{ "uniprot_canonical_ac": "A0A0G2JWF7-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2JWF7-1|A0A0G2JWF7_RAT Isoform 1 of MORC family CW-type zinc finger 2 OS=Rattus norvegicus OX=10116 GN=Morc2 PE=1 SV=1 CANONICAL=A0A0G2JWF7-1", "length": 1031, "sequence": "MAFTNYSSLNRAQLTFEYLHTNSTTHEFLFGALAELVDNARDADATRIDIYAERREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTPESTQIGQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGIDEVIVPLPTWNARTREPITDNVEKFAIETELVYKYSPFHTEEQVMNQFMKIPGNSGTLVIIFNLKLMDNGEPELDIISNPKDIQMAETSPEGTKPERRSFRAYAAVLYIDPRMRIFIHGHKVQTKRLSCCLYKPRMYKYTSSRFKTRAEQEVKKAEHVARIAEEKAREAESKARTLEVRMGGDLTRDSRVMLRQVQNAAITLRREADVKKRIKDAKQRALKEPKELNFVFGVNIEHRDLDGMFIYNCSRLIKMYEKVGPQLEGGMACGGVVGVVDVPYLVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYWKDIAIAQRGIIKFWDEFGYLSANWNQPPSSELRFKRRRAMEIPTTIQCDLCLKWRTLPFQLSSVEKDYPDTWVCSMNPDPEQDRCEASEQKQKVPLGTLKKDPKSQEEKQKQLTEKIRQQQEKLEALQKTTPIRSQADLKKLPLEVTTRPSTEEPVRRPQRPRSPPLPAVIKNAPSRPPSIQTPRPATQLRKTSVISSPKPPATAARGETSTSRILQPAEAPRKPANLPIKTVPRPTPTVQTPSPSLIPNSKNLREVPAQKAIKTPMVKKPEPPAKQSMASSGRKRSLVVSDEEEAEEEAEKRKERCKRGKLAVKEEKKEANELSDSAGEDDPAELKKAQKDKGLHVEVRVNREWYTGRVTAVEMGKNVVRWKVKFDYVPTDTTPRDRWVEKGSEDVRLMKPPSPEHQSPDTQQEGGEEEEAMVAQQAVALPEPSTSDGLPIEPDTTATSTSHETIDLLVQILRNCLRYFLPPSFPISKKELSVMNSEELISFPLKEYFKQYEVGLQNLCHSYQSRADSRAKASEESLRTSEKKLRETEEKLQKLRTNIVALLQKVQEDIDINTDDELDAYIEDLITKGD" }, "uniprot_id": "A0A0G2JWF7_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWF7", "id": "A0A0G2JWF7", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "type": [ "PubMed" ], "id": "22673903" } ], "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWF7", "id": "A0A0G2JWF7", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012" } ], "uniprot_ac": "A0A0G2JWF7", "site_annotation": [ { "end_pos": 24, "annotation": "n_glycosylation_sequon", "start_pos": 22 }, { "end_pos": 388, "annotation": "n_glycosylation_sequon", "start_pos": 386 }, { "end_pos": 7, "annotation": "n_glycosylation_sequon", "start_pos": 5 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWF7#A0A0G2JWF7-1", "isoform_ac": "A0A0G2JWF7-1", "locus": { "end_pos": 83889160, "strand": "-", "start_pos": 83928895, "chromosome": "14", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000078980", "id": "ENSRNOT00000078980", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000069862", "id": "ENSRNOP00000069862", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JWF7-1|A0A0G2JWF7_RAT Isoform 1 of MORC family CW-type zinc finger 2 OS=Rattus norvegicus OX=10116 GN=Morc2 PE=1 SV=1 CANONICAL=A0A0G2JWF7-1", "length": 1031, "sequence": "MAFTNYSSLNRAQLTFEYLHTNSTTHEFLFGALAELVDNARDADATRIDIYAERREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTPESTQIGQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGIDEVIVPLPTWNARTREPITDNVEKFAIETELVYKYSPFHTEEQVMNQFMKIPGNSGTLVIIFNLKLMDNGEPELDIISNPKDIQMAETSPEGTKPERRSFRAYAAVLYIDPRMRIFIHGHKVQTKRLSCCLYKPRMYKYTSSRFKTRAEQEVKKAEHVARIAEEKAREAESKARTLEVRMGGDLTRDSRVMLRQVQNAAITLRREADVKKRIKDAKQRALKEPKELNFVFGVNIEHRDLDGMFIYNCSRLIKMYEKVGPQLEGGMACGGVVGVVDVPYLVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYWKDIAIAQRGIIKFWDEFGYLSANWNQPPSSELRFKRRRAMEIPTTIQCDLCLKWRTLPFQLSSVEKDYPDTWVCSMNPDPEQDRCEASEQKQKVPLGTLKKDPKSQEEKQKQLTEKIRQQQEKLEALQKTTPIRSQADLKKLPLEVTTRPSTEEPVRRPQRPRSPPLPAVIKNAPSRPPSIQTPRPATQLRKTSVISSPKPPATAARGETSTSRILQPAEAPRKPANLPIKTVPRPTPTVQTPSPSLIPNSKNLREVPAQKAIKTPMVKKPEPPAKQSMASSGRKRSLVVSDEEEAEEEAEKRKERCKRGKLAVKEEKKEANELSDSAGEDDPAELKKAQKDKGLHVEVRVNREWYTGRVTAVEMGKNVVRWKVKFDYVPTDTTPRDRWVEKGSEDVRLMKPPSPEHQSPDTQQEGGEEEEAMVAQQAVALPEPSTSDGLPIEPDTTATSTSHETIDLLVQILRNCLRYFLPPSFPISKKELSVMNSEELISFPLKEYFKQYEVGLQNLCHSYQSRADSRAKASEESLRTSEKKLRETEEKLQKLRTNIVALLQKVQEDIDINTDDELDAYIEDLITKGD" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JWF7#D4A2C4-1", "isoform_ac": "D4A2C4-1", "locus": { "end_pos": 