{ "uniprot_canonical_ac": "A3KFT3-1", "ptm_annotation": [], "sequence": { "header": "sp|A3KFT3-1|OR2M5_HUMAN Isoform 1 of Olfactory receptor 2M5 OS=Homo sapiens OX=9606 GN=OR2M5 PE=3 SV=1 CANONICAL=A3KFT3-1", "length": 312, "sequence": "MAWENQTFNSDFILLGIFNHSPTHTFLFFLVLAIFSVAFMGNSVMVLLIYLDTQLHTPMYFLLSQLFLMDLMLICSTVPKMAFNYLSGSKSISMAGCATQIFFYVSLLGSECFLLAVMSYDRYIAICHPLRYTNLMRPKICGLMTAFSWILGSMDAIIDAVATFSFSYCGSREIAHFFCDFPSLLILSCNDTSIFEKVLFICCIVMIVFPVAIIIASYARVILAVIHMGSGEGRRKAFTTCSSHLMVVGMYYGAGLFMYIRPTSDRSPMQDKLVSVFYTILTPMLNPLIYSLRNKEVTRALRKVLGKGKCGE" }, "uniprot_id": "OR2M5_HUMAN", "enzyme_annotation": [], "glycation": [], "keywords": [ "glycoprotein", "predicted.uniprotkb_gly" ], "species": [ { "common_name": "Human", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KFT3", "id": "A3KFT3", "database": "UniProtKB" } ], "taxid": 9606, "name": "Homo sapiens" } ], "crossref_internal": { "gene": [ "OR2M5" ], "species": [ 9606 ], "disease": [ "DOID:1793", "DOID:4159", "DOID:11054", "DOID:9256", "DOID:2531", "DOID:2394", "DOID:11934", "DOID:1612", "DOID:10283", "DOID:4362", "DOID:1781", "DOID:1324", "DOID:363", "DOID:3907", "DOID:1319", "DOID:10534" ], "site": [ "A3KFT3-1.88.88", "A3KFT3-1.261.261", "A3KFT3-1.118.118", "A3KFT3-1.152.152", "A3KFT3-1.84.84", "A3KFT3-1.16.16", "A3KFT3-1.136.136", "A3KFT3-1.5.5", "A3KFT3-1.291.291", "A3KFT3-1.303.303", "A3KFT3-1.191.191", "A3KFT3-1.266.266", "A3KFT3-1.197.197", "A3KFT3-1.293.293", "A3KFT3-1.234.234", "A3KFT3-1.7.7", "A3KFT3-1.172.172" ] }, "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/14983052", "type": [ "PubMed" ], "id": "14983052" } ], "title": "The human olfactory receptor gene family.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004690.1", "id": "NP_001004690.1", "database": "RefSeq" } ], "authors": "Malnic B, Godfrey PA, Buck LB", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21248752", "type": [ "PubMed" ], "id": "21248752" } ], "title": "Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.", "journal": "Nature", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KFT3", "id": "A3KFT3", "database": "UniProtKB" } ], "authors": "Adams D.J., Bignell G., Butler A., Dalgliesh G.L., Davies H., Futreal P.A., Greenman C., Jones D., McLaren S., Menzies A., Raine K., Stephens P., Stratton M.R., Teague J., Teh B.T., Anema J., Campbell P.J., Chan-On W., Cho J., Dykema K., Fischer A., Furge K., Galappaththige D., Hardy C., Huang D., Jia M., Kahnoski R.J., Largaespada D.A., Latimer C., Lau K.W., Lin M.L., Marshall J., Mudie L., Mustonen V., Ong C.K., Perez-Mancera P.A., Richard S., Rust A., Stebbings L., Subimerb C., Tarpey P., Tuveson D.A., Varela I., Wessels L.F.A.", "date": "2011" } ], "uniprot_ac": "A3KFT3", "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A3KFT3", "type": "synonym", "resource": "RefSeq", "name": "OR2M5P" }, { "url": "https://www.uniprot.org/uniprot/A3KFT3", "type": "synonym", "resource": "UniProtKB", "name": "OR2M5P" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A3KFT3", "type": "synonym", "resource": "RefSeq", "name": "OR2M5" }, { "url": "https://www.uniprot.org/uniprot/A3KFT3", "type": "recommended", "resource": "UniProtKB", "name": "OR2M5" } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A3KFT3#A3KFT3-1", "isoform_ac": "A3KFT3-1", "locus": { "end_pos": 248145148, "strand": "-", "start_pos": 248146083, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000366476", "id": "ENST00000366476", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000355432", "id": "ENSP00000355432", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A3KFT3-1|OR2M5_HUMAN Isoform 1 of Olfactory receptor 2M5 OS=Homo sapiens OX=9606 GN=OR2M5 PE=3 SV=1 CANONICAL=A3KFT3-1", "length": 312, "sequence": "MAWENQTFNSDFILLGIFNHSPTHTFLFFLVLAIFSVAFMGNSVMVLLIYLDTQLHTPMYFLLSQLFLMDLMLICSTVPKMAFNYLSGSKSISMAGCATQIFFYVSLLGSECFLLAVMSYDRYIAICHPLRYTNLMRPKICGLMTAFSWILGSMDAIIDAVATFSFSYCGSREIAHFFCDFPSLLILSCNDTSIFEKVLFICCIVMIVFPVAIIIASYARVILAVIHMGSGEGRRKAFTTCSSHLMVVGMYYGAGLFMYIRPTSDRSPMQDKLVSVFYTILTPMLNPLIYSLRNKEVTRALRKVLGKGKCGE" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:127059", "resource": "KEGG Pathway", "id": "hsa:127059", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381753", "resource": "Reactome", "id": "R-HSA-381753", "name": "Olfactory Signaling Pathway" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A3KFT3#function", "annotation": "Odorant receptor.