{
    "uniprot_canonical_ac": "A3QJZ6-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A3QJZ6-1|PRA22_HUMAN Isoform 1 of PRAME family member 22  OS=Homo sapiens OX=9606 GN=PRAMEF22 PE=3 SV=3 CANONICAL=A3QJZ6-1", 
        "length": 481, 
        "sequence": "MRMSLQAPRRLLELAGQSLLGDQALAISILDELPRELFPPLFVEAFTSRRCEVLKVMVQAWPFPCLPLGSLMKTPDLEILHYVVDGIDCLLAQKVRPRRWKLQVLELRDVDENFWTIWSGARPLSCSPEAMSKRQTVEDCPRTGEKQPLKVFMDVCLKEKFMDEDLSFFSGWVQHRRGSVHLCCTKVVNYSMSILNFRNILETVYPDSIQVLEIWNMCWPCMIVEFSRYLSQMRNLRKLFISDGCRYLLSSDSQEQLVAEFSSVLLRLEYLQMLYVRRVCFFRGHLDQLIRCLRSPLETLALTYGFLEKVDLKCLPRYPSLSQLKQLNLSHGALRFIRLEPLRALLEKVAATLQTLFLVDCGIRDSKLRVILPALSCCSNLTTFCFHGNDTSMDGLKDLLRHTGRLSNLSLETYPAPRESLDDRGRVISELLTPLQAELMRILREVREPKRIFFGPVSCPCCGTSPTEQLEFNFCLWGRPA"
    }, 
    "uniprot_id": "PRA22_HUMAN", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Human", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A3QJZ6", 
                    "id": "A3QJZ6", 
                    "database": "UniProtKB"
                }
            ], 
            "taxid": 9606, 
            "name": "Homo sapiens"
        }
    ], 
    "crossref_internal": {
        "gene": [
            "PRAMEF22"
        ], 
        "species": [
            9606
        ], 
        "disease": [
            "DOID:1324", 
            "DOID:9256", 
            "DOID:2531", 
            "DOID:1781", 
            "DOID:10283", 
            "DOID:3910", 
            "DOID:10534", 
            "DOID:3571", 
            "DOID:363"
        ], 
        "site": [
            "A3QJZ6-1.333.333", 
            "A3QJZ6-1.472.472", 
            "A3QJZ6-1.309.309", 
            "A3QJZ6-1.237.237", 
            "A3QJZ6-1.50.50", 
            "A3QJZ6-1.310.310", 
            "A3QJZ6-1.204.204", 
            "A3QJZ6-1.119.119", 
            "A3QJZ6-1.423.423", 
            "A3QJZ6-1.377.377"
        ]
    }, 
    "publication": [], 
    "uniprot_ac": "A3QJZ6", 
    "gene_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A3QJZ6", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "PRAMEF22"
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A3QJZ6#A3QJZ6-1", 
            "isoform_ac": "A3QJZ6-1", 
            "locus": {}, 
            "sequence": {
                "header": "sp|A3QJZ6-1|PRA22_HUMAN Isoform 1 of PRAME family member 22  OS=Homo sapiens OX=9606 GN=PRAMEF22 PE=3 SV=3 CANONICAL=A3QJZ6-1", 
                "length": 481, 
                "sequence": "MRMSLQAPRRLLELAGQSLLGDQALAISILDELPRELFPPLFVEAFTSRRCEVLKVMVQAWPFPCLPLGSLMKTPDLEILHYVVDGIDCLLAQKVRPRRWKLQVLELRDVDENFWTIWSGARPLSCSPEAMSKRQTVEDCPRTGEKQPLKVFMDVCLKEKFMDEDLSFFSGWVQHRRGSVHLCCTKVVNYSMSILNFRNILETVYPDSIQVLEIWNMCWPCMIVEFSRYLSQMRNLRKLFISDGCRYLLSSDSQEQLVAEFSSVLLRLEYLQMLYVRRVCFFRGHLDQLIRCLRSPLETLALTYGFLEKVDLKCLPRYPSLSQLKQLNLSHGALRFIRLEPLRALLEKVAATLQTLFLVDCGIRDSKLRVILPALSCCSNLTTFCFHGNDTSMDGLKDLLRHTGRLSNLSLETYPAPRESLDDRGRVISELLTPLQAELMRILREVREPKRIFFGPVSCPCCGTSPTEQLEFNFCLWGRPA"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:653606", 
            "resource": "KEGG Pathway", 
            "id": "hsa:653606", 
            "name": ""
        }
    ], 
    "function": [], 
    "orthologs": [], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [
        {
            "sequence_org": "S", 
            "start_pos": 119, 
            "alt_nt": "G", 
            "chr_id": "1", 
            "ref_nt": "C", 
            "chr_pos": "13036284", 
            "disease": [
                {
                    "synonyms": [], 
                    "recommended_name": {
                        "url": "http://disease-ontology.org/term/DOID:9256", 
                        "resource": "Disease Ontology", 
                        "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum.", 
                        "name": "colorectal cancer", 
                        "id": "DOID:9256"
                    }
                }
            ], 
            "frequency": "1.1", 
            "sequence_mut": "C", 
            "subjects_tested": "94", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (1.1%).", 
            "end_pos": 119, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A3QJZ6", 
                    "id": "A3QJZ6", 
                    "database": "BioMuta"
                }
            ]
        }, 
        {
            "sequence_org": "V", 
            "start_pos": 204, 
            "alt_nt": "A", 
            "chr_id": "1", 
            "ref_nt": "G", 
            "chr_pos": "13036538", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "Thyroid gland neoplasm", 
                            "id": "DOID:1781"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "malignant neoplasm of thyroid gland", 
                            "id": "DOID:1781"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "malignant tumour of thyroid gland", 
                            "id": "DOID:1781"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "neoplasm of thyroid gland", 
                            "id": "DOID:1781"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "thyroid neoplasm", 
                            "id": "DOID:1781"
                        }
                    ], 
                    "recommended_name": {
                        "url": "http://disease-ontology.org/term/DOID:1781", 
                        "resource": "Disease Ontology", 
                        "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage.", 
                        "name": "thyroid gland cancer", 
                        "id": "DOID:1781"
                    }
                }
            ], 
            "frequency": "4.0", 
            "sequence_mut": "I", 
            "subjects_tested": "50", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (4.0%).", 
