{ "uniprot_canonical_ac": "A0A096MJY4-1", "ptm_annotation": [ { "annotation": "Acetylated by p300 on several sites in diffentiating myocytes. Acetylation on Lys-4 increases DNA binding and transactivation.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ] }, { "annotation": "Phosphorylated on Ser-59; which enhances DNA binding activity. Phosphorylated on Ser-396; which is required for Lys-391 sumoylation and inhibits transcriptional activity.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ] }, { "annotation": "Proteolytically cleaved in cerebellar granule neurons on several sites by caspase 3 and caspase 7 following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ] }, { "annotation": "Sumoylated on Lys-391 with SUMO2 but not SUMO1; which represses transcriptional activity.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ] } ], "sequence": { "header": "sp|A0A096MJY4-1|MEF2C_RAT Isoform 1 of Myocyte-specific enhancer factor 2C OS=Rattus norvegicus OX=10116 GN=Mef2c PE=1 SV=1 CANONICAL=A0A096MJY4-1", "length": 473, "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT" }, "uniprot_id": "MEF2C_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15862299", "type": [ "PubMed" ], "id": "15862299" } ], "title": "MEF2C DNA-binding activity is inhibited through its interaction with the regulatory protein Ki-1/57.", "journal": "FEBS Lett.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "authors": "Kobarg J., Crosara-Alberto D.P., Franchini K.G., Kobarg C.B., Theizen T.H.", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "type": [ "PubMed" ], "id": "22673903" } ], "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012" } ], "uniprot_ac": "A0A096MJY4", "site_annotation": [ { "end_pos": 285, "annotation": "n_glycosylation_sequon", "start_pos": 283 }, { "end_pos": 381, "annotation": "n_glycosylation_sequon", "start_pos": 379 }, { "end_pos": 51, "annotation": "n_glycosylation_sequon", "start_pos": 49 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4#A0A096MJ09-1", "isoform_ac": "A0A096MJ09-1", "locus": { "end_pos": 11730033, "strand": "-", "start_pos": 11818305, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000076992", "id": "ENSRNOT00000076992", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000067948", "id": "ENSRNOP00000067948", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A096MJ09-1|MEF2C_RAT Computationally mapped isoform of Myocyte-specific enhancer factor 2C OS=Rattus norvegicus OX=10116 GN=Mef2c PE=1 SV=1 CANONICAL=A0A096MJY4-1", "length": 431, "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVEALNKKENKGSESPDPDSSYALTPRTEEKYKKINEEFDNMIKSHKIPAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT" } }, { "url": "https://www.uniprot.org/uniprot/A0A096MJY4#A0A096MJ23-1", "isoform_ac": "A0A096MJ23-1", "locus": { "end_pos": 11730033, "strand": "-", "start_pos": 11818305, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000076481", "id": "ENSRNOT00000076481", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000067963", "id": "ENSRNOP00000067963", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A096MJ23-1|MEF2C_RAT Computationally mapped isoform of Myocyte-specific enhancer factor 2C OS=Rattus norvegicus OX=10116 GN=Mef2c PE=1 SV=1 CANONICAL=A0A096MJY4-1", "length": 441, "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT" } }, { "url": "https://www.uniprot.org/uniprot/A0A096MJY4#A0A096MJD9-1", "isoform_ac": "A0A096MJD9-1", "locus": { "end_pos": 11730033, "strand": "-", "start_pos": 11818305, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000075931", "id": "ENSRNOT00000075931", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000067970", "id": "ENSRNOP00000067970", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A096MJD9-1|MEF2C_RAT Computationally mapped isoform of Myocyte-specific enhancer factor 2C OS=Rattus norvegicus OX=10116 GN=Mef2c PE=1 SV=1 CANONICAL=A0A096MJY4-1", "length": 471, "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVEALNKKENKGSESPDPDSSYALTPRTEEKYKKINEEFDNMIKSHKIPAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT" } }, { "url": "https://www.uniprot.org/uniprot/A0A096MJY4#A0A096MJY4-1", "isoform_ac": "A0A096MJY4-1", "locus": { "end_pos": 11730033, "strand": "-", "start_pos": 11818305, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000076710", "id": "ENSRNOT00000076710", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068307", "id": "ENSRNOP00000068307", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A0A096MJY4-1|MEF2C_RAT Isoform 1 of Myocyte-specific enhancer factor 2C OS=Rattus norvegicus OX=10116 GN=Mef2c PE=1 SV=1 CANONICAL=A0A096MJY4-1", "length": 473, "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT" } }, { "url": "https://www.uniprot.org/uniprot/A0A096MJY4#A0A096MJZ6-1", "isoform_ac": "A0A096MJZ6-1", "locus": { "end_pos": 11730033, "strand": "-", "start_pos": 11818305, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000076416", "id": "ENSRNOT00000076416", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068323", "id": "ENSRNOP00000068323", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A096MJZ6-1|MEF2C_RAT Computationally mapped isoform of Myocyte-specific enhancer factor 2C OS=Rattus norvegicus OX=10116 GN=Mef2c PE=1 SV=1 CANONICAL=A0A096MJY4-1", "length": 393, "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVEAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT" } }, { "url": "https://www.uniprot.org/uniprot/A0A096MJY4#A0A096MK01-1", "isoform_ac": "A0A096MK01-1", "locus": { "end_pos": 11730033, "strand": "-", "start_pos": 11818305, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000076408", "id": "ENSRNOT00000076408", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068328", "id": "ENSRNOP00000068328", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A096MK01-1|MEF2C_RAT Computationally mapped isoform of Myocyte-specific enhancer factor 2C OS=Rattus norvegicus OX=10116 GN=Mef2c PE=1 SV=1 CANONICAL=A0A096MJY4-1", "length": 417, "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVEAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT" } }, { "url": "https://www.uniprot.org/uniprot/A0A096MJY4#A0A096MK43-1", "isoform_ac": "A0A096MK43-1", "locus": { "end_pos": 11730033, "strand": "-", "start_pos": 11818305, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000076239", "id": "ENSRNOT00000076239", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068373", "id": "ENSRNOP00000068373", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A096MK43-1|MEF2C_RAT Computationally mapped isoform of Myocyte-specific enhancer factor 2C OS=Rattus norvegicus OX=10116 GN=Mef2c PE=1 SV=1 CANONICAL=A0A096MJY4-1", "length": 463, "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVEALNKKENKGSESPDPDSSYALTPRTEEKYKKINEEFDNMIKSHKIPAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT" } }, { "url": "https://www.uniprot.org/uniprot/A0A096MJY4#A0A096MK88-1", "isoform_ac": "A0A096MK88-1", "locus": { "end_pos": 11730033, "strand": "-", "start_pos": 11818305, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000076084", "id": "ENSRNOT00000076084", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068421", "id": "ENSRNOP00000068421", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A096MK88-1|MEF2C_RAT Computationally mapped isoform of Myocyte-specific enhancer factor 2C OS=Rattus norvegicus OX=10116 GN=Mef2c PE=1 SV=1 CANONICAL=A0A096MJY4-1", "length": 465, "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT" } }, { "url": "https://www.uniprot.org/uniprot/A0A096MJY4#A0A096MKI4-1", "isoform_ac": "A0A096MKI4-1", "locus": { "end_pos": 11730033, "strand": "-", "start_pos": 11818305, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000076230", "id": "ENSRNOT00000076230", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068527", "id": "ENSRNOP00000068527", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A096MKI4-1|MEF2C_RAT Computationally mapped isoform of Myocyte-specific enhancer factor 2C OS=Rattus norvegicus OX=10116 GN=Mef2c PE=1 SV=1 CANONICAL=A0A096MJY4-1", "length": 433, "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:499497", "resource": "KEGG Pathway", "id": "rno:499497", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-525793", "resource": "Reactome", "id": "R-RNO-525793", "name": "Myogenesis" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4#function", "annotation": "Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes (PubMed:15862299). Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4#function", "id": "A0A096MJY4", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q06413-1", "protein_name": "Myocyte-specific enhancer factor 2C", "sequence": { "length": 473, "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVSIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNMQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/31087", "id": "31087", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "MEF2C", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q8CFN5-1", "protein_name": "Myocyte-specific enhancer factor 2C", "sequence": { "length": 474, "sequence": "MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPSFEMPVTIPVSSHNSLVYSNPVSTLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLSIKSEPVSPPRDRTTTPSRYPQHTTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/31087", "id": "31087", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Mef2c", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006224017.1", "ac": "XP_006224017.1", "name": "myocyte-specific enhancer factor 2C isoform X1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "pmid": "19654000", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "DNA binding", "id": "GO:0003677" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008134", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "transcription factor binding", "id": "GO:0008134" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "pmid": "19654000", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003680", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "minor groove of adenine-thymine-rich DNA binding", "id": "GO:0003680" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "chromatin binding", "id": "GO:0003682" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "DNA-binding transcription factor activity", "id": "GO:0003700" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "protein heterodimerization activity", "id": "GO:0046982" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042826", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "histone deacetylase binding", "id": "GO:0042826" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "transcription regulatory region sequence-specific DNA binding", "id": "GO:0000976" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000987", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "cis-regulatory region sequence-specific DNA binding", "id": "GO:0000987" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "sequence-specific DNA binding", "id": "GO:0043565" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071837", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "HMG box domain binding", "id": "GO:0071837" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033613", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "activating transcription factor binding", "id": "GO:0033613" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837" } ], "total": 17, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000790", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "nuclear chromatin", "id": "GO:0000790" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "15862299", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "17696759", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "19654000", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030017", "pmid": "15862299", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "sarcomere", "id": "GO:0030017" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "nuclear speck", "id": "GO:0016607" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098794", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "postsynapse", "id": "GO:0098794" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "protein-containing complex", "id": "GO:0032991" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016528", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "sarcoplasm", "id": "GO:0016528" } ], "total": 9, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "pmid": "15486975", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "heart development", "id": "GO:0007507" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "cell differentiation", "id": "GO:0030154" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "pmid": "19654000", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071300", "pmid": "17568621", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "cellular response to retinoic acid", "id": "GO:0071300" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071333", "pmid": "18413674", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "cellular response to glucose stimulus", "id": "GO:0071333" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031667", "pmid": "20676734", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "response to nutrient levels", "id": "GO:0031667" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033197", "pmid": "16534476", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "response to vitamin E", "id": "GO:0033197" }, { "url": 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"https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "learning or memory", "id": "GO:0007611" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "positive regulation of gene expression", "id": "GO:0010628" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "negative regulation of gene expression", "id": "GO:0010629" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045666", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "positive regulation of neuron differentiation", "id": "GO:0045666" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060079", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "excitatory postsynaptic potential", "id": "GO:0060079" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000310", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "regulation of NMDA receptor activity", "id": "GO:2000310" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000165", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "MAPK cascade", "id": "GO:0000165" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001764", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJY4", "id": "A0A096MJY4", "database": "UniProtKB" } ], "name": "neuron migration", "id": "GO:0001764" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001974", "pmid": "", "evidence": 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