{ "uniprot_canonical_ac": "A0A0G2JTM9-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2JTM9-1|A0A0G2JTM9_RAT Isoform 1 of Similar to DnaJ (Hsp40) homolog, subfamily B, member 14 isoform 1, isoform CRA_b OS=Rattus norvegicus OX=10116 GN=Dnajb14 PE=4 SV=1 CANONICAL=A0A0G2JTM9-1", "length": 377, "sequence": "MEGNRDEAEKCVQIAREALSAGNRDKAQRFLQKAEKLYPLPAARALLEIIMKNGSTAGNSTHCRKPPGSSDQSKPSFGKDGTSGAGEGGKVYTKDQVEGVLSINKCKNYYEVLGVTKDAGDEDLKKAYRKLALKFHPDKNHAPGATDAFKKIGNAYAVLSNPEKRKQYDLTGSEEEACSPQSNGRFNFHRGCEADITPEDLFNIFFGGGFPSGSVHSFSNGRAAYSHQHQHRHSGHEREEERGDGGFSVFIQLMPVIVLILVSLLSQLMVSNPPYSLYPRSGQTIKMQTENLGVVYYVNKDFKSEYKGALLQKVEKSVEEDYVTNIRNNCWKERQQKTDMQYAAKVYRDERLRRKADALSMDNCKELERLTSLYKGG" }, "uniprot_id": "A0A0G2JTM9_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM9", "id": "A0A0G2JTM9", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27916661", "type": [ "PubMed" ], "id": "27916661" } ], "title": "Tetrameric Assembly of K(+) Channels Requires ER-Located Chaperone Proteins.", "journal": "Molecular cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102663.2", "id": "NP_001102663.2", "database": "RefSeq" } ], "authors": "Li K, Jiang Q, Bai X, Yang YF, Ruan MY, Cai SQ", "date": "2017" } ], "uniprot_ac": "A0A0G2JTM9", "site_annotation": [ { "end_pos": 55, "annotation": "n_glycosylation_sequon", "start_pos": 53 }, { "end_pos": 61, "annotation": "n_glycosylation_sequon", "start_pos": 59 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM9#A0A0G2JTM9-1", "isoform_ac": "A0A0G2JTM9-1", "locus": { "end_pos": 243108474, "strand": "-", "start_pos": 243151366, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000080941", "id": "ENSRNOT00000080941", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000074950", "id": "ENSRNOP00000074950", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JTM9-1|A0A0G2JTM9_RAT Isoform 1 of Similar to DnaJ (Hsp40) homolog, subfamily B, member 14 isoform 1, isoform CRA_b OS=Rattus norvegicus OX=10116 GN=Dnajb14 PE=4 SV=1 CANONICAL=A0A0G2JTM9-1", "length": 377, "sequence": "MEGNRDEAEKCVQIAREALSAGNRDKAQRFLQKAEKLYPLPAARALLEIIMKNGSTAGNSTHCRKPPGSSDQSKPSFGKDGTSGAGEGGKVYTKDQVEGVLSINKCKNYYEVLGVTKDAGDEDLKKAYRKLALKFHPDKNHAPGATDAFKKIGNAYAVLSNPEKRKQYDLTGSEEEACSPQSNGRFNFHRGCEADITPEDLFNIFFGGGFPSGSVHSFSNGRAAYSHQHQHRHSGHEREEERGDGGFSVFIQLMPVIVLILVSLLSQLMVSNPPYSLYPRSGQTIKMQTENLGVVYYVNKDFKSEYKGALLQKVEKSVEEDYVTNIRNNCWKERQQKTDMQYAAKVYRDERLRRKADALSMDNCKELERLTSLYKGG" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:499716", "resource": "KEGG Pathway", "id": "rno:499716", "name": "" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q149L6-1", "protein_name": "DnaJ homolog subfamily B member 14", "sequence": { "length": 379, "sequence": "MEGNRDEAEKCVQIAREALSAGNRDKAQRFLQKAEKLYPLPAARALLEIIMKNGSTAGSSTHCRKPPGSSDQSKPSCGKDGTSGAGEGGKVYTKDQVEGVLSINKCKNYYEVLGVTKDAGDEDLKKAYRKLALKFHPDKNHAPGATDAFKKIGNAYAVLSNPEKRKQYDLTGSEEQACNHQNNGRFNFHRGCEADITPEDLFNIFFGGGFPSGSVHSFSNGRAAYSHQHQHRHSGHEREEERADGGFSVFIQLMPIIVLILVSLLSQLMVSNPPYSLYPRSGSGQTIKMQTENLGVVYYVSKDFKSEYKGTLLQKVEKSVEEDYVTNIRNNCWKERQQKTDMQYAAKVYRDEQLRRKADALSMENCKELERLTSLYKGG" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/57015", "id": "57015", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A0G2JTM9/", "id": "A0A0G2JTM9", "database": "OMA" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Dnajb14", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q8TBM8-1", "protein_name": "DnaJ homolog subfamily B member 14", "sequence": { "length": 379, "sequence": "MEGNRDEAEKCVEIAREALNAGNREKAQRFLQKAEKLYPLPSARALLEIIMKNGSTAGNSPHCRKPSGSGDQSKPNCTKDSTSGSGEGGKGYTKDQVDGVLSINKCKNYYEVLGVTKDAGDEDLKKAYRKLALKFHPDKNHAPGATDAFKKIGNAYAVLSNPEKRKQYDLTGNEEQACNHQNNGRFNFHRGCEADITPEDLFNIFFGGGFPSGSVHSFSNGRAGYSQQHQHRHSGHEREEERGDGGFSVFIQLMPIIVLILVSLLSQLMVSNPPYSLYPRSGTGQTIKMQTENLGVVYYVNKDFKNEYKGMLLQKVEKSVEEDYVTNIRNNCWKERQQKTDMQYAAKVYRDDRLRRKADALSMDNCKELERLTSLYKGG" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/57015", "id": "57015", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A0G2JTM9/", "id": "A0A0G2JTM9", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "DNAJB14", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102663.2", "ac": "NP_001102663.2", "name": "dnaJ homolog subfamily B member 14", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030544", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM9", "id": "A0A0G2JTM9", "database": "UniProtKB" } ], "name": "Hsp70 protein binding", "id": "GO:0030544" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM9", "id": "A0A0G2JTM9", "database": "UniProtKB" } ], "name": "endoplasmic reticulum membrane", "id": "GO:0005789" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM9", "id": "A0A0G2JTM9", "database": "UniProtKB" } ], "name": "endoplasmic reticulum", "id": "GO:0005783" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM9", "id": "A0A0G2JTM9", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030433", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM9", "id": "A0A0G2JTM9", "database": "UniProtKB" } ], "name": "ubiquitin-dependent ERAD pathway", "id": "GO:0030433" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071218", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM9", "id": "A0A0G2JTM9", "database": "UniProtKB" } ], "name": "cellular