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KFT3#function", "id": "A3KFT3", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q8VFA2-1", "protein_name": "Olfactory receptor", "sequence": { "length": 313, "sequence": "MMQWNNWTRNSDFILLGFFDHSPLHTFFFSLILAIFFMALIGNSVMVILIYLDAQLHTPMYILLSQLSLMDLMLISTTVPQTAFNFLSGNKSISMAGCGVQIFFYVSLLGAECFLLAAMAYDRYVAICYPLRYPILMSHKICSLMAAFSWILGSLDGIIDVAAVLSFSYCGTREIPHFFCDIPALLTISCSDTLIFEKIIFFCCVIMLIFPVVIVIASYICVILAVIKMASAESRHKAFATCSSHVMVVVIYYGAAMFIYMQPSSSRSPNQDKLVSAFYTILTPLLNPLIYSLRNKEVARAFMKVLRMDKAAG" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/128262", "id": "128262", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [ { "sequence_org": "N", "start_pos": 84, "alt_nt": "A", "chr_id": "1", "ref_nt": "C", "chr_pos": "248308701", "disease": [ { "synonyms": [], "recommended_name": { "url": "http://disease-ontology.org/term/DOID:1324", "resource": "Disease Ontology", "description": "A respiratory system cancer that is located_in the lung.", "name": "lung cancer", "id": 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"DOID:2531" }, { "url": "http://disease-ontology.org/term/DOID:2531", "resource": "Disease Ontology", "description": "", "name": "hematopoietic and lymphoid system tumor", "id": "DOID:2531" }, { "url": "http://disease-ontology.org/term/DOID:2531", "resource": "Disease Ontology", "description": "", "name": "hematopoietic cancer", "id": "DOID:2531" }, { "url": "http://disease-ontology.org/term/DOID:2531", "resource": "Disease Ontology", "description": "", "name": "hematopoietic neoplasm", "id": "DOID:2531" }, { "url": "http://disease-ontology.org/term/DOID:2531", "resource": "Disease Ontology", "description": "", "name": "hematopoietic tumors", "id": "DOID:2531" }, { "url": "http://disease-ontology.org/term/DOID:2531", "resource": "Disease Ontology", "description": "", "name": "malignant hematopoietic neoplasm", "id": "DOID:2531" } ], "recommended_name": { "url": "http://disease-ontology.org/term/DOID:2531", "resource": "Disease Ontology", "description": "An organ system cancer located 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"url": "http://disease-ontology.org/term/DOID:2394", "resource": "Disease Ontology", "description": "", "name": "tumor of the Ovary", "id": "DOID:2394" } ], "recommended_name": { "url": "http://disease-ontology.org/term/DOID:2394", "resource": "Disease Ontology", "description": "A female reproductive organ cancer that is located_in the ovary.", "name": "ovarian cancer", "id": "DOID:2394" } }, { "synonyms": [ { "url": "http://disease-ontology.org/term/DOID:1319", "resource": "Disease Ontology", "description": "", "name": "BT - Brain tumour", "id": "DOID:1319" }, { "url": "http://disease-ontology.org/term/DOID:1319", "resource": "Disease Ontology", "description": "", "name": "adult brain tumor", "id": "DOID:1319" }, { "url": "http://disease-ontology.org/term/DOID:1319", "resource": "Disease Ontology", "description": "", "name": "adult malignant brain neoplasm", "id": "DOID:1319" }, { "url": "http://disease-ontology.org/term/DOID:1319", "resource": "Disease Ontology", "description": "", "name": "brain neoplasm", "id": "DOID:1319" }, { "url": "http://disease-ontology.org/term/DOID:1319", "resource": "Disease Ontology", "description": "", "name": "brain neoplasm, adult", "id": "DOID:1319" }, { "url": "http://disease-ontology.org/term/DOID:1319", "resource": "Disease Ontology", "description": "", "name": "malignant brain tumour", "id": "DOID:1319" }, { "url": "http://disease-ontology.org/term/DOID:1319", "resource": "Disease Ontology", "description": "", "name": "malignant primary brain neoplasm", "id": "DOID:1319" }, { "url": "http://disease-ontology.org/term/DOID:1319", "resource": "Disease Ontology", "description": "", "name": "malignant primary