{ "number_monosaccharides": 1, "inchi_key": { "url": "https://pubchem.ncbi.nlm.nih.gov/compound/OVRNDRQMDRJTHS-CBQIKETKSA-N", "key": "OVRNDRQMDRJTHS-CBQIKETKSA-N" }, "glycans": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "glytoucan_ac": "G57321FI" } ], "smiles_isomeric": "CC(=O)N[C@@H]1[C@H]([C@H]([C@H](O[C@@H]1O)CO)O)O", "mass_pme": 291.17, "names": [ { "domain": "Semantic Name", "name": "Tn antigen" }, { "domain": "motifname", "name": "Tn antigen" } ], "fully_determined": "yes", "keywords": [], "wurcs": "WURCS=2.0/1,1,0/[a2112h-1a_1-5_2*NCC/3=O]/1/", "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/1847560", "type": [ "PubMed" ], "id": "1847560" } ], "title": "Immunochemical studies on the differential binding properties of two monoclonal antibodies reacting with Tn red cells.", "journal": "Transfusion", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "King MJ, Parsons SF, Wu AM, Jones N", "date": "1991" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/2140570", "type": [ "PubMed" ], "id": "2140570" } ], "title": "Biosynthesis of truncated O-glycans in the T cell line Jurkat. Localization of O-glycan initiation.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Piller V, Piller F, Fukuda M", "date": "1990" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17694322", "type": [ "PubMed" ], "id": "17694322" } ], "title": "Changes in the profile of simple mucin-type O-glycans and polypeptide GalNAc-transferases in human testis and testicular neoplasms are associated with germ cell maturation and tumour differentiation.", "journal": "Virchows Archiv : an international journal of pathology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Rajpert-De Meyts E, Poll SN, Goukasian I, Jeanneau C, Herlihy AS, Bennett EP, Skakkebaek NE, Clausen H, Giwercman A, Mandel U", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16155793", "type": [ "PubMed" ], "id": "16155793" } ], "title": "Lack of polymorphism in MUC1 tandem repeats in cancer cells is related to breast cancer progression in Japanese women.", "journal": "Breast cancer research and treatment", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Kawaguchi T, Takazawa H, Imai S, Morimoto J, Watanabe T", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/9334809", "type": [ "PubMed" ], "id": "9334809" } ], "title": "Selection of tumor antigens as targets for immune attack using immunohistochemistry: II. Blood group-related antigens.", "journal": "International journal of cancer", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Zhang S, Zhang HS, Cordon-Cardo C, Reuter VE, Singhal AK, Lloyd KO, Livingston PO", "date": "1997" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15944793", "type": [ "PubMed" ], "id": "15944793" } ], "title": "Simple mucin-type cancer associated antigens are pre-cancerous biomarkers during 1,2-dimethylhydrazine-induced rat colon carcinogenesis.", "journal": "Oncology reports", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Berriel E, Hill M, Barcia JJ, Ubillos L, Gonzalez M, Detjen G, Rondan M, Navarrete H, Osinaga E", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15864748", "type": [ "PubMed" ], "id": "15864748" } ], "title": "Lectinochemical studies on the glyco-recognition factors of a Tn (GalNAcalpha1-->Ser/Thr) specific lectin isolated from the seeds of Salvia sclarea.", "journal": "Journal of biomedical science", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Wu AM", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15864747", "type": [ "PubMed" ], "id": "15864747" } ], "title": "Further characterization of the binding properties of two monoclonal antibodies recognizing human Tn red blood cells.", "journal": "Journal of biomedical science", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Wua AM, Wub JH, Kuoa HW, Herpa A", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16391846", "type": [ "PubMed" ], "id": "16391846" } ], "title": "Study of the expression of Tn antigen in different types of human breast cancer cells using VVA-B4 lectin.", "journal": "Oncology reports", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Konska G, Guerry M, Caldefie-Chezet F, De Latour M, Guillot J", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19863951", "type": [ "PubMed" ], "id": "19863951" } ], "title": "Studies on the interactions between glycosylated beta3-peptides and the lectin Vicia villosa by saturation transfer difference NMR spectroscopy.", "journal": "Carbohydrate research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Kaszowska M, Norgren AS, Arvidson PI, Sandstrom C", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/7681597", "type": [ "PubMed" ], "id": "7681597" } ], "title": "Epitopic structure of Tn glycophorin A for an anti-Tn antibody (MLS 128).", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Nakada H, Inoue M, Numata Y, Tanaka N, Funakoshi I, Fukui S, Mellors A, Yamashina I", "date": "1993" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/6175663", "type": [ "PubMed" ], "id": "6175663" } ], "title": "Clonal expression of the Tn antigen in erythroid and granulocyte colonies and its application to determination of the clonality of the human megakaryocyte colony assay.", "journal": "The Journal of clinical investigation", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Vainchenker W, Testa U, Deschamps JF, Henri A, Titeux M, Breton-Gorius J, Rochant H, Lee D, Cartron JP", "date": "1982" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16203776", "type": [ "PubMed" ], "id": "16203776" } ], "title": "Thomsen-Friedenreich and Tn antigens in nipple fluid: carbohydrate biomarkers for breast cancer detection.", "journal": "Clinical cancer research : an official journal of the American Association for Cancer Research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Kumar SR, Sauter ER, Quinn TP, Deutscher SL", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12820721", "type": [ "PubMed" ], "id": "12820721" } ], "title": "A rat model to study the role of STn antigen in colon cancer.", "journal": "Glycoconjugate journal", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Ogata S, Ho I, Maklansky J, Chen A, Werther JL, Reddish M, Longenecker BM, Sigurdson E, Iishi S, Zhang JY, Itzkowitz SH", "date": "2001" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12820722", "type": [ "PubMed" ], "id": "12820722" } ], "title": "Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase (ST6GalNac I) cDNA.", "journal": "Glycoconjugate journal", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Julien S, Krzewinski-Recchi MA, Harduin-Lepers A, Gouyer V, Huet G, Le Bourhis X, Delannoy P", "date": "2001" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/2943741", "type": [ "PubMed" ], "id": "2943741" } ], "title": "Structural variations of O-linked oligosaccharides present in leukosialin isolated from erythroid, myeloid, and T-lymphoid cell lines.