response to misfolded protein", "id": "GO:0071218" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051085", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM9", "id": "A0A0G2JTM9", "database": "UniProtKB" } ], "name": "chaperone cofactor-dependent protein refolding", "id": "GO:0051085" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034622", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM9", "id": "A0A0G2JTM9", "database": "UniProtKB" } ], "name": "cellular protein-containing complex assembly", "id": "GO:0034622" } ], "total": 4, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2JTM9", "type": "synonym", "resource": "RefSeq", "name": "Dnajb14" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM9", "type": "recommended", "resource": "UniProtKB", "name": "Dnajb14" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM9", "type": "synonym", "resource": "UniProtKB", "name": "LOC499716" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM9", "type": "synonym", "resource": "UniProtKB", "name": "rCG_29010" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000060107", "id": "ENSRNOG00000060107", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06257", "id": "cd06257", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/499716", "id": "499716", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001623", "id": "IPR001623", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015399", "id": "IPR015399", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018253", "id": "IPR018253", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036869", "id": "IPR036869", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:499716", "id": "rno:499716", "database": "KEGG Pathway" }, { "url": "https://omabrowser.org/oma/group/AELMTMD/", "id": "AELMTMD", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=1173544at2759", "id": "1173544at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00226", "id": "PF00226", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF09320", "id": "PF09320", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102663.2", "id": "NP_001102663.2", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1591949", "id": "1591949", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM9", "id": "A0A0G2JTM9", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [ { "synonyms": [ { "id": "MONDO:0007739", "url": "https://monarchinitiative.org/disease/MONDO:0007739", "resource": "MONDO", "name": "Huntington disease", "description": "" }, { "id": "MONDO:0007739", "url": "https://monarchinitiative.org/disease/MONDO:0007739", "resource": "MONDO", "name": "Huntington's chorea", "description": "" }, { "id": "MONDO:0007739", "url": "https://monarchinitiative.org/disease/MONDO:0007739", "resource": "MONDO", "name": "HD", "description": "" }, { "id": "MONDO:0007739", "url": "https://monarchinitiative.org/disease/MONDO:0007739", "resource": "MONDO", "name": "Huntington disease; HD", "description": "" }, { "id": "MONDO:0007739", "url": "https://monarchinitiative.org/disease/MONDO:0007739", "resource": "MONDO", "name": "Huntington chorea", "description": "" }, { "id": "DOID:12858", "url": "http://disease-ontology.org/term/DOID:12858", "resource": "Disease Ontology", "name": "HD", "description": "" }, { "id": "DOID:12858", "url": "http://disease-ontology.org/term/DOID:12858", "resource": "Disease Ontology", "name": "Huntington disease", "description": "" }, { "id": "DOID:12858", "url": "http://disease-ontology.org/term/DOID:12858", "resource": "Disease Ontology", "name": "Huntington's chorea", "description": "" } ], "recommended_name": { "id": "DOID:12858", "url": "http://disease-ontology.org/term/DOID:12858", "resource": "Disease Ontology", "name": "Huntington's disease", "description": "A neurodegenerative disease that has_material_basis_in autosomal dominant inheritance and is characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia and has_material_basis_in expansion of CAG triplet repeats (glutamine) resulting in neuron degeneration affecting muscle coordination, cognitive abilities." }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/12858#disease-associations", "id": "12858", "database": "Alliance of Genome Resources" } ] } ], "phosphorylation": [], "mass": { "monoisotopic_mass": 42142.0, "chemical_mass": 42142.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM9", "name": "Dnajb14", "locus": { "end_pos": 243151933, "strand": "+", "start_pos": 243018975, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000060107", "id": "ENSRNOG00000060107", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2JTM9", "type": "synonym", "resource": "RefSeq", "name": "DnaJ (Hsp40) homolog, subfamily B, member 14" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM9#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "DnaJ heat shock protein family (Hsp40) member B14" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JTM9#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Similar to DnaJ (Hsp40) homolog, subfamily B, member 14 isoform 1, isoform CRA_b" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2JTM9", "type": "synonym", "resource": "RefSeq", "name": "dnaJ homolog subfamily B member 14" } ] }