{
    "uniprot_canonical_ac": "A0A075B7D4-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "tr|A0A075B7D4-1|A0A075B7D4_HUMAN Isoform 1 of Immunoglobulin kappa variable 1/OR2-108 (non-functional)  OS=Homo sapiens OX=9606 GN=IGKV1OR2-108 PE=1 SV=1 CANONICAL=A0A075B7D4-1", 
        "length": 117, 
        "sequence": "MEMRVPAQLLGLLLLWLRGARCDIQVTQSPSSLSASVGDRVTITCRASQGISNGLSWYQQKPGQAPTLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQDYTTP"
    }, 
    "uniprot_id": "A0A075B7D4_HUMAN", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Human", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A075B7D4", 
                    "id": "A0A075B7D4", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "publication": [], 
    "uniprot_ac": "A0A075B7D4", 
    "site_annotation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A075B7D4#A0A075B7D4-1", 
            "isoform_ac": "A0A075B7D4-1", 
            "locus": {
                "end_pos": 113406396, 
                "strand": "-", 
                "start_pos": 113406870, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000453673", 
                        "id": "ENST00000453673", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000474395", 
                        "id": "ENSP00000474395", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A075B7D4-1|A0A075B7D4_HUMAN Isoform 1 of Immunoglobulin kappa variable 1/OR2-108 (non-functional)  OS=Homo sapiens OX=9606 GN=IGKV1OR2-108 PE=1 SV=1 CANONICAL=A0A075B7D4-1", 
                "length": 117, 
                "sequence": "MEMRVPAQLLGLLLLWLRGARCDIQVTQSPSSLSASVGDRVTITCRASQGISNGLSWYQQKPGQAPTLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQDYTTP"
            }
        }
    ], 
    "pathway": [], 
    "function": [], 
    "orthologs": [], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [
        {
            "sequence_org": "L", 
            "start_pos": 17, 
            "alt_nt": "A", 
            "chr_id": "2", 
            "ref_nt": "C", 
            "chr_pos": "114164021", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "Thyroid gland neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumour of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "thyroid neoplasm", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:1781", 
                        "url": "http://disease-ontology.org/term/DOID:1781", 
                        "resource": "Disease Ontology", 
                        "name": "thyroid gland cancer", 
                        "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A075B7D4", 
                    "id": "A0A075B7D4", 
                    "database": "BioMuta"
                }
            ], 
            "glycoeffect": [], 
            "frequency": "2.0", 
            "sequence_mut": "I", 
            "subjects_tested": "50", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (2.0%).", 
            "end_pos": 17, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "1"
        }
    ], 
    "cluster_types": [], 
    "refseq": {}, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A075B7D4", 
                                "id": "A0A075B7D4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "extracellular space", 
                        "id": "GO:0005615"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A075B7D4", 
                                "id": "A0A075B7D4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "immune response", 
                        "id": "GO:0006955"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002377", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A075B7D4", 
                                "id": "A0A075B7D4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "immunoglobulin production", 
                        "id": "GO:0002377"
                    }
                ], 
                "total": 2, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A075B7D4", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "IGKV1OR2-108"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000231292", 
            "id": "ENSG00000231292", 
            "database": "Bgee"
        }, 
        {
            "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A075B7D4", 
            "id": "A0A075B7D4", 
            "database": "BioMuta"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=IGKV1OR2-108", 
            "id": "IGKV1OR2-108", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=5767", 
            "id": "5767", 
            "database": "HGNC"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", 
            "id": "IPR003599", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", 
            "id": "IPR007110", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", 
            "id": "IPR013106", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", 
            "id": "IPR013783", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", 
            "id": "IPR036179", 
            "database": "InterPro"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/SNGLSWY/", 
            "id": "SNGLSWY", 
            "database": "OMA"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF07686", 
            "id": "PF07686", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A075B7D4", 
            "id": "A0A075B7D4", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 12535.0, 
        "chemical_mass": 12535.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A075B7D4", 
            "name": "IGKV1OR2-108", 
            "locus": {
                "end_pos": 113406872, 
                "strand": "+", 
                "start_pos": 113406396, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSG00000231292", 
                        "id": "ENSG00000231292", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A075B7D4#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Immunoglobulin kappa variable 1/OR2-108 (non-functional)"
        }
    ]
}