            "end_pos": 204, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "2", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A3QJZ6", 
                    "id": "A3QJZ6", 
                    "database": "BioMuta"
                }
            ]
        }, 
        {
            "sequence_org": "R", 
            "start_pos": 237, 
            "alt_nt": "A", 
            "chr_id": "1", 
            "ref_nt": "G", 
            "chr_pos": "13036638", 
            "disease": [
                {
                    "synonyms": [], 
                    "recommended_name": {
                        "url": "http://disease-ontology.org/term/DOID:9256", 
                        "resource": "Disease Ontology", 
                        "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum.", 
                        "name": "colorectal cancer", 
                        "id": "DOID:9256"
                    }
                }, 
                {
                    "synonyms": [
                        {
                            "url": "http://disease-ontology.org/term/DOID:10534", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "Ca body - stomach", 
                            "id": "DOID:10534"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:10534", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "Ca lesser curvature - stomach", 
                            "id": "DOID:10534"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:10534", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "ca greater curvature of stomach", 
                            "id": "DOID:10534"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:10534", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "gastric cancer", 
                            "id": "DOID:10534"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:10534", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "gastric neoplasm", 
                            "id": "DOID:10534"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:10534", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "malignant neoplasm of body of stomach", 
                            "id": "DOID:10534"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:10534", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "malignant neoplasm of lesser curve of stomach", 
                            "id": "DOID:10534"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:10534", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "malignant tumor of body of stomach", 
                            "id": "DOID:10534"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:10534", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "malignant tumor of greater curve of stomach", 
                            "id": "DOID:10534"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:10534", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "malignant tumor of lesser curve of stomach", 
                            "id": "DOID:10534"
                        }
                    ], 
                    "recommended_name": {
                        "url": "http://disease-ontology.org/term/DOID:10534", 
                        "resource": "Disease Ontology", 
                        "description": "A gastrointestinal system cancer that is located_in the stomach.", 
                        "name": "stomach cancer", 
                        "id": "DOID:10534"
                    }
                }, 
                {
                    "synonyms": [
                        {
                            "url": "http://disease-ontology.org/term/DOID:363", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "CA - cancer of uterus", 
                            "id": "DOID:363"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:363", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "Tumour of uterus", 
                            "id": "DOID:363"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:363", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "malignant neoplasm of uterus", 
                            "id": "DOID:363"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:363", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "malignant uterine tumor", 
                            "id": "DOID:363"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:363", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "neoplasm of uterus", 
                            "id": "DOID:363"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:363", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "uterine tumor", 
                            "id": "DOID:363"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:363", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "uterus neoplasm", 
                            "id": "DOID:363"
                        }
                    ], 
                    "recommended_name": {
                        "url": "http://disease-ontology.org/term/DOID:363", 
                        "resource": "Disease Ontology", 
                        "description": "A female reproductive organ cancer that is located_in the uterus.", 
                        "name": "uterine cancer", 
                        "id": "DOID:363"
                    }
                }, 
                {
                    "synonyms": [], 
                    "recommended_name": {
                        "url": "http://disease-ontology.org/term/DOID:1324", 
                        "resource": "Disease Ontology", 
                        "description": "A respiratory system cancer that is located_in the lung.", 
                        "name": "lung cancer", 
                        "id": "DOID:1324"
