{ "uniprot_canonical_ac": "A0A0G2JDS2-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2JDS2-1|A0A0G2JDS2_MOUSE Isoform 1 of Chitinase-like 5 OS=Mus musculus OX=10090 GN=Chil5 PE=4 SV=1 CANONICAL=A0A0G2JDS2-1", "length": 431, "sequence": "MTKLILVTGLALLLNPQLGSAYQLMCYYNNVAQNRPKLGSFNPADIDPCLCTHLIYAFAGMQNNKVTMRSMNDLTDYQALNTLKSRNVQLKTLLAIGGRDFGPAPFSAMVSTPHNQQTFINSAIKFLRQYGFDGLNLDWQFPGSRGSPSRDKHLFTVLVQKIREAFELEAIENKSPRLMVTATVAGVISTIQSGYEIPQLSHFLDYIQVMTYNLHGSQDGYTGENSPLYKSLNDTGINTLLNVDYIMTYWNENGAAPEKLIVGFPAYGQTFTLSDPSNNGISAPTASAGTLGPYTEESGTWAYYEICSFLNDGATEAWDSAQEVPYAYQGNKWVGYDNVKSFRIKAEWLKQNNLGGAMLWTLDMDDFTGSFCNQGQFPLTSTLKNALLVYSTSCMASVSDLQQVNAPLYSGNRNWKRGSKAMDSVSPVPRE" }, "uniprot_id": "A0A0G2JDS2_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2", "id": "A0A0G2JDS2", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16537572", "type": [ "PubMed" ], "id": "16537572" } ], "title": "Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.", "journal": "Human molecular genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074285.1", "id": "NP_001074285.1", "database": "RefSeq" } ], "authors": "Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Culiat CT", "date": "2006" } ], "uniprot_ac": "A0A0G2JDS2", "site_annotation": [ { "end_pos": 175, "annotation": "n_glycosylation_sequon", "start_pos": 173 }, { "end_pos": 235, "annotation": "n_glycosylation_sequon", "start_pos": 233 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2#A0A0G2JDS2-1", "isoform_ac": "A0A0G2JDS2-1", "locus": { "end_pos": 106017135, "strand": "+", "start_pos": 106032814, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000200146", "id": "ENSMUST00000200146", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000142477", "id": "ENSMUSP00000142477", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JDS2-1|A0A0G2JDS2_MOUSE Isoform 1 of Chitinase-like 5 OS=Mus musculus OX=10090 GN=Chil5 PE=4 SV=1 CANONICAL=A0A0G2JDS2-1", "length": 431, "sequence": "MTKLILVTGLALLLNPQLGSAYQLMCYYNNVAQNRPKLGSFNPADIDPCLCTHLIYAFAGMQNNKVTMRSMNDLTDYQALNTLKSRNVQLKTLLAIGGRDFGPAPFSAMVSTPHNQQTFINSAIKFLRQYGFDGLNLDWQFPGSRGSPSRDKHLFTVLVQKIREAFELEAIENKSPRLMVTATVAGVISTIQSGYEIPQLSHFLDYIQVMTYNLHGSQDGYTGENSPLYKSLNDTGINTLLNVDYIMTYWNENGAAPEKLIVGFPAYGQTFTLSDPSNNGISAPTASAGTLGPYTEESGTWAYYEICSFLNDGATEAWDSAQEVPYAYQGNKWVGYDNVKSFRIKAEWLKQNNLGGAMLWTLDMDDFTGSFCNQGQFPLTSTLKNALLVYSTSCMASVSDLQQVNAPLYSGNRNWKRGSKAMDSVSPVPRE" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2#F7AQE8-1", "isoform_ac": "F7AQE8-1", "locus": { "end_pos": 106017135, "strand": "+", "start_pos": 106024911, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000066537", "id": "ENSMUST00000066537", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000065043", "id": "ENSMUSP00000065043", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F7AQE8-1|A0A0G2JDS2_MOUSE Computationally mapped isoform of Chitinase-like 5 OS=Mus musculus OX=10090 GN=Chil5 PE=4 SV=1 CANONICAL=A0A0G2JDS2-1", "length": 251, "sequence": "GRDFGPAPFSAMVSTPHNQQTFINSAIKFLRQYGFDGLNLDWQFPGSRGSPSRDKHLFTVLVQDYIMTYWNENGAAPEKLIVGFPAYGQTFTLSDPSNNGISAPTASAGTLGPYTEESGTWAYYEICSFLNDGATEAWDSAQEVPYAYQGNKWVGYDNVKSFRIKAEWLKQNNLGGAMLWTLDMDDFTGSFCNQGQFPLTSTLKNALLVYSTSCMASVSDLQQVNAPLYSGNRNWKRGSKAMDSVSPVPRE" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2#F7D8T8-1", "isoform_ac": "F7D8T8-1", "locus": { "end_pos": 106019619, "strand": "+", "start_pos": 106024916, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000054973", "id": "ENSMUST00000054973", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000052345", "id": "ENSMUSP00000052345", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F7D8T8-1|A0A0G2JDS2_MOUSE Computationally mapped isoform of Chitinase-like 5 OS=Mus musculus OX=10090 GN=Chil5 PE=4 SV=1 CANONICAL=A0A0G2JDS2-1", "length": 96, "sequence": "XGGRDFGPAPFSAMVSTPHNQQTFINSAIKFLRQYGFDGLNLDWQFPGSRGSPSRDKHLFTVLVQLPRLHPGHDLQSPWLPRWLYWGKQPTLQIPK" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:229687", "resource": "KEGG Pathway", "id": "mmu:229687", "name": "" } ], "function": [], "orthologs": [], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074285.1", "ac": "NP_001074285.1", "name": "chitinase like precursor", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008061", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2", "id": "A0A0G2JDS2", "database": "UniProtKB" } ], "name": "chitin binding", "id": "GO:0008061" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2", "id": "A0A0G2JDS2", "database": "UniProtKB" } ], "name": "extracellular region", "id": "GO:0005576" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006032", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2", "id": "A0A0G2JDS2", "database": "UniProtKB" } ], "name": "chitin catabolic process", "id": "GO:0006032" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2", "id": "A0A0G2JDS2", "database": "UniProtKB" } ], "name": "carbohydrate metabolic process", "id": "GO:0005975" } ], "total": 2, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2JDS2", "type": "synonym", "resource": "RefSeq", "name": "Bcl; Bclp; Bclp1; Bclp2; Chi3; Chi3l7" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2JDS2", "type": "synonym", "resource": "RefSeq", "name": "Chil5" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2", "type": "recommended", "resource": "UniProtKB", "name": "Chil5" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000043873", "id": "ENSMUSG00000043873", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/229687", "id": "229687", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001223", "id": "IPR001223", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011583", "id": "IPR011583", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017853", "id": "IPR017853", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029070", "id": "IPR029070", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:229687", "id": "mmu:229687", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:2676649", "id": "2676649", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/NQFYNCS/", "id": "NQFYNCS", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=826687at2759", "id": "826687at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00704", "id": "PF00704", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074285.1", "id": "NP_001074285.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2", "id": "A0A0G2JDS2", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [ { "synonyms": [], "recommended_name": { "id": "DOID:0050127", "url": "http://disease-ontology.org/term/DOID:0050127", "resource": "Disease Ontology", "name": "sinusitis", "description": "A paranasal sinus disease involving inflammation of the paranasal sinuses resulting from bacterial, fungal, viral infection, allergic or autoimmune issues. Symptoms can include fever, weakness, fatigue, cough and congestion. There may also be mucus drainage in the back of the throat, called postnasal drip." }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/0050127#disease-associations", "id": "0050127", "database": "Alliance of Genome Resources" } ] }, { "synonyms": [ { "id": "MONDO:0010940", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "resource": "MONDO", "name": "inherited susceptibility to asthma", "description": "" }, { "id": "MONDO:0010940", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "resource": "MONDO", "name": "asthma-related traits, susceptibility to", "description": "" }, { "id": "MONDO:0010940", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "resource": "MONDO", "name": "asthma, diminished response to Antileukotriene treatment 1N", "description": "" }, { "id": "MONDO:0010940", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "resource": "MONDO", "name": "asthma, protection against", "description": "" }, { "id": "MONDO:0010940", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "resource": "MONDO", "name": "asthma, susceptibility to", "description": "" }, { "id": "MONDO:0010940", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "resource": "MONDO", "name": "asthma, bronchial", "description": "" }, { "id": "DOID:2841", "url": "http://disease-ontology.org/term/DOID:2841", "resource": "Disease Ontology", "name": "Exercise induced asthma", "description": "" }, { "id": "DOID:2841", "url": "http://disease-ontology.org/term/DOID:2841", "resource": "Disease Ontology", "name": "bronchial hyperreactivity", "description": "" }, { "id": "DOID:2841", "url": "http://disease-ontology.org/term/DOID:2841", "resource": "Disease Ontology", "name": "chronic obstructive asthma", "description": "" }, { "id": "DOID:2841", "url": "http://disease-ontology.org/term/DOID:2841", "resource": "Disease Ontology", "name": "chronic obstructive asthma with acute exacerbation", "description": "" }, { "id": "DOID:2841", "url": "http://disease-ontology.org/term/DOID:2841", "resource": "Disease Ontology", "name": "chronic obstructive asthma with status asthmaticus", "description": "" }, { "id": "DOID:2841", "url": "http://disease-ontology.org/term/DOID:2841", "resource": "Disease Ontology", "name": "exercise-induced asthma", "description": "" } ], "recommended_name": { "id": "DOID:2841", "url": "http://disease-ontology.org/term/DOID:2841", "resource": "Disease Ontology", "name": "asthma", "description": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing." }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/2841#disease-associations", "id": "2841", "database": "Alliance of Genome Resources" } ] } ], "phosphorylation": [], "mass": { "monoisotopic_mass": 47746.0, "chemical_mass": 47746.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2", "name": "Chil5", "locus": { "end_pos": 106016919, "strand": "-", "start_pos": 106032814, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000043873", "id": "ENSMUSG00000043873", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Chitinase-like 5" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2JDS2", "type": "synonym", "resource": "RefSeq", "name": "chitinase like precursor" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2JDS2", "type": "synonym", "resource": "RefSeq", "name": "chitinase like protein 2; chitinase 3-like 7" } ] }