{ "uniprot_canonical_ac": "A0A087WPF7-1", "ptm_annotation": [], "sequence": { "header": "sp|A0A087WPF7-1|AUTS2_MOUSE Isoform 1 of Autism susceptibility gene 2 protein homolog OS=Mus musculus OX=10090 GN=Auts2 PE=1 SV=2 CANONICAL=A0A087WPF7-1", "length": 1261, "sequence": "MDGPTRGHGLRKKRRSRSQRDRERRSRAGLGTGAAGGIGAGRTRAPSLASSSGSDKEDNGKPPSSAPSRPRPPRRKRRESTSAEEDIIDGFAMTSFVTFEALEKDVAVKPQERAEKRQTPLTKKKREALTNGLSFHSKKSRLSHSHHYSSDRENDRNLCQHLGKRKKMPKGLRQLKPGQNSCRDSDSESASGESKGFQRSSSRERLSDSSAPSSLGTGYFCDSDSDQEEKASDASSEKLFNTVLVNKDPELGVGALPEHNQDAGPIVPKISGLERSQEKSQDCCKEPVFEPVVLKDPHPQLPQLPSQAQAEPQLQIPSPGPDLVPRTEAPPQFPPPSTQPAQGPPEAQLQPAPLPQVQQRPPRPQSPSHLLQQTLPPVQSHPSSQSLSQPLSAYNSSSLSLNSLSSRSSTPAKTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQPPAHSHHPNMFAPPTALPPPPPLTSGSLQVPGHPAGSTYSEQDILRQELNTRFLASQSADRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMFDKYPTKVDPFYRHSLFHSYPPAVSGIPPMIPPTGPFGSLQGAFQPKTSNPIDVAARPGTVPHTLLQKDPRLTDPFRPMLRKPGKWCAMHVHIAWQIYHHQQKVKKQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGTPFGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSVFGHKDSPSVQNFSNPHEPWNRLHRTPPSFPTPPPWLKPGELERSASAAAHDRDRDVDKRDSSVSKDDKERESVEKRHPSHPSPAPPVPVSALGHNRSSTDPTTRGHLNTEAREKDKPKEKERDHSGSRKDLTTEEHKAKESHLPERDGHSHEGRAAGEEPKQLSRVPSPYVRTPGVDSTRPNSTSSREAEPRKGEPAYENPKKNAEVKVKEERKEDHDLPTEAPQAHRTSEAPPPSSSASASVHPGPLASMPMTVGVTGIHAMNSIGSLDRTRMVTPFMGLSPIPGGERFPYPSFHWDPMRDPLRDPYRDLDMHRRDPLGRDFLLRNDPLHRLSTPRLYEADRSFRDREPHDYSHHHHHHHHPLAVDPRREHERGGHLDERERLHVLREDYEHPRLHPVHPASLDGHLPHPSLLTPGLPSMHYPRISPTAGHQNGLLNKTPPTAALSAPPPLISTLGGRPGSPRRTTPLSAEIRERPPSHTLKDIEAR" }, "uniprot_id": "AUTS2_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A087WPF7", "id": "A0A087WPF7", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19948250", "type": [ "PubMed" ], "id": "19948250" } ], "title": "Autism susceptibility candidate 2 (Auts2) encodes a nuclear protein expressed in developing brain regions implicated in autism neuropathology.", "journal": "Gene Expr. Patterns", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A087WPF7", "id": "A0A087WPF7", "database": "UniProtKB" } ], "authors": "Hevner R.F., Hodge R.D., Nelson B.R., Bedogni F., Daza R.A., Frederick E.A., Shiba N.", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25519132", "type": [ "PubMed" ], "id": "25519132" } ], "title": "An AUTS2-polycomb complex activates gene expression in the CNS.", "journal": "Nature", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A087WPF7", "id": "A0A087WPF7", "database": "UniProtKB" } ], "authors": "Reinberg D., Schaefer A., Gao Z., Lee P., Stafford J.M., von Schimmelmann M.", "date": "2014" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25533347", "type": [ "PubMed" ], "id": "25533347" } ], "title": "Cytoskeletal regulation by AUTS2 in neuronal migration and neuritogenesis.", "journal": "Cell Rep.