{
    "uniprot_canonical_ac": "A0A0G2K142-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "tr|A0A0G2K142-1|A0A0G2K142_RAT Isoform 1 of Transglutaminase 5  OS=Rattus norvegicus OX=10116 GN=Tgm5 PE=4 SV=1 CANONICAL=A0A0G2K142-1", 
        "length": 611, 
        "sequence": "MAAVGRYLLKVRIDSYQGSVTAYQLGEFILLFNPWCPADTVYLESEPQRQEYVVNDYGFIYQGSKSWIRPCPWNYGQFEENIIDICLELLEKSLNFQVDPSTDCALRGSPVYISRVVCAMINSNDDSGVLNGNWSENYMDGANPAEWTGSVAILKQWHATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRILENMKKDTVWNFHVWNECWMARKDLPPGYGGWQVLDATPQETSNGLYCCGPASVKAIKEGEVDLNYDTRFAFSMVNADCMSWLVYGGKEQKLHQDTATVGNFISTKSIQSDERDDVTENYKYEEGSLQERQVFLKALQKLQAGRSQGPHQANSNPFSSMPPRQDSARSPTTPSLRPSDVLQVSLKFELLDSPKMGQDINFVLLAVNMSPQFKDLKLNLSAQSLLHDGSPLAPFWQDTAFITLFPKEEKTYPCKILYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLTFPGIMINVLGAAFVNQPLTVQVVFSNPLSEPVEDCVLTLEGSGLFRKQQRVLIGVLKPHNKASITLKTVPFKSGQRQIQANLRSNRFKDIKGYKNVYVDIGL"
    }, 
    "uniprot_id": "A0A0G2K142_RAT", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Rat", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0G2K142", 
                    "id": "A0A0G2K142", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "publication": [], 
    "uniprot_ac": "A0A0G2K142", 
    "site_annotation": [
        {
            "end_pos": 135, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 133
        }, 
        {
            "end_pos": 424, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 422
        }, 
        {
            "end_pos": 435, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 433
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2K142#A0A0G2K142-1", 
            "isoform_ac": "A0A0G2K142-1", 
            "locus": {
                "end_pos": 112995762, 
                "strand": "+", 
                "start_pos": 113023431, 
                "chromosome": "3", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000084921", 
                        "id": "ENSRNOT00000084921", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000071692", 
                        "id": "ENSRNOP00000071692", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A0G2K142-1|A0A0G2K142_RAT Isoform 1 of Transglutaminase 5  OS=Rattus norvegicus OX=10116 GN=Tgm5 PE=4 SV=1 CANONICAL=A0A0G2K142-1", 
                "length": 611, 
                "sequence": "MAAVGRYLLKVRIDSYQGSVTAYQLGEFILLFNPWCPADTVYLESEPQRQEYVVNDYGFIYQGSKSWIRPCPWNYGQFEENIIDICLELLEKSLNFQVDPSTDCALRGSPVYISRVVCAMINSNDDSGVLNGNWSENYMDGANPAEWTGSVAILKQWHATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRILENMKKDTVWNFHVWNECWMARKDLPPGYGGWQVLDATPQETSNGLYCCGPASVKAIKEGEVDLNYDTRFAFSMVNADCMSWLVYGGKEQKLHQDTATVGNFISTKSIQSDERDDVTENYKYEEGSLQERQVFLKALQKLQAGRSQGPHQANSNPFSSMPPRQDSARSPTTPSLRPSDVLQVSLKFELLDSPKMGQDINFVLLAVNMSPQFKDLKLNLSAQSLLHDGSPLAPFWQDTAFITLFPKEEKTYPCKILYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLTFPGIMINVLGAAFVNQPLTVQVVFSNPLSEPVEDCVLTLEGSGLFRKQQRVLIGVLKPHNKASITLKTVPFKSGQRQIQANLRSNRFKDIKGYKNVYVDIGL"
            }
        }
    ], 
    "pathway": [], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q9D7I9-1", 
            "protein_name": "Protein-glutamine gamma-glutamyltransferase 5", 
            "sequence": {
                "length": 724, 
                "sequence": "MAQGCPITGLEVALTDLQSSQNNVRHHTEEISVDRLVVRRGQAFSITLYFKNRGFQPGMDSIMFVAETGPLPDLAKGTRAVFSFTGSGGPSPWIASLEANRANSLEVSLCAPPIAAVGRYLLKIRIDSYQGFVTAYQLGEFILLFNPWCPADSVYLESEPQRQEYVVNDYGFIYQGSKSWIRPCPWNYGQFEENIIDICLELLEKSLNFQVDPSTDCALRGSPVYTSRVVCAMINSNDDNGVLNGNWSENYVDGINPAEWTGSVAILKQWHATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRILENMKKDTVWNFHVWNECWMARKDLPPGYGGWQVLDATPQETSNGLYCCGPASVKAIKEGEIDLNYDTRFAFSMVNADCMSWLVYGGKEQKLHQDTATVGNFISTKSIQSDERDDITESYKYEEGSLQEREVFLKALQKLQATRSQGPHQANSNPFSSVPPRHNSARSPDSPSLQPSDVLQVSLKFELLDSPKMGQDINFVLLAVNMSPQFKDLKLNLSAQSLLHDGSPLVPFWQDTAFITLFPEEEKSYPCKILYSQYSQYLSTDKLIRISALGEEKNSPEKILVNKIITLTFPGIMINVLGAAFVNQPLTVQVVFSNPLSEPVEDCVLTLEGSGLFRKQQRVLIGVLKPHHKASITLKTVPFKSGQRQIQANLRSNRFKDIKGYKNVYVDIGL"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A0A0G2K142/", 
                    "id": "A0A0G2K142", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Mouse", 
            "organism": "Mus musculus", 
            "gene_name": "Tgm5", 
            "tax_id": 10090
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }
    ], 
    "refseq": {}, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003810", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K142", 
                                "id": "A0A0G2K142", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein-glutamine gamma-glutamyltransferase activity", 
                        "id": "GO:0003810"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K142", 
                                "id": "A0A0G2K142", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "metal ion binding", 
                        "id": "GO:0046872"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018149", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K142", 
                                "id": "A0A0G2K142", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "peptide cross-linking", 
                        "id": "GO:0018149"
                    }
                ], 