83897144, "strand": "-", "start_pos": 83928895, "chromosome": "14", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000026569", "id": "ENSRNOT00000026569", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000026569", "id": "ENSRNOP00000026569", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D4A2C4-1|A0A0G2JWF7_RAT Computationally mapped isoform of MORC family CW-type zinc finger 2 OS=Rattus norvegicus OX=10116 GN=Morc2 PE=1 SV=2 CANONICAL=A0A0G2JWF7-1", "length": 981, "sequence": "MQERREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTPESTQIGQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGIDEVIVPLPTWNARTREPITDNVEKFAIETELVYKYSPFHTEEQVMNQFMKIPGNSGTLVIIFNLKLMDNGEPELDIISNPKDIQMAETSPEGTKPERRSFRAYAAVLYIDPRMRIFIHGHKVQTKRLSCCLYKPRMYKYTSSRFKTRAEQEVKKAEHVARIAEEKAREAESKARTLEVRMGGDLTRDSRVMLRQVQNAAITLRREADVKKRIKDAKQRALKEPKELNFVFGVNIEHRDLDGMFIYNCSRLIKMYEKVGPQLEGGMACGGVVGVVDVPYLVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYWKDIAIAQRGIIKFWDEFGYLSANWNQPPSSELRFKRRRAMEIPTTIQCDLCLKWRTLPFQLSSVEKDYPDTWVCSMNPDPEQDRCEASEQKQKVPLGTLKKDPKSQEEKQKQLTEKIRQQQEKLEALQKTTPIRSQADLKKLPLEVTTRPSTEEPVRRPQRPRSPPLPAVIKNAPSRPPSIQTPRPATQLRKTSVISSPKPPATAARGETSTSRILQPAEAPRKPANLPIKTVPRPTPTVQTPSPSLIPNSKNLREVPAQKAIKTPMVKKPEPPAKQSMASSGRKRSLVVSDEEEAEEEAEKRKERCKRGKLAVKEEKKEANELSDSAGEDDPAELKKAQKDKGLHVEVRVNREWYTGRVTAVEMGKNVVRWKVKFDYVPTDTTPRDRWVEKGSEDVRLMKPPSPEHQSPDTQQEGGEEEEAMVAQQAVALPEPSTSDGLPIEPDTTATSTSHETIDLLVQILRNCLRYFLPPSFPISKKELSVMNSEELISFPLKEYFKQYEVGLQNLCHSYQSRADSRAKASEESLRTSEKKLRETEEKLQKLRTNIVALLQKVQEDIDINTDDELDAYIEDLITKGD" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-75105", "resource": "Reactome", "id": "R-RNO-75105", "name": "Fatty acyl-CoA biosynthesis" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q69ZX6-1", "protein_name": "ATPase MORC2A", "sequence": { "length": 1030, "sequence": "MAFTNYSSLNRAQLTFEYLHTNSTTHEFLFGALAELVDNARDADATRIDIYAERREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTPESTQIGQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGIDEVIVPLPTWNARTREPITDNVEKFAIETELVYKYSPFHTEEQVMNQFMKIPGNSGTLVIIFNLKLMDNGEPELDIISNPKDIQMAETSPEGTKPERRSFRAYAAVLYIDPRMRIFIHGHKVQTKRLSCCLYKPRMYKYTSSRFKTRAEQEVKKAEHVARIAEEKAREAESKARTLEVRMGGDLTRDSRVMLRQVQNTAITLRREADVKKRIKDAKQRALKEPKELNFVFGVNIEHRDLDGMFIYNCSRLIKMYEKVGPQLEGGMACGGVVGVVDVPYLVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYWKDIAIAQRGIIKFWDEFGYLSANWNQPPSSELRFKRRRAMEIPTTIQCDLCLKWRTLPFQLSSVETDYPDTWVCSMNPDPEQDRCEASEQKQKVPLGTLKKDPKTQEEKQKQLTEKIRQQQEKLEALQKTTPIRSQADLKKLPLEVTTRPIEEPVRRPQRPRSPPLPAVIKNAPSRPPSIQTPRPSTQLRKTSVISLPKPPTTAARGETSTSRLLQPTEAPRKPANPPIKTVPRPTPPVHTPPLSLIPSSKSLREVPAQKAIKTPVVKKPEPPVKQSVATSGRKRSLAVSDEEEAEEEAEKRRERCKRGKLAVKEEKKEANELSDSAGEDHPAELRKAQKDKGLHVEVRVNREWYTGRVTAVEVGKNAVRWKVKFDYVPTDTTPRDRWVEKGSEDVRLMKPPSPEHQSPDTQQEGGEEEEAMVARQAVALPEPSTSDGLPIEPDTTATSPSHETIDLLVQILRNCLRYFLPPSFPISKKELSVMNSEELISFPLKEYFKQYEVGLQNLCHSYQSRADSRAKASEESLRTSEKKLRETEEKLQKLRTNIVALLQKVQEDIDINTDDELDAYIEDLITKGD" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2JWF7/", "id": "A0A0G2JWF7", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/8966", "id": "8966", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Morc2a", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q9Y6X9-1", "protein_name": "ATPase