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A087WPF7", "id": "A0A087WPF7", "database": "UniProtKB" } ], "authors": "Abe M., Nagai T., Yamada K., Yamazaki M., Kaibuchi K., Hayashi T., Hori K., Nakao K., Sakamoto A., Taya S., Hashimoto R., Hoshino M., Sakimura K., Nishioka T., Shan W.", "date": "2014" } ], "uniprot_ac": "A0A087WPF7", "site_annotation": [ { "end_pos": 1213, "annotation": "n_glycosylation_sequon", "start_pos": 1211 }, { "end_pos": 397, "annotation": "n_glycosylation_sequon", "start_pos": 395 }, { "end_pos": 438, "annotation": "n_glycosylation_sequon", "start_pos": 436 }, { "end_pos": 786, "annotation": "n_glycosylation_sequon", "start_pos": 784 }, { "end_pos": 870, "annotation": "n_glycosylation_sequon", "start_pos": 868 }, { "end_pos": 957, "annotation": "n_glycosylation_sequon", "start_pos": 955 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A087WPF7#A0A087WPF7-1", "isoform_ac": "A0A087WPF7-1", "locus": {}, "sequence": { "header": "sp|A0A087WPF7-1|AUTS2_MOUSE Isoform 1 of Autism susceptibility gene 2 protein homolog OS=Mus musculus OX=10090 GN=Auts2 PE=1 SV=2 CANONICAL=A0A087WPF7-1", "length": 1261, "sequence": "MDGPTRGHGLRKKRRSRSQRDRERRSRAGLGTGAAGGIGAGRTRAPSLASSSGSDKEDNGKPPSSAPSRPRPPRRKRRESTSAEEDIIDGFAMTSFVTFEALEKDVAVKPQERAEKRQTPLTKKKREALTNGLSFHSKKSRLSHSHHYSSDRENDRNLCQHLGKRKKMPKGLRQLKPGQNSCRDSDSESASGESKGFQRSSSRERLSDSSAPSSLGTGYFCDSDSDQEEKASDASSEKLFNTVLVNKDPELGVGALPEHNQDAGPIVPKISGLERSQEKSQDCCKEPVFEPVVLKDPHPQLPQLPSQAQAEPQLQIPSPGPDLVPRTEAPPQFPPPSTQPAQGPPEAQLQPAPLPQVQQRPPRPQSPSHLLQQTLPPVQSHPSSQSLSQPLSAYNSSSLSLNSLSSRSSTPAKTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQPPAHSHHPNMFAPPTALPPPPPLTSGSLQVPGHPAGSTYSEQDILRQELNTRFLASQSADRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMFDKYPTKVDPFYRHSLFHSYPPAVSGIPPMIPPTGPFGSLQGAFQPKTSNPIDVAARPGTVPHTLLQKDPRLTDPFRPMLRKPGKWCAMHVHIAWQIYHHQQKVKKQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGTPFGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSVFGHKDSPSVQNFSNPHEPWNRLHRTPPSFPTPPPWLKPGELERSASAAAHDRDRDVDKRDSSVSKDDKERESVEKRHPSHPSPAPPVPVSALGHNRSSTDPTTRGHLNTEAREKDKPKEKERDHSGSRKDLTTEEHKAKESHLPERDGHSHEGRAAGEEPKQLSRVPSPYVRTPGVDSTRPNSTSSREAEPRKGEPAYENPKKNAEVKVKEERKEDHDLPTEAPQAHRTSEAPPPSSSASASVHPGPLASMPMTVGVTGIHAMNSIGSLDRTRMVTPFMGLSPIPGGERFPYPSFHWDPMRDPLRDPYRDLDMHRRDPLGRDFLLRNDPLHRLSTPRLYEADRSFRDREPHDYSHHHHHHHHPLAVDPRREHERGGHLDERERLHVLREDYEHPRLHPVHPASLDGHLPHPSLLTPGLPSMHYPRISPTAGHQNGLLNKTPPTAALSAPPPLISTLGGRPGSPRRTTPLSAEIRERPPSHTLKDIEAR" } }, { "url": "https://www.uniprot.org/uniprot/A0A087WPF7#A0A087WPF7-2", "isoform_ac": "A0A087WPF7-2", "locus": {}, "sequence": { "header": "sp|A0A087WPF7-2|AUTS2_MOUSE Isoform 2 of Autism susceptibility gene 2 protein homolog OS=Mus musculus OX=10090 GN=Auts2 PE=1 SV=2 CANONICAL=A0A087WPF7-1", "length": 258, "sequence": "MDGPTRGHGLRKKRRSRSQRDRERRSRAGLGTGAAGGIGAGRTRAPSLASSSGSDKEDNGKPPSSAPSRPRPPRRKRRESTSAEEDIIDGFAMTSFVTFEALEKDVAVKPQERAEKRQTPLTKKKREALTNGLSFHSKKSRLSHSHHYSSDRENDRNLCQHLGKRKKMPKGLRQLKPGQNSCRDSDSESASGESKGFQRSSSRERLSDSSAPSSLGTGYFCDSDSDQEEKVRRHPLHCKHNPQGSGCTVTCLLVPVPL" } }, { "url": "https://www.uniprot.org/uniprot/A0A087WPF7#A0A087WPF7-3", "isoform_ac": "A0A087WPF7-3", "locus": { "end_pos": 131439439, "strand": "+", "start_pos": 131475016, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000161374", "id": "ENSMUST00000161374", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000124730", "id": "ENSMUSP00000124730", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A0A087WPF7-3|AUTS2_MOUSE