{ "uniprot_canonical_ac": "A0A087WRR7-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A087WRR7-1|A0A087WRR7_MOUSE Isoform 1 of Zinc finger protein 383 OS=Mus musculus OX=10090 GN=Zfp383 PE=1 SV=1 CANONICAL=A0A087WRR7-1", "length": 490, "sequence": "MSAPLLQRYPVEKRGMAVDHAKNKKPVVFSDVSLDFSQEEWECLGPAQRDLYKDVMLENYSNLLSVGLHIPKPQVISLLEQGKEPWMIGKELTRGLCSALESMCESKLLSLKKEVYEIESCQRELMRLSKHSLSCSGFTDAPECGGQFQGGHGSQELLTREYMPTFFQQTFFTLHQIINNDEKPYECKKCKKVFTQNSQFIQHQRIHIGEKSYECKECGKFFSCGSHVTRHLKIHTGEKPFECKDCGKAFSCSSYLSQHQRIHTGKKPYECKECGKAFSYCSNLIDHQRIHTGEKPYACKVCGKAFTKSSQLFQHVRVHTGEKPYECKECGKAFTQSSKLVQHQRIHTGEKPYECKECGKAFSSGSALTNHQRIHTGEKPYECKECGKAFTQSSQLRQHQRIHAGEKPFECLECGKAFTQNSQLFQHQRVHSDEKPYECNKCGKAFNKCSNLTRHLRTHRDDKPHSCTECGKTFSNDSDLISHQETHTNE" }, "uniprot_id": "A0A087WRR7_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A087WRR7", "id": "A0A087WRR7", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", "type": [ "PubMed" ], "id": "12520002" } ], "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230837.1", "id": "NP_001230837.1", "database": "RefSeq" } ], "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", "date": "2003" } ], "uniprot_ac": "A0A087WRR7", "site_annotation": [ { "end_pos": 453, "annotation": "n_glycosylation_sequon", "start_pos": 451 }, { "end_pos": 478, "annotation": "n_glycosylation_sequon", "start_pos": 476 }, { "end_pos": 61, "annotation": "n_glycosylation_sequon", "start_pos": 59 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A087WRR7#A0A087WRR7-1", "isoform_ac": "A0A087WRR7-1", "locus": { "end_pos": 29908645, "strand": "-", "start_pos": 29915791, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000186475", "id": "ENSMUST00000186475", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000140742", "id": "ENSMUSP00000140742", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A087WRR7-1|A0A087WRR7_MOUSE Isoform 1 of Zinc finger protein 383 OS=Mus musculus OX=10090 GN=Zfp383 PE=1 SV=1 CANONICAL=A0A087WRR7-1", "length": 490, "sequence": "MSAPLLQRYPVEKRGMAVDHAKNKKPVVFSDVSLDFSQEEWECLGPAQRDLYKDVMLENYSNLLSVGLHIPKPQVISLLEQGKEPWMIGKELTRGLCSALESMCESKLLSLKKEVYEIESCQRELMRLSKHSLSCSGFTDAPECGGQFQGGHGSQELLTREYMPTFFQQTFFTLHQIINNDEKPYECKKCKKVFTQNSQFIQHQRIHIGEKSYECKECGKFFSCGSHVTRHLKIHTGEKPFECKDCGKAFSCSSYLSQHQRIHTGKKPYECKECGKAFSYCSNLIDHQRIHTGEKPYACKVCGKAFTKSSQLFQHVRVHTGEKPYECKECGKAFTQSSKLVQHQRIHTGEKPYECKECGKAFSSGSALTNHQRIHTGEKPYECKECGKAFTQSSQLRQHQRIHAGEKPFECLECGKAFTQNSQLFQHQRVHSDEKPYECNKCGKAFNKCSNLTRHLRTHRDDKPHSCTECGKTFSNDSDLISHQETHTNE" } }, { "url": "https://www.uniprot.org/uniprot/A0A087WRR7#A0A087WSF1-1", "isoform_ac": "A0A087WSF1-1", "locus": { "end_pos": 29908645, "strand": "-", "start_pos": 29912525, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000187028", "id": "ENSMUST00000187028", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000141019", "id": "ENSMUSP00000141019", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A087WSF1-1|A0A087WRR7_MOUSE Computationally mapped isoform of Zinc finger protein 383 OS=Mus musculus OX=10090 GN=Zfp383 PE=1 SV=1 CANONICAL=A0A087WRR7-1", "length": 143, "sequence": "MSAPLLQRYPVEKRGMAVDHAKNKKPVVFSDVSLDFSQEEWECLGPAQRDLYKDVMLENYSNLLSVGKDTCISSAAISAVSASSSRNFSAAFQACHLNSCSLFANTWFQLGGNRSLRDRRLRWAVAKASSSSLAVPVLTSLAW" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:73729", "resource": "KEGG Pathway", "id": "mmu:73729", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-212436", "resource": "Reactome", "id": "R-MMU-212436", "name": "Generic Transcription Pathway" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "M0R5R2-1", "protein_name": "Zinc finger protein 420", "sequence": { "length": 528, "sequence": "MVAIFPASSHRRLHFPEAPAISRQPLLLPAGPSSSGDRKVYALPLQRYPVERGGMAADHAKHKKQVAFSDVSLDFSQEEWACLGPAQRALYKDVMLENYSHLLSVGLHIPKPQVISLLEQGKEPWMVGKELTRGLCSALESMCESKLLSLKKEVYELESCQREFMRLTKQGLDYPGFRDVLECGSQLQNGHGSQEPLAREYMPTFVQQTFLTLHQIINDEKPYECKKCRKVFTQNSQFIQHQRIHIGEKSYECKECGKFFSCGSHVTRHLKIHTGEKPFECKDCGKAFSCSSYLSQHQRIHTGKKPYECKDCGKAFSYCSNLIDHQRIHTGEKPYACKVCGKAFTKSSQLFQHVRVHTGEKPYECKECGKAFTQSSKLVQHQRIHTGEKPYECKECGKAFSSGSALTNHQRIHTGEKPYECKDCGKAFTQSSQLRQHQRIHAGEKPFECLECGKAFTQNSQLFQHQRVHSDEKPYECNKCGKAFNKCSNLTRHLRTHRDDKPCSCNECGKTFSNESELIRHQEVHSNE" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A087WRR7/", "id": "A0A087WRR7", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "LOC103690163", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q8NA42-1", "protein_name": "Zinc