MORC2", "sequence": { "length": 1032, "sequence": "MAFTNYSSLNRAQLTFEYLHTNSTTHEFLFGALAELVDNARDADATRIDIYAERREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTPESTQIGQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGIDEVIVPLPTWNARTREPVTDNVEKFAIETELIYKYSPFRTEEEVMTQFMKIPGDSGTLVIIFNLKLMDNGEPELDIISNPRDIQMAETSPEGTKPERRSFRAYAAVLYIDPRMRIFIHGHKVQTKRLSCCLYKPRMYKYTSSRFKTRAEQEVKKAEHVARIAEEKAREAESKARTLEVRLGGDLTRDSRVMLRQVQNRAITLRREADVKKRIKEAKQRALKEPKELNFVFGVNIEHRDLDGMFIYNCSRLIKMYEKVGPQLEGGMACGGVVGVVDVPYLVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYWKDIAIAQRGIIKFWDEFGYLSANWNQPPSSELRYKRRRAMEIPTTIQCDLCLKWRTLPFQLSSVEKDYPDTWVCSMNPDPEQDRCEASEQKQKVPLGTFRKDMKTQEEKQKQLTEKIRQQQEKLEALQKTTPIRSQADLKKLPLEVTTRPSTEEPVRRPQRPRSPPLPAVIRNAPSRPPSLPTPRPASQPRKAPVISSTPKLPALAAREEASTSRLLQPPEAPRKPANTLVKTASRPAPLVQQLSPSLLPNSKSPREVPSPKVIKTPVVKKTESPIKLSPATPSRKRSVAVSDEEEVEEEAERRKERCKRGRFVVKEEKKDSNELSDSAGEEDSADLKRAQKDKGLHVEVRVNREWYTGRVTAVEVGKHVVRWKVKFDYVPTDTTPRDRWVEKGSEDVRLMKPPSPEHQSLDTQQEGGEEEVGPVAQQAIAVAEPSTSECLRIEPDTTALSTNHETIDLLVQILRNCLRYFLPPSFPISKKQLSAMNSDELISFPLKEYFKQYEVGLQNLCNSYQSRADSRAKASEESLRTSERKLRETEEKLQKLRTNIVALLQKVQEDIDINTDDELDAYIEDLITKGD" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2JWF7/", "id": "A0A0G2JWF7", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/8966", "id": "8966", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "MORC2", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006251260.1", "ac": "XP_006251260.1", "name": "MORC family CW-type zinc finger protein 2 isoform X1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWF7", "id": "A0A0G2JWF7", "database": "UniProtKB" } ], "name": "magnesium ion binding", "id": "GO:0000287" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWF7", "id": "A0A0G2JWF7", "database": "UniProtKB" } ], "name": "chromatin binding", "id": "GO:0003682" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWF7", "id": "A0A0G2JWF7", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWF7", "id": "A0A0G2JWF7", "database": "UniProtKB" } ], "name": "zinc ion binding", "id": "GO:0008270" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWF7", "id": "A0A0G2JWF7", "database": "UniProtKB" } ], "name": "protein homodimerization activity", "id": "GO:0042803" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWF7", "id": "A0A0G2JWF7", "database": "UniProtKB" } ], "name": "ATPase activity", "id": "GO:0016887" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWF7", "id": "A0A0G2JWF7", "database": "UniProtKB" } ], "name": "histone binding", "id": "GO:0042393" } ], "total": 7, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWF7", "id": "A0A0G2JWF7", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWF7", "id": "A0A0G2JWF7", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016363", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWF7", "id": "A0A0G2JWF7", "database": "UniProtKB" } ], "name": "nuclear