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "http://www.unicarbkb.org/structure/25", "id": "25", "database": "UniCarbKB" } ], "authors": "Carlsson SR, Sasaki H, Fukuda M", "date": "1986" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16525726", "type": [ "PubMed" ], "id": "16525726" } ], "title": "The influence of N- and O-glycosylation inhibitors on the glycosylation profile of cellular membrane proteins and adhesive properties of carcinoma cell lines.", "journal": "International journal of molecular medicine", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Paszkiewicz-Gadek A, Porowska H, Lemancewicz D, Wolczynski S, Gindzienski A", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12547345", "type": [ "PubMed" ], "id": "12547345" } ], "title": "Mucin-type O-glycosylation in Fasciola hepatica: characterisation of carcinoma-associated Tn and sialyl-Tn antigens and evaluation of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity.", "journal": "International journal for parasitology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Freire T, Casaravilla C, Carmona C, Osinaga E", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16251947", "type": [ "PubMed" ], "id": "16251947" } ], "title": "Protein glycosylation: chaperone mutation in Tn syndrome.", "journal": "Nature", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Ju T, Cummings RD", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8793500", "type": [ "PubMed" ], "id": "8793500" } ], "title": "Tn and sialyl-Tn antigens as potential prognostic markers in human ovarian carcinoma.", "journal": "Gynecologic and obstetric investigation", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Ogawa H, Ghazizadeh M, Araki T", "date": "1996" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16965854", "type": [ "PubMed" ], "id": "16965854" } ], "title": "Biological significance of cancer-associated sialyl-Tn antigen: modulation of malignant phenotype in gastric carcinoma cells.", "journal": "Cancer letters", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Pinho S, Marcos NT, Ferreira B, Carvalho AS, Oliveira MJ, Santos-Silva F, Harduin-Lepers A, Reis CA", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15221966", "type": [ "PubMed" ], "id": "15221966" } ], "title": "Thomsen-Friedenreich (T) antigen expression increases sensitivity of natural killer cell lysis of cancer cells.", "journal": "International journal of cancer", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Sotiriadis J, Shin SC, Yim D, Sieber D, Kim YB", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19261632", "type": [ "PubMed" ], "id": "19261632" } ], "title": "Tumor-associated carbohydrate antigens: Sialyl Lea and T/Tn antigens in canine mammary tumors.", "journal": "Veterinary pathology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Nowak M, Madej J, Dziegiel P, Lopuszynski W, Rodo A, Ugorski M", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/1567169", "type": [ "PubMed" ], "id": "1567169" } ], "title": "Monoclonal antibody 83D4 immunoreactivity in human tissues: cellular distribution and microcytophotometric analysis of immunoprecipitates on tissue sections.", "journal": "Anticancer research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Charpin C, Pancino G, Osinaga E, Bonnier P, Lavaut MN, Allasia C, Roseto A", "date": "1992" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18474217", "type": [ "PubMed" ], "id": "18474217" } ], "title": "Down-modulation of B cell signal transduction by ligation of mucins to CD22.", "journal": "Biochemical and biophysical research communications", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Toda M, Akita K, Inoue M, Taketani S, Nakada H", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/1997178", "type": [ "PubMed" ], "id": "1997178" } ], "title": "Induction of alpha-N-acetylgalactosamine-O-serine/threonine (Tn) antigen-mediated cellular immune response for active immunotherapy in mice.", "journal": "Cancer research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Singhal A, Fohn M, Hakomori S", "date": "1991" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/1121486", "type": [ "PubMed" ], "id": "1121486" } ], "title": "Subcellular location of human parathyroid hormone immunoreactive peptides and preliminary evidence for a precursor to human PTH-1 (38545).", "journal": "Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Wong ET, Lindall AW", "date": "1975" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16615117", "type": [ "PubMed" ], "id": "16615117" } ], "title": "Interference with O-glycosylation in RMA lymphoma cells leads to a reduced in vivo growth of the tumor.", "journal": "International journal of cancer", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Chen L, Sundback J, Olofsson S, Jondal M", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/14685826", "type": [ "PubMed" ], "id": "14685826" } ], "title": "Structural and immunocytochemical studies on alpha-N-acetylgalactosaminidase deficiency (Schindler/Kanzaki disease).", "journal": "Journal of human genetics", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Sakuraba H, Matsuzawa F, Aikawa S, Doi H, Kotani M, Nakada H, Fukushige T, Kanzaki T", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16174741", "type": [ "PubMed" ], "id": "16174741" } ], "title": "Distinct functional units of the Golgi complex in Drosophila cells.