{ "uniprot_canonical_ac": "A0A0B4J2F2-1", "ptm_annotation": [], "sequence": { "header": "sp|A0A0B4J2F2-1|SIK1B_HUMAN Isoform 1 of Probable serine/threonine-protein kinase SIK1B OS=Homo sapiens OX=9606 GN=SIK1B PE=1 SV=1 CANONICAL=A0A0B4J2F2-1", "length": 783, "sequence": "MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQVPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ" }, "uniprot_id": "SIK1B_HUMAN", "enzyme_annotation": [ { "ec": "2.7.11.1", "activity": "" }, { "ec": "2.7.11.1", "activity": "ATP + a protein = ADP + a phosphoprotein." } ], "glycation": [], "keywords": [], "species": [ { "common_name": "Human", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0B4J2F2", "id": "A0A0B4J2F2", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "publication": [], "uniprot_ac": "A0A0B4J2F2", "site_annotation": [ { "end_pos": 330, "annotation": "n_glycosylation_sequon", "start_pos": 328 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0B4J2F2#A0A0B4J2F2-1", "isoform_ac": "A0A0B4J2F2-1", "locus": { "end_pos": 6112084, "strand": "-", "start_pos": 6121516, "chromosome": "21", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000613488", "id": "ENST00000613488", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000482829", "id": "ENSP00000482829", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A0A0B4J2F2-1|SIK1B_HUMAN Isoform 1 of Probable serine/threonine-protein kinase SIK1B OS=Homo sapiens OX=9606 GN=SIK1B PE=1 SV=1 CANONICAL=A0A0B4J2F2-1", "length": 783, "sequence": "MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQVPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:102724428", "resource": "KEGG Pathway", "id": "hsa:102724428", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A0A0B4J2F2#function", "annotation": "Probable serine/threonine-protein kinase.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0B4J2F2#function", "id": "A0A0B4J2F2", "database": "UniProtKB" } ] } ], "orthologs": [], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [], "refseq": {}, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0B4J2F2", "id": "A0A0B4J2F2", "database": "UniProtKB" } ], "name": "protein serine/threonine kinase activity", "id": "GO:0004674" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0B4J2F2", "id": "A0A0B4J2F2", "database": "UniProtKB" } ], "name": "magnesium ion binding", "id": "GO:0000287" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0B4J2F2", "id": "A0A0B4J2F2", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0B4J2F2", "id": "A0A0B4J2F2", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0B4J2F2", "id": "A0A0B4J2F2", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006468", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0B4J2F2", "id": "A0A0B4J2F2", "database": "UniProtKB" } ], "name": "protein phosphorylation", "id": "GO:0006468" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0B4J2F2", "id": "A0A0B4J2F2", "database": "UniProtKB" } ], "name": "intracellular signal transduction", "id": "GO:0035556" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042149", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0B4J2F2", "id": "A0A0B4J2F2", "database": "UniProtKB" } ], "name": "cellular response to glucose starvation", "id": "GO:0042149" } ], "total": 3, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0B4J2F2", "type": "recommended", "resource": "UniProtKB", "name": "SIK1B" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000275993", "id": "ENSG00000275993", "database": "Bgee" }, { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0B4J2F2", "id": "A0A0B4J2F2", "database": "BioMuta" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14071", "id": "cd14071", "database": "CDD" }, { "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=SIK1B", "id": "SIK1B", "database": "GeneCards" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/102724428", "id": "102724428", "database": "GeneID" }, { "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=52389", "id": "52389", "database": "HGNC" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A0A0B4J2F2*", "id": "A0A0B4J2F2", "database": "IntAct" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "id": "IPR000719", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "id": "IPR008271", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "id": "IPR011009", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015940", "id": "IPR015940", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017090", "id": "IPR017090", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "id": "IPR017441", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR034672", "id": "IPR034672", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:102724428", "id": "hsa:102724428", "database": "KEGG Pathway" }, { "url": "https://www.nextprot.org/entry/NX_A0A0B4J2F2", "id": "NX_A0A0B4J2F2", "database": "neXtProt" }, { "url": "https://omabrowser.org/oma/group/XVMETKD/", "id": "XVMETKD", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=1127668at2759", "id": "1127668at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00069", "id": "PF00069", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A0A0B4J2F2", "id": "PR_A0A0B4J2F2", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307572.1", "id": "NP_001307572.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A0A0B4J2F2", "id": "A0A0B4J2F2", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 84930.0, "chemical_mass": 84930.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0B4J2F2", "name": "SIK1B", "locus": { "end_pos": 6123739, "strand": "+", "start_pos": 6111134, "chromosome": "21", "evidence": [ { "url": "https://www.ensembl.org/id/ENSG00000275993", "id": "ENSG00000275993", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0B4J2F2#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "2.7.11.1" }, { "url": "https://www.uniprot.org/uniprot/A0A0B4J2F2#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Probable serine/threonine-protein kinase SIK1B" }, { "url": "https://www.uniprot.org/uniprot/A0A0B4J2F2#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Salt-inducible kinase 1B" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0B4J2F2", "type": "synonym", "resource": "RefSeq", "name": "probable serine/threonine-protein kinase SIK1B" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0B4J2F2", "type": "synonym", "resource": "RefSeq", "name": "serine/threonine-protein kinase SIK1; salt-inducible kinase 1B; Salt-inducible kinase 1; Serine/threonine-protein kinase SNF1-like kinase 1; Serine/threonine-protein kinase SNF1LK" } ] }