{ "uniprot_canonical_ac": "A0A0G2K2K7-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2K2K7-1|A0A0G2K2K7_RAT Isoform 1 of Interleukin 18 receptor accessory protein OS=Rattus norvegicus OX=10116 GN=Il18rap PE=3 SV=1 CANONICAL=A0A0G2K2K7-1", "length": 627, "sequence": "MLCLGWVFLWFVAGEKTTGFNHSACTTKKLLWTYSARGAENFVLFCDLQELQKQDFSHRSQSSSTLGPAHQPCSGSEKDLSDVQWYMQPRSGGPLEEINRNSPHMQNKGTLRILAPQMNSIWSYICRPRSRRPQDTACCVKTVLEVKPQRNISCGSSAQDEQVLLLGSTGSIHCPSLSCQSDVRSPEMTWYKDGRLLPEYKKNPIEMEDIYDFHQGLYVCDYTQSDNVSSWTVRAVVQVRTIDEDTNVKPDILDPVTDTLDVELGKAFTLPCRVQFGFQRYSKPVIKWYVKESTQEWEISEFVEKRIQSTLKNEVIEHTVFLREVTQRDLSRKFVCFAQNSIGNTTRTIRLRKKEGVVFLYILLGMTVMLVGVLVAAALLYWHWIEVVLLCRTFKNKDETLRDKKEFDAFVSYANWSSPETEATGSLSEEHLALNLFPEVLENTYGYSLCLFERDVTPGGVYTDDIVSIIKRSRRGIFILSPRYINGPRVFELQAAVNLALVDQTLKLILIKFCSFQEPESLPYLVKKALRVLPTVTWKGLKSVHATSRFWTQIRYHMPVKNSNRFMFNWLRLIPKGFSPEKDLATQKPLGGMPNSGNSHGAQNRTPDAGNRHGAQNLLLSGHQKRC" }, "uniprot_id": "A0A0G2K2K7_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [], "uniprot_ac": "A0A0G2K2K7", "site_annotation": [ { "end_pos": 153, "annotation": "n_glycosylation_sequon", "start_pos": 151 }, { "end_pos": 23, "annotation": "n_glycosylation_sequon", "start_pos": 21 }, { "end_pos": 229, "annotation": "n_glycosylation_sequon", "start_pos": 227 }, { "end_pos": 346, "annotation": "n_glycosylation_sequon", "start_pos": 344 }, { "end_pos": 417, "annotation": "n_glycosylation_sequon", "start_pos": 415 }, { "end_pos": 606, "annotation": "n_glycosylation_sequon", "start_pos": 604 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7#A0A0G2K2K7-1", "isoform_ac": "A0A0G2K2K7-1", "locus": { "end_pos": 47233601, "strand": "-", "start_pos": 47255649, "chromosome": "9", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000077303", "id": "ENSRNOT00000077303", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000072281", "id": "ENSRNOP00000072281", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K2K7-1|A0A0G2K2K7_RAT Isoform 1 of Interleukin 18 receptor accessory protein OS=Rattus norvegicus OX=10116 GN=Il18rap PE=3 SV=1 CANONICAL=A0A0G2K2K7-1", "length": 627, "sequence": "MLCLGWVFLWFVAGEKTTGFNHSACTTKKLLWTYSARGAENFVLFCDLQELQKQDFSHRSQSSSTLGPAHQPCSGSEKDLSDVQWYMQPRSGGPLEEINRNSPHMQNKGTLRILAPQMNSIWSYICRPRSRRPQDTACCVKTVLEVKPQRNISCGSSAQDEQVLLLGSTGSIHCPSLSCQSDVRSPEMTWYKDGRLLPEYKKNPIEMEDIYDFHQGLYVCDYTQSDNVSSWTVRAVVQVRTIDEDTNVKPDILDPVTDTLDVELGKAFTLPCRVQFGFQRYSKPVIKWYVKESTQEWEISEFVEKRIQSTLKNEVIEHTVFLREVTQRDLSRKFVCFAQNSIGNTTRTIRLRKKEGVVFLYILLGMTVMLVGVLVAAALLYWHWIEVVLLCRTFKNKDETLRDKKEFDAFVSYANWSSPETEATGSLSEEHLALNLFPEVLENTYGYSLCLFERDVTPGGVYTDDIVSIIKRSRRGIFILSPRYINGPRVFELQAAVNLALVDQTLKLILIKFCSFQEPESLPYLVKKALRVLPTVTWKGLKSVHATSRFWTQIRYHMPVKNSNRFMFNWLRLIPKGFSPEKDLATQKPLGGMPNSGNSHGAQNRTPDAGNRHGAQNLLLSGHQKRC" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:373540", "resource": "KEGG Pathway", "id": "rno:373540", "name": "" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "O95256-1", "protein_name": "Interleukin-18 receptor accessory protein", "sequence": { "length": 599, "sequence": "MLCLGWIFLWLVAGERIKGFNISGCSTKKLLWTYSTRSEEEFVLFCDLPEPQKSHFCHRNRLSPKQVPEHLPFMGSNDLSDVQWYQQPSNGDPLEDIRKSYPHIIQDKCTLHFLTPGVNNSGSYICRPKMIKSPYDVACCVKMILEVKPQTNASCEYSASHKQDLLLGSTGSISCPSLSCQSDAQSPAVTWYKNGKLLSVERSNRIVVDEVYDYHQGTYVCDYTQSDTVSSWTVRAVVQVRTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIKDSDLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFILSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITSRIFQWKGLSRTETTGRSSQPKEW" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/2859", "id": "2859", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A0G2K2K7/", "id": "A0A0G2K2K7", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "IL18RAP", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q9Z2B1-1", "protein_name": "Interleukin-18 receptor accessory protein", "sequence": { "length": 614, "sequence": "MLCLGWVFLWFVAGEKTTGFNHSACATKKLLWTYSARGAENFVLFCDLQELQEQKFSHASQLSPTQSPAHKPCSGSQKDLSDVQWYMQPRSGSPLEEISRNSPHMQSEGMLHILAPQTNSIWSYICRPRIRSPQDMACCIKTVLEVKPQRNVSCGNTAQDEQVLLLGSTGSIHCPSLSCQSDVQSPEMTWYKDGRLLPEHKKNPIEMADIYVFNQGLYVCDYTQSDNVSSWTVRAVVKVRTIGKDINVKPEILDPITDTLDVELGKPLTLPCRVQFGFQRLSKPVIKWYVKESTQEWEMSVFEEKRIQSTFKNEVIERTIFLREVTQRDLSRKFVCFAQNSIGNTTRTIRLRKKEEVVFVYILLGTALMLVGVLVAAAFLYWYWIEVVLLCRTYKNKDETLGDKKEFDAFVSYSNWSSPETDAVGSLSEEHLALNLFPEVLEDTYGYRLCLLDRDVTPGGVYADDIVSIIKKSRRGIFILSPSYLNGPRVFELQAAVNLALVDQTLKLILIKFCSFQEPESLPYLVKKALRVLPTVTWKGLKSVHASSRFWTQIRYHMPVKNSNRFMFNGLRIFLKGFSPEKDLVTQKPLEGMPKSGNDHGAQNLLLYSDQKRC" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/2859", "id": "2859", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A0G2K2K7/", "id": "A0A0G2K2K7", "database": "OMA" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Il18rap", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008756243.1", "ac": "XP_008756243.1", "name": "interleukin-18 receptor accessory protein", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042007", "pmid": "14644029", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "interleukin-18 