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Yano H, Yamamoto-Hino M, Abe M, Kuwahara R, Haraguchi S, Kusaka I, Awano W, Kinoshita-Toyoda A, Toyoda H, Goto S", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/9852066", "type": [ "PubMed" ], "id": "9852066" } ], "title": "Phosphorylation and O-glycosylation sites of human chromogranin A (CGA79-439) from urine of patients with carcinoid tumors.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "http://www.unicarbkb.org/structure/25", "id": "25", "database": "UniCarbKB" } ], "authors": "Gadroy P, Stridsberg M, Capon C, Michalski JC, Strub JM, Van Dorsselaer A, Aunis D, Metz-Boutigue MH", "date": "1998" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/2413456", "type": [ "PubMed" ], "id": "2413456" } ], "title": "Blood group A cross-reacting epitope defined by monoclonal antibodies NCC-LU-35 and -81 expressed in cancer of blood group O or B individuals: its identification as Tn antigen.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Hirohashi S, Clausen H, Yamada T, Shimosato Y, Hakomori S", "date": "1985" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/14736333", "type": [ "PubMed" ], "id": "14736333" } ], "title": "Rhesus monkey gastric mucins: oligomeric structure, glycoforms and Helicobacter pylori binding.", "journal": "The Biochemical journal", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Linden S, Boren T, Dubois A, Carlstedt I", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19528665", "type": [ "PubMed" ], "id": "19528665" } ], "title": "A newly generated functional antibody identifies Tn antigen as a novel determinant in the cancer cell-lymphatic endothelium interaction.", "journal": "Glycobiology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Danussi C, Coslovi A, Campa C, Mucignat MT, Spessotto P, Uggeri F, Paoletti S, Colombatti A", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22678432", "type": [ "PubMed" ], "id": "22678432" } ], "title": "Determination of site-specific glycan heterogeneity on glycoproteins.", "journal": "Nature protocols", "evidence": [ { "url": "http://www.unicarbkb.org/structure/25", "id": "25", "database": "UniCarbKB" } ], "authors": "Kolarich D, Jensen PH, Altmann F, Packer NH", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8623771", "type": [ "PubMed" ], "id": "8623771" } ], "title": "Expression of mucin carbohydrate antigens (T, Tn and sialyl Tn) and MUC-1 gene product in intraductal papillary-mucinous neoplasm of the pancreas.", "journal": "American journal of clinical pathology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Terada T, Nakanuma Y", "date": "1996" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/7174794", "type": [ "PubMed" ], "id": "7174794" } ], "title": "Surface modifications in the platelets of a patient with alpha-N-acetyl-D-galactosamine residues, the Tn-syndrome.", "journal": "The Journal of clinical investigation", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Nurden AT, Dupuis D, Pidard D, Kieffer N, Kunicki TJ, Cartron JP", "date": "1982" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/1988363", "type": [ "PubMed" ], "id": "1988363" } ], "title": "Blood group and blood-group-related antigens in normal pancreas and pancreas cancer: enhanced expression of precursor type 1, Tn and sialyl-Tn in pancreas cancer.", "journal": "International journal of cancer", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Schuessler MH, Pintado S, Welt S, Real FX, Xu M, Melamed MR, Lloyd KO, Oettgen HF", "date": "1991" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18798567", "type": [ "PubMed" ], "id": "18798567" } ], "title": "Structural basis for sugar recognition, including the Tn carcinoma antigen, by the lectin SNA-II from Sambucus nigra.", "journal": "Proteins", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Maveyraud L, Niwa H, Guillet V, Svergun DI, Konarev PV, Palmer RA, Peumans WJ, Rouge P, Van Damme EJ, Reynolds CD, Mourey L", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16140958", "type": [ "PubMed" ], "id": "16140958" } ], "title": "Molecular basis of incomplete O-glycan synthesis in MCF-7 breast cancer cells: putative role of MUC6 in Tn antigen expression.", "journal": "Cancer research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Freire T, Bay S, von Mensdorff-Pouilly S, Osinaga E", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17607374", "type": [ "PubMed" ], "id": "17607374" } ], "title": "Lewis x is highly expressed in normal tissues: a comparative immunohistochemical study and literature revision.", "journal": "Pathology oncology research : POR", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Croce MV, Isla-Larrain M, Rabassa ME, Demichelis S, Colussi AG, Crespo M, Lacunza E, Segal-Eiras A", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15791836", "type": [ "PubMed" ], "id": "15791836" } ], "title": "The comparative study on ultrastructure and immunohistochemistry in AFP negative and positive hepatocellular carcinoma.", "journal": "Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Zheng M, Ruan Y, Yang M, Guan Y, Wu Z", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/2467192", "type": [ "PubMed" ], "id": "2467192" } ], "title": "Tn epitope (N-acetyl-D-galactosamine alpha-O-serine/threonine) density in primary breast carcinoma: a functional predictor of aggressiveness.", "journal": "Molecular immunology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Springer GF", "date": "1989" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8261467", "type": [ "PubMed" ], "id": "8261467" } ], "title": "Tn antigen is expressed on leukosialin from T-lymphoid cells.", "journal": "Cancer research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Inoue M, Nakada H, Tanaka N, Yamashina I", "date": "1994" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/1422133", "type": [ "PubMed" ], "id": "1422133" } ], "title": "Application of chemically desialylated and degalactosylated human glycophorin for induction and characterization of anti-Tn monoclonal antibodies.", "journal": "Glycoconjugate journal", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Duk M, Steuden I, Dus D, Radzikowski C, Lisowska E", "date": "1992" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/7767313", "type": [ "PubMed" ], "id": "7767313" } ], "title": "Radioimmunoimaging of colon cancer xenografts with anti-Tn monoclonal antibody.", "journal": "Nuclear medicine and biology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Yao Z, Sakahara H, Zhang M, Kobayashi H, Nakada H, Yamashina I, Konishi J", "date": "1995" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/2908846", "type": [ "PubMed" ], "id": "2908846" } ], "title": "Expression of Tn, sialosyl-Tn, and T antigens in human colon cancer.", "journal": "Cancer research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Itzkowitz SH, Yuan M, Montgomery CK, Kjeldsen T, Takahashi HK, Bigbee WL, Kim YS", "date": "1989" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/3235849", "type": [ "PubMed" ], "id": "3235849" } ], "title": "Molecular profile, tissue distribution and prognostic evaluation of a human melanoma-carcinoma antigen recognized by the murine monoclonal antibody B1.1.", "journal": "The International journal of biological markers", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Natali PG, Nicotra MR, Nuti M, Bigotti G, Calabro A, Schlom J, Giacomini P", "date": "1988" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17616966", "type": [ "PubMed" ], "id": "17616966" } ], "title": "MGL-mediated internalization and antigen presentation by dendritic cells: a role for tyrosine-5.", "journal": "European journal of immunology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "van Vliet SJ, Aarnoudse CA, Broks-van den Berg VC, Boks M, Geijtenbeek TB, van Kooyk Y", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17485527", "type": [ "PubMed" ], "id": "17485527" } ], "title": "Glycoprotein I of herpes simplex virus type 1 contains a unique polymorphic tandem-repeated mucin region.", "journal": "The Journal of general virology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Norberg P, Olofsson S, Tarp MA, Clausen H, Bergstrom T, Liljeqvist JA", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20103942", "type": [ "PubMed" ], "id": "20103942" } ], "title": "Inhibition of cancer cell growth by anti-Tn monoclonal antibody MLS128.", "journal": "Bioscience trends", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Morita N, Yajima Y, Asanuma H, Nakada H, Fujita-Yamaguchi Y", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/10571017", "type": [ "PubMed" ], "id": "10571017" } ], "title": "Tn-syndrome.", "journal": "Biochimica et biophysica acta", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Berger EG", "date": "1999" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/14533679", "type": [ "PubMed" ], "id": "14533679" } ], "title": "Mucin-type O-glycosylation in helminth parasites from major taxonomic groups: evidence for widespread distribution of the Tn antigen (GalNAc-Ser/Thr) and identification of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity.", "journal": "The Journal of parasitology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Casaravilla C, Freire T, Malgor R, Medeiros A, Osinaga E, Carmona C", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/3479188", "type": [ "PubMed" ], "id": "3479188" } ], "title": "Detection of the Tn antigen in leukaemia using monoclonal anti-Tn antibody and immunohistochemistry.", "journal": "British journal of haematology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Roxby DJ, Morley AA, Burpee M", "date": "1987" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/2971663", "type": [ "PubMed" ], "id": "2971663" } ], "title": "Human T-lymphocyte activation is associated with changes in O-glycan biosynthesis.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "http://www.unicarbkb.org/structure/25", "id": "25", "database": "UniCarbKB" } ], "authors": "Piller F, Piller V, Fox RI, Fukuda M", "date": "1988" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/3390832", "type": [ "PubMed" ], "id": "3390832" } ], "title": "Immunoglobulin G3 monoclonal antibody directed to Tn antigen (tumor-associated alpha-N-acetylgalactosaminyl epitope) that does not cross-react with blood group A antigen.", "journal": "Cancer research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Takahashi HK, Metoki R, Hakomori S", "date": "1988" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16177266", "type": [ "PubMed" ], "id": "16177266" } ], "title": "Elucidation of binding specificity of Jacalin toward O-glycosylated peptides: quantitative analysis by frontal affinity chromatography.", "journal": "Glycobiology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Tachibana K, Nakamura S, Wang H, Iwasaki H, Tachibana K, Maebara K, Cheng L, Hirabayashi J, Narimatsu H", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/1520302", "type": [ "PubMed" ], "id": "1520302" } ], "title": "Cancer-associated glycoproteins defined by a monoclonal antibody, MLS 128, recognizing the Tn antigen.", "journal": "Biochemical and biophysical research communications", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Nakada H, Inoue M, Numata Y, Tanaka N, Funakoshi I, Fukui S, Yamashina I", "date": "1992" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19756298", "type": [ "PubMed" ], "id": "19756298" } ], "title": "The repertoire of glycan determinants in the human glycome.", "journal": "Molecular bioSystems", "evidence": [ { "url": "https://glycomotif.glyomics.org/glycomotif/GGM.000008", "id": "GGM.000008", "database": "Glycan Motif" } ], "authors": "Cummings RD", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18925876", "type": [ "PubMed" ], "id": "18925876" } ], "title": "Ligation of tumour-produced mucins to CD22 