{ "uniprot_canonical_ac": "A0A0G2JUG7-1", "ptm_annotation": [], "sequence": { "header": "sp|A0A0G2JUG7-1|IQEC1_RAT Isoform 1 of IQ motif and SEC7 domain-containing protein 1 OS=Rattus norvegicus OX=10116 GN=Iqsec1 PE=1 SV=1 CANONICAL=A0A0G2JUG7-1", "length": 962, "sequence": "MACRRRYLSSLETGSSLSTDRYSVEGEAPSSETGTSLDSPSAYHQGPLVPGSSLSPDHYEHTSVGAYGLYAGPGPQQRTRRPRLQHSTSVLRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTNDGSQLGALVPSECGDLSDPALKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHSEEVPASDTARARDTEPKPGLHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRSGGAAQDYWALAHKEDKADTDTSCRSTPSLERPEPRLRVEHLPLLTIEPPSDSSVELSDRSDRSSLKRQSAYERSLGGQQGSPKHGPHGGPPKGLPREEPELRPRPPRPLESHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKETRNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKGIQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSAMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCVCNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGEDIPRETLIGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSAVPGADIKVLINFNAPNPQDRKKFTDDLRESVAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGRRSSAGSLESNVEFQPFQPSQPPVLCS" }, "uniprot_id": "IQEC1_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20547133", "type": [ "PubMed" ], "id": "20547133" } ], "title": "AMPA receptor signaling through BRAG2 and Arf6 critical for long-term synaptic depression.", "journal": "Neuron", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "authors": "Koehr G., Kolleker A., Scholz R., Kornau H.C., Berberich S., Rathgeber L.", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "type": [ "PubMed" ], "id": "22673903" } ], "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012" } ], "uniprot_ac": "A0A0G2JUG7", "site_annotation": [ { "end_pos": 453, "annotation": "n_glycosylation_sequon", "start_pos": 451 }, { "end_pos": 471, "annotation": "n_glycosylation_sequon", "start_pos": 469 }, { "end_pos": 475, "annotation": "n_glycosylation_sequon", "start_pos": 473 }, { "end_pos": 481, "annotation": "n_glycosylation_sequon", "start_pos": 479 }, { "end_pos": 485, "annotation": "n_glycosylation_sequon", "start_pos": 483 }, { "end_pos": 900, "annotation": "n_glycosylation_sequon", "start_pos": 898 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7#A0A0G2JUG7-1", "isoform_ac": "A0A0G2JUG7-1", "locus": { "end_pos": 123307990, "strand": "-", "start_pos": 123453277, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000085466", "id": "ENSRNOT00000085466", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000069092", "id": "ENSRNOP00000069092", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A0A0G2JUG7-1|IQEC1_RAT Isoform 1 of IQ motif and SEC7 domain-containing protein 1 OS=Rattus norvegicus OX=10116 GN=Iqsec1 PE=1 SV=1 CANONICAL=A0A0G2JUG7-1", "length": 962, "sequence": "MACRRRYLSSLETGSSLSTDRYSVEGEAPSSETGTSLDSPSAYHQGPLVPGSSLSPDHYEHTSVGAYGLYAGPGPQQRTRRPRLQHSTSVLRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTNDGSQLGALVPSECGDLSDPALKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHSEEVPASDTARARDTEPKPGLHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRSGGAAQDYWALAHKEDKADTDTSCRSTPSLERPEPRLRVEHLPLLTIEPPSDSSVELSDRSDRSSLKRQSAYERSLGGQQGSPKHGPHGGPPKGLPREEPELRPRPPRPLESHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKETRNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKGIQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSAMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCVCNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGEDIPRETLIGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSAVPGADIKVLINFNAPNPQDRKKFTDDLRESVAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGRRSSAGSLESNVEFQPFQPSQPPVLCS" } } ], "pathway": [], "function": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7#function", "annotation": "Guanine nucleotide exchange factor for ARF1 and ARF6. Guanine nucleotide exchange factor activity is enhanced by lipid binding. Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin. Involved in neuronal development (By similarity). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (PubMed:20547133).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7#function", "id": "A0A0G2JUG7", "database": "UniProtKB" } ] } ], "orthologs": [], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [], "refseq": {}, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "name": "protein kinase binding", "id": "GO:0019901" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "name": "lipid binding", "id": "GO:0008289" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005086", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "name": "ARF guanyl-nucleotide exchange factor activity", "id": "GO:0005086" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "name": "glutamatergic synapse", "id": "GO:0098978" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008021", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "name": "synaptic vesicle", "id": "GO:0008021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099092", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "name": "postsynaptic density, intracellular component", "id": "GO:0099092" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098685", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "name": "Schaffer collateral - CA1 