{ "uniprot_canonical_ac": "A0A0G2JUD2-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2JUD2-1|A0A0G2JUD2_RAT Isoform 1 of Inorganic diphosphatase OS=Rattus norvegicus OX=10116 GN=Sar1a PE=1 SV=1 CANONICAL=A0A0G2JUD2-1", "length": 306, "sequence": "MSSFSSEERAAPFTLEYRVFIKNEKGQYISPFHDVPIYADKMTNAFSTLKDQQQVWQSQESLADVFHMVVEVPRWSNAKMEIATKDPLNPIKQDVKKGKLRYVANLFPYKGYIWNYGAIPQTWEDPGHSDEHTGCCGDNDPIDVCEIGSKVCARGEIIRVKVLGILAMIDEGETDWKVIAINVDDPDAANYHDISDVERLKPGYLEATVDWFRRYKVPDGKPENEFAFNAEFKNKEFAVDIIKNTHDYWKALVTKKTDGKGISCMNTTVSESPFKCDPDAAKAIVDALPPPCESACALPMDGCKHQ" }, "uniprot_id": "A0A0G2JUD2_RAT", "enzyme_annotation": [ { "ec": "3.6.1.1", "activity": "" }, { "ec": "3.6.1.1", "activity": "Diphosphate + H(2)O = 2 phosphate." } ], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUD2", "id": "A0A0G2JUD2", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [], "uniprot_ac": "A0A0G2JUD2", "site_annotation": [ { "end_pos": 268, "annotation": "n_glycosylation_sequon", "start_pos": 266 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUD2#A0A0G2JUD2-1", "isoform_ac": "A0A0G2JUD2-1", "locus": { "end_pos": 31265647, "strand": "-", "start_pos": 31302827, "chromosome": "20", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000079584", "id": "ENSRNOT00000079584", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000069053", "id": "ENSRNOP00000069053", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JUD2-1|A0A0G2JUD2_RAT Isoform 1 of Inorganic diphosphatase OS=Rattus norvegicus OX=10116 GN=Sar1a PE=1 SV=1 CANONICAL=A0A0G2JUD2-1", "length": 306, "sequence": "MSSFSSEERAAPFTLEYRVFIKNEKGQYISPFHDVPIYADKMTNAFSTLKDQQQVWQSQESLADVFHMVVEVPRWSNAKMEIATKDPLNPIKQDVKKGKLRYVANLFPYKGYIWNYGAIPQTWEDPGHSDEHTGCCGDNDPIDVCEIGSKVCARGEIIRVKVLGILAMIDEGETDWKVIAINVDDPDAANYHDISDVERLKPGYLEATVDWFRRYKVPDGKPENEFAFNAEFKNKEFAVDIIKNTHDYWKALVTKKTDGKGISCMNTTVSESPFKCDPDAAKAIVDALPPPCESACALPMDGCKHQ" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JUD2#F7EPH4-1", "isoform_ac": "F7EPH4-1", "locus": { "end_pos": 31265647, "strand": "-", "start_pos": 31292133, "chromosome": "20", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000000674", "id": "ENSRNOT00000000674", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000000674", "id": "ENSRNOP00000000674", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F7EPH4-1|A0A0G2JUD2_RAT Computationally mapped isoform of Inorganic diphosphatase OS=Rattus norvegicus OX=10116 GN=Sar1a PE=1 SV=1 CANONICAL=A0A0G2JUD2-1", "length": 289, "sequence": "MSSFSSEERAAPFTLEYRVFIKNEKGQYISPFHDVPIYADKDVFHMVVEVPRWSNAKMEIATKDPLNPIKQDVKKGKLRYVANLFPYKGYIWNYGAIPQTWEDPGHSDEHTGCCGDNDPIDVCEIGSKVCARGEIIRVKVLGILAMIDEGETDWKVIAINVDDPDAANYHDISDVERLKPGYLEATVDWFRRYKVPDGKPENEFAFNAEFKNKEFAVDIIKNTHDYWKALVTKKTDGKGISCMNTTVSESPFKCDPDAAKAIVDALPPPCESACALPMDVDKWFHHQKN" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JUD2#Q6AY18-1", "isoform_ac": "Q6AY18-1", "locus": { "end_pos": 31302830, "strand": "-", "start_pos": 31308782, "chromosome": "20", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000000673", "id": "ENSRNOT00000000673", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000000673", "id": "ENSRNOP00000000673", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Q6AY18-1|A0A0G2JUD2_RAT Computationally mapped isoform of Inorganic diphosphatase OS=Rattus norvegicus OX=10116 GN=Sar1a PE=1 SV=1 CANONICAL=A0A0G2JUD2-1", "length": 198, "sequence": "MSFIFEWIYNGFSSVLQFLGLYKKSGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPTSEELTIAGMTFTTFDLGGHEQARRVWKNYLPAINGIVFLVDCADHSRLMESKVELNALMTDETISNVPILILGNKIDRTDAISEEKLREIFGLYGQTTGKGNVTLKELNARPMEVFMCSVLKRQGYGEGFRWLSQYID" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-379716", "resource": "Reactome", "id": "R-RNO-379716", "name": "Cytosolic tRNA aminoacylation" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-71737", "resource": "Reactome", "id": "R-RNO-71737", "name": "Pyrophosphate hydrolysis" } ], "function": [], "orthologs": [], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "refseq": {}, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUD2", "id": "A0A0G2JUD2", "database": "UniProtKB" } ], "name": "magnesium ion binding", "id": "GO:0000287" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004427", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUD2", "id": "A0A0G2JUD2", "database": "UniProtKB" } ], "name": "inorganic diphosphatase activity", "id": "GO:0004427" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016462", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUD2", "id": "A0A0G2JUD2", "database": "UniProtKB" } ], "name": "pyrophosphatase activity", "id": "GO:0016462" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUD2", "id": "A0A0G2JUD2", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUD2", "id": "A0A0G2JUD2", "database": "UniProtKB" } ], "name": "Golgi membrane", "id": "GO:0000139" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUD2", "id": "A0A0G2JUD2", "database": "UniProtKB" } ], "name": "endoplasmic reticulum", "id": "GO:0005783" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUD2", "id": "A0A0G2JUD2", "database": "UniProtKB" } ], "name": "Golgi apparatus", "id": "GO:0005794" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016529", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUD2", "id": "A0A0G2JUD2", "database": "UniProtKB" } ], "name": "sarcoplasmic reticulum", "id": "GO:0016529" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030127", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUD2", "id": "A0A0G2JUD2", "database": "UniProtKB" } ], "name": "COPII vesicle 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"https://www.uniprot.org/uniprot/A0A0G2JUD2", "id": "A0A0G2JUD2", "database": "UniProtKB" } ], "name": "regulation of cargo loading into COPII-coated vesicle", "id": "GO:1901301" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901303", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUD2", "id": "A0A0G2JUD2", "database": "UniProtKB" } ], "name": "negative regulation of cargo loading into COPII-coated vesicle", "id": "GO:1901303" } ], "total": 5, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUD2", "type": "synonym", "resource": "UniProtKB", "name": "Ppa1" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JUD2", "type": "recommended", "resource": "UniProtKB", "name": "Sar1a" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000000557", "id": "ENSRNOG00000000557", "database": "Bgee" }, { "url": 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"https://www.uniprot.org/uniprot/A0A0G2JUD2", "id": "A0A0G2JUD2", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 34527.0, "chemical_mass": 34527.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUD2", "name": "Sar1a", "locus": {} } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUD2#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "3.6.1.1" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JUD2#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Inorganic diphosphatase" } ] }