{ "uniprot_canonical_ac": "A0A0G2K337-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2K337-1|A0A0G2K337_RAT Isoform 1 of Abhydrolase domain-containing 2, acylglycerol lipase OS=Rattus norvegicus OX=10116 GN=Abhd2 PE=1 SV=1 CANONICAL=A0A0G2K337-1", "length": 453, "sequence": "MSAAGSCGAAGTGLRAGWTAGVTEQRIKMNAMLETPELPAVFDGVKLAAVAAVLYVIVRCLNLKSPTAPPDLYFQDSGLSRFLLKSCPLLTKEYIPPLIWGKSGHIQTALYGKMGRVRSPHPYGHRKFITMSDGATSTFDLFEPLAEHCVGDDVTMVICPGIANHSEKQYIRTFVDYAQKNGYRCAVLNHLGALPNIELTSPRMFTYGCTWEFGAMVNYIKKTYPQTQLVVVGFSLGGNIVCKYLGETQANQEKVLCCVSVCQGYSALRAQETFMQWDQCRRFYNFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCMRYLHRIYVPLMLVNAADDPLVHESLLTIPKSLSEKRENVMFVLPLHGGHLGFFEGSVLFPEPLTWMDKLVVEYANAICQWERNKSQCSDTEQMEAELE" }, "uniprot_id": "A0A0G2K337_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K337", "id": "A0A0G2K337", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "type": [ "PubMed" ], "id": "22673903" } ], "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K337", "id": "A0A0G2K337", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012" } ], "uniprot_ac": "A0A0G2K337", "site_annotation": [ { "end_pos": 166, "annotation": "n_glycosylation_sequon", "start_pos": 164 }, { "end_pos": 440, "annotation": "n_glycosylation_sequon", "start_pos": 438 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K337#A0A0G2K337-1", "isoform_ac": "A0A0G2K337-1", "locus": { "end_pos": 140998282, "strand": "-", "start_pos": 141086883, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000090897", "id": "ENSRNOT00000090897", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000072489", "id": "ENSRNOP00000072489", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K337-1|A0A0G2K337_RAT Isoform 1 of Abhydrolase domain-containing 2, acylglycerol lipase OS=Rattus norvegicus OX=10116 GN=Abhd2 PE=1 SV=1 CANONICAL=A0A0G2K337-1", "length": 453, "sequence": "MSAAGSCGAAGTGLRAGWTAGVTEQRIKMNAMLETPELPAVFDGVKLAAVAAVLYVIVRCLNLKSPTAPPDLYFQDSGLSRFLLKSCPLLTKEYIPPLIWGKSGHIQTALYGKMGRVRSPHPYGHRKFITMSDGATSTFDLFEPLAEHCVGDDVTMVICPGIANHSEKQYIRTFVDYAQKNGYRCAVLNHLGALPNIELTSPRMFTYGCTWEFGAMVNYIKKTYPQTQLVVVGFSLGGNIVCKYLGETQANQEKVLCCVSVCQGYSALRAQETFMQWDQCRRFYNFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCMRYLHRIYVPLMLVNAADDPLVHESLLTIPKSLSEKRENVMFVLPLHGGHLGFFEGSVLFPEPLTWMDKLVVEYANAICQWERNKSQCSDTEQMEAELE" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K337#D4A7W1-1", "isoform_ac": "D4A7W1-1", "locus": { "end_pos": 141026588, "strand": "-", "start_pos": 141086883, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000023506", "id": "ENSRNOT00000023506", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000023506", "id": "ENSRNOP00000023506", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D4A7W1-1|A0A0G2K337_RAT Computationally mapped isoform of Abhydrolase domain-containing 2, acylglycerol lipase OS=Rattus norvegicus OX=10116 GN=Abhd2 PE=1 SV=1 CANONICAL=A0A0G2K337-1", "length": 425, "sequence": "MNAMLETPELPAVFDGVKLAAVAAVLYVIVRCLNLKSPTAPPDLYFQDSGLSRFLLKSCPLLTKEYIPPLIWGKSGHIQTALYGKMGRVRSPHPYGHRKFITMSDGATSTFDLFEPLAEHCVGDDVTMVICPGIANHSEKQYIRTFVDYAQKNGYRCAVLNHLGALPNIELTSPRMFTYGCTWEFGAMVNYIKKTYPQTQLVVVGFSLGGNIVCKYLGETQANQEKVLCCVSVCQGYSALRAQETFMQWDQCRRFYNFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCMRYLHRIYVPLMLVNAADDPLVHESLLTIPKSLSEKRENVMFVLPLHGGHLGFFEGSVLFPEPLTWMDKLVVEYANAICQWERNKSQCSDTEQMEAELE" } } ], "pathway": [], "function": [], "orthologs": [ { "uniprot_canonical_ac": "P08910-1", "protein_name": "Monoacylglycerol lipase ABHD2", "sequence": { "length": 425, "sequence": "MNAMLETPELPAVFDGVKLAAVAAVLYVIVRCLNLKSPTAPPDLYFQDSGLSRFLLKSCPLLTKEYIPPLIWGKSGHIQTALYGKMGRVRSPHPYGHRKFITMSDGATSTFDLFEPLAEHCVGDDITMVICPGIANHSEKQYIRTFVDYAQKNGYRCAVLNHLGALPNIELTSPRMFTYGCTWEFGAMVNYIKKTYPLTQLVVVGFSLGGNIVCKYLGETQANQEKVLCCVSVCQGYSALRAQETFMQWDQCRRFYNFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCMRYLHRIYVPLMLVNAADDPLVHESLLTIPKSLSEKRENVMFVLPLHGGHLGFFEGSVLFPEPLTWMDKLVVEYANAICQWERNKLQCSDTEQVEADLE" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2K337/", "id": "A0A0G2K337", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "ABHD2", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q9QXM0-1", "protein_name": "Monoacylglycerol lipase ABHD2", "sequence": { "length": 425, "sequence": "MNAMLETPELPAVFDGVKLAAVAAVLYVIVRCLNLKSPTAPPDLYFQDSGLSRFLLKSCPLLTKEYIPPLIWGKSGHIQTALYGKMGRVRSPHPYGHRKFITMSDGATSTFDLFEPLAEHCVGDDITMVICPGIANHSEKQYIRTFVDYAQKNGYRCAVLNHLGALPNIELTSPRMFTYGCTWEFGAMVNYIKRTYPQTQLVVVGFSLGGNIVCKYLGETQANQEKVLCCVSVCQGYSALRAQETFMQWDQCRRFYNFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCMRYLHRIYVPLMLVNAADDPLVHESLLTIPKSLSEKRENVMFVLPLHGGHLGFFEGSVLFPEPLTWMDKLVVEYANAICQWERNKSQCSDTEQMEAELE" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2K337/", "id": "A0A0G2K337", "database": "OMA" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Abhd2", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": {}, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034338", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K337", "id": "A0A0G2K337", "database": "UniProtKB" } ], "name": "short-chain carboxylesterase activity", "id": "GO:0034338" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047372", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K337", "id": "A0A0G2K337", "database": "UniProtKB" } ], "name": "acylglycerol