synapse", "id": "GO:0098685" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "name": "actin cytoskeleton organization", "id": "GO:0030036" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043547", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "name": "positive regulation of GTPase activity", "id": "GO:0043547" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051549", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "name": "positive regulation of keratinocyte migration", "id": "GO:0051549" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060996", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "name": "dendritic spine development", "id": "GO:0060996" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032012", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "name": "regulation of ARF protein signal transduction", "id": "GO:0032012" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120183", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "name": "positive regulation of focal adhesion disassembly", "id": "GO:0120183" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099149", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "name": "regulation of postsynaptic neurotransmitter receptor internalization", "id": "GO:0099149" } ], "total": 7, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "type": "synonym", "resource": "UniProtKB", "name": "Brag2" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "type": "recommended", "resource": "UniProtKB", "name": "Iqsec1" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000060350", "id": "ENSRNOG00000060350", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00171", "id": "cd00171", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13318", "id": "cd13318", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000048", "id": "IPR000048", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000904", "id": "IPR000904", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "id": "IPR011993", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR023394", "id": "IPR023394", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR030737", "id": "IPR030737", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR033742", "id": "IPR033742", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035999", "id": "IPR035999", "database": "InterPro" }, { "url": "https://omabrowser.org/oma/group/VQSECSD/", "id": "VQSECSD", "database": "OMA" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10663:SF327", "id": "PTHR10663:SF327", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF01369", "id": "PF01369", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF16453", "id": "PF16453", "database": "Pfam" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1596313", "id": "1596313", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [ { "synonyms": [ { "id": "DOID:0111674", "url": "http://disease-ontology.org/term/DOID:0111674", "resource": "Disease Ontology", "name": "IDDSSBA", "description": "" } ], "recommended_name": { "id": "DOID:0111674", "url": "http://disease-ontology.org/term/DOID:0111674", "resource": "Disease Ontology", "name": "intellectual developmental disorder with short stature and behavioral abnormalities", "description": "A syndrome characterized by intellectual disability, global developmental delay, short stature, aphasia, and hypotonia that has_material_basis_in homozygous or compound heterozygous mutation in IQSEC1 on chromosome 3p25.2-p25.1." }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/0111674#disease-associations", "id": "0111674", "database": "Alliance of Genome Resources" } ] } ], "phosphorylation": [ { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "start_pos": "105", "end_pos": "105", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "start_pos": "107", "end_pos": "107", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "start_pos": "180", "end_pos": "180", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "start_pos": "248", "end_pos": "248", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "start_pos": "252", "end_pos": "252", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "start_pos": "511", "end_pos": "511", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "start_pos": "514", "end_pos": "514", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "start_pos": "891", "end_pos": "891", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "start_pos": "89", "end_pos": "89", "kinase_uniprot_canonical_ac": "" }, { "residue": "Tyr", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "start_pos": "910", "end_pos": "910", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "start_pos": "923", "end_pos": "923", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "id": "A0A0G2JUG7", "database": "UniProtKB" } ], "start_pos": "924", "end_pos": "924", "kinase_uniprot_canonical_ac": "" } ], "mass": { "monoisotopic_mass": 108080.0, "chemical_mass": 108080.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7", "name": "Iqsec1", "locus": { "end_pos": 123453478, "strand": "+", "start_pos": 123307624, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000060350", "id": "ENSRNOG00000060350", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUG7#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "IQ motif and SEC7 domain-containing protein 1" } ] }