{ "uniprot_canonical_ac": "A0A0G2K2D4-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2K2D4-1|A0A0G2K2D4_RAT Isoform 1 of ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 OS=Rattus norvegicus OX=10116 GN=Agap3 PE=3 SV=1 CANONICAL=A0A0G2K2D4-1", "length": 812, "sequence": "MGAQRPYGWVGPGFRFCVWLDIGSPDFHPFLCGLAPSPWPFLGPSILFNLHVPSFLLSPSLRLSSCHLTTALPIPLLQGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNASEVPMVLVGTQDAISAANPRVIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQDVAQKVVALRKKQQLAIGPCKSLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASSTPTPIRKQSKRRSNIFTSRKGADPDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNKEWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPSTAPGTSPRGANGLALERSNTQLGGTTGRPHSASSASLHSERPHRSAWAGSRPEGLHQRSCSISSTDQWSAAAALPASVQRPETEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQSTALAVQTVRTARGNSFCVDCEAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGALDGYSKPGPEACREEKERWIRAKYEQKLFLAPLPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGEGCGLAPTPNREPANGTNPSAELHRSPSIL" }, "uniprot_id": "A0A0G2K2D4_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2D4", "id": "A0A0G2K2D4", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [], "uniprot_ac": "A0A0G2K2D4", "site_annotation": [ { "end_pos": 173, "annotation": "n_glycosylation_sequon", "start_pos": 171 }, { "end_pos": 561, "annotation": "n_glycosylation_sequon", "start_pos": 559 }, { "end_pos": 717, "annotation": "n_glycosylation_sequon", "start_pos": 715 }, { "end_pos": 799, "annotation": "n_glycosylation_sequon", "start_pos": 797 }, { "end_pos": 85, "annotation": "n_glycosylation_sequon", "start_pos": 83 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2D4#A0A0G2JZ83-1", "isoform_ac": "A0A0G2JZ83-1", "locus": { "end_pos": 7203444, "strand": "+", "start_pos": 7253072, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000087120", "id": "ENSRNOT00000087120", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000070947", "id": "ENSRNOP00000070947", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JZ83-1|A0A0G2K2D4_RAT Computationally mapped isoform of ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 OS=Rattus norvegicus OX=10116 GN=Agap3 PE=3 SV=1 CANONICAL=A0A0G2K2D4-1", "length": 808, "sequence": "MNFQAGGGQSPQQQQSLAAPGGGGSGGGGAGGGGQFGGAGPGAGGGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLIERIEDLALQNQIREHVISIEDSFVNSQEWTLSRSVPELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNASEVPMVLVGTQDAISAANPRVIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQDVAQKVVALRKKQQLAIGPCKSLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASSTPTPIRKQSKRRSNIFTSRKGADPDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNKEWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPSTAPGTSPRGANGLALERSNTQLGGTTETEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQSTALAVQTVRTARGNSFCVDCEAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGALDGYSKPGPEACREEKERWIRAKYEQKLFLAPLPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGEGCGLAPTPNREPANGTNPSAELHRSPSIL" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K2D4#A0A0G2K2D4-1", "isoform_ac": "A0A0G2K2D4-1", "locus": { "end_pos": 7203444, "strand": "+", "start_pos": 7229225, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000084777", "id": "ENSRNOT00000084777", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000072199", "id": "ENSRNOP00000072199", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K2D4-1|A0A0G2K2D4_RAT Isoform 1 of ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 OS=Rattus norvegicus OX=10116 GN=Agap3 PE=3 SV=1 CANONICAL=A0A0G2K2D4-1", "length": 812, "sequence": "MGAQRPYGWVGPGFRFCVWLDIGSPDFHPFLCGLAPSPWPFLGPSILFNLHVPSFLLSPSLRLSSCHLTTALPIPLLQGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNASEVPMVLVGTQDAISAANPRVIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQDVAQKVVALRKKQQLAIGPCKSLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASSTPTPIRKQSKRRSNIFTSRKGADPDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNKEWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPSTAPGTSPRGANGLALERSNTQLGGTTGRPHSASSASLHSERPHRSAWAGSRPEGLHQRSCSISSTDQWSAAAALPASVQRPETEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQSTALAVQTVRTARGNSFCVDCEAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGALDGYSKPGPEACREEKERWIRAKYEQKLFLAPLPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGEGCGLAPTPNREPANGTNPSAELHRSPSIL" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K2D4#G3V9Z5-1", "isoform_ac": "G3V9Z5-1", "locus": { "end_pos": 7203444, "strand": "+", "start_pos": 7222370, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000064386", "id": "ENSRNOT00000064386", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000063846", "id": "ENSRNOP00000063846", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|G3V9Z5-1|A0A0G2K2D4_RAT Computationally mapped isoform of ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 