{
    "disease_id": "DOID:0060022", 
    "synonyms": [
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0010626", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0010626", 
            "name": "X-linked hyper-IgM syndrome"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0010626", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0010626", 
            "name": "XHIM"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0010626", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0010626", 
            "name": "HIGM1"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0010626", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0010626", 
            "name": "XHIGM"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0010626", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0010626", 
            "name": "immunodeficiency with hyper IgM type 1"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0010626", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0010626", 
            "name": "hyper-IgM syndrome, X-linked"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0010626", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0010626", 
            "name": "hyper IgM immunodeficiency, x-linked"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0010626", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0010626", 
            "name": "hyper-IgM immunodeficiency, X-linked"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0010626", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0010626", 
            "name": "immunodeficiency 3"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0010626", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0010626", 
            "name": "hyper-IgM syndrome type 1"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0010626", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0010626", 
            "name": "immunodeficiency with hyper-IgM, type 1; HIGM1"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0010626", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0010626", 
            "name": "IHIS"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0010626", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0010626", 
            "name": "immunodeficiency with hyper-IgM, type 1"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0010626", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0010626", 
            "name": "hyperimmunoglobulin M syndrome"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0010626", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0010626", 
            "name": "X-linked hyper IgM syndrome"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0010626", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0010626", 
            "name": "hyper-IgM syndrome due to CD40L deficiency"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0010626", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0010626", 
            "name": "hyper IgM syndrome 1"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0010626", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0010626", 
            "name": "hyper-IgM syndrome due to CD40 ligand deficiency"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0010626", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0010626", 
            "name": "HIGM"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0010626", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0010626", 
            "name": "hyper-IgM syndrome 1"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0010626", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0010626", 
            "name": "hyper IgM syndrome"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0010626", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0010626", 
            "name": "HIGMX-1"
        }, 
        {
            "url": "https://monarchinitiative.org/disease/MONDO:0010626", 
            "description": "", 
            "resource": "MONDO", 
            "id": "MONDO:0010626", 
            "name": "hyper-IgM syndrome"
        }, 
        {
            "url": "http://disease-ontology.org/term/DOID:0060022", 
            "description": "", 
            "resource": "Disease Ontology", 
            "id": "DOID:0060022", 
            "name": "HIGMX-1"
        }, 
        {
            "url": "http://disease-ontology.org/term/DOID:0060022", 
            "description": "", 
            "resource": "Disease Ontology", 
            "id": "DOID:0060022", 
            "name": "X-linked hyper-IgM syndrome"
        }
    ], 
    "recommended_name": {
        "url": "http://disease-ontology.org/term/DOID:0060022", 
        "description": "A combined T cell and B cell immunodeficiency that is a X-linked immunodeficiency with hyperimmunoglobulin M (XHIM) affecting isotype switching and is caused by the absence of CD40 ligand which is normally expressed on activated CD4+ T cells. Individuals with this mutation are unable to switch from IgM to IgG, IgA and IgE.", 
        "resource": "Disease Ontology", 
        "id": "DOID:0060022", 
        "name": "CD40 ligand deficiency"
    }, 
    "evidence": [
        {
            "url": "https://www.alliancegenome.org/gene/0060022#disease-associations", 
            "id": "0060022", 
            "database": "Alliance of Genome Resources"
        }
    ]
}