{ "number_monosaccharides": 2, "inchi_key": { "url": "https://pubchem.ncbi.nlm.nih.gov/compound/HMQPEDMEOBLSQB-IQKNWYLPSA-N", "key": "HMQPEDMEOBLSQB-IQKNWYLPSA-N" }, "glycans": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "glytoucan_ac": "G00031MO" } ], "smiles_isomeric": "CC(=O)N[C@@H]1[C@H]([C@H]([C@H](O[C@@H]1O)CO)O)O[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O)O)O", "mass_pme": 495.27, "names": [ { "domain": "Semantic Name", "name": "T antigen" }, { "domain": "motifname", "name": "T antigen" } ], "fully_determined": "yes", "keywords": [], "wurcs": "WURCS=2.0/2,2,1/[a2112h-1a_1-5_2*NCC/3=O][a2112h-1b_1-5]/1-2/a3-b1", "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21551457", "type": [ "PubMed" ], "id": "21551457" } ], "title": "Occurrence of the human tumor-specific antigen structure Galbeta1-3GalNAcalpha- (Thomsen-Friedenreich) and related structures on gut bacteria: prevalence, immunochemical analysis and structural confirmation.", "journal": "Glycobiology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Henderson G, Ulsemer P, Schober U, Loffler A, Alpert CA, Zimmermann-Kordmann M, Reutter W, Karsten U, Goletz S, Blaut M", "date": "2011" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/1516058", "type": [ "PubMed" ], "id": "1516058" } ], "title": "Human urinary bladder carcinoma glycoconjugates expressing T-(Gal beta(1-3)GalNAc alpha 1-O-R) and T-like antigens: a comparative study using peanut agglutinin and poly- and monoclonal antibodies.", "journal": "Cancer research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Langkilde NC, Wolf H, Clausen H, Orntoft TF", "date": "1992" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12946359", "type": [ "PubMed" ], "id": "12946359" } ], "title": "Structural basis of the carbohydrate specificities of jacalin: an X-ray and modeling study.", "journal": "Journal of molecular biology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Jeyaprakash AA, Katiyar S, Swaminathan CP, Sekar K, Surolia A, Vijayan M", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/3342257", "type": [ "PubMed" ], "id": "3342257" } ], "title": "Chemical structure of neutral sugar chains isolated from human mature milk kappa-casein.", "journal": "Biochimica et biophysica acta", "evidence": [ { "url": "http://www.unicarbkb.org/structure/4", "id": "4", "database": "UniCarbKB" } ], "authors": "Saito T, Itoh T, Adachi S", "date": "1988" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15505370", "type": [ "PubMed" ], "id": "15505370" } ], "title": "The potential role of tau protein O-glycosylation in Alzheimer's disease.", "journal": "Journal of Alzheimer's disease : JAD", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Robertson LA, Moya KL, Breen KC", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/9334809", "type": [ "PubMed" ], "id": "9334809" } ], "title": "Selection of tumor antigens as targets for immune attack using immunohistochemistry: II. Blood group-related antigens.", "journal": "International journal of cancer", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Zhang S, Zhang HS, Cordon-Cardo C, Reuter VE, Singhal AK, Lloyd KO, Livingston PO", "date": "1997" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15864746", "type": [ "PubMed" ], "id": "15864746" } ], "title": "Polyvalent GalNAcalpha1-->Ser/Thr (Tn) and Galbeta1-->3GalNAcalpha1-->Ser/Thr (T alpha) as the most potent recognition factors involved in Maclura pomifera agglutinin-glycan interactions.", "journal": "Journal of biomedical science", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Wu AM", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19021580", "type": [ "PubMed" ], "id": "19021580" } ], "title": "Lectin-epithelial interactions in the human colon.", "journal": "Biochemical Society transactions", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Rhodes JM, Campbell BJ, Yu LG", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/3469463", "type": [ "PubMed" ], "id": "3469463" } ], "title": "Monoclonal antibodies and synthetic tumor-associated glycoconjugates in the study of the expression of Thomsen-Friedenreich-like and Tn-like antigens on human cancers.", "journal": "Journal of the National Cancer Institute", "evidence": [ { "url": "https://glycomotif.glyomics.org/glycomotif/GGM.000009", "id": "GGM.000009", "database": "Glycan Motif" } ], "authors": "Longenecker BM, Willans DJ, MacLean GD, Selvaraj S, Suresh MR, Noujaim AA", "date": "1987" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16547942", "type": [ "PubMed" ], "id": "16547942" } ], "title": "Elevated Golgi pH in breast and colorectal cancer cells correlates with the expression of oncofetal carbohydrate T-antigen.", "journal": "Journal of cellular physiology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Rivinoja A, Kokkonen N, Kellokumpu I, Kellokumpu S", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17708590", "type": [ "PubMed" ], "id": "17708590" } ], "title": "A serial lectin approach to the mucin-type O-glycoproteome of Drosophila melanogaster S2 cells.", "journal": "Proteomics", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Schwientek T, Mandel U, Roth U, Muller S, Hanisch FG", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18301385", "type": [ "PubMed" ], "id": "18301385" } ], "title": "Distribution of the alphaGal- and the non-alphaGal T-antigens in the pig kidney: potential targets for rejection in pig-to-man xenotransplantation.", "journal": "Immunology and cell biology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Kirkeby S, Mikkelsen HB", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8323299", "type": [ "PubMed" ], "id": "8323299" } ], "title": "Assignment of O-glycan attachment sites to the hinge-like regions of human lysosomal membrane glycoproteins lamp-1 and lamp-2.", "journal": "Archives of biochemistry and biophysics", "evidence": [ { "url": "http://www.unicarbkb.org/structure/4", "id": "4", "database": "UniCarbKB" } ], "authors": "Carlsson SR, Lycksell PO, Fukuda M", "date": "1993" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17694322", "type": [ "PubMed" ], "id": "17694322" } ], "title": "Changes in the profile of simple mucin-type O-glycans and polypeptide GalNAc-transferases in human testis and testicular neoplasms are associated with germ cell maturation and tumour differentiation.", "journal": "Virchows Archiv : an international journal of pathology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Rajpert-De Meyts E, Poll SN, Goukasian I, Jeanneau C, Herlihy AS, Bennett EP, Skakkebaek NE, Clausen H, Giwercman A, Mandel U", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/10441114", "type": [ "PubMed" ], "id": "10441114" } ], "title": "Novel glycosylated forms of human plasma endostatin and circulating endostatin-related fragments of collagen XV.", "journal": "Biochemistry", "evidence": [ { "url": "http://www.unicarbkb.org/structure/4", "id": "4", "database": "UniCarbKB" } ], "authors": "John H, Preissner KT, Forssmann WG, Standker L", "date": "1999" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8384526", "type": [ "PubMed" ], "id": "8384526" } ], "title": "An improved approach to the analysis of the structure of small oligosaccharides of glycoproteins: application to the O-linked oligosaccharides from human glycophorin A.", "journal": "Carbohydrate research", "evidence": [ { "url": "http://www.unicarbkb.org/structure/4", "id": "4", "database": "UniCarbKB" } ], "authors": "Krotkiewski H, Lisowska E, Nilsson G, Gronberg G, Nilsson B", "date": "1993" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19756298", "type": [ "PubMed" ], "id": "19756298" } ], "title": "The repertoire of glycan determinants in the human glycome.", "journal": "Molecular bioSystems", "evidence": [ { "url": "https://glycomotif.glyomics.org/glycomotif/GGM.000009", "id": "GGM.000009", "database": "Glycan Motif" } ], "authors": "Cummings RD", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11326683", "type": [ "PubMed" ], "id": "11326683" } ], "title": "Expression of the Thomsen-Friedenreich (TF) antigen in the human placenta.", "journal": "Anticancer research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Richter DU, Jeschke U, Makovitzky J, Goletz S, Karsten U, Briese V, Friese K", "date": "2000" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15843572", "type": [ "PubMed" ], "id": "15843572" } ], "title": "Antibodies against tumor cell glycolipids and proteins, but not mucins, mediate complement-dependent cytotoxicity.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Ragupathi G, Liu NX, Musselli C, Powell S, Lloyd K, Livingston PO", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/9449027", "type": [ "PubMed" ], "id": "9449027" } ], "title": "Carbohydrate and peptide structure of the alpha- and beta-subunits of human chorionic gonadotropin from normal and aberrant pregnancy and choriocarcinoma.", "journal": "Endocrine", "evidence": [ { "url": "http://www.unicarbkb.org/structure/4", "id": "4", "database": "UniCarbKB" } ], "authors": "Elliott MM, Kardana A, Lustbader JW, Cole LA", "date": "1997" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17652409", "type": [ "PubMed" ], "id": "17652409" } ], "title": "Structural basis for recognition of breast and colon cancer epitopes Tn antigen and Forssman disaccharide by Helix pomatia lectin.", "journal": "Glycobiology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Lescar J, Sanchez JF, Audfray A, Coll JL, Breton C, Mitchell EP, Imberty A", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8631363", "type": [ "PubMed" ], "id": "8631363" } ], "title": "O-glycosylated species of natural human tumor-necrosis factor-alpha.", "journal": "European journal of biochemistry", "evidence": [ { "url": "http://www.unicarbkb.org/structure/4", "id": "4", "database": "UniCarbKB" } ], "authors": "Takakura-Yamamoto R, Yamamoto S, Fukuda S, Kurimoto M", "date": "1996" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17057347", "type": [ "PubMed" ], "id": "17057347" } ], "title": "Structural studies on peanut lectin complexed with disaccharides involving different linkages: further insights into the structure and interactions of the lectin.", "journal": "Acta crystallographica. Section D, Biological crystallography", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Natchiar SK, Srinivas O, Mitra N, Surolia A, Jayaraman N, Vijayan M", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16990264", "type": [ "PubMed" ], "id": "16990264" } ], "title": "Crystal structure of the galectin-9 N-terminal carbohydrate recognition domain from Mus musculus reveals the basic mechanism of carbohydrate recognition.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Nagae M, Nishi N, Murata T, Usui T, Nakamura T, Wakatsuki S, Kato R", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19496993", "type": [ "PubMed" ], "id": "19496993" } ], "title": "Specific interaction of the legume lectins, concanavalin a and peanut agglutinin, with phycocyanin.", "journal": "Photochemistry and photobiology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Pandey G, Fatma T, Komath SS", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/2404571", "type": [ "PubMed" ], "id": "2404571" } ], "title": "Glycine to aspartic acid mutations at codon 13 of the c-Ki-ras gene in human gastrointestinal cancers.", "journal": "Cancer research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Nagata Y, Abe M, Kobayashi K, Yoshida K, Ishibashi T, Naoe T, Nakayama E, Shiku H", "date": "1990" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/2033371", "type": [ "PubMed" ], "id": "2033371" } ], "title": "Altered O-glycan synthesis in lymphocytes from patients with Wiskott-Aldrich