{ "uniprot_canonical_ac": "A0A088MLT8-1", "ptm_annotation": [], "sequence": { "header": "sp|A0A088MLT8-1|IQIP1_MOUSE Isoform 1 of IQCJ-SCHIP1 readthrough transcript protein OS=Mus musculus OX=10090 GN=Iqcj-Schip1 PE=1 SV=2 CANONICAL=A0A088MLT8-1", "length": 559, "sequence": "MRLEELKRLQNPLEQVDDGKYLLENHQLAMDVENNIENYPLSLQPLESKVKIIQRAWREYLQRQDPLEKRSPSPPSVSSDKLSSSVSMNTFSDSSTPDYREDGMDLGSDAGSSSSSRASSQSNSTKVTPCSECKSSSSPGGSLDLVSALEDYEEPFPVYQKKVIDEWAPEEDGEEEEEEDDRGYRDDGCPAREPGDVSARIGSSGSGSRSAATTMPSPMPNGNLHPHDPQDLRHNGNVVVAGRPNASRVPRRPIQKTQPPGSRRGGRNRASGGLCLQPPDGGTRVPEEPPAPPMDWEALEKHLAGLQFREQEVRNQGQARTNSTSAQKNERESIRQKLALGSFFDDGPGIYTSCSKSGKPSLSARLQSGMNLQICFVNDSGSDKDSDADDSKTETSLDTPLSPMSKQSSSYSDRDTTEEESESLDDMDFLTRQKKLQAEAKMALAMAKPMAKMQVEVEKQNRKKSPVADLLPHMPHISECLMKRSLKPTDLRDMTIGQLQVIVNDLHSQIESLNEELVQLLLIRDELHTEQDAMLVDIEDLTRHAESQQKHMAEKMPAK" }, "uniprot_id": "IQIP1_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A088MLT8", "id": "A0A088MLT8", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17045569", "type": [ "PubMed" ], "id": "17045569" } ], "title": "IQCJ-SCHIP1, a novel fusion transcript encoding a calmodulin-binding IQ motif protein.", "journal": "Biochemical and biophysical research communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106890.1", "id": "NP_001106890.1", "database": "RefSeq" } ], "authors": "Kwasnicka-Crawford DA, Carson AR, Scherer SW", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18550753", "type": [ "PubMed" ], "id": "18550753" } ], "title": "Schwannomin-interacting protein-1 isoform IQCJ-SCHIP-1 is a late component of nodes of Ranvier and axon initial segments.", "journal": "J. Neurosci.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A088MLT8", "id": "A0A088MLT8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106890.1", "id": "NP_001106890.1", "database": "RefSeq" } ], "authors": "Dargent B., Goutebroze L., Irondelle M., Martin P.M., Carnaud M., Girault J.A., Garcia del Cano G., Irinopoulou T.", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25950943", "type": [ "PubMed" ], "id": "25950943" } ], "title": "CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1 association with AnkG contributes to the maintenance of the axon initial segment.", "journal": "J. Neurochem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A088MLT8", "id": "A0A088MLT8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106890.1", "id": "NP_001106890.1", "database": "RefSeq" } ], "authors": "Dargent B., Debarnot C., Fache M.P., Ferracci G., Garcia Del Cano G., Goutebroze L., Klingler E., Papandreou M.J., Piperoglou C., Rueda-Boroni F., Vacher H.", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25953347", "type": [ "PubMed" ], "id": "25953347" } ], "title": "The cytoskeleton-associated protein SCHIP1 is involved in axon guidance, and is required for piriform cortex and anterior commissure development.", "journal": "Development", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A088MLT8", "id": "A0A088MLT8", "database": "UniProtKB" } ], "authors": "Garcia M., Goutebroze L., Klingler E., Giovannini M., Chedotal A., Martin P.M., Falk J., Girault J.A., Chareyre F., Moreau-Fauvarque C.", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27979964", "type": [ "PubMed" ], "id": "27979964" } ], "title": "Schwannomin-interacting protein 1 isoform IQCJ-SCHIP1 is a multipartner ankyrin- and spectrin-binding protein involved in the organization of nodes of Ranvier.", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A088MLT8", "id": "A0A088MLT8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106890.1", "id": "NP_001106890.1", "database": "RefSeq" } ], "authors": "Garcia