                "total": 1, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2K142", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Tgm5"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2K142", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Tgm7l1"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000058755", 
            "id": "ENSRNOG00000058755", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002931", 
            "id": "IPR002931", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008958", 
            "id": "IPR008958", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", 
            "id": "IPR013783", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013808", 
            "id": "IPR013808", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", 
            "id": "IPR014756", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR023608", 
            "id": "IPR023608", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036238", 
            "id": "IPR036238", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036985", 
            "id": "IPR036985", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR038765", 
            "id": "IPR038765", 
            "database": "InterPro"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/RSSWNNV/", 
            "id": "RSSWNNV", 
            "database": "OMA"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00927", 
            "id": "PF00927", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF01841", 
            "id": "PF01841", 
            "database": "Pfam"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1593350", 
            "id": "1593350", 
            "database": "RGD"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2K142", 
            "id": "A0A0G2K142", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [
        {
            "synonyms": [
                {
                    "id": "MONDO:0024548", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0024548", 
                    "resource": "MONDO", 
                    "name": "peeling skin syndrome 1", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0024548", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0024548", 
                    "resource": "MONDO", 
                    "name": "deciduous skin", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0024548", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0024548", 
                    "resource": "MONDO", 
                    "name": "CDSN peeling skin syndrome", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0024548", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0024548", 
                    "resource": "MONDO", 
                    "name": "skin peeling, familial continuous generalized", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0024548", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0024548", 
                    "resource": "MONDO", 
                    "name": "PSS1", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0024548", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0024548", 
                    "resource": "MONDO", 
                    "name": "peeling skin syndrome 1; PSS1", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0024548", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0024548", 
                    "resource": "MONDO", 
                    "name": "PSS", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0024548", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0024548", 
                    "resource": "MONDO", 
                    "name": "peeling skin syndrome caused by mutation in CDSN", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0024548", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0024548", 
                    "resource": "MONDO", 
                    "name": "keratolysis exfoliativa congenita", 
                    "description": ""
                }
            ], 
            "recommended_name": {
                "id": "DOID:0060283", 
                "url": "http://disease-ontology.org/term/DOID:0060283", 
                "resource": "Disease Ontology", 
                "name": "peeling skin syndrome", 
                "description": "A skin disease that is characterized by the painless peeling of the top layer of skin predominately on the hands and feet, has_material_basis_in autosomal recessive inheritance of mutation in the TGM5 gene and/pr CSTA gene."
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/0060283#disease-associations", 
                    "id": "0060283", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }
    ], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 68771.0, 
        "chemical_mass": 68771.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2K142", 
            "name": "Tgm5", 
            "locus": {
                "end_pos": 112995568, 
                "strand": "-", 
                "start_pos": 113023532, 
                "chromosome": "3", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000058755", 
                        "id": "ENSRNOG00000058755", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2K142#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Transglutaminase 5"
        }
    ]
}