dramatically impairs splenic marginal zone B-cells.", "journal": "The Biochemical journal", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Toda M, Hisano R, Yurugi H, Akita K, Maruyama K, Inoue M, Adachi T, Tsubata T, Nakada H", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/7949653", "type": [ "PubMed" ], "id": "7949653" } ], "title": "Two different glycosyltransferase defects that result in GalNAc alpha-O-peptide (Tn) expression.", "journal": "Glycobiology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "King MJ, Chan A, Roe R, Warren BF, Dell A, Morris HR, Bartolo DC, Durdey P, Corfield AP", "date": "1994" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/7683697", "type": [ "PubMed" ], "id": "7683697" } ], "title": "Persistent repression of a functional allele can be responsible for galactosyltransferase deficiency in Tn syndrome.", "journal": "The Journal of clinical investigation", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Thurnher M, Rusconi S, Berger EG", "date": "1993" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15730515", "type": [ "PubMed" ], "id": "15730515" } ], "title": "Epitope recognition of antibodies that define the sialomucin, endolyn (CD164), a negative regulator of haematopoiesis.", "journal": "Tissue antigens", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Jorgensen-Tye B, Levesque JP, Royle L, Doyonnas R, Chan JY, Dwek RA, Rudd PM, Harvey DJ, Simmons PJ, Watt SM", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11396208", "type": [ "PubMed" ], "id": "11396208" } ], "title": "Immunohistochemical expression of T, Tn and sialyl-Tn antigens and clinical outcome in human breast carcinoma.", "journal": "Anticancer research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Imai J, Ghazizadeh M, Naito Z, Asano G", "date": "2001" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18662810", "type": [ "PubMed" ], "id": "18662810" } ], "title": "Catfish (Clarias batrachus) serum lectin recognizes polyvalent Tn [alpha-D-GalpNAc1-Ser/Thr], Talpha [beta-D-Galp-(1-->3)-alpha-D-GalpNAc1-Ser/Thr], and II [beta-D-Galp(1-->4)-beta-D-GlcpNAc1-] mammalian glycotopes.", "journal": "Carbohydrate research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Singha B, Adhya M, Chatterjee BP", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8323299", "type": [ "PubMed" ], "id": "8323299" } ], "title": "Assignment of O-glycan attachment sites to the hinge-like regions of human lysosomal membrane glycoproteins lamp-1 and lamp-2.", "journal": "Archives of biochemistry and biophysics", "evidence": [ { "url": "http://www.unicarbkb.org/structure/25", "id": "25", "database": "UniCarbKB" } ], "authors": "Carlsson SR, Lycksell PO, Fukuda M", "date": "1993" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16310781", "type": [ "PubMed" ], "id": "16310781" } ], "title": "Structural basis for the specificity of basic winged bean lectin for the Tn-antigen: a crystallographic, thermodynamic and modelling study.", "journal": "FEBS letters", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Kulkarni KA, Sinha S, Katiyar S, Surolia A, Vijayan M, Suguna K", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17195076", "type": [ "PubMed" ], "id": "17195076" } ], "title": "The C-type lectin MGL expressed by dendritic cells detects glycan changes on MUC1 in colon carcinoma.", "journal": "Cancer immunology, immunotherapy : CII", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Saeland E, van Vliet SJ, Backstrom M, van den Berg VC, Geijtenbeek TB, Meijer GA, van Kooyk Y", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12761161", "type": [ "PubMed" ], "id": "12761161" } ], "title": "SRCL/CL-P1 recognizes GalNAc and a carcinoma-associated antigen, Tn antigen.", "journal": "Journal of biochemistry", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Yoshida T, Tsuruta Y, Iwasaki M, Yamane S, Ochi T, Suzuki R", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21999536", "type": [ "PubMed" ], "id": "21999536" } ], "title": "Structural diversity of the core oligosaccharide domain of Pseudomonas aeruginosa lipopolysaccharide.", "journal": "Biochemistry. Biokhimiia", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Kocincova D, Lam JS", "date": "2011" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/9212232", "type": [ "PubMed" ], "id": "9212232" } ], "title": "Immunoreactivities of polyclonal and monoclonal anti-T and anti-Tn antibodies with human carcinoma cells, grown in vitro and in a xenograft model.", "journal": "International journal of cancer", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Avichezer D, Springer GF, Schechter B, Arnon R", "date": "1997" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/7516636", "type": [ "PubMed" ], "id": "7516636" } ], "title": "Simple mucins (T, sialosyl-T, Tn and sialosyl-Tn) are not diagnostic for malignant breast lesions.", "journal": "Anticancer research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Reed W, Bryne M, Clausen H, Dabelsteen E, Nesland JM", "date": "1994" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17892882", "type": [ "PubMed" ], "id": "17892882" } ], "title": "Mucin-type O-glycosylation in Mesocestoides vogae (syn. corti).", "journal": "International journal for parasitology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Medeiros A, Chiribao ML, Ubillos L, Festari MF, Saldana J, Robello C, Dominguez L, Calvete JJ, Osinaga E", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8616877", "type": [ "PubMed" ], "id": "8616877" } ], "title": "Expression of Tn and sialyl-Tn antigens in the neoplastic transformation of uterine cervical epithelial cells.", "journal": "Cancer research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Terasawa K, Furumoto H, Kamada M, Aono T", "date": "1996" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/7827404", "type": [ "PubMed" ], "id": "7827404" } ], "title": "Carbohydrate receptor-mediated gene transfer to human T leukaemic cells.", "journal": "Glycobiology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Thurnher