chromosome 11p15." }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/0080440#disease-associations", "id": "0080440", "database": "Alliance of Genome Resources" } ] } ], "phosphorylation": [], "mass": { "monoisotopic_mass": 34662.0, "chemical_mass": 34662.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2", "name": "LOC100911440", "locus": { "end_pos": 213973489, "strand": "-", "start_pos": 213981330, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000018450", "id": "ENSRNOG00000018450", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Mitochondrial glutamate carrier 1-like" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "RCG47744, isoform CRA_c" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2K5L2", "type": "synonym", "resource": "RefSeq", "name": "mitochondrial glutamate carrier 1 isoform X1" } ] }