Isoform 3 of Autism susceptibility gene 2 protein homolog OS=Mus musculus OX=10090 GN=Auts2 PE=1 SV=2 CANONICAL=A0A087WPF7-1", "length": 789, "sequence": "MFAPPTALPPPPPLTSGSLQVPGHPAGSTYSEQDILRQELNTRFLASQSADRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMLFHSYPPAVSGIPPMIPPTGPFGSLQGAFQPKTSNPIDVAARPGTVPHTLLQKDPRLTDPFRPMLRKPGKWCAMHVHIAWQIYHHQQKVKKQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGTPFGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSVFGHKDSPSVQNFSNPHEPWNRLHRTPPSFPTPPPWLKPGELERSASAAAHDRDRDVDKRDSSVSKDDKERESVEKRHPSHPSPAPPVPVSALGHNRSSTDPTTRGHLNTEAREKDKPKEKERDHSGSRKDLTTEEHKAKESHLPERDGHSHEGRAAGEEPKQLSRVPSPYVRTPGVDSTRPNSTSSREAEPRKGEPAYENPKKNAEVKVKEERKEDHDLPTEAPQAHRTSEAPPPSSSASASVHPGPLASMPMTVGVTGIHAMNSIGSLDRTRMVTPFMGLSPIPGGERFPYPSFHWDPMRDPLRDPYRDLDMHRRDPLGRDFLLRNDPLHRLSTPRLYEADRSFRDREPHDYSHHHHHHHHPLAVDPRREHERGGHLDERERLHVLREDYEHPRLHPVHPASLDGHLPHPSLLTPGLPSMHYPRISPTAGHQNGLLNKTPPTAALSAPPPLISTLGGRPGSPRRTTPLSAEIRERPPSHTLKDIEAR" } }, { "url": "https://www.uniprot.org/uniprot/A0A087WPF7#A0A087WSK2-1", "isoform_ac": "A0A087WSK2-1", "locus": { "end_pos": 132030909, "strand": "+", "start_pos": 132050409, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000185450", "id": "ENSMUST00000185450", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000141082", "id": "ENSMUSP00000141082", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A087WSK2-1|AUTS2_MOUSE Computationally mapped isoform of Autism susceptibility gene 2 protein homolog OS=Mus musculus OX=10090 GN=Auts2 PE=1 SV=1 CANONICAL=A0A087WPF7-1", "length": 48, "sequence": "LKPGQNSCRDSDSESASGESKGFQRSSSRERLSDSSAPSSLGTGYFCE" } }, { "url": "https://www.uniprot.org/uniprot/A0A087WPF7#A0A2C9F2I4-1", "isoform_ac": "A0A2C9F2I4-1", "locus": { "end_pos": 131439439, "strand": "+", "start_pos": 131477024, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000187544", "id": "ENSMUST00000187544", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000139759", "id": "ENSMUSP00000139759", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A2C9F2I4-1|AUTS2_MOUSE Computationally mapped isoform of Autism susceptibility gene 2 protein homolog OS=Mus musculus OX=10090 GN=Auts2 PE=1 SV=1 CANONICAL=A0A087WPF7-1", "length": 1013, "sequence": "DPELGVGALPEHNQDAGPIVPKISGLERSQEKSQDCCKEPVFEPVVLKDPHPQLPQLPSQAQAEPQLQIPSPGPDLVPRTEAPPQFPPPSTQPAQGPPEAQLQPAPLQVQQRPPRPQSPSHLLQQTLPPVQSHPSSQSLSQPLSAYNSSSLSLNSLSSRSSTPAKTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQPPAHSHHPNMFAPPTALPPPPPLTSGSLQVPGHPAGSTYSEQDILRQELNTRFLASQSADRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMFDKYPTKVDPFYRHSLFHSYPPAVSGIPPMIPPTGPFGSLQGAFQPKTSNPIDVAARPGTVPHTLLQKDPRLTDPFRPMLRKPGKWCAMHVHIAWQIYHHQQKVKKQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGTPFGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSVFGHKDSPSVQNFSNPHEPWNRLHRTPPSFPTPPPWLKPGELERSASAAAHDRDRDVDKRDSSVSKDDKERESVEKRHPSHPSPAPPVPVSALGHNRSSTDPTTRGHLNTEAREKDKPKEKERDHSGSRKDLTTEEHKAKESHLPERDGHSHEGRAAGEEPKQLSRVPSPYVRTPGVDSTRPNSTSSREAEPRKGEPAYENPKKNAEVKVKEERKEDHDLPTEAPQAHRTSEAPPPSSSASASVHPGPLASMPMTVGVTGIHAMNSIGSLDRTRMVTPFMGLSPIPGGERFPYPSFHWDPMRDPLRDPYRDLDMHRRDPLGRDFLLRNDPLHRLSTPRLYEADRSFRDREPHDYSHHHHHHHHPLAVDPRREHERGGHLDERERLHVLREDYEHPRLHPVHPASLDGHLPHPSLLTPGLPSMHYPRISPTAGHQNGLLNKTPPTAALSAPPPLISTLGGRPGSPRRTTPLSAEIRERPPSHTLKDIEAR" } }, { "url": "https://www.uniprot.org/uniprot/A0A087WPF7#E0CZ47-1", "isoform_ac": "E0CZ47-1", "locus": { "end_pos": 