{ "uniprot_canonical_ac": "A0A0G2K4P8-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2K4P8-1|A0A0G2K4P8_RAT Isoform 1 of E3 ubiquitin-protein ligase NRDP1 OS=Rattus norvegicus OX=10116 GN=Rnf41 PE=4 SV=1 CANONICAL=A0A0G2K4P8-1", "length": 317, "sequence": "MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDSLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQTRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI" }, "uniprot_id": "A0A0G2K4P8_RAT", "enzyme_annotation": [ { "ec": "2.3.2.27", "activity": "" }, { "ec": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine." } ], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "id": "A0A0G2K4P8", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [], "uniprot_ac": "A0A0G2K4P8", "site_annotation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8#A0A0G2K4P8-1", "isoform_ac": "A0A0G2K4P8-1", "locus": { "end_pos": 2842633, "strand": "-", "start_pos": 2851713, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000090689", "id": "ENSRNOT00000090689", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000073126", "id": "ENSRNOP00000073126", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K4P8-1|A0A0G2K4P8_RAT Isoform 1 of E3 ubiquitin-protein ligase NRDP1 OS=Rattus norvegicus OX=10116 GN=Rnf41 PE=4 SV=1 CANONICAL=A0A0G2K4P8-1", "length": 317, "sequence": "MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDSLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQTRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8#G3V930-1", "isoform_ac": "G3V930-1", "locus": { "end_pos": 2842633, "strand": "-", "start_pos": 2851713, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000029778", "id": "ENSRNOT00000029778", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000034376", "id": "ENSRNOP00000034376", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|G3V930-1|A0A0G2K4P8_RAT Computationally mapped isoform of E3 ubiquitin-protein ligase NRDP1 OS=Rattus norvegicus OX=10116 GN=Rnf41 PE=4 SV=2 CANONICAL=A0A0G2K4P8-1", "length": 297, "sequence": "MGYDVTRFQGDVDEDLICPICSGVLEEPVQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDSLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQTRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1358803", "resource": "Reactome", "id": "R-RNO-1358803", "name": "Downregulation of ERBB2:ERBB3 signaling" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168", "resource": "Reactome", "id": "R-RNO-983168", "name": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q8BH75-1", "protein_name": "E3 ubiquitin-protein ligase NRDP1", "sequence": { "length": 317, "sequence": "MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQSRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/4226", "id": "4226", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Rnf41", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q9H4P4-1", "protein_name": "E3 ubiquitin-protein ligase NRDP1", "sequence": { "length": 317, "sequence": "MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQTRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/4226", "id": "4226", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "RNF41", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006240834.1", "ac": "XP_006240834.1", "name": "E3 ubiquitin-protein ligase NRDP1 isoform X1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005135", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "id": "A0A0G2K4P8", "database": "UniProtKB" } ], "name": "interleukin-3 receptor binding", "id": "GO:0005135" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "id": "A0A0G2K4P8", "database": "UniProtKB" } ], "name": "protein domain specific binding", "id": "GO:0019904" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "id": "A0A0G2K4P8", "database": "UniProtKB" } ], "name": "identical protein binding", "id": "GO:0042802" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "id": "A0A0G2K4P8", "database": "UniProtKB" } ], "name": "metal ion binding", "id": "GO:0046872" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "id": "A0A0G2K4P8", "database": "UniProtKB" } ], "name": "ubiquitin protein ligase activity", "id": "GO:0061630" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030971", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "id": "A0A0G2K4P8", "database": "UniProtKB" } ], "name": "receptor tyrosine kinase binding", "id": "GO:0030971" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "id": "A0A0G2K4P8", "database": "UniProtKB" } ], "name": "ubiquitin-protein transferase activity", "id": "GO:0004842" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005128", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "id": "A0A0G2K4P8", "database": "UniProtKB" } ], "name": "erythropoietin receptor binding", "id": "GO:0005128" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017160", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "id": "A0A0G2K4P8", "database": "UniProtKB" } ], "name": "Ral GTPase binding", "id": "GO:0017160" } ], "total": 9, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "id": "A0A0G2K4P8", "database": "UniProtKB" } ], "name": "perinuclear region of cytoplasm", "id": "GO:0048471" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071782", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "id": "A0A0G2K4P8", "database": "UniProtKB" } ], "name": "endoplasmic reticulum tubular network", "id": "GO:0071782" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051896", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "id": "A0A0G2K4P8", "database": "UniProtKB" } ], "name": "regulation