{
    "uniprot_canonical_ac": "A0A075B767-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A0A075B767-1|PAL4H_HUMAN Isoform 1 of Peptidyl-prolyl cis-trans isomerase A-like 4H  OS=Homo sapiens OX=9606 GN=PPIAL4H PE=3 SV=1 CANONICAL=A0A075B767-1", 
        "length": 164, 
        "sequence": "MVNSVVFFDITVDGKPLGRISIKLFADKIPKTAENFRALSTGEKGFRYKGSCFHRIIPGFMCQGGDFTRPNGTDDKSIYGEKFDDENLIRKHTGSGILSMVNAGPNTNGSQLFICTAKTEWLDGKHVAFGKVKERVNIVEAMEHFGYRNSKTSKKITIADCGQF"
    }, 
    "uniprot_id": "PAL4H_HUMAN", 
    "enzyme_annotation": [
        {
            "ec": "5.2.1.8", 
            "activity": ""
        }, 
        {
            "ec": "5.2.1.8", 
            "activity": "Peptidylproline (omega=180) = peptidylproline (omega=0)."
        }
    ], 
    "glycation": [], 
    "keywords": [
        "glycoprotein", 
        "reported.uniprotkb_gly"
    ], 
    "species": [
        {
            "common_name": "Human", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A075B767", 
                    "id": "A0A075B767", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "publication": [], 
    "uniprot_ac": "A0A075B767", 
    "site_annotation": [
        {
            "end_pos": 110, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 108
        }, 
        {
            "end_pos": 73, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 71
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A075B767#A0A075B767-1", 
            "isoform_ac": "A0A075B767-1", 
            "locus": {
                "end_pos": 146344224, 
                "strand": "+", 
                "start_pos": 146344715, 
                "chromosome": "1", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000584068", 
                        "id": "ENST00000584068", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000464619", 
                        "id": "ENSP00000464619", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A0A075B767-1|PAL4H_HUMAN Isoform 1 of Peptidyl-prolyl cis-trans isomerase A-like 4H  OS=Homo sapiens OX=9606 GN=PPIAL4H PE=3 SV=1 CANONICAL=A0A075B767-1", 
                "length": 164, 
                "sequence": "MVNSVVFFDITVDGKPLGRISIKLFADKIPKTAENFRALSTGEKGFRYKGSCFHRIIPGFMCQGGDFTRPNGTDDKSIYGEKFDDENLIRKHTGSGILSMVNAGPNTNGSQLFICTAKTEWLDGKHVAFGKVKERVNIVEAMEHFGYRNSKTSKKITIADCGQF"
            }
        }
    ], 
    "pathway": [], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A075B767#function", 
            "annotation": "PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A075B767#function", 
                    "id": "A0A075B767", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [
        {
            "sequence_org": "I", 
            "alt_nt": "null", 
            "chr_id": "1", 
            "ref_nt": "T", 
            "chr_pos": "146344375A>", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1367848572", 
                    "id": "rs1367848572", 
                    "database": "dbSNP"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/snp/rs1367848572#frequency_tab", 
                    "id": "rs1367848572", 
                    "database": "TOPMed"
                }
            ], 
            "glycoeffect": [
                "n-glyco-sequon-gain"
            ], 
            "sequence_mut": "N", 
            "start_pos": 114, 
            "keywords": [
                "ebi", 
                "germline"
            ], 
            "end_pos": 114, 
            "minor_allelic_frequency": "", 
            "annotation": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (ICT->NCT)."
        }, 
        {
            "sequence_org": "K", 
            "alt_nt": "null", 
            "chr_id": "1", 
            "ref_nt": "G", 
            "chr_pos": "146344263C>", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1350254794", 
                    "id": "rs1350254794", 
                    "database": "dbSNP"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/snp/rs1350254794#frequency_tab", 
                    "id": "rs1350254794", 
                    "database": "TOPMed"
                }
            ], 
            "glycoeffect": [
                "n-glyco-sequon-gain", 
                "o-glyco-site-loss"
            ], 
            "sequence_mut": "N", 
            "start_pos": 151, 
            "keywords": [
                "ebi", 
                "germline"
            ], 
            "end_pos": 151, 
            "minor_allelic_frequency": "", 
            "annotation": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KTS->NTS)."
        }
    ], 
    "cluster_types": [], 
    "refseq": {}, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016018", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A075B767", 
                                "id": "A0A075B767", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cyclosporin A binding", 
                        "id": "GO:0016018"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003755", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A075B767", 
                                "id": "A0A075B767", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "peptidyl-prolyl cis-trans isomerase activity", 
                        "id": "GO:0003755"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A075B767", 
                                "id": "A0A075B767", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A075B767", 
                                "id": "A0A075B767", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "intracellular membrane-bounded organelle", 
                        "id": "GO:0043231"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A075B767", 
                                "id": "A0A075B767", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein folding", 
                        "id": "GO:0006457"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000413", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A075B767", 
                                "id": "A0A075B767", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein peptidyl-prolyl isomerization", 
                        "id": "GO:0000413"
                    }
                ], 
                "total": 2, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A075B767", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "PPIAL4H"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000270339", 
            "id": "ENSG00000270339", 
            "database": "Bgee"
        }, 
        {
            "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A075B767", 
            "id": "A0A075B767", 
            "database": "BioMuta"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=PPIAL4H", 
            "id": "PPIAL4H", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=53889", 
            "id": "53889", 
            "database": "HGNC"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002130", 
            "id": "IPR002130", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR020892", 
            "id": "IPR020892", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR024936", 
            "id": "IPR024936", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029000", 
            "id": "IPR029000", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A0A075B767", 
            "id": "NX_A0A075B767", 
            "database": "neXtProt"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1403619at2759", 
            "id": "1403619at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00160", 
            "id": "PF00160", 
            "database": "Pfam"
        }, 
        {
            "url": "http://purl.obolibrary.org/obo/PR_PR_A0A075B767", 
            "id": "PR_A0A075B767", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011506967.1", 
            "id": "XP_011506967.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A075B767", 
            "id": "A0A075B767", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [
        {
            "residue": "Asn", 
            "site_category": "reported", 
            "end_pos": 108, 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A075B767#ptm_processing", 
                    "id": "A0A075B767", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://prosite.expasy.org/rule/PRU00498", 
                    "id": "PRU00498", 
                    "database": "PROSITE-PRORULE"
                }
            ], 
            "subtype": "", 
            "relation": "attached", 
            "start_pos": 108, 
            "glytoucan_ac": "", 
            "type": "N-linked"
        }, 
        {
            "residue": "Asn", 
            "site_category": "reported", 
            "end_pos": 71, 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A075B767#ptm_processing", 
                    "id": "A0A075B767", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://prosite.expasy.org/rule/PRU00498", 
                    "id": "PRU00498", 
                    "database": "PROSITE-PRORULE"
                }
            ], 
            "subtype": "", 
            "relation": "attached", 
            "start_pos": 71, 
            "glytoucan_ac": "", 
            "type": "N-linked"
        }
    ], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 18208.0, 
        "chemical_mass": 18208.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A075B767", 
            "name": "PPIAL4H", 
            "locus": {
                "end_pos": 146344131, 
                "strand": "-", 
                "start_pos": 146344790, 
                "chromosome": "1", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSG00000270339", 
                        "id": "ENSG00000270339", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A075B767#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "5.2.1.8"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A075B767#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "PPIase A-like 4H"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A075B767#names_and_taxonomy", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Peptidyl-prolyl cis-trans isomerase A-like 4H"
        }
    ]
}