{ "uniprot_canonical_ac": "A0A0G2JTZ2-1", "ptm_annotation": [ { "annotation": "Sumoylation inhibits the transcriptional activity.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/P35712", "id": "P35712", "database": "PubMed" } ] } ], "sequence": { "header": "sp|A0A0G2JTZ2-1|SOX6_RAT Isoform 1 of Transcription factor SOX-6 OS=Rattus norvegicus OX=10116 GN=Sox6 PE=1 SV=2 CANONICAL=A0A0G2JTZ2-1", "length": 827, "sequence": "MSSKQATSPFACTVDGEETMTQDLTSREKEEGSDQHPASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSREREIMNSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQKGHVSHPQINPRLKGISDRLGRNLDPYEHGGGHSYNHKQIEQLYAAQLASMQVSPGAKMPSTPQPPNSAGAVSPTGIKNEKRGTSPVTQVKDETTAQPLNLSSRPKTAEPVKSPTSPTQSLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQPHGVDGKLSSMNSMGLSNCRNEKERTRFENLGPQLTGKSSEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQIPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKMDGASLAGNDMINGEDEMEAYDDYEDDPKSDYSSENEAPEPVSAN" }, "uniprot_id": "SOX6_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/10760285", "type": [ "PubMed" ], "id": "10760285" } ], "title": "Sox6 is a candidate gene for p100H myopathy, heart block, and sudden neonatal death.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922.1", "id": "NP_001019922.1", "database": "RefSeq" } ], "authors": "Hagiwara N, Klewer SE, Samson RA, Erickson DT, Lyon MF, Brilliant MH", "date": "2000" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12081133", "type": [ "PubMed" ], "id": "12081133" } ], "title": "cDNA cloning of the Sry-related gene Sox6 from rat with tissue-specific expression.", "journal": "Biological & pharmaceutical bulletin", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922.1", "id": "NP_001019922.1", "database": "RefSeq" } ], "authors": "Narahara M, Yamada A, Hamada-Kanazawa M, Kawai Y, Miyake M", "date": "2002" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/14530442", "type": [ "PubMed" ], "id": "14530442" } ], "title": "Sox6 regulation of cardiac myocyte development.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922.1", "id": "NP_001019922.1", "database": "RefSeq" } ], "authors": "Cohen-Barak O, Yi Z, Hagiwara N, Monzen K, Komuro I, Brilliant MH", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26150426", "type": [ "PubMed" ], "id": "26150426" } ], "title": "The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis.", "journal": "Nucleic Acids Res.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ], "authors": "Liu C.F., Lefebvre V.", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26345464", "type": [ "PubMed" ], "id": "26345464" } ], "title": "Transcription factors Sox5 and Sox6 exert direct and indirect influences on oligodendroglial migration in spinal cord and forebrain.", "journal": "Glia", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922.1", "id": "NP_001019922.1", "database": "RefSeq" } ], "authors": "Baroti T, Zimmermann Y, Schillinger A, Liu L, Lommes P, Wegner M, Stolt CC", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26525805", "type": [ "PubMed" ], "id": "26525805" } ], "title": "Sox13 functionally complements the related Sox5 and Sox6 as important developmental modulators in mouse spinal cord oligodendrocytes.", "journal": "Journal of neurochemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922.1", "id": "NP_001019922.1", "database": "RefSeq" } ], "authors": "Baroti T, Schillinger A, Wegner M, Stolt CC", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26659076", "type": [ "PubMed" ], "id": "26659076" } ], "title": "SOX6 and PDCD4 enhance cardiomyocyte apoptosis through LPS-induced miR-499 inhibition.", "journal": "Apoptosis : an international journal on programmed cell death", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922.1", "id": "NP_001019922.1", "database": "RefSeq" } ], "authors": "Jia Z, Wang J, Shi Q, Liu S, Wang W, Tian Y, Lu Q, Chen P, Ma K, Zhou C", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/31076992", "type": [ "PubMed" ], "id": "31076992" } ], "title": "MiR-499 inhibited hypoxia/reoxygenation induced cardiomyocytes injury by targeting SOX6.", "journal": "Biotechnology letters", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922.1", "id": "NP_001019922.1", "database": "RefSeq" } ], "authors": "Shi