{
    "uniprot_canonical_ac": "A0A0G2JZL2-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "tr|A0A0G2JZL2-1|A0A0G2JZL2_RAT Isoform 1 of Alkaline phosphatase  OS=Rattus norvegicus OX=10116 GN=Akp3 PE=3 SV=1 CANONICAL=A0A0G2JZL2-1", 
        "length": 558, 
        "sequence": "MQGAWVLLLLGFRLQLSLSVIPVEEENPAFWNQKAADALNVAKKLQPIQTSAKNLIIFLGDGMGVPTVTATRILKGQLEGNLGPETPLAMDHFPYMALSKTYSVDRQVPDSASTATAYLCGVKTNYKTIGVSAAARFDQCNTTFGNEVLSVMYRAKKAGKSVGVVTTTRVQHASPAGTYVHTVNRNWYGDADMPASALQEGCKDIATQLVSNMDINVILGGGRKYMFPAGTPDPEYPNDVNETGTRLDGKNLVQEWLSKHQGSQYVWNRQELIQKSLDPSVTYLMGLFEPVDTKFEIQRDPLMDPSLKDMTEAALHVLSRNPKGFYLFVEGGRIDRGHHLGTAYLALTEAVMFDSAIERASQLTSEQDTLTIVTADHSHVFSFGGYTLRGTSIFGLAPLNALDGKPYTSILYGNGPGYVGTGERPNVTDAESHDPSYQQQAAVPVKSETHGGEDVAIFARGPQAHLLHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPADENRPTTPVQNSTTTTTTTTTTTTTRVQNSASSLGPATGPLALALLAKALMLLLGAPADF"
    }, 
    "uniprot_id": "A0A0G2JZL2_RAT", 
    "enzyme_annotation": [
        {
            "ec": "3.1.3.1", 
            "activity": ""
        }, 
        {
            "ec": "3.1.3.1", 
            "activity": "A phosphate monoester + H(2)O = an alcohol + phosphate."
        }
    ], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Rat", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0G2JZL2", 
                    "id": "A0A0G2JZL2", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "publication": [], 
    "uniprot_ac": "A0A0G2JZL2", 
    "site_annotation": [
        {
            "end_pos": 143, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 141
        }, 
        {
            "end_pos": 243, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 241
        }, 
        {
            "end_pos": 428, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 426
        }, 
        {
            "end_pos": 511, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 509
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JZL2#A0A0G2JWW9-1", 
            "isoform_ac": "A0A0G2JWW9-1", 
            "locus": {
                "end_pos": 94228960, 
                "strand": "-", 
                "start_pos": 94231966, 
                "chromosome": "9", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000083137", 
                        "id": "ENSRNOT00000083137", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000070046", 
                        "id": "ENSRNOP00000070046", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A0G2JWW9-1|A0A0G2JZL2_RAT Computationally mapped isoform of Alkaline phosphatase  OS=Rattus norvegicus OX=10116 GN=Akp3 PE=3 SV=1 CANONICAL=A0A0G2JZL2-1", 
                "length": 547, 
                "sequence": "MQGAWVLLLLGFRLQLSLSVIPVEEENPAFWNQKAADALNVAKKLQPIQTSAKNLIIFLGDGMGVPTVTATRILKGQLEGNLGPETPLAMDHFPYMALSKTYSVDRQVPDSASTATAYLCGVKTNYKTIGVSAAARFDQCNTTFGNEVLSVMYRAKKAGKSVGVVTTTRVQHASPAGTYVHTVNRNWYGDADMPASALQEGCKDIATQLVSNMDINVILGGGRKYMFPAGTPDPEYPNDVNETGTRLDGKNLVQEWLSKHQGSQYVWNRQELIQKSLDPSVTYLMGLFEPVDTKFEIQRDPLMDPSLKDMTEAALHVLSRNPKGFYLFVEGGRIDRGHHLGTAYLALTEAVMFDSAIERASQLTSEQDTLTIVTADHSHVFSFGGYTLRGTSIFGLAPLNALDGKPYTSILYGNGPGYVGTGERPNVTDAESHDPSYQQQAAVPVKSETHGGEDVAIFARGPQAHLLHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPADENRPTTPVQNSTTTTTTTTTTTTTRVQNSASSLGPATGPLAWHYWPRR"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JZL2#A0A0G2JZL2-1", 
            "isoform_ac": "A0A0G2JZL2-1", 
            "locus": {
                "end_pos": 94228960, 
                "strand": "-", 
                "start_pos": 94231998, 
                "chromosome": "9", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000080897", 
                        "id": "ENSRNOT00000080897", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000071091", 
                        "id": "ENSRNOP00000071091", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A0G2JZL2-1|A0A0G2JZL2_RAT Isoform 1 of Alkaline phosphatase  OS=Rattus norvegicus OX=10116 GN=Akp3 PE=3 SV=1 CANONICAL=A0A0G2JZL2-1", 
                "length": 558, 
                "sequence": "MQGAWVLLLLGFRLQLSLSVIPVEEENPAFWNQKAADALNVAKKLQPIQTSAKNLIIFLGDGMGVPTVTATRILKGQLEGNLGPETPLAMDHFPYMALSKTYSVDRQVPDSASTATAYLCGVKTNYKTIGVSAAARFDQCNTTFGNEVLSVMYRAKKAGKSVGVVTTTRVQHASPAGTYVHTVNRNWYGDADMPASALQEGCKDIATQLVSNMDINVILGGGRKYMFPAGTPDPEYPNDVNETGTRLDGKNLVQEWLSKHQGSQYVWNRQELIQKSLDPSVTYLMGLFEPVDTKFEIQRDPLMDPSLKDMTEAALHVLSRNPKGFYLFVEGGRIDRGHHLGTAYLALTEAVMFDSAIERASQLTSEQDTLTIVTADHSHVFSFGGYTLRGTSIFGLAPLNALDGKPYTSILYGNGPGYVGTGERPNVTDAESHDPSYQQQAAVPVKSETHGGEDVAIFARGPQAHLLHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPADENRPTTPVQNSTTTTTTTTTTTTTRVQNSASSLGPATGPLALALLAKALMLLLGAPADF"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-163125", 
            "resource": "Reactome", 
            "id": "R-RNO-163125", 
            "name": "Post-translational modification: synthesis of GPI-anchored proteins"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6811438", 
            "resource": "Reactome", 
            "id": "R-RNO-6811438", 
            "name": "Intra-Golgi traffic"
        }
    ], 
    "function": [], 
    "orthologs": [], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb", 
            "label": "Isoforms"
        }
    ], 
    "refseq": {}, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004035", 
                        "pmid": "15885097", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JZL2", 
                                "id": "A0A0G2JZL2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "alkaline phosphatase activity", 
                        "id": "GO:0004035"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", 
                        "pmid": "15885097", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JZL2", 
                                "id": "A0A0G2JZL2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "magnesium ion binding", 