syndrome.", "journal": "The Journal of experimental medicine", "evidence": [ { "url": "http://www.unicarbkb.org/structure/4", "id": "4", "database": "UniCarbKB" } ], "authors": "Piller F, Le Deist F, Weinberg KI, Parkman R, Fukuda M", "date": "1991" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16563047", "type": [ "PubMed" ], "id": "16563047" } ], "title": "H-deficient Bombay and para-Bombay red blood cells are most strongly agglutinated by the galactophilic lectins of Aplysia and Pseudomonas aeruginosa that detect I and P1 antigens.", "journal": "Immunohematology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Gilboa-Garber N, Sudakevitz D, Levene C, Rahimi-Levene N, Yahalom V", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/3731131", "type": [ "PubMed" ], "id": "3731131" } ], "title": "Comparison of T-antigen expression in normal, premalignant, and malignant human colonic tissue using lectin and antibody immunohistochemistry.", "journal": "Cancer research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Yuan M, Itzkowitz SH, Boland CR, Kim YD, Tomita JT, Palekar A, Bennington JL, Trump BF, Kim YS", "date": "1986" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8985092", "type": [ "PubMed" ], "id": "8985092" } ], "title": "Human monoclonal antibodies specific for the tumour associated Thomsen-Friedenreich antigen.", "journal": "International journal of cancer", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Dahlenborg K, Hultman L, Carlsson R, Jansson B", "date": "1997" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11501845", "type": [ "PubMed" ], "id": "11501845" } ], "title": "Expression of mucin-associated carbohydrate core antigens in esophageal squamous cell carcinomas.", "journal": "Anticancer research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Flucke U, Zirbes TK, Schroder W, Monig SP, Koch V, Schmitz K, Thiele J, Dienes HP, Holscher AH, Baldus SE", "date": "2001" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/7539400", "type": [ "PubMed" ], "id": "7539400" } ], "title": "A new monoclonal antibody (A78-G/A7) to the Thomsen-Friedenreich pan-tumor antigen.", "journal": "Hybridoma", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Karsten U, Butschak G, Cao Y, Goletz S, Hanisch FG", "date": "1995" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16203776", "type": [ "PubMed" ], "id": "16203776" } ], "title": "Thomsen-Friedenreich and Tn antigens in nipple fluid: carbohydrate biomarkers for breast cancer detection.", "journal": "Clinical cancer research : an official journal of the American Association for Cancer Research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Kumar SR, Sauter ER, Quinn TP, Deutscher SL", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15179519", "type": [ "PubMed" ], "id": "15179519" } ], "title": "Unexpected mortality in pediatric patients with postoperative Hirschsprung's disease.", "journal": "Pediatric surgery international", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Wang JS, Lee HC, Huang FY, Chang PY, Sheu JC", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/2793860", "type": [ "PubMed" ], "id": "2793860" } ], "title": "Expression of human interleukin-2 in recombinant baby hamster kidney, Ltk-, and Chinese hamster ovary cells. Structure of O-linked carbohydrate chains and their location within the polypeptide.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "http://www.unicarbkb.org/structure/4", "id": "4", "database": "UniCarbKB" } ], "authors": "Conradt HS, Nimtz M, Dittmar KE, Lindenmaier W, Hoppe J, Hauser H", "date": "1989" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/3514617", "type": [ "PubMed" ], "id": "3514617" } ], "title": "Membrane glycophorins in Sta blood group erythrocytes.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "http://www.unicarbkb.org/structure/4", "id": "4", "database": "UniCarbKB" } ], "authors": "Blumenfeld OO, Adamany AM, Kikuchi M, Sabo B, McCreary J", "date": "1986" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/1374031", "type": [ "PubMed" ], "id": "1374031" } ], "title": "The carbohydrate chains of the beta subunit of human chorionic gonadotropin produced by the choriocarcinoma cell line BeWo. Novel O-linked and novel bisecting-GlcNAc-containing N-linked carbohydrates.", "journal": "European journal of biochemistry", "evidence": [ { "url": "http://www.unicarbkb.org/structure/4", "id": "4", "database": "UniCarbKB" } ], "authors": "Hard K, Damm JB, Spruijt MP, Bergwerff AA, Kamerling JP, Van Dedem GW, Vliegenthart JF", "date": "1992" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/9852066", "type": [ "PubMed" ], "id": "9852066" } ], "title": "Phosphorylation and O-glycosylation sites of human chromogranin A (CGA79-439) from urine of patients with carcinoid tumors.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "http://www.unicarbkb.org/structure/4", "id": "4", "database": "UniCarbKB" } ], "authors": "Gadroy P, Stridsberg M, Capon C, Michalski JC, Strub JM, Van Dorsselaer A, Aunis D, Metz-Boutigue MH", "date": "1998" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/6619126", "type": [ "PubMed" ], "id": "6619126" } ], "title": "A carbohydrate structural variant of MM glycoprotein (glycophorin A).", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "http://www.unicarbkb.org/structure/4", "id": "4", "database": "UniCarbKB" } ], "authors": "Adamany AM, Blumenfeld OO, Sabo B, McCreary J", "date": "1983" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/7516636", "type": [ "PubMed" ], "id": "7516636" } ], "title": "Simple mucins (T, sialosyl-T, Tn and sialosyl-Tn) are not diagnostic for malignant breast lesions.", "journal": "Anticancer research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Reed W, Bryne M, Clausen H, Dabelsteen E, Nesland JM", "date": "1994" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22678432", "type": [ "PubMed" ], "id": "22678432" } ], "title": "Determination of site-specific glycan heterogeneity on glycoproteins.", "journal": "Nature protocols", "evidence": [ { "url": "http://www.unicarbkb.org/structure/4", "id": "4", "database": "UniCarbKB" } ], "authors": "Kolarich D, Jensen PH, Altmann F, Packer NH", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/9212232", "type": [ "PubMed" ], "id": "9212232" } ], "title": "Immunoreactivities of polyclonal and monoclonal anti-T and anti-Tn antibodies with human carcinoma cells, grown in vitro and in a xenograft model.", "journal": "International journal of cancer", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Avichezer D, Springer GF, Schechter B, Arnon R", "date": "1997" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11406562", "type": [ "PubMed" ], "id": "11406562" } ], "title": "The role of Thomsen-Friedenreich antigen in adhesion of human breast and prostate cancer cells to the endothelium.", "journal": "Cancer research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Glinsky VV, Glinsky GV, Rittenhouse-Olson K, Huflejt ME, Glinskii OV, Deutscher SL, Quinn TP", "date": "2001" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18824562", "type": [ "PubMed" ], "id": "18824562" } ], "title": "Identification of the Drosophila core 1 beta1,3-galactosyltransferase gene that synthesizes T antigen in the embryonic central nervous system and hemocytes.", "journal": "Glycobiology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Yoshida H, Fuwa TJ, Arima M, Hamamoto H, Sasaki N, Ichimiya T, Osawa K, Ueda R, Nishihara S", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12995288", "type": [ "PubMed" ], "id": "12995288" } ], "title": "[The new ophthalmologic hospital in Djeddah (Arabia)].", "journal": "Techniques hospitalieres, medico-sociales et sanitaires", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "RULE L", "date": "1952" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18282768", "type": [ "PubMed" ], "id": "18282768" } ], "title": "Purification and characterization of a T-antigen specific lectin from the coelomic fluid of a marine invertebrate, sea cucumber (Holothuria scabra).", "journal": "Fish & shellfish immunology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Gowda NM, Goswami U, Khan MI", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16615117", "type": [ "PubMed" ], "id": "16615117" } ], "title": "Interference with O-glycosylation in RMA lymphoma cells leads to a reduced in vivo growth of the tumor.", "journal": "International journal of cancer", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Chen L, Sundback J, Olofsson S, Jondal M", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/468798", "type": [ "PubMed" ], "id": "468798" } ], "title": "Structure and location of the O-glycosidic carbohydrate units of human chorionic gonadotropin.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "http://www.unicarbkb.org/structure/4", "id": "4", "database": "UniCarbKB" } ], "authors": "Kessler MJ, Mise T, Ghai RD, Bahl OP", "date": "1979" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18662810", "type": [ "PubMed" ], "id": "18662810" } ], "title": "Catfish (Clarias batrachus) serum lectin recognizes polyvalent Tn [alpha-D-GalpNAc1-Ser/Thr], Talpha [beta-D-Galp-(1-->3)-alpha-D-GalpNAc1-Ser/Thr], and II [beta-D-Galp(1-->4)-beta-D-GlcpNAc1-] mammalian glycotopes.", "journal": "Carbohydrate research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Singha B, Adhya M, Chatterjee BP", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12761161", "type": [ "PubMed" ], "id": "12761161" } ], "title": "SRCL/CL-P1 recognizes GalNAc and a carcinoma-associated antigen, Tn antigen.", "journal": "Journal of biochemistry", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Yoshida T, Tsuruta Y, Iwasaki M, Yamane S, Ochi T, Suzuki R", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16965854", "type": [ "PubMed" ], "id": "16965854" } ], "title": "Biological significance of cancer-associated sialyl-Tn antigen: modulation of malignant phenotype in gastric carcinoma cells.", "journal": "Cancer letters", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Pinho S, Marcos NT, Ferreira B, Carvalho AS, Oliveira MJ, Santos-Silva F, Harduin-Lepers A, Reis CA", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/2335739", "type": [ "PubMed" ], "id": "2335739" } ], "title": "Expression patterns of the T antigen and the cryptic T antigen in rat fetuses: detection with the lectin amaranthin.", "journal": "The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Sata T, Zuber C, Rinderle SJ, Goldstein IJ, Roth J", "date": "1990" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/2450649", "type": [ "PubMed" ], "id": "2450649" } ], "title": "Preparation and characterization of monoclonal antibodies directed to the tumor-associated O-linked sialosyl-2----6 alpha-N-acetylgalactosaminyl (sialosyl-Tn) epitope.", "journal": "Cancer research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Kjeldsen T, Clausen H, Hirohashi S, Ogawa T, Iijima H, Hakomori S", "date": "1988" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11389097", "type": [ "PubMed" ], "id": "11389097" } ], "title": "Overexpression of sialyltransferase CMP-sialic acid:Galbeta1,3GalNAc-R alpha6-Sialyltransferase is related to poor patient survival in human colorectal carcinomas.", "journal": "Cancer research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Schneider F, Kemmner W, Haensch W, Franke G, Gretschel S, Karsten U, Schlag PM", "date": "2001" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8625037", "type": [ "PubMed" ], "id": "8625037" } ], "title": "Expression of Thomsen-Friedenreich-related antigens in primary and metastatic colorectal carcinomas. A reevaluation.", "journal": "Cancer", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Cao