{ "uniprot_canonical_ac": "A0A0G2K2F0-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2K2F0-1|A0A0G2K2F0_RAT Isoform 1 of Cation channel, sperm-associated 1 OS=Rattus norvegicus OX=10116 GN=Catsper1 PE=1 SV=1 CANONICAL=A0A0G2K2F0-1", "length": 620, "sequence": "MDQPSRTDESYYETHSGSLDPSHHFHPPSSYPYPHPTLYRPSLGGVLHHESPQHGVSPQPSQQHAGFYQQNESQHLRGSDFHDSAFPHHSYHQDRAHFSTSPTNVPHTYGGPHPLAESQHSGGPQDGSHIESYHSHQGNPRKPSVALSHPSSIGSHQGKTHHHYERPQYLDPRQSRRQSDLSDNLSHRSGEEYQNQERSGLQVGQQQEGQRASSKRGEHRRRRGDYLKYKDRIRHRRPSASQLSHKSHSTEGTSPSHMRSKSLASMPQSHLGVQSYVSSQVHSGDSLKESVSWSDEDHVQKRKKAQRTHKKAHSGNVFHLIWEKISQLLLGLRQMLLTLTQSLCFETFIFLVVCLNTIVLVAQTFTELEIRGEWYFMVLDSIFLSIYVIEAFLKLIALGMEYFYDPWNNLDFFIMVMAALDFVLLQINSLSYSFYNHSMFRILKVFKSMRALRAIRVLRRLSILTSLHEVTGTLSGSLPSITAILSLMFTCLFLFSVVLRALFQESDPKRFNNIFTTLFTLFTMLTLDDWSLIYIDNRAQGAWYIIPILVIYIIIQYFIFLNLVIAVLVDNFQMALLKGLEKVKQEQAARVHEKLLDDSLTDLNKAGTDLSPLPPVRVLS" }, "uniprot_id": "A0A0G2K2F0_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2F0", "id": "A0A0G2K2F0", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "type": [ "PubMed" ], "id": "22673903" } ], "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2F0", "id": "A0A0G2K2F0", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012" } ], "uniprot_ac": "A0A0G2K2F0", "site_annotation": [ { "end_pos": 186, "annotation": "n_glycosylation_sequon", "start_pos": 184 }, { "end_pos": 438, "annotation": "n_glycosylation_sequon", "start_pos": 436 }, { "end_pos": 73, "annotation": "n_glycosylation_sequon", "start_pos": 71 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2F0#A0A0G2K2F0-1", "isoform_ac": "A0A0G2K2F0-1", "locus": { "end_pos": 220715100, "strand": "-", "start_pos": 220719918, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000091244", "id": "ENSRNOT00000091244", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000072218", "id": "ENSRNOP00000072218", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K2F0-1|A0A0G2K2F0_RAT Isoform 1 of Cation channel, sperm-associated 1 OS=Rattus norvegicus OX=10116 GN=Catsper1 PE=1 SV=1 CANONICAL=A0A0G2K2F0-1", "length": 620, "sequence": "MDQPSRTDESYYETHSGSLDPSHHFHPPSSYPYPHPTLYRPSLGGVLHHESPQHGVSPQPSQQHAGFYQQNESQHLRGSDFHDSAFPHHSYHQDRAHFSTSPTNVPHTYGGPHPLAESQHSGGPQDGSHIESYHSHQGNPRKPSVALSHPSSIGSHQGKTHHHYERPQYLDPRQSRRQSDLSDNLSHRSGEEYQNQERSGLQVGQQQEGQRASSKRGEHRRRRGDYLKYKDRIRHRRPSASQLSHKSHSTEGTSPSHMRSKSLASMPQSHLGVQSYVSSQVHSGDSLKESVSWSDEDHVQKRKKAQRTHKKAHSGNVFHLIWEKISQLLLGLRQMLLTLTQSLCFETFIFLVVCLNTIVLVAQTFTELEIRGEWYFMVLDSIFLSIYVIEAFLKLIALGMEYFYDPWNNLDFFIMVMAALDFVLLQINSLSYSFYNHSMFRILKVFKSMRALRAIRVLRRLSILTSLHEVTGTLSGSLPSITAILSLMFTCLFLFSVVLRALFQESDPKRFNNIFTTLFTLFTMLTLDDWSLIYIDNRAQGAWYIIPILVIYIIIQYFIFLNLVIAVLVDNFQMALLKGLEKVKQEQAARVHEKLLDDSLTDLNKAGTDLSPLPPVRVLS" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1300642", "resource": "Reactome", "id": "R-RNO-1300642", "name": "Sperm Motility And Taxes" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q8NEC5-1", "protein_name": "Cation channel sperm-associated protein 1", "sequence": { "length": 