brain tumor", "id": "DOID:1319" }, { "url": "http://disease-ontology.org/term/DOID:1319", "resource": "Disease Ontology", "description": "", "name": "malignant tumor of Brain", "id": "DOID:1319" }, { "url": "http://disease-ontology.org/term/DOID:1319", "resource": "Disease Ontology", "description": "", "name": "malignant tumor 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"https://bgee.org/?page=gene&gene_id=ENSG00000162727", "id": "ENSG00000162727", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000992", "uberon": "0000992", "name": "Ovary" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162727", "id": "ENSG00000162727", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0000996", "uberon": "0000996", "name": "Vagina" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162727", "id": "ENSG00000162727", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001043", "uberon": "0001043", "name": "Esophagus" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162727", "id": "ENSG00000162727", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001150", "uberon": "0001150", "name": "Body of pancreas" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162727", "id": "ENSG00000162727", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001155", "uberon": "0001155", "name": "Colon" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162727", "id": "ENSG00000162727", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001160", "uberon": "0001160", "name": "Fundus of stomach" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162727", "id": "ENSG00000162727", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001161", "uberon": "0001161", "name": "Body of stomach" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162727", "id": "ENSG00000162727", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001255", "uberon": "0001255", "name": "Urinary bladder" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162727", "id": "ENSG00000162727", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0001987", "uberon": "0001987", "name": "Placenta" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162727", "id": "ENSG00000162727", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002046", "uberon": "0002046", "name": "Thyroid gland" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162727", "id": "ENSG00000162727", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002048", "uberon": "0002048", "name": "Lung" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162727", "id": "ENSG00000162727", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002107", "uberon": "0002107", "name": "Liver" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162727", "id": "ENSG00000162727", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002367", "uberon": "0002367", "name": "Prostate gland" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162727", "id": "ENSG00000162727", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0002369", "uberon": "0002369", "name": "Adrenal gland" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162727", "id": "ENSG00000162727", "database": "Bgee" } ] }, { "tissue": { "url": "http://purl.obolibrary.org/obo/UBERON_0009853", "uberon": "0009853", "name": "Body of uterus" }, "present": "no", "evidence": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162727", "id": "ENSG00000162727", "database": "Bgee" } ] } ], "gene": [ { "url": "https://www.uniprot.org/uniprot/A3KFT3", "name": "OR2M5", "locus": { "end_pos": 248146086, "strand": "+", "start_pos": 248145148, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSG00000162727", "id": "ENSG00000162727", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A3KFT3", "type": "recommended", "resource": "UniProtKB", "name": "Olfactory receptor 2M5" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A3KFT3", "type": "synonym", "resource": "RefSeq", "name": "olfactory receptor 2M5" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A3KFT3", "type": "synonym", "resource": "RefSeq", "name": "olfactory receptor, family 2, subfamily M, member 5 pseudogene" } ] }