{
    "uniprot_canonical_ac": "A0A087WT02-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A0A087WT02-1|TVA92_HUMAN Isoform 1 of T cell receptor alpha variable 9-2  OS=Homo sapiens OX=9606 GN=TRAV9-2 PE=3 SV=1 CANONICAL=A0A087WT02-1", 
        "length": 112, 
        "sequence": "MNYSPGLVSLILLLLGRTRGDSVTQMEGPVTLSEEAFLTINCTYTATGYPSLFWYVQYPGEGLQLLLKATKADDKGSNKGFEATYRKETTSFHLEKGSVQVSDSAVYFCALS"
    }, 
    "uniprot_id": "TVA92_HUMAN", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [
        "glycoprotein", 
        "predicted.uniprotkb_gly"
    ], 
    "species": [
        {
            "common_name": "Human", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A087WT02", 
                    "id": "A0A087WT02", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/15040585", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "15040585"
                }
            ], 
            "title": "The many important facets of T-cell repertoire diversity.", 
            "journal": "Nat. Rev. Immunol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A087WT02", 
                    "id": "A0A087WT02", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Messaoudi I., Nikolich-Zugich J., Slifka M.K.", 
            "date": "2004"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/20452950", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "20452950"
                }
            ], 
            "title": "Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling.", 
            "journal": "Cold Spring Harb. Perspect. Biol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A087WT02", 
                    "id": "A0A087WT02", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Gagnon E., Wucherpfennig K.W., Call M.E., Call M.J., Huseby E.S.", 
            "date": "2010"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/23524462", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "23524462"
                }
            ], 
            "title": "T cell receptor signalling networks: branched, diversified and bounded.", 
            "journal": "Nat. Rev. Immunol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A087WT02", 
                    "id": "A0A087WT02", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Zamoyska R., Brownlie R.J.", 
            "date": "2013"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/24600447", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "24600447"
                }
            ], 
            "title": "Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise of Immunoinformatics.", 
            "journal": "Front. Immunol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A087WT02", 
                    "id": "A0A087WT02", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Lefranc M.P.", 
            "date": "2014"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/25493333", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "25493333"
                }
            ], 
            "title": "T cell antigen receptor recognition of antigen-presenting molecules.", 
            "journal": "Annu. Rev. Immunol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A087WT02", 
                    "id": "A0A087WT02", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Rossjohn J., Gras S., McCluskey J., Godfrey D.I., Miles J.J., Turner S.J.", 
            "date": "2015"
        }
    ], 
    "uniprot_ac": "A0A087WT02", 
    "site_annotation": [
        {
            "end_pos": 4, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 2
        }, 
        {
            "end_pos": 43, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 41
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A087WT02#A0A087WT02-1", 
            "isoform_ac": "A0A087WT02-1", 
            "locus": {
                "end_pos": 21941184, 
                "strand": "-", 
                "start_pos": 21941655, 
                "chromosome": "14", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000390441", 
                        "id": "ENST00000390441", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000452011", 
                        "id": "ENSP00000452011", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A0A087WT02-1|TVA92_HUMAN Isoform 1 of T cell receptor alpha variable 9-2  OS=Homo sapiens OX=9606 GN=TRAV9-2 PE=3 SV=1 CANONICAL=A0A087WT02-1", 
                "length": 112, 
                "sequence": "MNYSPGLVSLILLLLGRTRGDSVTQMEGPVTLSEEAFLTINCTYTATGYPSLFWYVQYPGEGLQLLLKATKADDKGSNKGFEATYRKETTSFHLEKGSVQVSDSAVYFCALS"
            }
        }
    ], 
    "pathway": [], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A087WT02#function", 
            "annotation": "V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A087WT02#function", 
                    "id": "A0A087WT02", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "A0A075B603-1", 
            "protein_name": "T cell receptor alpha variable 6D-6", 
            "sequence": {
                "length": 114, 
                "sequence": "MDSSPGFVAVILLILGRTHGDSVTQTEGPVTVSESESLIINCTYSATSIAYPNLFWYVRYPGEGLQLLLKVITAGQKGSSRGFEATYNKETTSFHLQKASVQESDSAVYYCALG"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A0A087WT02/", 
                    "id": "A0A087WT02", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Mouse", 
            "organism": "Mus musculus", 
            "gene_name": "Trav6-6", 
            "tax_id": 10090
        }, 
        {
            "uniprot_canonical_ac": "A0A0G2K6L2-1", 
            "protein_name": "Ig-like domain-containing protein", 
            "sequence": {
                "length": 112, 
                "sequence": "MDSSPGFVAVILLLLGRTHGDSVTQTEGQVTISENGFLRINCTYSATRIVYPNLFWYVQYPGEGLQLLLKVITAGEKGSSRGFEATYNKETTSFHLEKASVQESDSAVYYCA"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A0A087WT02/", 
                    "id": "A0A087WT02", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Rat", 
            "organism": "Rattus norvegicus", 
            "gene_name": "", 
            "tax_id": 10116
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [
        {
            "sequence_org": "N", 
            "alt_nt": "null", 
            "chr_id": "14", 
            "ref_nt": "G", 
            "chr_pos": "21941442C>", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs752959848", 
                    "id": "rs752959848", 
                    "database": "dbSNP"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs752959848", 
                    "id": "rs752959848", 
                    "database": "ExAC"
                }, 
                {
                    "url": "http://gnomad.broadinstitute.org/awesome?query=rs752959848", 
                    "id": "rs752959848", 
                    "database": "gnomAD"
                }
            ], 
            "glycoeffect": [
                "n-glyco-sequon-loss"
            ], 
            "sequence_mut": "K", 
            "start_pos": 41, 
            "keywords": [
                "ebi", 
                "germline"
            ], 
            "end_pos": 41, 
            "minor_allelic_frequency": "", 
            "annotation": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NCT->KCT)."