                    }
                }
            ], 
            "frequency": "0.2", 
            "sequence_mut": "H", 
            "subjects_tested": "456", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: num. of cancers (4).", 
            "end_pos": 237, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A3QJZ6", 
                    "id": "A3QJZ6", 
                    "database": "BioMuta"
                }
            ]
        }, 
        {
            "sequence_org": "K", 
            "start_pos": 309, 
            "alt_nt": "G", 
            "chr_id": "1", 
            "ref_nt": "A", 
            "chr_pos": "13037860", 
            "disease": [
                {
                    "synonyms": [], 
                    "recommended_name": {
                        "url": "http://disease-ontology.org/term/DOID:1324", 
                        "resource": "Disease Ontology", 
                        "description": "A respiratory system cancer that is located_in the lung.", 
                        "name": "lung cancer", 
                        "id": "DOID:1324"
                    }
                }
            ], 
            "frequency": "1.5", 
            "sequence_mut": "E", 
            "subjects_tested": "66", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (1.5%).", 
            "end_pos": 309, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A3QJZ6", 
                    "id": "A3QJZ6", 
                    "database": "BioMuta"
                }
            ]
        }, 
        {
            "sequence_org": "V", 
            "start_pos": 310, 
            "alt_nt": "A", 
            "chr_id": "1", 
            "ref_nt": "T", 
            "chr_pos": "13037864", 
            "disease": [
                {
                    "synonyms": [], 
                    "recommended_name": {
                        "url": "http://disease-ontology.org/term/DOID:1324", 
                        "resource": "Disease Ontology", 
                        "description": "A respiratory system cancer that is located_in the lung.", 
                        "name": "lung cancer", 
                        "id": "DOID:1324"
                    }
                }
            ], 
            "frequency": "1.5", 
            "sequence_mut": "E", 
            "subjects_tested": "66", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (1.5%).", 
            "end_pos": 310, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A3QJZ6", 
                    "id": "A3QJZ6", 
                    "database": "BioMuta"
                }
            ]
        }, 
        {
            "sequence_org": "A", 
            "start_pos": 333, 
            "alt_nt": "A", 
            "chr_id": "1", 
            "ref_nt": "G", 
            "chr_pos": "13037932", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "Thyroid gland neoplasm", 
                            "id": "DOID:1781"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "malignant neoplasm of thyroid gland", 
                            "id": "DOID:1781"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "malignant tumour of thyroid gland", 
                            "id": "DOID:1781"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "neoplasm of thyroid gland", 
                            "id": "DOID:1781"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "thyroid neoplasm", 
                            "id": "DOID:1781"
                        }
                    ], 
                    "recommended_name": {
                        "url": "http://disease-ontology.org/term/DOID:1781", 
                        "resource": "Disease Ontology", 
                        "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage.", 
                        "name": "thyroid gland cancer", 
                        "id": "DOID:1781"
                    }
                }
            ], 
            "frequency": "2.0", 
            "sequence_mut": "T", 
            "subjects_tested": "50", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (2.0%).", 
            "end_pos": 333, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A3QJZ6", 
                    "id": "A3QJZ6", 
                    "database": "BioMuta"
                }
            ]
        }, 
        {
            "sequence_org": "C", 
            "start_pos": 377, 
            "alt_nt": "C", 
            "chr_id": "1", 
            "ref_nt": "T", 
            "chr_pos": "13038064", 
            "disease": [
                {
                    "synonyms": [], 
                    "recommended_name": {
                        "url": "http://disease-ontology.org/term/DOID:1324", 
                        "resource": "Disease Ontology", 
                        "description": "A respiratory system cancer that is located_in the lung.", 
                        "name": "lung cancer", 
                        "id": "DOID:1324"
                    }
                }
            ], 
            "frequency": "3.0", 
            "sequence_mut": "R", 
            "subjects_tested": "66", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (3.0%).", 
            "end_pos": 377, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "2", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A3QJZ6", 
                    "id": "A3QJZ6", 
                    "database": "BioMuta"
                }
            ]
        }, 
        {
            "sequence_org": "D", 
            "start_pos": 423, 
            "alt_nt": "A", 
            "chr_id": "1", 
            "ref_nt": "G", 
            "chr_pos": "13038202", 
            "disease": [
                {
                    "synonyms": [], 