Y, Han Y, Niu L, Li J, Chen Y", "date": "2019" } ], "uniprot_ac": "A0A0G2JTZ2", "site_annotation": [ { "end_pos": 171, "annotation": "n_glycosylation_sequon", "start_pos": 169 }, { "end_pos": 428, "annotation": "n_glycosylation_sequon", "start_pos": 426 }, { "end_pos": 462, "annotation": "n_glycosylation_sequon", "start_pos": 460 }, { "end_pos": 584, "annotation": "n_glycosylation_sequon", "start_pos": 582 }, { "end_pos": 651, "annotation": "n_glycosylation_sequon", "start_pos": 649 }, { "end_pos": 96, "annotation": "n_glycosylation_sequon", "start_pos": 94 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2#A0A0G2JTZ2-1", "isoform_ac": "A0A0G2JTZ2-1", "locus": {}, "sequence": { "header": "sp|A0A0G2JTZ2-1|SOX6_RAT Isoform 1 of Transcription factor SOX-6 OS=Rattus norvegicus OX=10116 GN=Sox6 PE=1 SV=2 CANONICAL=A0A0G2JTZ2-1", "length": 827, "sequence": "MSSKQATSPFACTVDGEETMTQDLTSREKEEGSDQHPASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSREREIMNSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQKGHVSHPQINPRLKGISDRLGRNLDPYEHGGGHSYNHKQIEQLYAAQLASMQVSPGAKMPSTPQPPNSAGAVSPTGIKNEKRGTSPVTQVKDETTAQPLNLSSRPKTAEPVKSPTSPTQSLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQPHGVDGKLSSMNSMGLSNCRNEKERTRFENLGPQLTGKSSEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQIPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKMDGASLAGNDMINGEDEMEAYDDYEDDPKSDYSSENEAPEPVSAN" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2#A0A0G2JTZ2-2", "isoform_ac": "A0A0G2JTZ2-2", "locus": {}, "sequence": { "header": "sp|A0A0G2JTZ2-2|SOX6_RAT Isoform 2 of Transcription factor SOX-6 OS=Rattus norvegicus OX=10116 GN=Sox6 PE=1 SV=2 CANONICAL=A0A0G2JTZ2-1", "length": 786, "sequence": "MSSKQATSPFACTVDGEETMTQDLTSREKEEGSDQHPASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSREREIMNSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQQLYAAQLASMQVSPGAKMPSTPQPPNSAGAVSPTGIKNEKRGTSPVTQVKDETTAQPLNLSSRPKTAEPVKSPTSPTQSLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQPHGVDGKLSSMNSMGLSNCRNEKERTRFENLGPQLTGKSSEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQIPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKMDGASLAGNDMINGEDEMEAYDDYEDDPKSDYSSENEAPEPVSAN" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2#A0A6I8PLH1-1", "isoform_ac": "A0A6I8PLH1-1", "locus": { "end_pos": 185878827, "strand": "-", "start_pos": 186182628, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000048020", "id": "ENSRNOT00000048020", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000044088", "id": "ENSRNOP00000044088", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A6I8PLH1-1|SOX6_RAT Computationally mapped isoform of Transcription factor SOX-6 OS=Rattus norvegicus OX=10116 GN=Sox6 PE=1 SV=1 CANONICAL=A0A0G2JTZ2-1", "length": 787, "sequence": "MSSKQATSPFACTVDGEETMTQDLTSREKEEGSDQHPASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSREREIMNSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQQLYAAQLASMQVSPGAKMPSTPQPPNSAGAVSPTGIKNEKRGTSPVTQVKDETTAQPLNLSSRPKTAEPVKSPTSPTQSLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQPHGVDGKLSSMNSMGLSNCRNEKERTRFENLGPQLTGKSSEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQIPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKMDGASLAGNDMINGEDEMEAYDDYEDDPKSDYSSENEAPEPVSAN" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2#A0A6R0V8A0-1", "isoform_ac": "A0A6R0V8A0-1", "locus": {}, "sequence": { "header": "tr|A0A6R0V8A0-1|SOX6_RAT Computationally mapped isoform of Transcription factor SOX-6 OS=Rattus norvegicus OX=10116 GN=Sox6 PE=1 SV=1 CANONICAL=A0A0G2JTZ2-1", "length": 854, "sequence": "MPSSSEVLADVARESRIEEWRNSYFVRMSSKQATSPFACTVDGEETMTQDLTSREKEEGSDQHPASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSREREIMNSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQKGHVSHPQINPRLKGISDRLGRNLDPYEHGGGHSYNHKQIEQLYAAQLASMQVSPGAKMPSTPQPPNSAGAVSPTGIKNEKRGTSPVTQVKDETTAQPLNLSSRPKTAEPVKSPTSPTQSLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQPHGVDGKLSSMNSMGLSNCRNEKERTRFENLGPQLTGKSSEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQIPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKMDGASLAGNDMINGEDEMEAYDDYEDDPKSDYSSENEAPEPVSAN" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3769402", "resource": "Reactome", "id": "R-RNO-3769402", "name": "Deactivation of the beta-catenin transactivating complex" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922.1", "annotation": "Sox6 was specifically expressed in the neonatal brain and adult testis with Northern blotting.