M., Goutebroze L., Klingler E., Devaux J., Martin P.M., Cifuentes-Diaz C., Girault J.A., Bureau J., Thomasseau S.", "date": "2017" } ], "uniprot_ac": "A0A088MLT8", "site_annotation": [ { "end_pos": 125, "annotation": "n_glycosylation_sequon", "start_pos": 123 }, { "end_pos": 247, "annotation": "n_glycosylation_sequon", "start_pos": 245 }, { "end_pos": 324, "annotation": "n_glycosylation_sequon", "start_pos": 322 }, { "end_pos": 380, "annotation": "n_glycosylation_sequon", "start_pos": 378 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A088MLT8#A0A088MLT8-1", "isoform_ac": "A0A088MLT8-1", "locus": { "end_pos": 67892313, "strand": "-", "start_pos": 68625855, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000182006", "id": "ENSMUST00000182006", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000138212", "id": "ENSMUSP00000138212", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A0A088MLT8-1|IQIP1_MOUSE Isoform 1 of IQCJ-SCHIP1 readthrough transcript protein OS=Mus musculus OX=10090 GN=Iqcj-Schip1 PE=1 SV=2 CANONICAL=A0A088MLT8-1", "length": 559, "sequence": "MRLEELKRLQNPLEQVDDGKYLLENHQLAMDVENNIENYPLSLQPLESKVKIIQRAWREYLQRQDPLEKRSPSPPSVSSDKLSSSVSMNTFSDSSTPDYREDGMDLGSDAGSSSSSRASSQSNSTKVTPCSECKSSSSPGGSLDLVSALEDYEEPFPVYQKKVIDEWAPEEDGEEEEEEDDRGYRDDGCPAREPGDVSARIGSSGSGSRSAATTMPSPMPNGNLHPHDPQDLRHNGNVVVAGRPNASRVPRRPIQKTQPPGSRRGGRNRASGGLCLQPPDGGTRVPEEPPAPPMDWEALEKHLAGLQFREQEVRNQGQARTNSTSAQKNERESIRQKLALGSFFDDGPGIYTSCSKSGKPSLSARLQSGMNLQICFVNDSGSDKDSDADDSKTETSLDTPLSPMSKQSSSYSDRDTTEEESESLDDMDFLTRQKKLQAEAKMALAMAKPMAKMQVEVEKQNRKKSPVADLLPHMPHISECLMKRSLKPTDLRDMTIGQLQVIVNDLHSQIESLNEELVQLLLIRDELHTEQDAMLVDIEDLTRHAESQQKHMAEKMPAK" } }, { "url": "https://www.uniprot.org/uniprot/A0A088MLT8#A0A088MLT8-2", "isoform_ac": "A0A088MLT8-2", "locus": {}, "sequence": { "header": "sp|A0A088MLT8-2|IQIP1_MOUSE Isoform 2 of IQCJ-SCHIP1 readthrough transcript protein OS=Mus musculus OX=10090 GN=Iqcj-Schip1 PE=1 SV=2 CANONICAL=A0A088MLT8-1", "length": 331, "sequence": "MRLEELKRLQNPLEQVDDGKYLLENHQLAMDVENNIENYPLSLQPLESKVKIIQRAWREYLQRQDPLEKRSPSPPSVSSDKLSSSVSMNTFSDSSTPAQKNERESIRQKLALGSFFDDGPGIYTSCSKSGKPSLSARLQSGMNLQICFVNDSGSDKDSDADDSKTETSLDTPLSPMSKQSSSYSDRDTTEEESESLDDMDFLTRQKKLQAEAKMALAMAKPMAKMQVEVEKQNRKKSPVADLLPHMPHISECLMKRSLKPTDLRDMTIGQLQVIVNDLHSQIESLNEELVQLLLIRDELHTEQDAMLVDIEDLTRHAESQQKHMAEKMPAK" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:100505386", "resource": "KEGG Pathway", "id": "mmu:100505386", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A0A088MLT8#function", "annotation": "May play a role in action potential conduction in myelinated cells through the organization of molecular complexes at nodes of Ranvier and axon initial segments (PubMed:25953347, PubMed:25950943, PubMed:27979964). May also play a role in axon outgrowth and guidance (PubMed:25953347).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A088MLT8#function", "id": "A0A088MLT8", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "B3KU38-1", "protein_name": "IQCJ-SCHIP1 readthrough transcript protein", "sequence": { "length": 563, "sequence": "MRLEELKRLQNPLEQVNDGKYSFENHQLAMDAENNIEKYPLNLQPLESKVKIIQRAWREYLQRQEPLGKRSPSPPSVSSEKLSSSVSMNTFSDSSTPDYREDGMDLGSDAGSSSSSSRASSQSNSTKVTPCSECKSSSSPGGSLDLVSALEDYEEPFPVYQKKVIDEWAPEEDGEEEEEEDERDQRGYRDDRSPAREPGDVSARTRSGGGGGRSATTAMPPPVPNGNLHQHDPQDLRHNGNVVVAGRPSCSRGPRRAIQKPQPAGGRRSGRGPAAGGLCLQPPDGGTCVPEEPPVPPMDWEALEKHLAGLQFREQEVRNQGQARTNSTSAQKNERESIRQKLALGSFFDDGPGIYTSCSKSGKPSLSSRLQSGMNLQICFVNDSGSDKDSDADDSKTETSLDTPLSPMSKQSSSYSDRDTTEEESESLDDMDFLTRQKKLQAEAKMALAMAKPMAKMQVEVEKQNRKKSPVADLLPHMPHISECLMKRSLKPTDLRDMTIGQLQVIVNDLHSQIESLNEELVQLLLIRDELHTEQDAMLVDIEDLTRHAESQQKHMAEKMPAK" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A088MLT8/", "id": "A0A088MLT8", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/32200", "id": "32200", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "IQCJ-SCHIP1", "tax_id": 