Y, Karsten UR, Liebrich W, Haensch W, Springer GF, Schlag PM", "date": "1995" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15466199", "type": [ "PubMed" ], "id": "15466199" } ], "title": "Role of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigen.", "journal": "Cancer research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Marcos NT, Pinho S, Grandela C, Cruz A, Samyn-Petit B, Harduin-Lepers A, Almeida R, Silva F, Morais V, Costa J, Kihlberg J, Clausen H, Reis CA", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/14736333", "type": [ "PubMed" ], "id": "14736333" } ], "title": "Rhesus monkey gastric mucins: oligomeric structure, glycoforms and Helicobacter pylori binding.", "journal": "The Biochemical journal", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Linden S, Boren T, Dubois A, Carlstedt I", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17100645", "type": [ "PubMed" ], "id": "17100645" } ], "title": "A novel antiproliferative and antifungal lectin from Amaranthus viridis Linn seeds.", "journal": "Protein and peptide letters", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Kaur N, Dhuna V, Kamboj SS, Agrewala JN, Singh J", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/6725284", "type": [ "PubMed" ], "id": "6725284" } ], "title": "The structure of the carbohydrate units of human plasma galactoglycoprotein determined by 500-megahertz 1H NMR spectroscopy.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "http://www.unicarbkb.org/structure/4", "id": "4", "database": "UniCarbKB" } ], "authors": "Akiyama K, Simons ER, Bernasconi P, Schmid K, van Halbeek H, Vliegenthart JF, Haupt H, Schwick HG", "date": "1984" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17090649", "type": [ "PubMed" ], "id": "17090649" } ], "title": "Variations in glycosylation of von Willebrand factor with O-linked sialylated T antigen are associated with its plasma levels.", "journal": "Blood", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "van Schooten CJ, Denis CV, Lisman T, Eikenboom JC, Leebeek FW, Goudemand J, Fressinaud E, van den Berg HM, de Groot PG, Lenting PJ", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/2908846", "type": [ "PubMed" ], "id": "2908846" } ], "title": "Expression of Tn, sialosyl-Tn, and T antigens in human colon cancer.", "journal": "Cancer research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Itzkowitz SH, Yuan M, Montgomery CK, Kjeldsen T, Takahashi HK, Bigbee WL, Kim YS", "date": "1989" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/14741734", "type": [ "PubMed" ], "id": "14741734" } ], "title": "Recognition profile of Bauhinia purpurea agglutinin (BPA).", "journal": "Life sciences", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Wu AM, Wu JH, Liu JH, Singh T", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16776550", "type": [ "PubMed" ], "id": "16776550" } ], "title": "Binding of T-antigen disaccharides to Artocarpus hirsuta lectin and jacalin are energetically different.", "journal": "Photochemistry and photobiology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Gaikwad SM, Khan MI", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/6190803", "type": [ "PubMed" ], "id": "6190803" } ], "title": "Primary structure of the oligosaccharide determinant of blood group Cad specificity.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "http://www.unicarbkb.org/structure/4", "id": "4", "database": "UniCarbKB" } ], "authors": "Blanchard D, Cartron JP, Fournet B, Montreuil J, van Halbeek H, Vliegenthart JF", "date": "1983" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/2943741", "type": [ "PubMed" ], "id": "2943741" } ], "title": "Structural variations of O-linked oligosaccharides present in leukosialin isolated from erythroid, myeloid, and T-lymphoid cell lines.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "http://www.unicarbkb.org/structure/4", "id": "4", "database": "UniCarbKB" } ], "authors": "Carlsson SR, Sasaki H, Fukuda M", "date": "1986" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/1370965", "type": [ "PubMed" ], "id": "1370965" } ], "title": "Studies on the Thomsen-Friedenreich antigen in human colon with the lectin Amaranthin. Normal and neoplastic epithelium express only cryptic T antigen.", "journal": "Laboratory investigation; a journal of technical methods and pathology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Sata T, Roth J, Zuber C, Stamm B, Rinderle SJ, Goldstein IJ, Heitz PU", "date": "1992" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16033536", "type": [ "PubMed" ], "id": "16033536" } ], "title": "Immune response to Thomsen-Friedenreich disaccharide and glycan engineering.", "journal": "Immunology and cell biology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Irazoqui FJ, Sendra VG, Lardone RD, Nores GA", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/13756766", "type": [ "PubMed" ], "id": "13756766" } ], "title": "[On the isolation of mucoids containing neuraminic acid from human erythrocyte stroma, a contribution to the chemistry of agglutinogens].", "journal": "Hoppe-Seyler's Zeitschrift fur physiologische Chemie", "evidence": [ { "url": "https://glycomotif.glyomics.org/glycomotif/GGM.000009", "id": "GGM.000009", "database": "Glycan Motif" } ], "authors": "KLENK E, UHLENBRUCK G", "date": "1960" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8344280", "type": [ "PubMed" ], "id": "8344280" } ], "title": "Biosynthesis and secretion of human interleukin 2 glycoprotein variants from baculovirus-infected Sf21 cells. Characterization of polypeptides and posttranslational modifications.", "journal": "European journal of biochemistry", "evidence": [ { "url": "http://www.unicarbkb.org/structure/4", "id": "4", "database": "UniCarbKB" } ], "authors": "Grabenhorst E, Hofer B, Nimtz M, Jager V, Conradt