matrix", "id": "GO:0016363" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000792", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWF7", "id": "A0A0G2JWF7", "database": "UniProtKB" } ], "name": "heterochromatin", "id": "GO:0000792" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090309", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWF7", "id": "A0A0G2JWF7", "database": "UniProtKB" } ], "name": "positive regulation of DNA methylation-dependent heterochromatin assembly", "id": "GO:0090309" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWF7", "id": "A0A0G2JWF7", "database": "UniProtKB" } ], "name": "chromatin remodeling", "id": "GO:0006338" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWF7", "id": "A0A0G2JWF7", "database": "UniProtKB" } ], "name": "cellular response to DNA damage stimulus", "id": "GO:0006974" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045869", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWF7", "id": "A0A0G2JWF7", "database": "UniProtKB" } ], "name": "negative regulation of single stranded viral RNA replication via double stranded DNA intermediate", "id": "GO:0045869" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045814", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWF7", "id": "A0A0G2JWF7", "database": "UniProtKB" } ], "name": "negative regulation of gene expression, epigenetic", "id": "GO:0045814" } ], "total": 5, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2JWF7", "type": "synonym", "resource": "RefSeq", "name": "Morc2a; Zcwcc1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2JWF7", "type": "synonym", "resource": "RefSeq", "name": "Morc2" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JWF7", "type": "recommended", "resource": "UniProtKB", "name": "Morc2" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000019624", "id": "ENSRNOG00000019624", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/289736", "id": "289736", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011124", "id": "IPR011124", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036890", "id": "IPR036890", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041006", "id": "IPR041006", "database": "InterPro" }, { "url": "https://omabrowser.org/oma/group/SQDRCDA/", "id": "SQDRCDA", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=193855at2759", "id": "193855at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF07496", "id": "PF07496", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF17942", "id": "PF17942", "database": "Pfam" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-75105", "id": "R-RNO-75105", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006251260.1", "id": "XP_006251260.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310842", "id": "1310842", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JWF7", "id": "A0A0G2JWF7", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [ { "synonyms": [ { "id": "MONDO:0014736", "url": "https://monarchinitiative.org/disease/MONDO:0014736", "resource": "MONDO", "name": "Charcot-Marie-Tooth disease, axonal, type 2z", "description": "" }, { "id": "MONDO:0014736", "url": "https://monarchinitiative.org/disease/MONDO:0014736", "resource": "MONDO", "name": "autosomal dominant axonal Charcot-Marie-Tooth disease type 