9606 }, { "uniprot_canonical_ac": "F1M6Q1-1", "protein_name": "Schwannomin-interacting protein 1", "sequence": { "length": 457, "sequence": "MDLGSDAGSSSSSSRASSQSNSTKVTPCSECKSSSSPGGSLDLVSALEDYEEPFPVYQKKVIDEWAPEEDGEEEEEEDDRGYRDDRCPAREPGDVSARIGGSGSGNRSAATTMPSPMPNGNLHPHDPQDLRHNGNLVIAGRPNASRVPRRPIQKTQPPGNRRGGRNRASGGLCLQPPDGGMRVPEEPPAPPMDWEALEKHLAGLQFREQEVRNQGQARTNSTSAQKNERESIRQKLALGSFFDDGPGIYTSCSKSGKPSLSSRLQSGMNLQICFVNDSGSDKDSDADDSKTETSLDTPLSPMSKQSSSYSDRDTTEEESESLDDMDFLTRQKKLQAEAKMALAMAKPMAKMQVEVEKQNRKKSPVADLLPHMPHISECLMKRSLKPTDLRDMTIGQLQVIVNDLHSQIESLNEELVQLLLIRDELHTEQDAMLVDIEDLTRHAESQQKHMAEKMPSK" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/32200", "id": "32200", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Schip1", "tax_id": 10116 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106890.1", "ac": "NP_001106890.1", "name": "IQCJ-SCHIP1 readthrough transcript protein", "summary": "This locus represents naturally occurring read-through transcription from the neighboring IQ motif containing J (Iqcj) and schwannomin interacting protein 1 (Schip1) genes. This locus produces a transcript that is composed of in-frame exons from each individual gene. The resulting fusion protein is thought to be a component of the multimolecular complexes of axon initial segments and nodes of Ranvier, and it may play a role in calcium-mediated responses. [provided by RefSeq, Oct 2010]." }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "pmid": "18550753", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A088MLT8", "id": "A0A088MLT8", "database": "UniProtKB" } ], "name": "calmodulin binding", "id": "GO:0005516" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044325", "pmid": "27979964", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A088MLT8", "id": "A0A088MLT8", "database": "UniProtKB" } ], "name": "ion channel binding", "id": "GO:0044325" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030506", "pmid": "18550753", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A088MLT8", "id": "A0A088MLT8", "database": "UniProtKB" } ], "name": "ankyrin binding", "id": "GO:0030506" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A088MLT8", "id": "A0A088MLT8", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030054", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A088MLT8", "id": "A0A088MLT8", "database": "UniProtKB" } ], "name": "cell junction", "id": "GO:0030054" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033268", "pmid": "18550753", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A088MLT8", "id": "A0A088MLT8", "database": "UniProtKB" } ], "name": "node of Ranvier", "id": "GO:0033268" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043194", "pmid": "18550753", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A088MLT8", "id": "A0A088MLT8", "database": "UniProtKB" } ], "name": "axon initial segment", "id": "GO:0043194" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A088MLT8", "id": "A0A088MLT8", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008366", "pmid": "27979964", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A088MLT8", "id": "A0A088MLT8", "database": "UniProtKB" } ], "name": "axon