{
    "uniprot_canonical_ac": "A0A0G2JVZ2-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "tr|A0A0G2JVZ2-1|A0A0G2JVZ2_RAT Isoform 1 of T-cell leukemia homeobox 2  OS=Rattus norvegicus OX=10116 GN=Tlx2 PE=4 SV=1 CANONICAL=A0A0G2JVZ2-1", 
        "length": 284, 
        "sequence": "MEPAVLAPHHLPHHEPISFGIDQILSGPEPPGGGLGPGQVGQSQGESAAFSSGFHGTSGYAPAGSLASLPRGSGVGPGGVIRVPAHRPVPVPPPSGAAPAVAGPSGLGGPGGLAGLTFPWMDSGRRFAKDRLTAALSPFSGTRRIGHPYQNRTPPKRKKPRTSFSRSQVLELERRFLRQKYLASAERAALAKALRMTDAQVKTWFQNRRTKWRRQTAEEREAERHRAGRLLLHLQQDALPRPLRPPLPPDPLCLHNSSLFALQNLQPWAEDNKVASVSGLASVV"
    }, 
    "uniprot_id": "A0A0G2JVZ2_RAT", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Rat", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0G2JVZ2", 
                    "id": "A0A0G2JVZ2", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/10869550", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "10869550"
                }
            ], 
            "title": "Identification of an optimal Ncx binding sequence required for transcriptional activation.", 
            "journal": "FEBS letters", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165596.1", 
                    "id": "NP_001165596.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Shimizu H, Kang M, Iitsuka Y, Ichinose M, Tokuhisa T, Hatano M", 
            "date": "2000"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/16291166", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "16291166"
                }
            ], 
            "title": "Evaluation of Hox11L1 in the fmc/fmc rat model of chronic intestinal pseudo-obstruction.", 
            "journal": "Journal of pediatric surgery", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165596.1", 
                    "id": "NP_001165596.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Parisi MA, Lipman NS, Clarke CM, Taylor B, Kapur RP", 
            "date": "2005"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/9550720", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "9550720"
                }
            ], 
            "title": "The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development.", 
            "journal": "Development (Cambridge, England)", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165596.1", 
                    "id": "NP_001165596.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Tang SJ, Hoodless PA, Lu Z, Breitman ML, McInnes RR, Wrana JL, Buchwald M", 
            "date": "1998"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/9738002", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "9738002"
                }
            ], 
            "title": "Association of the TLX-2 homeodomain and 14-3-3eta signaling proteins.", 
            "journal": "The Journal of biological chemistry", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165596.1", 
                    "id": "NP_001165596.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Tang SJ, Suen TC, McInnes RR, Buchwald M", 
            "date": "1998"
        }
    ], 
    "uniprot_ac": "A0A0G2JVZ2", 
    "site_annotation": [
        {
            "end_pos": 153, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 151
        }, 
        {
            "end_pos": 258, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 256
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVZ2#A0A0G2JVZ2-1", 
            "isoform_ac": "A0A0G2JVZ2-1", 
            "locus": {
                "end_pos": 113900872, 
                "strand": "+", 
                "start_pos": 113902185, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000087788", 
                        "id": "ENSRNOT00000087788", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000069677", 
                        "id": "ENSRNOP00000069677", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A0G2JVZ2-1|A0A0G2JVZ2_RAT Isoform 1 of T-cell leukemia homeobox 2  OS=Rattus norvegicus OX=10116 GN=Tlx2 PE=4 SV=1 CANONICAL=A0A0G2JVZ2-1", 
                "length": 284, 
                "sequence": "MEPAVLAPHHLPHHEPISFGIDQILSGPEPPGGGLGPGQVGQSQGESAAFSSGFHGTSGYAPAGSLASLPRGSGVGPGGVIRVPAHRPVPVPPPSGAAPAVAGPSGLGGPGGLAGLTFPWMDSGRRFAKDRLTAALSPFSGTRRIGHPYQNRTPPKRKKPRTSFSRSQVLELERRFLRQKYLASAERAALAKALRMTDAQVKTWFQNRRTKWRRQTAEEREAERHRAGRLLLHLQQDALPRPLRPPLPPDPLCLHNSSLFALQNLQPWAEDNKVASVSGLASVV"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:103692164", 
            "resource": "KEGG Pathway", 
            "id": "rno:103692164", 
            "name": ""
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:680117", 
            "resource": "KEGG Pathway", 
            "id": "rno:680117", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165596.1", 
            "annotation": "Despite the phenotypic similarities between fmc/fmc rats and Hox11L1-/- mice, fmc does not appear to be a mutant allele of the Hox11L1 gene", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165596.1", 
                    "id": "NP_001165596.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "O43763-1", 
            "protein_name": "T-cell leukemia homeobox protein 2", 
            "sequence": {
                "length": 284, 
                "sequence": "MEPGMLGPHNLPHHEPISFGIDQILSGPETPGGGLGLGRGGQGHGENGAFSGGYHGASGYGPAGSLAPLPGSSGVGPGGVIRVPAHRPLPVPPPAGGAPAVPGPSGLGGAGGLAGLTFPWMDSGRRFAKDRLTAALSPFSGTRRIGHPYQNRTPPKRKKPRTSFSRSQVLELERRFLRQKYLASAERAALAKALRMTDAQVKTWFQNRRTKWRRQTAEEREAERHRAGRLLLHLQQDALPRPLRPPLPPDPLCLHNSSLFALQNLQPWAEDNKVASVSGLASVV"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/7575", 
                    "id": "7575", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "gene_name": "TLX2", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "Q61663-1", 
            "protein_name": "T-cell leukemia homeobox protein 2", 
            "sequence": {
                "length": 284, 
                "sequence": "MEPAVLAAHHLPHHEPISFGIDQILSGPEPPGGGLGPGQSGQSHGESAAFSSGFHGASGYAPAGSLASLPRGSGVGPGGVIRVPAHRPLPVPPPSGAAPAVPGPSGLGGAGGLAGLTFPWMDSGRRFAKDRLTAALSPFSGTRRIGHPYQNRTPPKRKKPRTSFSRSQVLELERRFLRQKYLASAERAALAKALRMTDAQVKTWFQNRRTKWRRQTAEEREAERHRAGRLLLHLQQDALPRPLRPPLPPDPLCLHNSSLFALQNLQPWAEDNKVASVSGLASVV"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/7575", 