lipase activity", "id": "GO:0047372" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003707", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K337", "id": "A0A0G2K337", "database": "UniProtKB" } ], "name": "steroid hormone receptor activity", "id": "GO:0003707" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042562", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K337", "id": "A0A0G2K337", "database": "UniProtKB" } ], "name": "hormone binding", "id": "GO:0042562" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033878", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K337", "id": "A0A0G2K337", "database": "UniProtKB" } ], "name": "hormone-sensitive lipase activity", "id": "GO:0033878" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008126", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K337", "id": "A0A0G2K337", "database": "UniProtKB" } ], "name": "acetylesterase activity", "id": "GO:0008126" } ], "total": 6, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K337", "id": "A0A0G2K337", "database": "UniProtKB" } ], "name": "acrosomal vesicle", "id": "GO:0001669" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K337", "id": "A0A0G2K337", "database": "UniProtKB" } ], "name": "sperm flagellum", "id": "GO:0036126" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097524", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K337", "id": "A0A0G2K337", "database": "UniProtKB" } ], "name": "sperm plasma membrane", "id": "GO:0097524" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044255", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K337", "id": "A0A0G2K337", "database": "UniProtKB" } ], "name": "cellular lipid metabolic process", "id": "GO:0044255" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051793", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K337", "id": "A0A0G2K337", "database": "UniProtKB" } ], "name": "medium-chain fatty acid catabolic process", "id": "GO:0051793" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051792", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K337", "id": "A0A0G2K337", "database": "UniProtKB" } ], "name": "medium-chain fatty acid biosynthetic process", "id": "GO:0051792" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030336", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K337", "id": "A0A0G2K337", "database": "UniProtKB" } ], "name": "negative regulation of cell migration", "id": "GO:0030336" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046464", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K337", "id": "A0A0G2K337", "database": "UniProtKB" } ], "name": "acylglycerol catabolic process", "id": "GO:0046464" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007340", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K337", "id": "A0A0G2K337", "database": "UniProtKB" } ], "name": "acrosome reaction", "id": "GO:0007340" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009611", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K337", "id": "A0A0G2K337", "database": "UniProtKB" } ], "name": "response to wounding", "id": "GO:0009611" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032570", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K337", "id": "A0A0G2K337", "database": "UniProtKB" } ], "name": "response to progesterone", "id": "GO:0032570" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043401", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K337", "id": "A0A0G2K337", "database": "UniProtKB" } ], "name": "steroid hormone mediated signaling pathway", "id": "GO:0043401" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048240", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K337", "id": "A0A0G2K337", "database": "UniProtKB" } ], "name": "sperm capacitation", "id": "GO:0048240" } ], "total": 10, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K337", "type": "recommended", "resource": "UniProtKB", "name": "Abhd2" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000017120", "id": "ENSRNOG00000017120", "database": "Bgee" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000073", "id": "IPR000073", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000952", "id": "IPR000952", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR012020", "id": "IPR012020", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "id": "IPR029058", "database": "InterPro" }, { "url": "https://omabrowser.org/oma/group/CPWPIGE/", "id": "CPWPIGE", "database": "OMA" }, { "url": "http://pfam.xfam.org/family/PF00561", "id": "PF00561", "database": "Pfam" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311389", "id": "1311389", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K337", "id": "A0A0G2K337", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 51026.0, "chemical_mass": 51026.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K337", "name": "Abhd2", "locus": { "end_pos": 141087405, "strand": "+", "start_pos": 140998240, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000017120", "id": "ENSRNOG00000017120", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K337#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Abhydrolase domain-containing 2, acylglycerol lipase" } ] }