        }, 
        {
            "sequence_org": "T", 
            "alt_nt": "null", 
            "chr_id": "14", 
            "ref_nt": "A", 
            "chr_pos": "21941447C>", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs376824841", 
                    "id": "rs376824841", 
                    "database": "dbSNP"
                }, 
                {
                    "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs376824841", 
                    "id": "rs376824841", 
                    "database": "1000Genomes"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs376824841", 
                    "id": "rs376824841", 
                    "database": "ExAC"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/snp/rs376824841#frequency_tab", 
                    "id": "rs376824841", 
                    "database": "TOPMed"
                }, 
                {
                    "url": "http://gnomad.broadinstitute.org/awesome?query=rs376824841", 
                    "id": "rs376824841", 
                    "database": "gnomAD"
                }
            ], 
            "glycoeffect": [
                "n-glyco-sequon-loss", 
                "o-glyco-site-loss"
            ], 
            "sequence_mut": "K", 
            "start_pos": 43, 
            "keywords": [
                "ebi", 
                "germline"
            ], 
            "end_pos": 43, 
            "minor_allelic_frequency": "2.0E-4", 
            "annotation": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NCT->NCK)."
        }, 
        {
            "sequence_org": "T", 
            "alt_nt": "null", 
            "chr_id": "14", 
            "ref_nt": "T", 
            "chr_pos": "21941447C>", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs376824841", 
                    "id": "rs376824841", 
                    "database": "dbSNP"
                }, 
                {
                    "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs376824841", 
                    "id": "rs376824841", 
                    "database": "1000Genomes"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs376824841", 
                    "id": "rs376824841", 
                    "database": "ExAC"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/snp/rs376824841#frequency_tab", 
                    "id": "rs376824841", 
                    "database": "TOPMed"
                }, 
                {
                    "url": "http://gnomad.broadinstitute.org/awesome?query=rs376824841", 
                    "id": "rs376824841", 
                    "database": "gnomAD"
                }
            ], 
            "glycoeffect": [
                "n-glyco-sequon-loss", 
                "o-glyco-site-loss"
            ], 
            "sequence_mut": "M", 
            "start_pos": 43, 
            "keywords": [
                "ebi", 
                "germline"
            ], 
            "end_pos": 43, 
            "minor_allelic_frequency": "2.0E-4", 
            "annotation": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NCT->NCM)."
        }, 
        {
            "sequence_org": "G", 
            "alt_nt": "null", 
            "chr_id": "14", 
            "ref_nt": "A", 
            "chr_pos": "21941557G>", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1299269607", 
                    "id": "rs1299269607", 
                    "database": "dbSNP"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/snp/rs1299269607#frequency_tab", 
                    "id": "rs1299269607", 
                    "database": "TOPMed"
                }
            ], 
            "glycoeffect": [
                "n-glyco-sequon-gain"
            ], 
            "sequence_mut": "S", 
            "start_pos": 80, 
            "keywords": [
                "ebi", 
                "germline"
            ], 
            "end_pos": 80, 
            "minor_allelic_frequency": "", 
            "annotation": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NKG->NKS)."
        }
    ], 
    "cluster_types": [
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }
    ], 
    "refseq": {}, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A087WT02", 
                                "id": "A0A087WT02", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "extracellular space", 
                        "id": "GO:0005615"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042101", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A087WT02", 
                                "id": "A0A087WT02", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "T cell receptor complex", 
                        "id": "GO:0042101"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A087WT02", 
                                "id": "A0A087WT02", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "immune response", 
                        "id": "GO:0006955"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002377", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A087WT02", 
                                "id": "A0A087WT02", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "immunoglobulin production", 
                        "id": "GO:0002377"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A087WT02", 
                                "id": "A0A087WT02", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "adaptive immune response", 
                        "id": "GO:0002250"
                    }
                ], 
                "total": 3, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A087WT02", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "TRAV9-2"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211793", 
            "id": "ENSG00000211793", 
            "database": "Bgee"
        }, 
        {
            "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A087WT02", 
            "id": "A0A087WT02", 
            "database": "BioMuta"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=TRAV9-2", 
            "id": "TRAV9-2", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=12154", 
            "id": "12154", 
            "database": "HGNC"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", 
            "id": "IPR007110", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", 
            "id": "IPR013106", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", 
            "id": "IPR013783", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", 
            "id": "IPR036179", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A0A087WT02", 
            "id": "NX_A0A087WT02", 
            "database": "neXtProt"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/YYCALEN/", 
            "id": "YYCALEN", 
            "database": "OMA"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF07686", 
            "id": "PF07686", 
            "database": "Pfam"
        }, 
        {
            "url": "http://purl.obolibrary.org/obo/PR_PR_A0A087WT02", 
            "id": "PR_A0A087WT02", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A087WT02", 
            "id": "A0A087WT02", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [
        {
            "residue": "Asn", 
            "site_category": "predicted", 
            "end_pos": 41, 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A087WT02#ptm_processing", 
                    "id": "A0A087WT02", 
                    "database": "UniProtKB"
                }
            ], 
            "subtype": "", 
            "relation": "attached", 
            "start_pos": 41, 
            "glytoucan_ac": "", 
            "type": "N-linked"
        }
    ], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 12289.0, 
        "chemical_mass": 12289.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A087WT02", 
            "name": "TRAV9-2", 
            "locus": {
                "end_pos": 21941657, 
                "strand": "+", 
                "start_pos": 21941128, 
                "chromosome": "14", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSG00000211793", 
                        "id": "ENSG00000211793", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A087WT02#names_and_taxonomy", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "T cell receptor alpha variable 9-2"
        }
    ]
}