binding", "id": "GO:0042007" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042008", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "interleukin-18 receptor activity", "id": "GO:0042008" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045092", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "interleukin-18 receptor complex", "id": "GO:0045092" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070301", "pmid": "12684057", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "cellular response to hydrogen peroxide", "id": "GO:0070301" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071345", "pmid": "18547159", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "cellular response to cytokine stimulus", "id": "GO:0071345" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071351", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "cellular response to interleukin-18", "id": "GO:0071351" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008283", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "cell population proliferation", "id": "GO:0008283" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051092", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "positive regulation of NF-kappaB transcription factor activity", "id": "GO:0051092" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035655", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "interleukin-18-mediated signaling pathway", "id": "GO:0035655" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045954", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "positive regulation of natural killer cell mediated cytotoxicity", "id": "GO:0045954" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032635", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "interleukin-6 production", "id": "GO:0032635" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042119", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "neutrophil activation", "id": "GO:0042119" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032609", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "interferon-gamma production", "id": "GO:0032609" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035744", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "name": "T-helper 1 cell cytokine production", "id": "GO:0035744" } ], "total": 11, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2K2K7", "type": "synonym", "resource": "RefSeq", "name": "Il18rap" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "type": "recommended", "resource": "UniProtKB", "name": "Il18rap" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "type": "synonym", "resource": "UniProtKB", "name": "rCG_22315" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000054218", "id": "ENSRNOG00000054218", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/373540", "id": "373540", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000157", "id": "IPR000157", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "id": "IPR003599", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "id": "IPR007110", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013151", "id": "IPR013151", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "id": "IPR013783", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015621", "id": "IPR015621", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035897", "id": "IPR035897", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "id": "IPR036179", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041416", "id": "IPR041416", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:373540", "id": "rno:373540", "database": "KEGG Pathway" }, { "url": "https://omabrowser.org/oma/group/YVCDYTQ/", "id": "YVCDYTQ", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=985064at2759", "id": "985064at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11890", "id": "PTHR11890", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF00047", "id": "PF00047", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF01582", "id": "PF01582", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF18452", "id": "PF18452", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008756243.1", "id": "XP_008756243.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=727867", "id": "727867", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "id": "A0A0G2K2K7", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 71630.0, "chemical_mass": 71630.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "name": "Il18rap", "locus": { "end_pos": 47258503, "strand": "+", "start_pos": 47225585, "chromosome": "9", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000054218", "id": "ENSRNOG00000054218", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Interleukin 18 receptor accessory protein" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "RCG22315" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2K2K7", "type": "synonym", "resource": "RefSeq", "name": "interleukin-18 receptor accessory protein" } ] }