M, Wagner E, Clausen H, Mechtler K, Rusconi S, Dinter A, Birnstiel ML, Berger EG, Cotten M", "date": "1994" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/2033371", "type": [ "PubMed" ], "id": "2033371" } ], "title": "Altered O-glycan synthesis in lymphocytes from patients with Wiskott-Aldrich syndrome.", "journal": "The Journal of experimental medicine", "evidence": [ { "url": "http://www.unicarbkb.org/structure/25", "id": "25", "database": "UniCarbKB" } ], "authors": "Piller F, Le Deist F, Weinberg KI, Parkman R, Fukuda M", "date": "1991" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11465993", "type": [ "PubMed" ], "id": "11465993" } ], "title": "O-glycosylation in Echinococcus granulosus: identification and characterization of the carcinoma-associated Tn antigen.", "journal": "Experimental parasitology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Alvarez Errico D, Medeiros A, Miguez M, Casaravilla C, Malgor R, Carmona C, Nieto A, Osinaga E", "date": "2001" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16752227", "type": [ "PubMed" ], "id": "16752227" } ], "title": "Expression of Vicia villosa agglutinin (VVA)-binding glycoprotein in primary breast cancer cells in relation to lymphatic metastasis: is atypical MUC1 bearing Tn antigen a receptor of VVA?", "journal": "Breast cancer research and treatment", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Kawaguchi T, Takazawa H, Imai S, Morimoto J, Watanabe T, Kanno M, Igarashi S", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/14741734", "type": [ "PubMed" ], "id": "14741734" } ], "title": "Recognition profile of Bauhinia purpurea agglutinin (BPA).", "journal": "Life sciences", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Wu AM, Wu JH, Liu JH, Singh T", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17522109", "type": [ "PubMed" ], "id": "17522109" } ], "title": "O-linked glycan expression during Drosophila development.", "journal": "Glycobiology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Tian E, Ten Hagen KG", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16809438", "type": [ "PubMed" ], "id": "16809438" } ], "title": "Use of lectins for probing differentiated human embryonic stem cells for carbohydrates.", "journal": "Glycobiology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Wearne KA, Winter HC, O'Shea K, Goldstein IJ", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8609376", "type": [ "PubMed" ], "id": "8609376" } ], "title": "Concurrent immunohistochemical staining of tumor-infiltrating lymphocytes and carcinoma-associated T (Thomsen-Friedenreich)/Tn antigens in human breast carcinoma.", "journal": "The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Wang BL, Springer GF, Kaufman MW", "date": "1996" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/9857245", "type": [ "PubMed" ], "id": "9857245" } ], "title": "Immunohistochemical study of Tn, sialosyl-Tn and T antigens in human meningiomas.", "journal": "European journal of histochemistry : EJH", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Giuffre G, Vitarelli E, Tuccari G, Barresi G", "date": "1998" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/2981150", "type": [ "PubMed" ], "id": "2981150" } ], "title": "Tn, a carcinoma-associated antigen, reacts with anti-Tn of normal human sera.", "journal": "Cancer", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Springer GF, Taylor CR, Howard DR, Tegtmeyer H, Desai PR, Murthy SM, Felder B, Scanlon EF", "date": "1985" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17823742", "type": [ "PubMed" ], "id": "17823742" } ], "title": "[Relationship of the sialomucins (Tn and Stn antigens) with adenocarcinoma in Barrett's esophagus].", "journal": "Revista da Associacao Medica Brasileira (1992)", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "de Faria PC Jr, Andreollo NA, Trevisan MA, Lopes LR", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/7841802", "type": [ "PubMed" ], "id": "7841802" } ], "title": "Coexpression of cancer-associated carbohydrate antigens, Tn and sialyl Tn.", "journal": "Glycoconjugate journal", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Nakada H, Inoue M, Tanaka N, Yamashina I", "date": "1994" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19162326", "type": [ "PubMed" ], "id": "19162326" } ], "title": "Characterization of murine MGL1 and MGL2 C-type lectins: distinct glycan specificities and tumor binding properties.", "journal": "Molecular immunology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Singh SK, Streng-Ouwehand I, Litjens M, Weelij DR, Garcia-Vallejo JJ, van Vliet SJ, Saeland E, van Kooyk Y", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/1471247", "type": [ "PubMed" ], "id": "1471247" } ], "title": "Expression of the Tn antigen in myelodysplasia, lymphoma, and leukemia.", "journal": "Transfusion", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Roxby DJ, Pfeiffer MB, Morley AA, Kirkland MA", "date": "1992" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/2450649", "type": [ "PubMed" ], "id": "2450649" } ], "title": "Preparation and characterization of monoclonal antibodies directed to the tumor-associated O-linked sialosyl-2----6 alpha-N-acetylgalactosaminyl (sialosyl-Tn) epitope.", "journal": "Cancer research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Kjeldsen T, Clausen H, Hirohashi S, Ogawa T, Iijima H, Hakomori S", "date": "1988" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/10491017", "type": [ "PubMed" ], "id": "10491017" } ], "title": "Identification and characterization of different subpopulations in a human lung adenocarcinoma cell line (A549).", "journal": "Pathology oncology research : POR", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Croce MV, Colussi AG, Price MR, Segal-Eiras A", "date": "1999" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/9545556", "type": [ "PubMed" ], "id": "9545556" } ], "title": "Repressed beta-1,3-galactosyltransferase in the Tn syndrome.", "journal": "Biochimica et biophysica