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922.1", "id": "NP_001019922.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922.1", "annotation": "Study revealed that Sox5 and Sox6 prevent oligodendroglial differentiation, thus ensuring that the progenitor cells first reach their proper destination and only then lose their migratory capacity", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922.1", "id": "NP_001019922.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922.1", "annotation": "The apoptosis process enhanced by overexpression of SOX6 or PDCD4, was rescued by the cardiac-abundant miR-499 in rat cardiomyocytes.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922.1", "id": "NP_001019922.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922.1", "annotation": "The authors proved that miR-499-5p inhibited hypoxia/reoxygenation-induced cardiomyocytes injury by targeting SOX6.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922.1", "id": "NP_001019922.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2#function", "annotation": "Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (By similarity). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis (By similarity). Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate (PubMed:26150426). Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes (By similarity). Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts (By similarity). Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2#function", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "P35712-1", "protein_name": "Transcription factor SOX-6", "sequence": { "length": 828, "sequence": "MSSKQATSPFACAADGEDAMTQDLTSREKEEGSDQHVASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSRDREIMTSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQKGHVSHPQINQRLKGLSDRFGRNLDTFEHGGGHSYNHKQIEQLYAAQLASMQVSPGAKMPSTPQPPNTAGTVSPTGIKNEKRGTSPVTQVKDEAAAQPLNLSSRPKTAEPVKSPTSPTQNLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQQPHGVDGKLSSINNMGLNSCRNEKERTRFENLGPQLTGKSNEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQIPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKTDGGSLAGNEMINGEDEMEMYDDYEDDPKSDYSSENEAPEAVSAN" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/22631", "id": "22631", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "SOX6", "tax_id": 9606 }, { "uniprot_canonical_ac": "P40645-1", "protein_name": "Transcription factor SOX-6", "sequence": { "length": 827, "sequence": "MSSKQATSPFACTADGEEAMTQDLTSREKEEGSDQHPASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSREREIMNSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQKGHVSHPQINPRLKGISDRFGRNLDPSEHGGGHSYNHRQIEQLYAAQLASMQVSPGAKMPSTPQPPNSAGAVSPTGIKNEKRGTSPVTQVKDETTAQPLNLSSRPKTAEPVKSPTSPTQNLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQPHGVDGKLSSMNNMGLSNCRTEKERTRFENLGPQLTGKSSEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQMPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKMDGASLAGNDMINGEDEMEAYDDYEDDPKSDYSSENEAPEPVSAN" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/22631", "id": "22631", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Sox6", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922.1", "ac": "NP_001019922.1", "name": "transcription factor SOX-6", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000987", "pmid": "26150426", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ], "name": "cis-regulatory region sequence-specific DNA binding", "id": "GO:0000987" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ], "name": "DNA binding", "id": "GO:0003677" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ], "name": "DNA-binding transcription factor activity", "id": "GO:0003700" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ], "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "id": "A0A0G2JTZ2", "database": "UniProtKB" } ], "name": "transcription regulatory region sequence-specific DNA binding", "id": "GO:0000976" }, { "url": 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