of protein kinase B signaling", "id": "GO:0051896" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901525", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "id": "A0A0G2K4P8", "database": "UniProtKB" } ], "name": "negative regulation of mitophagy", 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"database": "UniProtKB" } ], "name": "positive regulation of reactive oxygen species metabolic process", "id": "GO:2000379" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "id": "A0A0G2K4P8", "database": "UniProtKB" } ], "name": "protein ubiquitination", "id": "GO:0016567" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097191", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "id": "A0A0G2K4P8", "database": "UniProtKB" } ], "name": "extrinsic apoptotic signaling pathway", "id": "GO:0097191" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045732", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "id": "A0A0G2K4P8", "database": "UniProtKB" } ], "name": "positive regulation of protein catabolic process", "id": "GO:0045732" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010498", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "id": "A0A0G2K4P8", "database": "UniProtKB" } ], "name": "proteasomal protein catabolic process", "id": "GO:0010498" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000377", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "id": "A0A0G2K4P8", "database": "UniProtKB" } ], "name": "regulation of reactive oxygen species metabolic process", "id": "GO:2000377" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "id": "A0A0G2K4P8", "database": "UniProtKB" } ], "name": "protein polyubiquitination", "id": "GO:0000209" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "id": "A0A0G2K4P8", "database": "UniProtKB" } ], "name": "regulation of gene expression", "id": "GO:0010468" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051865", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "id": "A0A0G2K4P8", "database": "UniProtKB" } ], "name": "protein autoubiquitination", "id": "GO:0051865" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045637", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "id": "A0A0G2K4P8", "database": "UniProtKB" } ], "name": "regulation of myeloid cell differentiation", "id": "GO:0045637" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000114", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "id": "A0A0G2K4P8", "database": "UniProtKB" } ], "name": "regulation of establishment of cell polarity", "id": "GO:2000114" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043408", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "id": "A0A0G2K4P8", "database": "UniProtKB" } ], "name": "regulation of MAPK cascade", "id": "GO:0043408" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045619", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "id": "A0A0G2K4P8", "database": "UniProtKB" } ], "name": "regulation of lymphocyte differentiation", "id": "GO:0045619" } ], "total": 18, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2K4P8", "type": "synonym", "resource": "RefSeq", "name": "Rnf41" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "type": "recommended", "resource": "UniProtKB", "name": "Rnf41" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "type": "synonym", "resource": "UniProtKB", "name": "rCG_42493" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000023456", "id": "ENSRNOG00000023456", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/362814", "id": "362814", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "id": 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"https://www.reactome.org/PathwayBrowser/#R-RNO-983168", "id": "R-RNO-983168", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006240834.1", "id": "XP_006240834.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309557", "id": "1309557", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "id": "A0A0G2K4P8", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [ { "synonyms": [ { "id": "DOID:1289", "url": "http://disease-ontology.org/term/DOID:1289", "resource": "Disease Ontology", "name": "degenerative disease", "description": "" } ], "recommended_name": { "id": "DOID:1289", "url": "http://disease-ontology.org/term/DOID:1289", "resource": "Disease Ontology", "name": "neurodegenerative disease", "description": "A central nervous system disease that results in the progressive deterioration of function or structure of neurons." }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/1289#disease-associations", "id": "1289", "database": "Alliance of Genome Resources" } ] } ], "phosphorylation": [], "mass": { "monoisotopic_mass": 35878.0, "chemical_mass": 35878.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8", "name": "Rnf41", "locus": { "end_pos": 2852681, "strand": "+", "start_pos": 2827247, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000023456", "id": "ENSRNOG00000023456", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "2.3.2.27" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2K4P8", "type": "synonym", "resource": "RefSeq", "name": "E3 ubiquitin-protein ligase NRDP1 isoform X1" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "E3 ubiquitin-protein ligase NRDP1" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "RING finger protein 41" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K4P8#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "RING-type E3 ubiquitin transferase NRDP1" } ] }