{ "uniprot_canonical_ac": "A0A096MJF9-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A096MJF9-1|A0A096MJF9_RAT Isoform 1 of Transmembrane protein 132E OS=Rattus norvegicus OX=10116 GN=Tmem132e PE=3 SV=1 CANONICAL=A0A096MJF9-1", "length": 1073, "sequence": "MAPGMLGRRGAALLCLSVLLAHAASRSHPASPSPPGPQASPVLPVSYRLSHTRLAFFLKEARPPTPTAMNGSLQRSEPFVVFQTKELPVLNVSLGPFSTSQVVARELLQPSSTLDIPERLTVNWKVRAFIVRARVPASQPVAQVLFYVAGRDWDDFGVTERLPCVRLHAFRDAREVRSSCRLGGALATCLVRAELPLAWFGPPAPAAPPSTRRKSPDGLEPEATAESQQVELYYTLHAPDAAGGCGSARRGSGPGPAARAESPTQHPLLRIGSISLFRPPPRRAMQEHRLDSNLMIRLPDRPLRPGEVLSILLYLAPNSSSAASPSLEHFTLRVKAKKGVTLLGTKSRNGQWHVTSELLTGAKHSTATVDVAWAQGTPLPPWESQGPLEILQLDFEMENFTSQSVKRRIMWHIDYRGHSALPDLERAVTELTVIQRDVQAILPLAMDTEIINTAILTGRTVAIPVKVIAIEVTGVVLDVSDLVECQSHREDIIKVSSSCDYVFVSGKESRGSMNARVTFRYDVLSAPLEMTVWVPKLPLHIELSDARLSQVKGWRVPILPDRRSARESEDEEEEEEERRQSANRGCTLQYQHATLQVFTQFHTTSSEGTEQVVTMLGPDWLVEVTDLVSDFMRVGDPRVAHLVDSNTLAGLEPGTTPFKVVSPLTEAVLGETLLTVTEEKVSITQLQAQVVASLTLSLRPSPGSSHTILATTAAQPTLSSVKQEALLSLWLSYSDGTTAPLSLYSPRDYGLLVNSLDERVATVTQDKAFPLLVAEAEGAGDLLRAELTISESCQKTKRKSVLATTPVGLRVHFGRDEEDPTYDYPGPSQPGPGGGEDEARGAGPPGTAIPAGEVPGLGTAGPMPPTEDFLPLPTGFLQMPRGLTDLEIGMYALLGVFCLAILVFLINCIVFVLRYRHKRIPPEGQTSMDHSHHWVFLGNGQPLRVQGELSPPAGSALETVPACCHGDHHSSGSSQTSVQSQVHGRGDGSSGGSARDQTEDPASSPTSKRKRVKFTTFTTLPSEELAYDSVPAGEEDEEDEEDLGWGCPDVAGTTRPTPPPDLHNYMRRIKDIA" }, "uniprot_id": "A0A096MJF9_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJF9", "id": "A0A096MJF9", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [], "uniprot_ac": "A0A096MJF9", "site_annotation": [ { "end_pos": 320, "annotation": "n_glycosylation_sequon", "start_pos": 318 }, { "end_pos": 401, "annotation": "n_glycosylation_sequon", "start_pos": 399 }, { "end_pos": 72, "annotation": "n_glycosylation_sequon", "start_pos": 70 }, { "end_pos": 93, "annotation": "n_glycosylation_sequon", "start_pos": 91 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJF9#A0A096MJF9-1", "isoform_ac": "A0A096MJF9-1", "locus": { "end_pos": 69737569, "strand": "-", "start_pos": 69793968, "chromosome": "10", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000076773", "id": "ENSRNOT00000076773", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068114", "id": "ENSRNOP00000068114", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A096MJF9-1|A0A096MJF9_RAT Isoform 1 of Transmembrane protein 132E OS=Rattus norvegicus OX=10116 GN=Tmem132e PE=3 SV=1 CANONICAL=A0A096MJF9-1", "length": 1073, "sequence": "MAPGMLGRRGAALLCLSVLLAHAASRSHPASPSPPGPQASPVLPVSYRLSHTRLAFFLKEARPPTPTAMNGSLQRSEPFVVFQTKELPVLNVSLGPFSTSQVVARELLQPSSTLDIPERLTVNWKVRAFIVRARVPASQPVAQVLFYVAGRDWDDFGVTERLPCVRLHAFRDAREVRSSCRLGGALATCLVRAELPLAWFGPPAPAAPPSTRRKSPDGLEPEATAESQQVELYYTLHAPDAAGGCGSARRGSGPGPAARAESPTQHPLLRIGSISLFRPPPRRAMQEHRLDSNLMIRLPDRPLRPGEVLSILLYLAPNSSSAASPSLEHFTLRVKAKKGVTLLGTKSRNGQWHVTSELLTGAKHSTATVDVAWAQGTPLPPWESQGPLEILQLDFEMENFTSQSVKRRIMWHIDYRGHSALPDLERAVTELTVIQRDVQAILPLAMDTEIINTAILTGRTVAIPVKVIAIEVTGVVLDVSDLVECQSHREDIIKVSSSCDYVFVSGKESRGSMNARVTFRYDVLSAPLEMTVWVPKLPLHIELSDARLSQVKGWRVPILPDRRSARESEDEEEEEEERRQSANRGCTLQYQHATLQVFTQFHTTSSEGTEQVVTMLGPDWLVEVTDLVSDFMRVGDPRVAHLVDSNTLAGLEPGTTPFKVVSPLTEAVLGETLLTVTEEKVSITQLQAQVVASLTLSLRPSPGSSHTILATTAAQPTLSSVKQEALLSLWLSYSDGTTAPLSLYSPRDYGLLVNSLDERVATVTQDKAFPLLVAEAEGAGDLLRAELTISESCQKTKRKSVLATTPVGLRVHFGRDEEDPTYDYPGPSQPGPGGGEDEARGAGPPGTAIPAGEVPGLGTAGPMPPTEDFLPLPTGFLQMPRGLTDLEIGMYALLGVFCLAILVFLINCIVFVLRYRHKRIPPEGQTSMDHSHHWVFLGNGQPLRVQGELSPPAGSALETVPACCHGDHHSSGSSQTSVQSQVHGRGDGSSGGSARDQTEDPASSPTSKRKRVKFTTFTTLPSEELAYDSVPAGEEDEEDEEDLGWGCPDVAGTTRPTPPPDLHNYMRRIKDIA" } }, { "url": "https://www.uniprot.org/uniprot/A0A096MJF9#D4A2A3-1", "isoform_ac": "D4A2A3-1", "locus": { "end_pos": 69737569, "strand": "-", "start_pos": 69793968, "chromosome": "10", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000055999", "id": "ENSRNOT00000055999", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000052853", "id": "ENSRNOP00000052853", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D4A2A3-1|A0A096MJF9_RAT Computationally mapped isoform of Transmembrane protein 132E OS=Rattus norvegicus OX=10116 GN=Tmem132e PE=3 SV=1 CANONICAL=A0A096MJF9-1", "length": 983, "sequence": "MAPGMLGRRGAALLCLSVLLAHAASRSHPASPSPPGPQASPVLPVSYRLSHTRLAFFLKEARPPTPTAMNGSLQRSEPFVVFQTKELPVLNVSLGPFSTSQVVARELLQPSSTLDIPERLTVNWKVRAFIVRARVPASQPVAQVLFYVAGRDWDDFGVTERLPCVRLHAFRDAREHPLLRIGSISLFRPPPRRAMQEHRLDSNLMIRLPDRPLRPGEVLSILLYLAPNSSSAASPSLEHFTLRVKAKKGVTLLGTKSRNGQWHVTSELLTGAKHSTATVDVAWAQGTPLPPWESQGPLEILQLDFEMENFTSQSVKRRIMWHIDYRGHSALPDLERAVTELTVIQRDVQAILPLAMDTEIINTAILTGRTVAIPVKVIAIEVTGVVLDVSDLVECQSHREDIIKVSSSCDYVFVSGKESRGSMNARVTFRYDVLSAPLEMTVWVPKLPLHIELSDARLSQVKGWRVPILPDRRSARESEDEEEEEEERRQSANRGCTLQYQHATLQVFTQFHTTSSEGTEQVVTMLGPDWLVEVTDLVSDFMRVGDPRVAHLVDSNTLAGLEPGTTPFKVVSPLTEAVLGETLLTVTEEKVSITQLQAQVVASLTLSLRPSPGSSHTILATTAAQPTLSSVKQEALLSLWLSYSDGTTAPLSLYSPRDYGLLVNSLDERVATVTQDKAFPLLVAEAEGAGDLLRAELTISESCQKTKRKSVLATTPVGLRVHFGRDEEDPTYDYPGPSQPGPGGGEDEARGAGPPGTAIPAGEVPGLGTAGPMPPTEDFLPLPTGFLQMPRGLTDLEIGMYALLGVFCLAILVFLINCIVFVLRYRHKRIPPEGQTSMDHSHHWVFLGNGQPLRVQGELSPPAGSALETVPACCHGDHHSSGSSQTSVQSQVHGRGDGSSGGSARDQTEDPASSPTSKRKRVKFTTFTTLPSEELAYDSVPAGEEDEEDEEDLGWGCPDVAGTTRPTPPPDLHNYMRRIKDIA" } } ], "pathway": [], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q6IEE6-1", "protein_name": "Transmembrane protein 132E", "sequence": { "length": 1074, "sequence": "MAPGMSGRRGAALLCLSVLLAHAASRSHPASPSPPGTQASPILPVSYRLSHTRLAFFLKEARPLTPAAINGSLQRSEPFVVFQTKELPVLNVSLGPFSTSQVVARELLQPSSTLDIPERLTVNWKVRAFIVRARVPASQPVAQVLFYVAGRDWDDFGVTERLPCVRLHAFRDAREVRSSCRLGGALATCLVRAELPLAWFGPPAPAAPPSARRKSPDGLEPEAAAESQQVELYYTLHAPDASGGCGSARRGPGPGPGAAARAESPTQHPLLRIGSISLFRPPPRRAVQEHRLDSNLMIRLPDRPLRPGEVLSILLYLAPNSSSAASPSVEHFTLRVKAKKGVTLLGTKSRSGQWRVTSELLTGAKHSTATVDVAWALDTPLPPWEGQGPLEILQLDFEMENFTSQSVKRRIMWHIDYRGHSALPDLERAVTELTVIQRDVQAILPLAMDTEIINTAILTGRTVAIPVKVIAIEVTGLVLDVSDLVECQSHSEDIIKVSSSCDYVFVSGKESRGSMNARVTFRYDVLSAPLEMTVWVPKLPLHIELSDARLSQVKGWRVPILPDRRSARESEDEEEEEEERRQSANRGCTLQYQHATLQVFTQFHTTSSEGTDQVVTMLGPDWLVEVTDLVSDFMRVGDPRVAHLVDSNTLAGLEPGTTPFKVVSPLTEAVLGETLLTVTEEKVSITQLQAQVVASLTLSLRPSPGSSHTILATTAAQPTLSLVKQEALLSLWLSYSDGTTAPLSLYSSRDYGLLVSSLDERVATVTQDKAFPLVVAEAEGSGDLLRAELTISESCQKTKRKSVLATTPVSLRVHFGRDEEDPTYDYPGPSQPGPGGGEDEARGAGPPGTAIPAGEVPGLGTAGPVPPTEDYLPLPTGFLQMPRGLTDLEIGMYALLGVFCLAILVFLINCIVFVLRYRHKRIPPEGQTSMDHSHHWVFLGNGQPLRVQGELSPPAGSALETVPACCHGDHHSSGSSQTSVQSQVHGRGDGSSGGSARDQTEDPASSPTSKRKRVKFTTFTTLPTEELAYDSVPAGEEEDEEEDLGWGCPDVAGTTRPTPPPDLHNYMRRIKDIA" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A096MJF9/", "id": "A0A096MJF9", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/41524", "id": "41524", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Tmem132e", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q6IEE7-1", "protein_name": "Transmembrane protein 132E", "sequence": { "length": 1074, "sequence": "MAPGMSGRGGAALLCLSALLAHASGRSHPASPSPPGPQASPVLPVSYRLSHTRLAFFLREARPPSPAVANSSLQRSEPFVVFQTKELPVLNVSLGPFSTSQVVARELLQPSSTLDIPERLTVNWKVRAFIVRSHVPASQPVVQVLFYVAGRDWDDFGVTERLPCVRLHAFRDAREVKSSCRLSGGLATCLVRAELPLAWFGPPAPAAPPTARRKSPDGLEPEATGESQQAELYYTLHAPDASGGCGGSRRGAGPGVGARAESPTQHPLLRIGSISLFRPPPRRTLQEHRLDSNLMIRLPDRPLKPGEVLSILLYLAPNSSSPSSPSVEHFTLRVKAKKGVTLLGTKSRSGQWHVTSELLTGAKHSTATVDVAWAQSTPLPPREGQGPLEILQLDFEMENFTSQSVKRRIMWHIDYRGHGALPDLERAVTELTVIQRDVQAILPLAMDTEIINTAILTGRTVAIPVKVIAIEVNGLVLDISALVECESDNEDIIKVSSSCDYVFVSGKESRGSMNARVTFRYDVLNAPLEMTVWVPKLPLHIELSDARLSQVKGWRVPILPDRRSVRESEDEDEEEEERRQSASRGCTLQYQHATLQVFTQFHTTSSEGTDQVVTMLGPDWLVEVTDLVSDFMRVGDPRVAHMVDSSTLAGLEPGTTPFKVVSPLTEAVLGETLLTVTEEKVSITQLQAQVVASLALSLRPSPGSSHTILATTAAQQTLSFLKQEALLSLWLSYSDGTTAPLSLYSPRDYGLLVSSLDEHVATVTQDRAFPLVVAEAEGSGELLRAELTIAESCQKTKRKSVLATTPVGLRVHFGRDEEDPTYDYPGPSQPGPGGGEDEARGAGPPGSALPAPEAPGPGTASPVVPPTEDFLPLPTGFLQVPRGLTDLEIGMYALLGVFCLAILVFLINCIVFVLRYRHKRIPPEGQTSMDHSHHWVFLGNGQPLRVQGELSPPAGNPLETVPAFCHGDHHSSGSSQTSVQSQVHGRGDGSSGGSARDQAEDPASSPTSKRKRVKFTTFTTLPSEELAYDSVPAGEEDEEEEEDLGWGCPDVAGPTRPTAPPDLHNYMRRIKEIA" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A096MJF9/", "id": "A0A096MJF9", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/41524", "id": "41524", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "TMEM132E", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008766187.1", "ac": "XP_008766187.1", "name": "transmembrane protein 132E isoform X1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJF9", "id": "A0A096MJF9", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044297", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJF9", "id": "A0A096MJF9", "database": "UniProtKB" } ], "name": "cell body", "id": "GO:0044297" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035677", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJF9", "id": "A0A096MJF9", "database": "UniProtKB" } ], "name": "posterior lateral line neuromast hair cell development", "id": "GO:0035677" } ], "total": 1, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A096MJF9", "type": "synonym", "resource": "RefSeq", "name": "RGD1565522" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A096MJF9", "type": "synonym", "resource": "RefSeq", "name": "Tmem132e" }, { "url": "https://www.uniprot.org/uniprot/A0A096MJF9", "type": "recommended", "resource": "UniProtKB", "name": "Tmem132e" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000007455", "id": "ENSRNOG00000007455", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/287564", "id": "287564", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR026307", "id": "IPR026307", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR031435", "id": "IPR031435", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR031436", "id": "IPR031436", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR031437", "id": "IPR031437", "database": "InterPro" }, { "url": "https://omabrowser.org/oma/group/QFHTTSA/", "id": "QFHTTSA", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=598074at2759", "id": "598074at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13388", "id": "PTHR13388", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF15705", "id": "PF15705", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF15706", "id": "PF15706", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF16070", "id": "PF16070", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008766187.1", "id": "XP_008766187.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1565522", "id": "1565522", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A0A096MJF9", "id": "A0A096MJF9", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [ { "synonyms": [ { "id": "DOID:0111634", "url": "http://disease-ontology.org/term/DOID:0111634", "resource": "Disease Ontology", "name": "DFNB99", "description": "" }, { "id": "DOID:0111634", "url": "http://disease-ontology.org/term/DOID:0111634", "resource": "Disease Ontology", "name": "autosomal recessive deafness 99", "description": "" } ], "recommended_name": { "id": "DOID:0111634", "url": "http://disease-ontology.org/term/DOID:0111634", "resource": "Disease Ontology", "name": "autosomal recessive nonsyndromic deafness 99", "description": "An autosomal recessive nonsyndromic deafness characterized by prelingual, severe to profound sensorineural hearing loss without vestibular dysfunction that has_material_basis_in homozygous or compound heterozygous mutation in TMEM132E on chromosome 17q12." }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/0111634#disease-associations", "id": "0111634", "database": "Alliance of Genome Resources" } ] } ], "phosphorylation": [], "mass": { "monoisotopic_mass": 116387.0, "chemical_mass": 116387.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJF9", "name": "Tmem132e", "locus": { "end_pos": 69794975, "strand": "+", "start_pos": 69737328, "chromosome": "10", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000007455", "id": "ENSRNOG00000007455", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJF9#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Transmembrane protein 132E" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A096MJF9", "type": "synonym", "resource": "RefSeq", "name": "transmembrane protein 132E isoform X1" } ] }