                        "id": "GO:0000287"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", 
                        "pmid": "15885097", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JZL2", 
                                "id": "A0A0G2JZL2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "zinc ion binding", 
                        "id": "GO:0008270"
                    }
                ], 
                "total": 3, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JZL2", 
                                "id": "A0A0G2JZL2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "plasma membrane", 
                        "id": "GO:0005886"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", 
                        "pmid": "7744844", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JZL2", 
                                "id": "A0A0G2JZL2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "external side of plasma membrane", 
                        "id": "GO:0009897"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031225", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JZL2", 
                                "id": "A0A0G2JZL2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "anchored component of membrane", 
                        "id": "GO:0031225"
                    }
                ], 
                "total": 3, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016311", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JZL2", 
                                "id": "A0A0G2JZL2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "dephosphorylation", 
                        "id": "GO:0016311"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031667", 
                        "pmid": "9021713", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JZL2", 
                                "id": "A0A0G2JZL2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "response to nutrient levels", 
                        "id": "GO:0031667"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006793", 
                        "pmid": "15885097", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JZL2", 
                                "id": "A0A0G2JZL2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "phosphorus metabolic process", 
                        "id": "GO:0006793"
                    }
                ], 
                "total": 3, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JZL2", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Akp3"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JZL2", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Alpi2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JZL2", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "rCG_24008"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000058652", 
            "id": "ENSRNOG00000058652", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16012", 
            "id": "cd16012", 
            "database": "CDD"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001952", 
            "id": "IPR001952", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017850", 
            "id": "IPR017850", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018299", 
            "id": "IPR018299", 
            "database": "InterPro"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/PERGWEN/", 
            "id": "PERGWEN", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11596", 
            "id": "PTHR11596", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00245", 
            "id": "PF00245", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-163125", 
            "id": "R-RNO-163125", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6811438", 
            "id": "R-RNO-6811438", 
            "database": "Reactome"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=621650", 
            "id": "621650", 
            "database": "RGD"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JZL2", 
            "id": "A0A0G2JZL2", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [
        {
            "synonyms": [
                {
                    "id": "MONDO:0009960", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960", 
                    "resource": "MONDO", 
                    "name": "inflammatory bowel disease 1", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0009960", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960", 
                    "resource": "MONDO", 
                    "name": "Crohn disease-associated Growth failure, susceptibility to", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0009960", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960", 
                    "resource": "MONDO", 
                    "name": "inflammatory bowel disease caused by mutation in NOD2", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0009960", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960", 
                    "resource": "MONDO", 
                    "name": "regional enteritis", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0009960", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960", 
                    "resource": "MONDO", 
                    "name": "NOD2 inflammatory bowel disease", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0009960", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960", 
                    "resource": "MONDO", 
                    "name": "pediatric ulcerative colitis", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0009960", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960", 
                    "resource": "MONDO", 
                    "name": "inflammatory bowel disease (Crohn disease) 1", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0009960", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960", 