acta", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Felner KM, Dinter A, Cartron JP, Berger EG", "date": "1998" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12146959", "type": [ "PubMed" ], "id": "12146959" } ], "title": "Effect of glycosylation on MUC1 humoral immune recognition: NMR studies of MUC1 glycopeptide-antibody interactions.", "journal": "Biochemistry", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Grinstead JS, Koganty RR, Krantz MJ, Longenecker BM, Campbell AP", "date": "2002" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16091596", "type": [ "PubMed" ], "id": "16091596" } ], "title": "Characterization of wheat germ agglutinin ligand on soluble glycoproteins in Caenorhabditis elegans.", "journal": "Journal of biochemistry", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Natsuka S, Kawaguchi M, Wada Y, Ichikawa A, Ikura K, Hase S", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/2417112", "type": [ "PubMed" ], "id": "2417112" } ], "title": "Tn epitopes, immunoreactive with ordinary anti-Tn antibodies, on normal, desialylated human erythrocytes and on Thomsen-Friedenreich antigen isolated therefrom.", "journal": "Molecular immunology", "evidence": [ { "url": "https://glycomotif.glyomics.org/glycomotif/GGM.000008", "id": "GGM.000008", "database": "Glycan Motif" } ], "authors": "Springer GF, Desai PR", "date": "1985" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8370596", "type": [ "PubMed" ], "id": "8370596" } ], "title": "Use of O-glycosylation-defective human lymphoid cell lines and flow cytometry to delineate the specificity of Moluccella laevis lectin and monoclonal antibody 5F4 for the Tn antigen (GalNAc alpha 1-O-Ser/Thr).", "journal": "Immunology letters", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Thurnher M, Clausen H, Sharon N, Berger EG", "date": "1993" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17038624", "type": [ "PubMed" ], "id": "17038624" } ], "title": "A mutant chaperone converts a wild-type protein into a tumor-specific antigen.", "journal": "Science (New York, N.Y.)", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Schietinger A, Philip M, Yoshida BA, Azadi P, Liu H, Meredith SC, Schreiber H", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16413042", "type": [ "PubMed" ], "id": "16413042" } ], "title": "Isolation and characterisation of a Salvia bogotensis seed lectin specific for the Tn antigen.", "journal": "Phytochemistry", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Vega N, Perez G", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11882908", "type": [ "PubMed" ], "id": "11882908" } ], "title": "MUC1 mucin and carbohydrate associated antigens as tumor markers in head and neck squamous cell carcinoma.", "journal": "Pathology oncology research : POR", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Croce MV, Rabassa ME, Price MR, Segal-Eiras A", "date": "2001" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17674202", "type": [ "PubMed" ], "id": "17674202" } ], "title": "Temporal changes in the carbohydrates expressed on BG01 human embryonic stem cells during differentiation as embryoid bodies.", "journal": "Glycoconjugate journal", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Wearne KA, Winter HC, Goldstein IJ", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/7751324", "type": [ "PubMed" ], "id": "7751324" } ], "title": "Distribution of Tn antigen recognized by an anti-Tn monoclonal antibody (MLS128) in normal and malignant tissues of the digestive tract.", "journal": "Journal of cancer research and clinical oncology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Ohshio G, Imamura T, Imamura M, Yamabe H, Sakahara H, Nakada H, Yamashina I", "date": "1995" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17652409", "type": [ "PubMed" ], "id": "17652409" } ], "title": "Structural basis for recognition of breast and colon cancer epitopes Tn antigen and Forssman disaccharide by Helix pomatia lectin.", "journal": "Glycobiology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Lescar J, Sanchez JF, Audfray A, Coll JL, Breton C, Mitchell EP, Imberty A", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11550228", "type": [ "PubMed" ], "id": "11550228" } ], "title": "Developmental expression of a unique carbohydrate antigen, Tn antigen, in mouse central nervous tissues.", "journal": "Journal of neuroscience research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Akita K, Fushiki S, Fujimoto T, Inoue M, Oguri K, Okayama M, Yamashina I, Nakada H", "date": "2001" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/10365852", "type": [ "PubMed" ], "id": "10365852" } ], "title": "Expression of sialyl-Tn, Tn and T antigens in primary liver cancer.", "journal": "Pathology international", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Sasaki M, Yamato T, Nakanuma Y", "date": "1999" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15843572", "type": [ "PubMed" ], "id": "15843572" } ], "title": "Antibodies against tumor cell glycolipids and proteins, but not mucins, mediate complement-dependent cytotoxicity.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Ragupathi G, Liu NX, Musselli C, Powell S, Lloyd K, Livingston PO", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/3469463", "type": [ "PubMed" ], "id": "3469463" } ], "title": "Monoclonal antibodies and synthetic tumor-associated glycoconjugates in the study of the expression of Thomsen-Friedenreich-like and Tn-like antigens on human cancers.", "journal": "Journal of the National Cancer Institute", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Longenecker BM, Willans DJ, MacLean GD, Selvaraj S, Suresh MR, Noujaim AA", "date": "1987" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16252298", "type": [ "PubMed" ], "id": "16252298" } ], "title": "Carbohydrate array analysis of anti-Tn antibodies and lectins reveals unexpected specificities: implications for diagnostic and vaccine development.", "journal": "Chembiochem : a European journal of chemical