                    "recommended_name": {
                        "url": "http://disease-ontology.org/term/DOID:1324", 
                        "resource": "Disease Ontology", 
                        "description": "A respiratory system cancer that is located_in the lung.", 
                        "name": "lung cancer", 
                        "id": "DOID:1324"
                    }
                }
            ], 
            "frequency": "1.5", 
            "sequence_mut": "N", 
            "subjects_tested": "66", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (1.5%).", 
            "end_pos": 423, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A3QJZ6", 
                    "id": "A3QJZ6", 
                    "database": "BioMuta"
                }
            ]
        }, 
        {
            "sequence_org": "F", 
            "start_pos": 472, 
            "alt_nt": "C", 
            "chr_id": "1", 
            "ref_nt": "T", 
            "chr_pos": "13038350", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "url": "http://disease-ontology.org/term/DOID:2531", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "Hematologic malignancy", 
                            "id": "DOID:2531"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:2531", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "Hematologic neoplasm", 
                            "id": "DOID:2531"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:2531", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "Hematological tumors", 
                            "id": "DOID:2531"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:2531", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "blood cancer", 
                            "id": "DOID:2531"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:2531", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "hematopoietic and lymphoid system tumor", 
                            "id": "DOID:2531"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:2531", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "hematopoietic cancer", 
                            "id": "DOID:2531"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:2531", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "hematopoietic neoplasm", 
                            "id": "DOID:2531"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:2531", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "hematopoietic tumors", 
                            "id": "DOID:2531"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:2531", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "malignant hematopoietic neoplasm", 
                            "id": "DOID:2531"
                        }
                    ], 
                    "recommended_name": {
                        "url": "http://disease-ontology.org/term/DOID:2531", 
                        "resource": "Disease Ontology", 
                        "description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes.", 
                        "name": "hematologic cancer", 
                        "id": "DOID:2531"
                    }
                }
            ], 
            "frequency": "3.2", 
            "sequence_mut": "S", 
            "subjects_tested": "125", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (3.2%).", 
            "end_pos": 472, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "4", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A3QJZ6", 
                    "id": "A3QJZ6", 
                    "database": "BioMuta"
                }
            ]
        }, 
        {
            "sequence_org": "R", 
            "start_pos": 50, 
            "alt_nt": "T", 
            "chr_id": "1", 
            "ref_nt": "C", 
            "chr_pos": "13035690", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "Thyroid gland neoplasm", 
                            "id": "DOID:1781"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "malignant neoplasm of thyroid gland", 
                            "id": "DOID:1781"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "malignant tumour of thyroid gland", 
                            "id": "DOID:1781"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "neoplasm of thyroid gland", 
                            "id": "DOID:1781"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "thyroid neoplasm", 
                            "id": "DOID:1781"
                        }
                    ], 
                    "recommended_name": {
                        "url": "http://disease-ontology.org/term/DOID:1781", 
                        "resource": "Disease Ontology", 
                        "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage.", 
                        "name": "thyroid gland cancer", 
                        "id": "DOID:1781"
                    }
                }
            ], 
            "frequency": "2.0", 
            "sequence_mut": "C", 
            "subjects_tested": "50", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (2.0%).", 
            "end_pos": 50, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "1", 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A3QJZ6", 
                    "id": "A3QJZ6", 
                    "database": "BioMuta"
                }
            ]
        }
    ], 
    "cluster_types": [], 
    "refseq": {}, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A3QJZ6", 
                                "id": "A3QJZ6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "id": "GO:0005737", 
                        "name": "cytoplasm"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A3QJZ6", 