finger protein 383", "sequence": { "length": 475, "sequence": "MAEGSVMFSDVSIDFSQEEWDCLDPVQRDLYRDVMLENYGNLVSMGLYTPKPQVISLLEQGKEPWMVGRELTRGLCSDLESMCETKLLSLKKEVYEIELCQREIMGLTKHGLEYSSFGDVLEYRSHLAKQLGYPNGHFSQEIFTPEYMPTFIQQTFLTLHQIINNEDRPYECKKCGKAFSQNSQFIQHQRIHIGEKSYECKECGKFFSCGSHVTRHLKIHTGEKPFECKECGKAFSCSSYLSQHQRIHTGKKPYECKECGKAFSYCSNLIDHQRIHTGEKPYECKVCGKAFTKSSQLFQHARIHTGEKPYECKECGKAFTQSSKLVQHQRIHTGEKPYECKECGKAFSSGSALTNHQRIHTGEKPYDCKECGKAFTQSSQLRQHQRIHAGEKPFECLECGKAFTQNSQLFQHQRIHTDEKPYECNECGKAFNKCSNLTRHLRIHTGEKPYNCKECGKAFSSGSDLIRHQGIHTNK" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/128413", "id": "128413", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A087WRR7/", "id": "A0A087WRR7", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "ZNF383", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230837.1", "ac": "NP_001230837.1", "name": "zinc finger protein 383", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A087WRR7", "id": "A0A087WRR7", "database": "UniProtKB" } ], "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A087WRR7", "id": "A0A087WRR7", "database": "UniProtKB" } ], "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A087WRR7", "id": "A0A087WRR7", "database": "UniProtKB" } ], "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A087WRR7", "id": "A0A087WRR7", "database": "UniProtKB" } ], "name": "metal ion binding", "id": "GO:0046872" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000790", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A087WRR7", "id": "A0A087WRR7", "database": "UniProtKB" } ], "name": "nuclear chromatin", "id": "GO:0000790" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A087WRR7", "id": "A0A087WRR7", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A087WRR7", "id": "A0A087WRR7", "database": "UniProtKB" } ], "name": "nuclear membrane", "id": "GO:0031965" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A087WRR7", "id": "A0A087WRR7", "database": "UniProtKB" } ], "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A087WRR7", "id": "A0A087WRR7", "database": "UniProtKB" } ], "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357" } ], "total": 2, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A087WRR7", "type": "synonym", "resource": "RefSeq", "name": "1110003H10Rik" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A087WRR7", "type": "synonym", "resource": "RefSeq", "name": "Zfp383" }, { "url": "https://www.uniprot.org/uniprot/A0A087WRR7", "type": "recommended", "resource": "UniProtKB", "name": "Zfp383" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000099689", "id": "ENSMUSG00000099689", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "id": "cd07765", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/73729", "id": "73729", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "id": "IPR001909", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "id": "IPR013087", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "id": "IPR036051", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "id": "IPR036236", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:73729", "id": "mmu:73729", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:1920979", "id": "1920979", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/YIPKPQV/", "id": "YIPKPQV", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=1318335at2759", "id": "1318335at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00096", "id": "PF00096", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF01352", "id": "PF01352", "database": "Pfam" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-212436", "id": "R-MMU-212436", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230837.1", "id": "NP_001230837.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A0A087WRR7", "id": "A0A087WRR7", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 56114.0, "chemical_mass": 56114.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A087WRR7", "name": "Zfp383", "locus": { "end_pos": 29916813, "strand": "+", "start_pos": 29908223, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000099689", "id": "ENSMUSG00000099689", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A087WRR7#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Zinc finger protein 383" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A087WRR7", "type": "synonym", "resource": "RefSeq", "name": "zinc finger protein 383" } ] }