HS", "date": "1993" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17457671", "type": [ "PubMed" ], "id": "17457671" } ], "title": "The oncofetal Thomsen-Friedenreich carbohydrate antigen in cancer progression.", "journal": "Glycoconjugate journal", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Yu LG", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11528254", "type": [ "PubMed" ], "id": "11528254" } ], "title": "Immunoreactivity of monoclonal antibody BW835 represents a marker of progression and prognosis in early gastric cancer.", "journal": "Oncology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Baldus SE, Zirbes TK, Glossmann J, Fromm S, Hanisch FG, Monig SP, Schroder W, Schneider PM, Flucke U, Karsten U, Thiele J, Holscher AH, Dienes HP", "date": "2001" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/9857245", "type": [ "PubMed" ], "id": "9857245" } ], "title": "Immunohistochemical study of Tn, sialosyl-Tn and T antigens in human meningiomas.", "journal": "European journal of histochemistry : EJH", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Giuffre G, Vitarelli E, Tuccari G, Barresi G", "date": "1998" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/9359491", "type": [ "PubMed" ], "id": "9359491" } ], "title": "Stimulation of proliferation in human colon cancer cells by human monoclonal antibodies against the TF antigen (galactose beta1-3 N-acetyl-galactosamine).", "journal": "International journal of cancer", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Yu LG, Jansson B, Fernig DG, Milton JD, Smith JA, Gerasimenko OV, Jones M, Rhodes JM", "date": "1997" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8609376", "type": [ "PubMed" ], "id": "8609376" } ], "title": "Concurrent immunohistochemical staining of tumor-infiltrating lymphocytes and carcinoma-associated T (Thomsen-Friedenreich)/Tn antigens in human breast carcinoma.", "journal": "The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Wang BL, Springer GF, Kaufman MW", "date": "1996" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11447138", "type": [ "PubMed" ], "id": "11447138" } ], "title": "Cell surface-expressed Thomsen-Friedenreich antigen in colon cancer is predominantly carried on high molecular weight splice variants of CD44.", "journal": "Glycobiology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Singh R, Campbell BJ, Yu LG, Fernig DG, Milton JD, Goodlad RA, FitzGerald AJ, Rhodes JM", "date": "2001" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/3880667", "type": [ "PubMed" ], "id": "3880667" } ], "title": "Comparative immunoperoxidase demonstration of T-antigens in human colorectal carcinomas and morphologically abnormal mucosa.", "journal": "Cancer research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Orntoft TF, Mors NP, Eriksen G, Jacobsen NO, Poulsen HS", "date": "1985" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/7496150", "type": [ "PubMed" ], "id": "7496150" } ], "title": "Expression of the T antigen on a T-lymphoid cell line, supT1.", "journal": "Glycoconjugate journal", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Nakada H, Inoue M, Tanaka N, Wakamiya N, Yamashina I", "date": "1995" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/7545084", "type": [ "PubMed" ], "id": "7545084" } ], "title": "Monoclonal antibody BW835 defines a site-specific Thomsen-Friedenreich disaccharide linked to threonine within the VTSA motif of MUC1 tandem repeats.", "journal": "Cancer research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Hanisch FG, Stadie T, Bosslet K", "date": "1995" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11396208", "type": [ "PubMed" ], "id": "11396208" } ], "title": "Immunohistochemical expression of T, Tn and sialyl-Tn antigens and clinical outcome in human breast carcinoma.", "journal": "Anticancer research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Imai J, Ghazizadeh M, Naito Z, Asano G", "date": "2001" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/2736629", "type": [ "PubMed" ], "id": "2736629" } ], "title": "Expression of Thomsen-Friedenreich (TF) antigens on lymphocytes. I. Distribution of cryptic and exposed TF antigens on murine lymphocytes from different lymphoid organs: detection with an anti-TF monoclonal antibody and peanut agglutinin.", "journal": "Cellular immunology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Wolf MF, Schmitt HR, Schumacher K", "date": "1989" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17537433", "type": [ "PubMed" ], "id": "17537433" } ], "title": "Galectin-1, an endogenous lectin produced by arterial cells, binds lipoprotein(a) [Lp(a)] in situ: relevance to atherogenesis.", "journal": "Experimental and molecular pathology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Chellan B, Narayani J, Appukuttan PS", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/4091823", "type": [ "PubMed" ], "id": "4091823" } ], "title": "Comparative study of glycophorin A derived O-glycans from human Cad, Sd(a+) and Sd(a-) erythrocytes.", "journal": "The Biochemical journal", "evidence": [ { "url": "http://www.unicarbkb.org/structure/4", "id": "4", "database": "UniCarbKB" } ], "authors": "Blanchard D, Capon C, Leroy Y, Cartron JP, Fournet B", "date": "1985" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/10365852", "type": [ "PubMed" ], "id": "10365852" } ], "title": "Expression of sialyl-Tn, Tn and T antigens in primary liver cancer.", "journal": "Pathology international", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Sasaki M, Yamato T, Nakanuma Y", "date": "1999" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15623485", "type": [ "PubMed" ], "id": "15623485" } ], "title": "Distribution of HPV infection and tumour markers in cervical intraepithelial neoplasia from cone biopsies of Mozambican women.", "journal": "Journal of clinical