                                "id": "A3QJZ6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "id": "GO:0008284", 
                        "name": "positive regulation of cell population proliferation"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A3QJZ6", 
                                "id": "A3QJZ6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "id": "GO:0043066", 
                        "name": "negative regulation of apoptotic process"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A3QJZ6", 
                                "id": "A3QJZ6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "id": "GO:0045892", 
                        "name": "negative regulation of transcription, DNA-templated"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045596", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A3QJZ6", 
                                "id": "A3QJZ6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "id": "GO:0045596", 
                        "name": "negative regulation of cell differentiation"
                    }
                ], 
                "total": 4, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 191, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 189
        }, 
        {
            "end_pos": 330, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 328
        }, 
        {
            "end_pos": 382, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 380
        }, 
        {
            "end_pos": 391, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 389
        }, 
        {
            "end_pos": 410, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 408
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A3QJZ6", 
            "id": "A3QJZ6", 
            "database": "BioMuta"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=PRAMEF22", 
            "id": "PRAMEF22", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/653606", 
            "id": "653606", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=34393", 
            "id": "34393", 
            "database": "HGNC"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR026271", 
            "id": "IPR026271", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", 
            "id": "IPR032675", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:653606", 
            "id": "hsa:653606", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A3QJZ6", 
            "id": "NX_A3QJZ6", 
            "database": "neXtProt"
        }, 
        {
            "url": "http://www.orthodb.org/?query=631249at2759", 
            "id": "631249at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "https://pharos.nih.gov/targets/A3QJZ6", 
            "id": "A3QJZ6", 
            "database": "PHAROS"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A3QJZ6", 
            "id": "PR_A3QJZ6", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094101.1", 
            "id": "NP_001094101.1", 
            "database": "RefSeq"
        }
    ], 
    "expression_disease": [
        {
            "name": "Prostate cancer [DO disease name]", 
            "trend": "Up", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "url": "http://disease-ontology.org/term/DOID:10283", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "NGP - new growth of prostate", 
                            "id": "DOID:10283"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:10283", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "hereditary prostate cancer", 
                            "id": "DOID:10283"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:10283", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "malignant tumor of the prostate", 
                            "id": "DOID:10283"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:10283", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "prostate cancer, familial", 
                            "id": "DOID:10283"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:10283", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "prostate neoplasm", 
                            "id": "DOID:10283"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:10283", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "prostatic cancer", 
                            "id": "DOID:10283"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:10283", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "prostatic neoplasm", 
                            "id": "DOID:10283"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:10283", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "tumor of the prostate", 
                            "id": "DOID:10283"
                        }
                    ], 
                    "recommended_name": {
                        "url": "http://disease-ontology.org/term/DOID:10283", 
                        "resource": "Disease Ontology", 
                        "description": "A male reproductive organ cancer that is located_in the prostate.", 
                        "name": "prostate cancer", 
                        "id": "DOID:10283"
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A3QJZ6", 
                    "id": "A3QJZ6", 
                    "database": "BioXpress"
                }
            ], 
            "url": "http://disease-ontology.org/term/DOID:10283", 
            "significant": "No"
        }, 
        {
            "name": "Thyroid gland cancer [DO disease name]", 
            "trend": "Up", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "Thyroid gland neoplasm", 
                            "id": "DOID:1781"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "malignant neoplasm of thyroid gland", 