ensheathment", "id": "GO:0008366" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035332", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A088MLT8", "id": "A0A088MLT8", "database": "UniProtKB" } ], "name": "positive regulation of hippo signaling", "id": "GO:0035332" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051494", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A088MLT8", "id": "A0A088MLT8", "database": "UniProtKB" } ], "name": "negative regulation of cytoskeleton organization", "id": "GO:0051494" } ], "total": 3, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A088MLT8", "type": "synonym", "resource": "RefSeq", "name": "Gm21949; IQCJ-SC; Iqcj-schip1; Schip-1-iqcj; Schip1" }, { "url": "https://www.uniprot.org/uniprot/A0A088MLT8", "type": "recommended", "resource": "UniProtKB", "name": "Iqcj-Schip1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A088MLT8", "type": "synonym", "resource": "RefSeq", "name": "Iqschfp" }, { "url": "https://www.uniprot.org/uniprot/A0A088MLT8", "type": "synonym", "resource": "UniProtKB", "name": "Iqschfp" }, { "url": "https://www.uniprot.org/uniprot/A0A088MLT8", "type": "synonym", "resource": "UniProtKB", "name": "Schip1" } ], "pro_annotation": [], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/gene/100505386", "id": "100505386", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015649", "id": "IPR015649", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029362", "id": "IPR029362", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR039045", "id": "IPR039045", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:100505386", "id": "mmu:100505386", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:5439400", "id": "5439400", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/XLQSGMN/", "id": "XLQSGMN", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=1290403at2759", "id": "1290403at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13103", "id": "PTHR13103", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF10148", "id": "PF10148", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF15157", "id": "PF15157", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A0A088MLT8", "id": "PR_A0A088MLT8", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106890.1", "id": "NP_001106890.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A0A088MLT8", "id": "A0A088MLT8", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [ { "sequence_org": "IQ", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A088MLT8", "id": "A0A088MLT8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18550753", "id": "18550753", "database": "PubMed" } ], "sequence_mut": "AA", "start_pos": 53, "end_pos": 54, "annotation": "Loss of interaction with calmodulin." } ], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 61917.0, "chemical_mass": 61917.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A088MLT8", "name": "Iqcj-Schip1", "locus": {} } ], "protein_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A088MLT8", "type": "synonym", "resource": "RefSeq", "name": "IQ motif containing J-schwannomin interacting protein 1 readthrough; IQ motif containing J-schwannomin interacting protein 1 fusion protein" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A088MLT8", "type": "synonym", "resource": "RefSeq", "name": "IQCJ-SCHIP1 readthrough transcript protein" }, { "url": "https://www.uniprot.org/uniprot/A0A088MLT8#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "IQCJ-SCHIP1 readthrough transcript protein" } ] }