2Z", "description": "" }, { "id": "MONDO:0014736", "url": "https://monarchinitiative.org/disease/MONDO:0014736", "resource": "MONDO", "name": "Charcot-Marie-Tooth disease caused by mutation in MORC2", "description": "" }, { "id": "MONDO:0014736", "url": "https://monarchinitiative.org/disease/MONDO:0014736", "resource": "MONDO", "name": "autosomal dominant Charcot-Marie-Tooth disease type 2Z", "description": "" }, { "id": "MONDO:0014736", "url": "https://monarchinitiative.org/disease/MONDO:0014736", "resource": "MONDO", "name": "Charcot-Marie-Tooth neuropathy type 2Z", "description": "" }, { "id": "MONDO:0014736", "url": "https://monarchinitiative.org/disease/MONDO:0014736", "resource": "MONDO", "name": "Charcot-Marie-Tooth disease, axonal, type 2Z; CMT2Z", "description": "" }, { "id": "MONDO:0014736", "url": "https://monarchinitiative.org/disease/MONDO:0014736", "resource": "MONDO", "name": "Charcot-Marie-Tooth neuropathy, type 2Z", "description": "" }, { "id": "MONDO:0014736", "url": "https://monarchinitiative.org/disease/MONDO:0014736", "resource": "MONDO", "name": "Charcot-Marie-Tooth disease, axonal, autosomal dominant, type 2Z", "description": "" }, { "id": "MONDO:0014736", "url": "https://monarchinitiative.org/disease/MONDO:0014736", "resource": "MONDO", "name": "MORC2 Charcot-Marie-Tooth disease", "description": "" }, { "id": "MONDO:0014736", "url": "https://monarchinitiative.org/disease/MONDO:0014736", "resource": "MONDO", "name": "autosomal dominant Charcot-Marie-Tooth disease type 2 due to MORC2 mutation", "description": "" }, { "id": "MONDO:0014736", "url": "https://monarchinitiative.org/disease/MONDO:0014736", "resource": "MONDO", "name": "CMT2Z", "description": "" }, { "id": "DOID:0110181", "url": "http://disease-ontology.org/term/DOID:0110181", "resource": "Disease Ontology", "name": "autosomal dominant axonal Charcot-Marie-Tooth disease type 2Z", "description": "" }, { "id": "DOID:0110181", "url": "http://disease-ontology.org/term/DOID:0110181", "resource": "Disease Ontology", "name": "CMT2Z", "description": "" }, { "id": "DOID:0110181", "url": "http://disease-ontology.org/term/DOID:0110181", "resource": "Disease Ontology", "name": "Charcot-Marie-Tooth neuropathy type 2Z", "description": "" } ], "recommended_name": { "id": "DOID:0110181", "url": "http://disease-ontology.org/term/DOID:0110181", "resource": "Disease Ontology", "name": "Charcot-Marie-Tooth disease axonal type 2Z", "description": "A Charcot-Marie-Tooth disease type 2 that has_material_basis_in heterozygous mutation in the MORC2 gene on chromosome 22q12." }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/0110181#disease-associations", "id": "0110181", "database": "Alliance of Genome Resources" } ] } ], "phosphorylation": [], "mass": { "monoisotopic_mass": 117333.0, "chemical_mass": 117333.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWF7", "name": "Morc2", "locus": { "end_pos": 83930522, "strand": "+", "start_pos": 83889089, "chromosome": "14", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000019624", "id": "ENSRNOG00000019624", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JWF7#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "MORC family CW-type zinc finger 2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2JWF7", "type": "synonym", "resource": "RefSeq", "name": "MORC family CW-type zinc finger protein 2 isoform X1" } ] }