biology", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Manimala JC, Li Z, Jain A, VedBrat S, Gildersleeve JC", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19882123", "type": [ "PubMed" ], "id": "19882123" } ], "title": "In vitro reconstitution of Escherichia coli O86 O antigen repeating unit.", "journal": "Methods in molecular biology (Clifton, N.J.)", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Han W, Li L, Pettit N, Yi W, Woodward R, Liu X, Guan W, Bhatt V, Song JK, Wang PG", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11193738", "type": [ "PubMed" ], "id": "11193738" } ], "title": "Lymph node metastasis-related carbohydrate epitopes of gastric cancer with submucosal invasion.", "journal": "Surgery today", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Takano Y, Teranishi Y, Terashima S, Motoki R, Kawaguchi T", "date": "2000" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15864746", "type": [ "PubMed" ], "id": "15864746" } ], "title": "Polyvalent GalNAcalpha1-->Ser/Thr (Tn) and Galbeta1-->3GalNAcalpha1-->Ser/Thr (T alpha) as the most potent recognition factors involved in Maclura pomifera agglutinin-glycan interactions.", "journal": "Journal of biomedical science", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Wu AM", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16770733", "type": [ "PubMed" ], "id": "16770733" } ], "title": "Differential binding to glycotopes among the layers of three mammalian retinal neurons by man-containing N-linked glycan, T(alpha) (Galbeta1-3GalNAcalpha1-), Tn (GalNAcalpha1-Ser/Thr) and I (beta)/II (beta) (Galbeta1-3/4GlcNAcbeta-) reactive lectins.", "journal": "Neurochemical research", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Wu WC, Lai CC, Liu JH, Singh T, Li LM, Peumans WJ, Van Damme EJ, Wu AM", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/13814231", "type": [ "PubMed" ], "id": "13814231" } ], "title": "Acquired hemolytic anemia with polyagglutinability of red blood cells due to a new factor present in normal human serum (Anti-Tn).", "journal": "Blood", "evidence": [ { "url": "https://glycomotif.glyomics.org/glycomotif/GGM.000008", "id": "GGM.000008", "database": "Glycan Motif" } ], "authors": "DAUSSET J, MOULLEC J, BERNARD J", "date": "1959" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12883744", "type": [ "PubMed" ], "id": "12883744" } ], "title": "Biochemical characterization of soluble Tn glycoproteins from malignant effusions of patients with carcinomas.", "journal": "Oncology reports", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Freire T, Medeiros A, Reis CA, Real FX, Osinaga E", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/6725284", "type": [ "PubMed" ], "id": "6725284" } ], "title": "The structure of the carbohydrate units of human plasma galactoglycoprotein determined by 500-megahertz 1H NMR spectroscopy.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "http://www.unicarbkb.org/structure/25", "id": "25", "database": "UniCarbKB" } ], "authors": "Akiyama K, Simons ER, Bernasconi P, Schmid K, van Halbeek H, Vliegenthart JF, Haupt H, Schwick HG", "date": "1984" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16630548", "type": [ "PubMed" ], "id": "16630548" } ], "title": "The wbnH gene of Escherichia coli O86:H2 encodes an alpha-1,3-N-acetylgalactosaminyl transferase involved in the O-repeating unit biosynthesis.", "journal": "Biochemical and biophysical research communications", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Yi W, Yao Q, Zhang Y, Motari E, Lin S, Wang PG", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/1421410", "type": [ "PubMed" ], "id": "1421410" } ], "title": "O-linked oligosaccharides of glycophorins A and B in erythrocytes of two individuals with the Tn polyagglutinability syndrome.", "journal": "Blood", "evidence": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "authors": "Blumenfeld OO, Lalezari P, Khorshidi M, Puglia K, Fukuda M", "date": "1992" } ], "subsumption": [ { "type": "Topology", "id": "G56558YT" }, { "type": "BaseComposition", "id": "G29068FM" }, { "type": "Composition", "id": "G39738WL" }, { "type": "Composition", "id": "G81202UN" }, { "type": "Topology", "id": "G70994MS" }, { "type": "Saccharide", "id": "G53869BW" }, { "type": "Topology", "id": "G27025MB" } ], "motif_ac": "GGM.000008", "glytoucan_ac": "G57321FI", "composition": [ { "residue": "hex", "count": 0, "url": "https://pubchem.ncbi.nlm.nih.gov/compound/206", "name": "Hexose", "cid": "206" }, { "residue": "neuac", "count": 0, "url": "https://pubchem.ncbi.nlm.nih.gov/compound/439197", "name": "N-Acetyl-Neuraminic Acid", "cid": "439197" }, { "residue": "hexnac", "count": 1, "url": "https://pubchem.ncbi.nlm.nih.gov/compound/899", "name": "N-Acetylhexosamine", "cid": "899" }, { "residue": "p", "count": 0, "url": "https://pubchem.ncbi.nlm.nih.gov/compound/1061", "name": "Phosphate", "cid": "1061" }, { "residue": "other", "count": 0, "name": "Other" }, { "residue": "s", "count": 0, "url": "https://pubchem.ncbi.nlm.nih.gov/compound/1117", "name": "Sulfate", "cid": "1117" }, { "residue": "dhex", "count": 0, "url": "https://pubchem.ncbi.nlm.nih.gov/compound/840", "name": "6-Deoxy-Hexose", "cid": "840" }, { "residue": "hexn", "count": 0, "url": "https://pubchem.ncbi.nlm.nih.gov/compound/739", "name": "2-Amino-2-Deoxy-Hexose", "cid": "739" }, { "residue": "neugc", "count": 0, "url": "https://pubchem.ncbi.nlm.nih.gov/compound/440001", "name": "N-Glycolyl-Neuraminic Acid", "cid": "440001" }, { "residue": "hexa", "count": 0, "url": "https://pubchem.ncbi.nlm.nih.gov/compound/610", "name": "Hexuronic Acid", "cid": "610" } ], "alignment_method": "Whole-Glycan", "residues": [], "glycam": "DGalpNAca1-", "inchi": "InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8+/m1/s1", "crossref": [ { "url": "https://glytoucan.org/Structures/Glycans/G57321FI", "id": "G57321FI", "database": "GlyTouCan" } ], "synonym": [], "reducing_end": "true", "glycoct": "RES 1b:a-dgal-HEX-1:5 2s:n-acetyl LIN 1:1d(2+1)2n", "iupac": "alpha-D-GalpNAc-(1->", "aglycon": "Ser/Thr", "mass": 221.09 }