pathology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Carrilho C, Cirnes L, Alberto M, Buane L, Mendes N, David L", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/1820200", "type": [ "PubMed" ], "id": "1820200" } ], "title": "Site-specific N-glycosylation of human chorionic gonadotrophin--structural analysis of glycopeptides by one- and two-dimensional 1H NMR spectroscopy.", "journal": "Glycobiology", "evidence": [ { "url": "http://www.unicarbkb.org/structure/4", "id": "4", "database": "UniCarbKB" } ], "authors": "Weisshaar G, Hiyama J, Renwick AG", "date": "1991" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16384952", "type": [ "PubMed" ], "id": "16384952" } ], "title": "Mucin characteristics of human corneal-limbal epithelial cells that exclude the rose bengal anionic dye.", "journal": "Investigative ophthalmology & visual science", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Argueso P, Tisdale A, Spurr-Michaud S, Sumiyoshi M, Gipson IK", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/2971663", "type": [ "PubMed" ], "id": "2971663" } ], "title": "Human T-lymphocyte activation is associated with changes in O-glycan biosynthesis.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "http://www.unicarbkb.org/structure/4", "id": "4", "database": "UniCarbKB" } ], "authors": "Piller F, Piller V, Fox RI, Fukuda M", "date": "1988" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16177266", "type": [ "PubMed" ], "id": "16177266" } ], "title": "Elucidation of binding specificity of Jacalin toward O-glycosylated peptides: quantitative analysis by frontal affinity chromatography.", "journal": "Glycobiology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Tachibana K, Nakamura S, Wang H, Iwasaki H, Tachibana K, Maebara K, Cheng L, Hirabayashi J, Narimatsu H", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15862866", "type": [ "PubMed" ], "id": "15862866" } ], "title": "IgA1 is the premier serum glycoprotein recognized by human galectin-1 since T antigen (Galbeta1-->3GalNAc-) is far superior to non-repeating N-acetyl lactosamine as ligand.", "journal": "International journal of biological macromolecules", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Sangeetha SR, Appukuttan PS", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11193738", "type": [ "PubMed" ], "id": "11193738" } ], "title": "Lymph node metastasis-related carbohydrate epitopes of gastric cancer with submucosal invasion.", "journal": "Surgery today", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Takano Y, Teranishi Y, Terashima S, Motoki R, Kawaguchi T", "date": "2000" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16770733", "type": [ "PubMed" ], "id": "16770733" } ], "title": "Differential binding to glycotopes among the layers of three mammalian retinal neurons by man-containing N-linked glycan, T(alpha) (Galbeta1-3GalNAcalpha1-), Tn (GalNAcalpha1-Ser/Thr) and I (beta)/II (beta) (Galbeta1-3/4GlcNAcbeta-) reactive lectins.", "journal": "Neurochemical research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Wu WC, Lai CC, Liu JH, Singh T, Li LM, Peumans WJ, Van Damme EJ, Wu AM", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16525726", "type": [ "PubMed" ], "id": "16525726" } ], "title": "The influence of N- and O-glycosylation inhibitors on the glycosylation profile of cellular membrane proteins and adhesive properties of carcinoma cell lines.", "journal": "International journal of molecular medicine", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Paszkiewicz-Gadek A, Porowska H, Lemancewicz D, Wolczynski S, Gindzienski A", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/3935432", "type": [ "PubMed" ], "id": "3935432" } ], "title": "Structures of the major carbohydrates of natural human interleukin-2.", "journal": "European journal of biochemistry", "evidence": [ { "url": "http://www.unicarbkb.org/structure/4", "id": "4", "database": "UniCarbKB" } ], "authors": "Conradt HS, Geyer R, Hoppe J, Grotjahn L, Plessing A, Mohr H", "date": "1985" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16804430", "type": [ "PubMed" ], "id": "16804430" } ], "title": "T-antigen activation for prediction of pneumococcus-induced hemolytic uremic syndrome and hemolytic anemia.", "journal": "The Pediatric infectious disease journal", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Huang DT, Chi H, Lee HC, Chiu NC, Huang FY", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/163330", "type": [ "PubMed" ], "id": "163330" } ], "title": "Blood group MN antigens and precursors in normal and malignant human breast glandular tissue.", "journal": "Journal of the National Cancer Institute", "evidence": [ { "url": "https://glycomotif.glyomics.org/glycomotif/GGM.000009", "id": "GGM.000009", "database": "Glycan Motif" } ], "authors": "Springer GF, Desai PR, Banatwala I", "date": "1975" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17674202", "type": [ "PubMed" ], "id": "17674202" } ], "title": "Temporal changes in the carbohydrates expressed on BG01 human embryonic stem cells during differentiation as embryoid bodies.", "journal": "Glycoconjugate journal", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Wearne KA, Winter HC, Goldstein IJ", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17607374", "type": [ "PubMed" ], "id": "17607374" } ], "title": "Lewis x is highly expressed in normal tissues: a comparative immunohistochemical study and literature revision.", "journal": "Pathology oncology research : POR", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Croce MV, Isla-Larrain M, Rabassa ME, Demichelis S, Colussi AG, Crespo M, Lacunza E, Segal-Eiras A", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/10861392", "type": [ "PubMed" ], "id": "10861392" } ], "title": "Metabolic shifts do not influence the glycosylation patterns of a recombinant fusion protein