OS=Rattus norvegicus OX=10116 GN=Agap3 PE=3 SV=1 CANONICAL=A0A0G2K2D4-1", "length": 538, "sequence": "MVPCSRKGADPDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNKEWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPSTAPGTSPRGANGLALERSNTQLGGTTGRPHSASSASLHSERPHRSAWAGSRPEGLHQRSCSISSTDQWSAAAALPASVQRPASGPAELLSSSPKLEPPPSPRSNRKKQRRKKSTGTPRPDGPNSAAEETEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQSTALAVQTVRTARGNSFCVDCEAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGALDGYSKPGPEACREEKERWIRAKYEQKLFLAPLPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGEGCGLAPTPNREPANGTNPSAELHRSPSIL" } } ], "pathway": [], "function": [], "orthologs": [], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "refseq": {}, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2D4", "id": "A0A0G2K2D4", "database": "UniProtKB" } ], "name": "GTPase activity", "id": "GO:0003924" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2D4", "id": "A0A0G2K2D4", "database": "UniProtKB" } ], "name": "GTPase activator activity", "id": "GO:0005096" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2D4", "id": "A0A0G2K2D4", "database": "UniProtKB" } ], "name": "GTP binding", "id": "GO:0005525" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031593", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2D4", "id": "A0A0G2K2D4", "database": "UniProtKB" } ], "name": "polyubiquitin modification-dependent protein binding", "id": "GO:0031593" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2D4", "id": "A0A0G2K2D4", "database": "UniProtKB" } ], "name": "metal ion binding", "id": "GO:0046872" } ], "total": 5, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2D4", "id": "A0A0G2K2D4", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2D4", "id": "A0A0G2K2D4", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2D4", "id": "A0A0G2K2D4", "database": "UniProtKB" } ], "name": "membrane", "id": "GO:0016020" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071944", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2D4", "id": "A0A0G2K2D4", "database": "UniProtKB" } ], "name": "cell periphery", "id": "GO:0071944" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2D4", "id": "A0A0G2K2D4", "database": "UniProtKB" } ], "name": "signal transduction", "id": "GO:0007165" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2D4", "id": "A0A0G2K2D4", "database": "UniProtKB" } ], "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034614", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2D4", "id": "A0A0G2K2D4", "database": "UniProtKB" } ], "name": "cellular response to reactive oxygen species", "id": "GO:0034614" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006606", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2D4", "id": "A0A0G2K2D4", "database": "UniProtKB" } ], "name": "protein import into nucleus", "id": "GO:0006606" } ], "total": 4, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2D4", "type": "recommended", "resource": "UniProtKB", "name": "Agap3" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000012764", "id": "ENSRNOG00000012764", "database": "Bgee" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001164", "id": "IPR001164", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001806", "id": "IPR001806", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "id": "IPR001849", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "id": "IPR002110", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR020683", "id": "IPR020683", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR020849", "id": "IPR020849", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "id": "IPR027417", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "id": "IPR036770", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR037278", "id": "IPR037278", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR038508", "id": "IPR038508", "database": "InterPro" }, { "url": "https://omabrowser.org/oma/group/NMSEVPK/", "id": "NMSEVPK", "database": "OMA" }, { "url": "http://pfam.xfam.org/family/PF00071", "id": "PF00071", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF01412", "id": "PF01412", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF12796", "id": "PF12796", "database": "Pfam" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310751", "id": "1310751", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K2D4", "id": "A0A0G2K2D4", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 88358.0, "chemical_mass": 88358.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2D4", "name": "Agap3", "locus": { "end_pos": 7202330, "strand": "-", "start_pos": 7253072, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000012764", "id": "ENSRNOG00000012764", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2D4#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "ArfGAP with GTPase domain, ankyrin repeat and PH domain 3" } ] }