{
    "disease_id": "DOID:0060023", 
    "synonyms": [
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0011735", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0011735", 
            "name": "hyper-IgM syndrome type 3"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0011735", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0011735", 
            "name": "type 3 hyper-IgM immunodeficiency"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0011735", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0011735", 
            "name": "hyper-IgM syndrome due to CD40 deficiency"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0011735", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0011735", 
            "name": "CD40 deficiency"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0011735", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0011735", 
            "name": "immunodeficiency with hyper-IgM, type 3"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0011735", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0011735", 
            "name": "CD40 hyper-IgM syndrome"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0011735", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0011735", 
            "name": "immunodeficiency with hyper-IgM, type 3; HIGM3"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0011735", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0011735", 
            "name": "hyper-IgM syndrome caused by mutation in CD40"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0011735", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0011735", 
            "name": "hyper-IgM syndrome 3"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0011735", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0011735", 
            "name": "HIGM3"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0011735", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0011735", 
            "name": "immunodeficiency with hyper-IgM type 3"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0011735", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0011735", 
            "name": "hyper IgM syndrome 3"
        }, 
        {
            "url": "http://disease-ontology.org/term/DOID:0060023", 
            "description": "", 
            "resource": "Disease Ontology", 
            "id": "DOID:0060023", 
            "name": "CD40 deficiency"
        }, 
        {
            "url": "http://disease-ontology.org/term/DOID:0060023", 
            "description": "", 
            "resource": "Disease Ontology", 
            "id": "DOID:0060023", 
            "name": "hyper-IgM syndrome due to CD40 deficiency"
        }, 
        {
            "url": "http://disease-ontology.org/term/DOID:0060023", 
            "description": "", 
            "resource": "Disease Ontology", 
            "id": "DOID:0060023", 
            "name": "type 3 hyper-IgM immunodeficiency"
        }
    ], 
    "recommended_name": {
        "url": "http://disease-ontology.org/term/DOID:0060023", 
        "description": "A hyper IgM syndrome that has_material_basis_in mutation in the TNFRSF5 gene, resulting in type 3 hyper-IgM immunodeficiency that is characterized by an inability of B cells to undergo isotype switching, an inability to mount an antibody-specific immune response, and a lack of germinal center formation.", 
        "resource": "Disease Ontology", 
        "id": "DOID:0060023", 
        "name": "immunodeficiency with hyper IgM type 3"
    }, 
    "evidence": [
        {
            "url": "https://www.alliancegenome.org/gene/0060023#disease-associations", 
            "id": "0060023", 
            "database": "Alliance of Genome Resources"
        }
    ]
}