                            "id": "DOID:1781"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "malignant tumour of thyroid gland", 
                            "id": "DOID:1781"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "neoplasm of thyroid gland", 
                            "id": "DOID:1781"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "thyroid neoplasm", 
                            "id": "DOID:1781"
                        }
                    ], 
                    "recommended_name": {
                        "url": "http://disease-ontology.org/term/DOID:1781", 
                        "resource": "Disease Ontology", 
                        "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage.", 
                        "name": "thyroid gland cancer", 
                        "id": "DOID:1781"
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A3QJZ6", 
                    "id": "A3QJZ6", 
                    "database": "BioXpress"
                }
            ], 
            "url": "http://disease-ontology.org/term/DOID:1781", 
            "significant": "No"
        }, 
        {
            "name": "Liver cancer [DO disease name]", 
            "trend": "Down", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "Ca liver - primary", 
                            "id": "DOID:3571"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "Resectable malignant neoplasm of Liver", 
                            "id": "DOID:3571"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "hepatic cancer", 
                            "id": "DOID:3571"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "hepatic neoplasm", 
                            "id": "DOID:3571"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "malignant hepato-biliary neoplasm", 
                            "id": "DOID:3571"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "malignant neoplasm of liver", 
                            "id": "DOID:3571"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "malignant neoplasm of liver, primary", 
                            "id": "DOID:3571"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "malignant tumor of liver", 
                            "id": "DOID:3571"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "neoplasm of liver", 
                            "id": "DOID:3571"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "non-resectable primary hepatic malignant neoplasm", 
                            "id": "DOID:3571"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "primary liver cancer", 
                            "id": "DOID:3571"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "primary malignant neoplasm of Liver", 
                            "id": "DOID:3571"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "resectable malignant neoplasm of the liver", 
                            "id": "DOID:3571"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "malignant neoplasm of liver, not specified as primary or secondary", 
                            "id": "DOID:3571"
                        }
                    ], 
                    "recommended_name": {
                        "url": "http://disease-ontology.org/term/DOID:3571", 
                        "resource": "Disease Ontology", 
                        "description": "A hepatobiliary system cancer that is located_in the liver.", 
                        "name": "liver cancer", 
                        "id": "DOID:3571"
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A3QJZ6", 
                    "id": "A3QJZ6", 
                    "database": "BioXpress"
                }
            ], 
            "url": "http://disease-ontology.org/term/DOID:3571", 
            "significant": "No"
        }, 
        {
            "name": "Lung adenocarcinoma [DO disease name]", 
            "trend": "Down", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "url": "http://disease-ontology.org/term/DOID:3910", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "bronchogenic lung adenocarcinoma", 
                            "id": "DOID:3910"
                        }, 
                        {
                            "url": "http://disease-ontology.org/term/DOID:3910", 
                            "resource": "Disease Ontology", 
                            "description": "", 
                            "name": "nonsmall cell adenocarcinoma", 
                            "id": "DOID:3910"
                        }
                    ], 
                    "recommended_name": {
                        "url": "http://disease-ontology.org/term/DOID:3910", 
                        "resource": "Disease Ontology", 
                        "description": "A lung cancer that derives_from epithelial cells of glandular origin.", 
                        "name": "lung adenocarcinoma", 
                        "id": "DOID:3910"
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A3QJZ6", 
                    "id": "A3QJZ6", 
                    "database": "BioXpress"
                }
            ], 
            "url": "http://disease-ontology.org/term/DOID:3910", 
            "significant": "No"
        }
    ], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 55489.0, 
        "chemical_mass": 55489.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A3QJZ6", 
            "name": "PRAMEF22", 
            "locus": {}
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A3QJZ6", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "PRAME family member 22"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A3QJZ6", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "PRAME family member 22"
        }
    ]
}