132030990, "strand": "+", "start_pos": 132449124, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000160135", "id": "ENSMUST00000160135", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000125706", "id": "ENSMUSP00000125706", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|E0CZ47-1|AUTS2_MOUSE Computationally mapped isoform of Autism susceptibility gene 2 protein homolog OS=Mus musculus OX=10090 GN=Auts2 PE=1 SV=2 CANONICAL=A0A087WPF7-1", "length": 119, "sequence": "MMKDVAVKPQERAEKRQTPLTKKKREALTNGLSFHSKKSRLSHSHHYSSDRENDRNLCQHLGKRKKMPKGLRQLKPGQNSCRDSDSESASGESKGFQRSSSRERLSDSSAPSSLGTGYF" } }, { "url": "https://www.uniprot.org/uniprot/A0A087WPF7#E9PZ86-1", "isoform_ac": "E9PZ86-1", "locus": { "end_pos": 131439439, "strand": "+", "start_pos": 131475016, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000161804", "id": "ENSMUST00000161804", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000124027", "id": "ENSMUSP00000124027", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|E9PZ86-1|AUTS2_MOUSE Computationally mapped isoform of Autism susceptibility gene 2 protein homolog OS=Mus musculus OX=10090 GN=Auts2 PE=1 SV=1 CANONICAL=A0A087WPF7-1", "length": 804, "sequence": "MFAPPTALPPPPPLTSGSLQVPGHPAGSTYSEQDILRQELNTRFLASQSADRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMFDKYPTKVDPFYRHSLFHSYPPAVSGIPPMIPPTGPFGSLQGAFQPKTSNPIDVAARPGTVPHTLLQKDPRLTDPFRPMLRKPGKWCAMHVHIAWQIYHHQQKVKKQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGTPFGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSVFGHKDSPSVQNFSNPHEPWNRLHRTPPSFPTPPPWLKPGELERSASAAAHDRDRDVDKRDSSVSKDDKERESVEKRHPSHPSPAPPVPVSALGHNRSSTDPTTRGHLNTEAREKDKPKEKERDHSGSRKDLTTEEHKAKESHLPERDGHSHEGRAAGEEPKQLSRVPSPYVRTPGVDSTRPNSTSSREAEPRKGEPAYENPKKNAEVKVKEERKEDHDLPTEAPQAHRTSEAPPPSSSASASVHPGPLASMPMTVGVTGIHAMNSIGSLDRTRMVTPFMGLSPIPGGERFPYPSFHWDPMRDPLRDPYRDLDMHRRDPLGRDFLLRNDPLHRLSTPRLYEADRSFRDREPHDYSHHHHHHHHPLAVDPRREHERGGHLDERERLHVLREDYEHPRLHPVHPASLDGHLPHPSLLTPGLPSMHYPRISPTAGHQNGLLNKTPPTAALSAPPPLISTLGGRPGSPRRTTPLSAEIRERPPSHTLKDIEAR" } }, { "url": "https://www.uniprot.org/uniprot/A0A087WPF7#J3QNT9-1", "isoform_ac": "J3QNT9-1", "locus": { "end_pos": 132541515, "strand": "+", "start_pos": 132541823, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000178555", "id": "ENSMUST00000178555", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000136954", "id": "ENSMUSP00000136954", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|J3QNT9-1|AUTS2_MOUSE Computationally mapped isoform of Autism susceptibility gene 2 protein homolog OS=Mus musculus OX=10090 GN=Auts2 PE=1 SV=1 CANONICAL=A0A087WPF7-1", "length": 103, "sequence": "MDGPTRGHGLRKKRRSRSQRDRERRSRAGLGTGAAGGIGAGRTRAPSLASSSGSDKEDNGKPPSSAPSRPRPPRRKRRESTSAEEDIIDGFAMTSFVTFEALE" } }, { "url": "https://www.uniprot.org/uniprot/A0A087WPF7#S4R200-1", "isoform_ac": "S4R200-1", "locus": { "end_pos": 