780, "sequence": "MDQNSVPEKAQNEADTNNADRFFRSHSSPPHHRPGHSRALHHYELHHHGVPHQRGESHHPPEFQDFHDQALSSHVHQSHHHSEARNHGRAHGPTGFGLAPSQGAVPSHRSYGEDYHDELQRDGRRHHDGSQYGGFHQQSDSHYHRGSHHGRPQYLGENLSHYSSGVPHHGEASHHGGSYLPHGPNPYSESFHHSEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHGKSPHHGETISPHSSVGSYQRGISDYHSEYHQGDHHPSEYHHGDHPHHTQHHYHQTHRHRDYHQHQDHHGAYHSSYLHGDYVQSTSQLSIPHTSRSLIHDAPGPAASRTGVFPYHVAHPRGSAHSMTRSSSTIRSRVTQMSKKVHTQDISTKHSEDWGKEEGQFQKRKTGRLQRTRKKGHSTNLFQWLWEKLTFLIQGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIALGLSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRKSDPKRFQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLKRLIEKKFGTMTEKQQELLFHYLQLVASVEQEQQKFRSQAAVIDEIVDTTFEAGEEDFRN" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2K2F0/", "id": "A0A0G2K2F0", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "CATSPER1", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q91ZR5-1", "protein_name": "Cation channel sperm-associated protein 1", "sequence": { "length": 686, "sequence": "MDQSSRRDESYHETHPGSLDPSHQSHPHPHPHPTLHRPNQGGVYYDSPQHGMFQQPYQQHGGFHQQNELQHLREFSDSHDNAFSHHSYQQDRAGVSTLPNNISHAYGGSHPLAESQHSGGPQSGPRIDPNHHPHQDDPHRPSEPLSHPSSTGSHQGTTHQQYHERSHHLNPQQNRDHADTISYRSSTRFYRSHAPFSRQERPHLHADHHHEGHHAHSHHGEHPHHKEQRHYHGDHMHHHIHHRSPSASQLSHKSHSTLATSPSHVGSKSTASGARYTFGARSQIFGKAQSRESLRESASLSEGEDHVQKRKKAQRAHKKAHTGNIFQLLWEKISHLLLGLQQMILSLTQSLGFETFIFIVVCLNTVILVAQTFTELEIRGEWYFMVLDSIFLSIYVLEAVLKLIALGLEYFYDPWNNLDFFIMVMAVLDFVLLQINSLSYSFYNHSLFRILKVFKSMRALRAIRVLRRLSILTSLHEVAGTLSGSLPSITAILTLMFTCLFLFSVVLRALFQDSDPKRFQNIFTTLFTLFTMLTLDDWSLIYIDNRAQGAWYIIPILMIYIVIQYFIFLNLVIAVLVDNFQMALLKGLEKVKLEQAARVHEKLLDDSLTDLNKADANAQMTEEALKMQLIEGMFGNMTVKQRVLHFQFLQLVAAVEQHQQKFRSQAYVIDELVDMAFEAGDDDYGK" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2K2F0/", "id": "A0A0G2K2F0", "database": "OMA" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Catsper1", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": {}, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005227", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2F0", "id": "A0A0G2K2F0", "database": "UniProtKB" } ], "name": "calcium activated cation channel activity", "id": "GO:0005227" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005245", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2F0", "id": "A0A0G2K2F0", "database": "UniProtKB" } ], "name": "voltage-gated calcium channel activity", "id": "GO:0005245" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036128", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2F0", "id": "A0A0G2K2F0", "database": "UniProtKB" } ], "name": "CatSper complex", "id": "GO:0036128" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2F0", "id": "A0A0G2K2F0", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2F0", "id": "A0A0G2K2F0", "database": "UniProtKB" } ], "name": "spermatogenesis", "id": "GO:0007283" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007342", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2F0", "id": "A0A0G2K2F0", "database": "UniProtKB" } ], "name": "fusion of sperm to egg plasma membrane involved in single fertilization", "id": "GO:0007342" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006816", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2F0", "id": "A0A0G2K2F0", "database": "UniProtKB" } ], "name": "calcium ion transport", "id": "GO:0006816" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2F0", "id": "A0A0G2K2F0", "database": "UniProtKB" } ], "name": "flagellated sperm motility", "id": "GO:0030317" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051924", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2F0", "id": "A0A0G2K2F0", "database": "UniProtKB" } ], "name": "regulation