expressed in BHK cells.", "journal": "Biotechnology and bioengineering", "evidence": [ { "url": "http://www.unicarbkb.org/structure/4", "id": "4", "database": "UniCarbKB" } ], "authors": "Cruz HJ, Peixoto CM, Nimtz M, Alves PM, Dias EM, Moreira JL, Carrondo MJ", "date": "2000" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15221966", "type": [ "PubMed" ], "id": "15221966" } ], "title": "Thomsen-Friedenreich (T) antigen expression increases sensitivity of natural killer cell lysis of cancer cells.", "journal": "International journal of cancer", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Sotiriadis J, Shin SC, Yim D, Sieber D, Kim YB", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16824489", "type": [ "PubMed" ], "id": "16824489" } ], "title": "Evidence that Agaricus bisporus agglutinin (ABA) has dual sugar-binding specificity.", "journal": "Biochemical and biophysical research communications", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Nakamura-Tsuruta S, Kominami J, Kuno A, Hirabayashi J", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8551046", "type": [ "PubMed" ], "id": "8551046" } ], "title": "Anti-Thomsen-Friedenreich (T) antibody-based ELISA and its application to human breast carcinoma detection.", "journal": "Journal of immunological methods", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Desai PR, Ujjainwala LH, Carlstedt SC, Springer GF", "date": "1995" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/10506931", "type": [ "PubMed" ], "id": "10506931" } ], "title": "Immunoreactivity of Thomsen-Friedenreich (TF) antigen in human neoplasms: the importance of carrier-specific glycotope expression on MUC1.", "journal": "Histology and histopathology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Baldus SE, Hanisch FG, Monaca E, Karsten UR, Zirbes TK, Thiele J, Dienes HP", "date": "1999" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19162326", "type": [ "PubMed" ], "id": "19162326" } ], "title": "Characterization of murine MGL1 and MGL2 C-type lectins: distinct glycan specificities and tumor binding properties.", "journal": "Molecular immunology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "authors": "Singh SK, Streng-Ouwehand I, Litjens M, Weelij DR, Garcia-Vallejo JJ, van Vliet SJ, Saeland E, van Kooyk Y", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/7430095", "type": [ "PubMed" ], "id": "7430095" } ], "title": "Structures of the asparagine-linked sugar chains of glycophorin A.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "http://www.unicarbkb.org/structure/4", "id": "4", "database": "UniCarbKB" } ], "authors": "Yoshima H, Furthmayr H, Kobata A", "date": "1980" } ], "subsumption": [ { "type": "Saccharide", "id": "G48849EN" }, { "type": "BaseComposition", "id": "G29931IJ" }, { "type": "Saccharide", "id": "G13342FP" }, { "type": "Saccharide", "id": "G79150MP" }, { "type": "Topology", "id": "G20015ZD" }, { "type": "Topology", "id": "G14660IB" }, { "type": "Saccharide", "id": "G01416HI" }, { "type": "Composition", "id": "G23052ZQ" }, { "type": "Saccharide", "id": "G65288NK" }, { "type": "Saccharide", "id": "G43326BY" }, { "type": "Saccharide", "id": "G30710NE" }, { "type": "Saccharide", "id": "G23202WP" }, { "type": "Saccharide", "id": "G89089XB" }, { "type": "Saccharide", "id": "G49632WD" }, { "type": "Saccharide", "id": "G50849VH" }, { "type": "Topology", "id": "G91785UC" }, { "type": "BaseComposition", "id": "G43417UB" }, { "type": "Composition", "id": "G64346BI" }, { "type": "Topology", "id": "G36124QZ" }, { "type": "Saccharide", "id": "G54499HR" }, { "type": "Topology", "id": "G68199DI" }, { "type": "Topology", "id": "G22015OG" }, { "type": "Saccharide", "id": "G76950LE" }, { "type": "Saccharide", "id": "G78436BB" }, { "type": "Saccharide", "id": "G00032MO" }, { "type": "Topology", "id": "G67221IP" }, { "type": "Saccharide", "id": "G00682IE" }, { "type": "Topology", "id": "G06105ER" }, { "type": "Topology", "id": "G67200RM" } ], "motif_ac": "GGM.000009", "glytoucan_ac": "G00031MO", "composition": [ { "residue": "hexnac", "count": 1, "url": "https://pubchem.ncbi.nlm.nih.gov/compound/899", "name": "N-Acetylhexosamine", "cid": "899" }, { "residue": "p", "count": 0, "url": "https://pubchem.ncbi.nlm.nih.gov/compound/1061", "name": "Phosphate", "cid": "1061" }, { "residue": "other", "count": 0, "name": "Other" }, { "residue": "neugc", "count": 0, "url": "https://pubchem.ncbi.nlm.nih.gov/compound/440001", "name": "N-Glycolyl-Neuraminic Acid", "cid": "440001" }, { "residue": "s", "count": 0, "url": "https://pubchem.ncbi.nlm.nih.gov/compound/1117", "name": "Sulfate", "cid": "1117" }, { "residue": "hexa", "count": 0, "url": "https://pubchem.ncbi.nlm.nih.gov/compound/610", "name": "Hexuronic Acid", "cid": "610" }, { "residue": "neuac", "count": 0, "url": "https://pubchem.ncbi.nlm.nih.gov/compound/439197", "name": "N-Acetyl-Neuraminic Acid", "cid": "439197" }, { "residue": "hexn", "count": 0, "url": "https://pubchem.ncbi.nlm.nih.gov/compound/739", "name": "2-Amino-2-Deoxy-Hexose", "cid": "739" }, { "residue": "dhex", "count": 0, "url": "https://pubchem.ncbi.nlm.nih.gov/compound/840", "name": "6-Deoxy-Hexose", "cid": "840" }, { "residue": "hex", "count": 1, "url": "https://pubchem.ncbi.nlm.nih.gov/compound/206", "name": "Hexose", "cid": "206" } ], "alignment_method": "Whole-Glycan", "residues": [], "glycam": "DGalpb1-3DGalpNAca1-", "inchi": "InChI=1S/C14H25NO11/c1-4(18)15-7-12(9(20)6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8+,9+,10+,11-,12-,13+,14+/m1/s1", "crossref": [ { "url": "https://glytoucan.org/Structures/Glycans/G00031MO", "id": "G00031MO", "database": "GlyTouCan" } ], "synonym": [ "TF antigen" ], "reducing_end": "true", "glycoct": "RES 1b:a-dgal-HEX-1:5 2s:n-acetyl 3b:b-dgal-HEX-1:5 LIN 1:1d(2+1)2n 2:1o(3+1)3d", "iupac": "beta-D-Galp-(1->3)-alpha-D-GalpNAc-(1->", "aglycon": "Ser/Thr", "mass": 383.14 }