131443781, "strand": "+", "start_pos": 131460151, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000162101", "id": "ENSMUST00000162101", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000138441", "id": "ENSMUSP00000138441", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|S4R200-1|AUTS2_MOUSE Computationally mapped isoform of Autism susceptibility gene 2 protein homolog OS=Mus musculus OX=10090 GN=Auts2 PE=1 SV=1 CANONICAL=A0A087WPF7-1", "length": 142, "sequence": "XDPFRPMLRKPGKWCAMHVHIAWQIYHHQQKVKKQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGTPFGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTANNMYSF" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8939243", "resource": "Reactome", "id": "R-MMU-8939243", "name": "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A0A087WPF7#function", "annotation": "Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B. As a consequence, the complex mediates transcriptional activation (By similarity). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (PubMed:25533347).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A087WPF7#function", "id": "A0A087WPF7", "database": "UniProtKB" } ] } ], "orthologs": [], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "refseq": {}, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A087WPF7", "id": "A0A087WPF7", "database": "UniProtKB" } ], "name": "chromatin binding", "id": "GO:0003682" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "25533347", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A087WPF7", "id": "A0A087WPF7", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "19948250", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A087WPF7", "id": "A0A087WPF7", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030426", "pmid": "25533347", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A087WPF7", "id": "A0A087WPF7", "database": "UniProtKB" } ], "name": "growth cone", "id": "GO:0030426" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A087WPF7", "id": "A0A087WPF7", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A087WPF7", "id": "A0A087WPF7", "database": "UniProtKB" } ], "name": "cytoskeleton", "id": "GO:0005856" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001764", "pmid": "25533347", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A087WPF7", "id": "A0A087WPF7", "database": "UniProtKB" } ], "name": "neuron migration", "id": "GO:0001764" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060013", "pmid": "25519132", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A087WPF7", "id": "A0A087WPF7", "database": "UniProtKB" } ], "name": "righting reflex", "id": "GO:0060013" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031532", "pmid": "25533347", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A087WPF7", "id": "A0A087WPF7", "database": "UniProtKB" } ], "name": "actin cytoskeleton reorganization", "id": "GO:0031532" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035022", "pmid": "25533347", "evidence": [ { 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