of calcium ion transport", "id": "GO:0051924" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060296", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2F0", "id": "A0A0G2K2F0", "database": "UniProtKB" } ], "name": "regulation of cilium beat frequency involved in ciliary motility", "id": "GO:0060296" } ], "total": 6, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2F0", "type": "recommended", "resource": "UniProtKB", "name": "Catsper1" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000056208", "id": "ENSRNOG00000056208", "database": "Bgee" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "id": "IPR005821", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027359", "id": "IPR027359", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR028746", "id": "IPR028746", "database": "InterPro" }, { "url": "https://omabrowser.org/oma/group/PEFQDFH/", "id": "PEFQDFH", "database": "OMA" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47193", "id": "PTHR47193", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF00520", "id": "PF00520", "database": "Pfam" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1300642", "id": "R-RNO-1300642", "database": "Reactome" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1593515", "id": "1593515", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K2F0", "id": "A0A0G2K2F0", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [ { "synonyms": [ { "id": "MONDO:0013070", "url": "https://monarchinitiative.org/disease/MONDO:0013070", "resource": "MONDO", "name": "Male infertility, nonsyndromic, autosomal recessive", "description": "" }, { "id": "MONDO:0013070", "url": "https://monarchinitiative.org/disease/MONDO:0013070", "resource": "MONDO", "name": "SPGF7", "description": "" }, { "id": "MONDO:0013070", "url": "https://monarchinitiative.org/disease/MONDO:0013070", "resource": "MONDO", "name": "spermatogenic failure 7; SPGF7", "description": "" }, { "id": "MONDO:0013070", "url": "https://monarchinitiative.org/disease/MONDO:0013070", "resource": "MONDO", "name": "spermatogenic failure type 7", "description": "" }, { "id": "DOID:0070173", "url": "http://disease-ontology.org/term/DOID:0070173", "resource": "Disease Ontology", "name": "SPGF7", "description": "" } ], "recommended_name": { "id": "DOID:0070173", "url": "http://disease-ontology.org/term/DOID:0070173", "resource": "Disease Ontology", "name": "spermatogenic failure 7", "description": "A male infertility characterized by autosomal recessive inheritance of impaired or absent sperm motility and increased incidence of morphologically abnormal sperm that has_material_basis_in mutation in the CATSPER1 gene on chromosome 11q13." }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/0070173#disease-associations", "id": "0070173", "database": "Alliance of Genome Resources" } ] } ], "phosphorylation": [], "mass": { "monoisotopic_mass": 70973.0, "chemical_mass": 70973.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2F0", "name": "Catsper1", "locus": { "end_pos": 220719939, "strand": "+", "start_pos": 220714995, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000056208", "id": "ENSRNOG00000056208", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2F0#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Cation channel, sperm-associated 1" } ] }