                    "id": "7575", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Mouse", 
            "organism": "Mus musculus", 
            "gene_name": "Tlx2", 
            "tax_id": 10090
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165596.1", 
        "ac": "NP_001165596.1", 
        "name": "T-cell leukemia, homeobox 2", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVZ2", 
                                "id": "A0A0G2JVZ2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", 
                        "id": "GO:0000978"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVZ2", 
                                "id": "A0A0G2JVZ2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "sequence-specific DNA binding", 
                        "id": "GO:0043565"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVZ2", 
                                "id": "A0A0G2JVZ2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", 
                        "id": "GO:0001228"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVZ2", 
                                "id": "A0A0G2JVZ2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "sequence-specific double-stranded DNA binding", 
                        "id": "GO:1990837"
                    }
                ], 
                "total": 4, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVZ2", 
                                "id": "A0A0G2JVZ2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleus", 
                        "id": "GO:0005634"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVZ2", 
                                "id": "A0A0G2JVZ2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVZ2", 
                                "id": "A0A0G2JVZ2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of transcription by RNA polymerase II", 
                        "id": "GO:0006357"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048513", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVZ2", 
                                "id": "A0A0G2JVZ2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "animal organ development", 
                        "id": "GO:0048513"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048484", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVZ2", 
                                "id": "A0A0G2JVZ2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "enteric nervous system development", 
                        "id": "GO:0048484"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVZ2", 
                                "id": "A0A0G2JVZ2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of transcription by RNA polymerase II", 
                        "id": "GO:0045944"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050774", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVZ2", 
                                "id": "A0A0G2JVZ2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of dendrite morphogenesis", 
                        "id": "GO:0050774"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001707", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVZ2", 
                                "id": "A0A0G2JVZ2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "mesoderm formation", 
                        "id": "GO:0001707"
                    }
                ], 
                "total": 6, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2JVZ2", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Hox11L.1"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2JVZ2", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Tlx2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVZ2", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Tlx2"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000055188", 
            "id": "ENSRNOG00000055188", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", 
            "id": "cd00086", 
            "database": "CDD"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/103692164", 
            "id": "103692164", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/680117", 
            "id": "680117", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", 
            "id": "IPR001356", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", 
            "id": "IPR009057", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", 
            "id": "IPR017970", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR020479", 
            "id": "IPR020479", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR042247", 
            "id": "IPR042247", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:103692164", 
            "id": "rno:103692164", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:680117", 
            "id": "rno:680117", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/SGYGPSC/", 
            "id": "SGYGPSC", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1391465at2759", 
            "id": "1391465at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45921", 
            "id": "PTHR45921", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00046", 
            "id": "PF00046", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165596.1", 
            "id": "NP_001165596.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1595506", 
            "id": "1595506", 
            "database": "RGD"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVZ2", 
            "id": "A0A0G2JVZ2", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 30406.0, 
        "chemical_mass": 30406.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVZ2", 
            "name": "Tlx2", 
            "locus": {
                "end_pos": 114766714, 
                "strand": "-", 
                "start_pos": 114768029, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000061571", 
                        "id": "ENSRNOG00000061571", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVZ2#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "T-cell leukemia homeobox 2"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2JVZ2", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "T-cell leukemia, homeobox 2"
        }
    ]
}