{ "uniprot_canonical_ac": "A0A0G2K2C0-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2K2C0-1|A0A0G2K2C0_RAT Isoform 1 of SIX homeobox 3 OS=Rattus norvegicus OX=10116 GN=Six3 PE=3 SV=1 CANONICAL=A0A0G2K2C0-1", "length": 336, "sequence": "MVFGXPLDLYSSHFLLLPSPILTTAPYFWRVAAGSGAGGGGGAGGGGGGGGGNRAGGGGAGGAGGGGGGGGGGSRAPPEELSMFQLPTLNFSPEQVASVCETLEETGDIERLGRFLWSLPVAPGACEAINKHESILRARAVVAFHTGNFRDLYHILENHKFTKESHGKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQHQAIGPSGMRSLAEPGCPTHGSAESPSTAASPTTSVSSLTERADTGTSILSVTSSDSECDV" }, "uniprot_id": "A0A0G2K2C0_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [], "uniprot_ac": "A0A0G2K2C0", "site_annotation": [ { "end_pos": 92, "annotation": "n_glycosylation_sequon", "start_pos": 90 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0#A0A0G2JWI0-1", "isoform_ac": "A0A0G2JWI0-1", "locus": { "end_pos": 8886591, "strand": "-", "start_pos": 8889728, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000091510", "id": "ENSRNOT00000091510", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000069889", "id": "ENSRNOP00000069889", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JWI0-1|A0A0G2K2C0_RAT Computationally mapped isoform of SIX homeobox 3 OS=Rattus norvegicus OX=10116 GN=Six3 PE=3 SV=1 CANONICAL=A0A0G2K2C0-1", "length": 335, "sequence": "VIVXPLDLYSSHFLLTFADSHHCSLLLASSGGGSGAGGGGGAGGGGGGGGGNRAGGGGAGGAGGGGGGGGGGSRAPPEELSMFQLPTLNFSPEQVASVCETLEETGDIERLGRFLWSLPVAPGACEAINKHESILRARAVVAFHTGNFRDLYHILENHKFTKESHGKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQHQAIGPSGMRSLAEPGCPTHGSAESPSTAASPTTSVSSLTERADTGTSILSVTSSDSECDV" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0#A0A0G2K2C0-1", "isoform_ac": "A0A0G2K2C0-1", "locus": { "end_pos": 8887075, "strand": "-", "start_pos": 8889728, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000089174", "id": "ENSRNOT00000089174", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000072181", "id": "ENSRNOP00000072181", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K2C0-1|A0A0G2K2C0_RAT Isoform 1 of SIX homeobox 3 OS=Rattus norvegicus OX=10116 GN=Six3 PE=3 SV=1 CANONICAL=A0A0G2K2C0-1", "length": 336, "sequence": "MVFGXPLDLYSSHFLLLPSPILTTAPYFWRVAAGSGAGGGGGAGGGGGGGGGNRAGGGGAGGAGGGGGGGGGGSRAPPEELSMFQLPTLNFSPEQVASVCETLEETGDIERLGRFLWSLPVAPGACEAINKHESILRARAVVAFHTGNFRDLYHILENHKFTKESHGKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQHQAIGPSGMRSLAEPGCPTHGSAESPSTAASPTTSVSSLTERADTGTSILSVTSSDSECDV" } } ], "pathway": [], "function": [], "orthologs": [ { "uniprot_canonical_ac": "O95343-1", "protein_name": "Homeobox protein SIX3", "sequence": { "length": 332, "sequence": "MVFRSPLDLYSSHFLLPNFADSHHRSILLASSGGGNGAGGGGGAGGGSGGGNGAGGGGAGGAGGGGGGGSRAPPEELSMFQLPTLNFSPEQVASVCETLEETGDIERLGRFLWSLPVAPGACEAINKHESILRARAVVAFHTGNFRDLYHILENHKFTKESHGKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQHQAIGPSGMRSLAEPGCPTHGSAESPSTAASPTTSVSSLTERADTGTSILSVTSSDSECDV" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2K2C0/", "id": "A0A0G2K2C0", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "SIX3", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q62233-1", "protein_name": "Homeobox protein SIX3", "sequence": { "length": 333, "sequence": "MVFRSPLDLYSSHFLLPNFADSHHCSLLLASSGGGSGASGGGGGAGGGGGGNRAGGGGAGGAGGGSGGGGSRAPPEELSMFQLPTLNFSPEQVASVCETLEETGDIERLGRFLWSLPVAPGACEAINKHESILRARAVVAFHTGNFRDLYHILENHKFTKESHGKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQHQAIGPSGMRSLAEPGCPTHGSAESPSTAASPTTSVSSLTERADTGTSILSVTSSDSECDV" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2K2C0/", "id": "A0A0G2K2C0", "database": "OMA" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Six3", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": {}, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "pmid": "12493766", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "signaling receptor binding", "id": "GO:0005102" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "transcription regulatory region sequence-specific DNA binding", "id": "GO:0000976" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "DNA binding", "id": "GO:0003677" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042826", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "histone deacetylase binding", "id": "GO:0042826" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "sequence-specific DNA binding", "id": "GO:0043565" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001222", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "transcription corepressor binding", "id": "GO:0001222" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837" } ], "total": 10, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "transcription regulator complex", "id": "GO:0005667" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "pmid": "12493766", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "negative regulation of transcription, DNA-templated", "id": "GO:0045892" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048856", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "anatomical structure development", "id": "GO:0048856" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014016", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "neuroblast differentiation", "id": "GO:0014016" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030878", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "thyroid gland development", "id": "GO:0030878" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990086", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "lens