                    "resource": "MONDO", 
                    "name": "inflammatory bowel disease type 1", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0009960", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960", 
                    "resource": "MONDO", 
                    "name": "inflammatory bowel disease 1; IBD1", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0009960", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960", 
                    "resource": "MONDO", 
                    "name": "IBD1", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0009960", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960", 
                    "resource": "MONDO", 
                    "name": "inflammatory bowel disease (Crohn disease) 1; IBD1", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0009960", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960", 
                    "resource": "MONDO", 
                    "name": "ulcerative colitis, pediatric", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0009960", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960", 
                    "resource": "MONDO", 
                    "name": "Crohn disease", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0009960", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960", 
                    "resource": "MONDO", 
                    "name": "ulcerative colitis", 
                    "description": ""
                }
            ], 
            "recommended_name": {
                "id": "DOID:0050589", 
                "url": "http://disease-ontology.org/term/DOID:0050589", 
                "resource": "Disease Ontology", 
                "name": "inflammatory bowel disease", 
                "description": "An intestinal disease characterized by inflammation located in all parts of digestive tract."
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/0050589#disease-associations", 
                    "id": "0050589", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
            "synonyms": [
                {
                    "id": "DOID:8577", 
                    "url": "http://disease-ontology.org/term/DOID:8577", 
                    "resource": "Disease Ontology", 
                    "name": "Left-sided ulcerative colitis", 
                    "description": ""
                }
            ], 
            "recommended_name": {
                "id": "DOID:8577", 
                "url": "http://disease-ontology.org/term/DOID:8577", 
                "resource": "Disease Ontology", 
                "name": "ulcerative colitis", 
                "description": "A colitis that is predominantly confined to the mucosa located_in colon and includes characteristic ulcers, or open sores."
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/8577#disease-associations", 
                    "id": "8577", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
            "synonyms": [
                {
                    "id": "DOID:8778", 
                    "url": "http://disease-ontology.org/term/DOID:8778", 
                    "resource": "Disease Ontology", 
                    "name": "Crohn disease", 
                    "description": ""
                }, 
                {
                    "id": "DOID:8778", 
                    "url": "http://disease-ontology.org/term/DOID:8778", 
                    "resource": "Disease Ontology", 
                    "name": "Crohn's disease of colon", 
                    "description": ""
                }, 
                {
                    "id": "DOID:8778", 
                    "url": "http://disease-ontology.org/term/DOID:8778", 
                    "resource": "Disease Ontology", 
                    "name": "Crohn's disease of large bowel", 
                    "description": ""
                }, 
                {
                    "id": "DOID:8778", 
                    "url": "http://disease-ontology.org/term/DOID:8778", 
                    "resource": "Disease Ontology", 
                    "name": "Granulomatous Colitis", 
                    "description": ""
                }, 
                {
                    "id": "DOID:8778", 
                    "url": "http://disease-ontology.org/term/DOID:8778", 
                    "resource": "Disease Ontology", 
                    "name": "Pediatric Crohn's disease", 
                    "description": ""
                }
            ], 
            "recommended_name": {
                "id": "DOID:8778", 
                "url": "http://disease-ontology.org/term/DOID:8778", 
                "resource": "Disease Ontology", 
                "name": "Crohn's disease", 
                "description": "An intestinal disease that involves inflammation located_in intestine."
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/8778#disease-associations", 
                    "id": "8778", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }
    ], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 60192.0, 
        "chemical_mass": 60192.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JZL2", 
            "name": "Akp3", 
            "locus": {
                "end_pos": 94232001, 
                "strand": "+", 
                "start_pos": 94228960, 
                "chromosome": "9", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000058652", 
                        "id": "ENSRNOG00000058652", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JZL2#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "3.1.3.1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JZL2#names_and_taxonomy", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Alkaline phosphatase"
        }
    ]
}
