{
    "uniprot_canonical_ac": "A0A0A0MS15-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A0A0A0MS15-1|HV349_HUMAN Isoform 1 of Immunoglobulin heavy variable 3-49  OS=Homo sapiens OX=9606 GN=IGHV3-49 PE=3 SV=1 CANONICAL=A0A0A0MS15-1", 
        "length": 119, 
        "sequence": "MEFGLSWVFLVAILKGVQCEVQLVESGGGLVQPGRSLRLSCTASGFTFGDYAMSWVRQAPGKGLEWVGFIRSKAYGGTTEYAASVKGRFTISRDDSKSIAYLQMNSLKTEDTAVYYCTR"
    }, 
    "uniprot_id": "HV349_HUMAN", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Human", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0A0MS15", 
                    "id": "A0A0A0MS15", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/11340299", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "11340299"
                }
            ], 
            "title": "Nomenclature of the human immunoglobulin heavy (IGH) genes.", 
            "journal": "Exp. Clin. Immunogenet.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0A0MS15", 
                    "id": "A0A0A0MS15", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Lefranc M.P.", 
            "date": "2001"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/17576170", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "17576170"
                }
            ], 
            "title": "Immunoglobulin somatic hypermutation.", 
            "journal": "Annu. Rev. Genet.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0A0MS15", 
                    "id": "A0A0A0MS15", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Teng G., Papavasiliou F.N.", 
            "date": "2007"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/20176268", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "20176268"
                }
            ], 
            "title": "Structure and function of immunoglobulins.", 
            "journal": "J. Allergy Clin. Immunol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0A0MS15", 
                    "id": "A0A0A0MS15", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Cavacini L., Schroeder H.W. Jr.", 
            "date": "2010"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/22158414", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "22158414"
                }
            ], 
            "title": "Molecular programming of B cell memory.", 
            "journal": "Nat. Rev. Immunol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0A0MS15", 
                    "id": "A0A0A0MS15", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Wang N., McHeyzer-Williams L., McHeyzer-Williams M., Okitsu S.", 
            "date": "2012"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/24600447", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "24600447"
                }
            ], 
            "title": "Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise of Immunoinformatics.", 
            "journal": "Front. Immunol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0A0MS15", 
                    "id": "A0A0A0MS15", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Lefranc M.P.", 
            "date": "2014"
        }
    ], 
    "uniprot_ac": "A0A0A0MS15", 
    "site_annotation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0A0MS15#A0A0A0MS15-1", 
            "isoform_ac": "A0A0A0MS15-1", 
            "locus": {
                "end_pos": 106581619, 
                "strand": "+", 
                "start_pos": 106582078, 
                "chromosome": "14", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000632211", 
                        "id": "ENST00000632211", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000488069", 
                        "id": "ENSP00000488069", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A0A0A0MS15-1|HV349_HUMAN Isoform 1 of Immunoglobulin heavy variable 3-49  OS=Homo sapiens OX=9606 GN=IGHV3-49 PE=3 SV=1 CANONICAL=A0A0A0MS15-1", 
                "length": 119, 
                "sequence": "MEFGLSWVFLVAILKGVQCEVQLVESGGGLVQPGRSLRLSCTASGFTFGDYAMSWVRQAPGKGLEWVGFIRSKAYGGTTEYAASVKGRFTISRDDSKSIAYLQMNSLKTEDTAVYYCTR"
            }
        }
    ], 
    "pathway": [], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0A0MS15#function", 
            "annotation": "V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0A0MS15#function", 
                    "id": "A0A0A0MS15", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [], 
    "refseq": {}, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034987", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0A0MS15", 
                                "id": "A0A0A0MS15", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "immunoglobulin receptor binding", 
                        "id": "GO:0034987"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003823", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0A0MS15", 
                                "id": "A0A0A0MS15", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "antigen binding", 
                        "id": "GO:0003823"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0A0MS15", 
                                "id": "A0A0A0MS15", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "external side of plasma membrane", 
                        "id": "GO:0009897"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042571", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0A0MS15", 
                                "id": "A0A0A0MS15", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "immunoglobulin complex, circulating", 
                        "id": "GO:0042571"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006911", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0A0MS15", 
                                "id": "A0A0A0MS15", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "phagocytosis, engulfment", 
                        "id": "GO:0006911"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0A0MS15", 
                                "id": "A0A0A0MS15", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "innate immune response", 
                        "id": "GO:0045087"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050853", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0A0MS15", 
                                "id": "A0A0A0MS15", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "B cell receptor signaling pathway", 
                        "id": "GO:0050853"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042742", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0A0MS15", 
                                "id": "A0A0A0MS15", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "defense response to bacterium", 
                        "id": "GO:0042742"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006910", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0A0MS15", 
                                "id": "A0A0A0MS15", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "phagocytosis, recognition", 
                        "id": "GO:0006910"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050871", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0A0MS15", 
                                "id": "A0A0A0MS15", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of B cell activation", 
                        "id": "GO:0050871"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006958", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0A0MS15", 
                                "id": "A0A0A0MS15", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "complement activation, classical pathway", 
                        "id": "GO:0006958"
                    }
                ], 
                "total": 7, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0A0MS15", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "IGHV3-49"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211965", 
            "id": "ENSG00000211965", 
            "database": "Bgee"
        }, 
        {
            "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A0A0MS15", 
            "id": "A0A0A0MS15", 
            "database": "BioMuta"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=IGHV3-49", 
            "id": "IGHV3-49", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=5607", 
            "id": "5607", 
            "database": "HGNC"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", 
            "id": "IPR007110", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", 
            "id": "IPR013106", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", 
            "id": "IPR013783", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", 
            "id": "IPR036179", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A0A0A0MS15", 
            "id": "NX_A0A0A0MS15", 
            "database": "neXtProt"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/EWIAATR/", 
            "id": "EWIAATR", 
            "database": "OMA"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF07686", 
            "id": "PF07686", 
            "database": "Pfam"
        }, 
        {
            "url": "https://pharos.nih.gov/targets/A0A0A0MS15", 
            "id": "A0A0A0MS15", 
            "database": "PHAROS"
        }, 
        {
            "url": "http://purl.obolibrary.org/obo/PR_PR_A0A0A0MS15", 
            "id": "PR_A0A0A0MS15", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0A0MS15", 
            "id": "A0A0A0MS15", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 13056.0, 
        "chemical_mass": 13056.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0A0MS15", 
            "name": "IGHV3-49", 
            "locus": {
                "end_pos": 106556936, 
                "strand": "-", 
                "start_pos": 106557477, 
                "chromosome": "14", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSG00000211965", 
                        "id": "ENSG00000211965", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0A0MS15#names_and_taxonomy", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Immunoglobulin heavy variable 3-49"
        }
    ]
}