fiber cell apoptotic process", "id": "GO:1990086" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061074", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "regulation of neural retina development", "id": "GO:0061074" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021536", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "diencephalon development", "id": "GO:0021536" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042127", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "regulation of cell population proliferation", "id": "GO:0042127" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045665", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "negative regulation of neuron differentiation", "id": "GO:0045665" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035264", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "multicellular organism growth", "id": "GO:0035264" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "brain development", "id": "GO:0007420" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021983", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "pituitary gland development", "id": "GO:0021983" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003404", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "optic vesicle morphogenesis", "id": "GO:0003404" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030178", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "negative regulation of Wnt signaling pathway", "id": "GO:0030178" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021846", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "cell proliferation in forebrain", "id": "GO:0021846" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021798", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "forebrain dorsal/ventral pattern formation", "id": "GO:0021798" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002070", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "epithelial cell maturation", "id": "GO:0002070" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009946", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "proximal/distal axis specification", "id": "GO:0009946" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097402", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "neuroblast migration", "id": "GO:0097402" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901987", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "regulation of cell cycle phase transition", "id": "GO:1901987" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001654", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "eye development", "id": "GO:0001654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043010", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "camera-type eye development", "id": "GO:0043010" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021537", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "telencephalon development", "id": "GO:0021537" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021978", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "telencephalon regionalization", "id": "GO:0021978" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060235", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "lens induction in camera-type eye", "id": "GO:0060235" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002088", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "lens development in camera-type eye", "id": "GO:0002088" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021797", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "forebrain anterior/posterior pattern specification", "id": "GO:0021797" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048512", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "circadian behavior", "id": "GO:0048512" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008406", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "gonad development", "id": "GO:0008406" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006606", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "protein import into nucleus", "id": "GO:0006606" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070306", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "lens fiber cell differentiation", "id": "GO:0070306" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000177", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "regulation of neural precursor cell proliferation", "id": "GO:2000177" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902692", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "regulation of neuroblast proliferation", "id": "GO:1902692" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902742", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "id": "A0A0G2K2C0", "database": "UniProtKB" } ], "name": "apoptotic process involved in development", "id": "GO:1902742" } ], "total": 35, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2C0", "type": "recommended", "resource": "UniProtKB", "name": "Six3" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000057031", "id": "ENSRNOG00000057031", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "id": "cd00086", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "id": "IPR001356", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "id": "IPR009057", "database": "InterPro" }, { "url": 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