{
    "uniprot_canonical_ac": "A2ARM1-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A2ARM1-1|PATL2_MOUSE Isoform 1 of Protein PAT1 homolog 2  OS=Mus musculus OX=10090 GN=Patl2 PE=2 SV=1 CANONICAL=A2ARM1-1", 
        "length": 529, 
        "sequence": "MKCLEGLHLQQRPSKFSVSLAPEEGLVCAFQLEEEKENEDECVCSDQAPEVKEEGCGLGDPAIVSAFQNTQVPQQRGLHSSHRVKVSGALGMSSASLHFMWQSVFPRASSPAHHFGPQQPSPDPFLFYSPLTPWPPKLSLPSHLTQLHPQHQQILQQQQRWRRRRSPTARSVPAQKPWSREPAASDAYANLMTRKEKDWVIRVQMVQLQSENPRLDDYYYQKYYQKLEKRQADKELLGQKTRAESLKLVTPYIQKPEVYESVVRIEGSLGQVAVSTCFSPRRAIDAVSHGTQEQDTGAASSQRLRVLSQIEKMFLQLLKIEEGQNDGLPQLYHTREQSSQVEKLFQALKTQEQNNLEEAADNLLQVLSVRKGKVLVARLLPFLPPDQAVSLLLYITYHLPLLIQRDMADQGLHMLFKPLGKYISHLTFHQLLHAMQGLMLLSPGSSERPVSVVLQNQFGISLLYALLSHGEQLVSLDPSLRSSSDCATWTDLVILIAWEIAQLPAASLAEPLAFPRNLLPCSAITWTSN"
    }, 
    "uniprot_id": "PATL2_MOUSE", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2ARM1", 
                    "id": "A2ARM1", 
                    "database": "UniProtKB"
                }
            ], 
            "taxid": 10090, 
            "name": "Mus musculus"
        }
    ], 
    "crossref_internal": {
        "gene": [
            "Patl2"
        ], 
        "species": [
            10090
        ]
    }, 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/17015433", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "17015433"
                }
            ], 
            "title": "Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.", 
            "journal": "Genes & development", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080527.2", 
                    "id": "NP_080527.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Evsikov AV, Graber JH, Brockman JM, Hampl A, Holbrook AE, Singh P, Eppig JJ, Solter D, Knowles BB", 
            "date": "2006"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/20826699", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "20826699"
                }
            ], 
            "title": "Distinct functions of maternal and somatic Pat1 protein paralogs.", 
            "journal": "RNA", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2ARM1", 
                    "id": "A2ARM1", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080527.2", 
                    "id": "NP_080527.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Kress M., Marnef A., Standart N., Weil D., Balasubramanian S., Bugaut A., Maldonado M.", 
            "date": "2010"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/29661911", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "29661911"
                }
            ], 
            "title": "PATL2 is a key actor of oocyte maturation whose invalidation causes infertility in women and mice.", 
            "journal": "EMBO molecular medicine", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080527.2", 
                    "id": "NP_080527.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Christou-Kent M, Kherraf ZE, Amiri-Yekta A, Le Blevec E, Karaouzene T, Conne B, Escoffier J, Assou S, Guttin A, Lambert E, Martinez G, Boguenet M, Fourati Ben Mustapha S, Cedrin Durnerin I, Halouani L, Marrakchi O, Makni M, Latrous H, Kharouf M, Coutton C, Thierry-Mieg N, Nef S, Bottari SP, Zouari R, Issartel JP, Ray PF, Arnoult C", 
            "date": "2018"
        }
    ], 
    "uniprot_ac": "A2ARM1", 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2ARM1", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "4930424G05Rik; Pat1a"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2ARM1", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Patl2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ARM1", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Patl2"
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2ARM1#A2ARM1-1", 
            "isoform_ac": "A2ARM1-1", 
            "locus": {
                "end_pos": 122121188, 
                "strand": "+", 
                "start_pos": 122129516, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000028665", 
                        "id": "ENSMUST00000028665", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000028665", 
                        "id": "ENSMUSP00000028665", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2ARM1-1|PATL2_MOUSE Isoform 1 of Protein PAT1 homolog 2  OS=Mus musculus OX=10090 GN=Patl2 PE=2 SV=1 CANONICAL=A2ARM1-1", 
                "length": 529, 
                "sequence": "MKCLEGLHLQQRPSKFSVSLAPEEGLVCAFQLEEEKENEDECVCSDQAPEVKEEGCGLGDPAIVSAFQNTQVPQQRGLHSSHRVKVSGALGMSSASLHFMWQSVFPRASSPAHHFGPQQPSPDPFLFYSPLTPWPPKLSLPSHLTQLHPQHQQILQQQQRWRRRRSPTARSVPAQKPWSREPAASDAYANLMTRKEKDWVIRVQMVQLQSENPRLDDYYYQKYYQKLEKRQADKELLGQKTRAESLKLVTPYIQKPEVYESVVRIEGSLGQVAVSTCFSPRRAIDAVSHGTQEQDTGAASSQRLRVLSQIEKMFLQLLKIEEGQNDGLPQLYHTREQSSQVEKLFQALKTQEQNNLEEAADNLLQVLSVRKGKVLVARLLPFLPPDQAVSLLLYITYHLPLLIQRDMADQGLHMLFKPLGKYISHLTFHQLLHAMQGLMLLSPGSSERPVSVVLQNQFGISLLYALLSHGEQLVSLDPSLRSSSDCATWTDLVILIAWEIAQLPAASLAEPLAFPRNLLPCSAITWTSN"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:67578", 
            "resource": "KEGG Pathway", 
            "id": "mmu:67578", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080527.2", 
            "annotation": "HPat1b localizes to P-bodies, while mPat1a-GFP is either found weakly in P-bodies or disperses P-bodies in a dominant-negative fashion.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080527.2", 
                    "id": "NP_080527.2", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ARM1#function", 
            "annotation": "RNA-binding protein that acts as a translational repressor.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2ARM1#function", 
                    "id": "A2ARM1", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "C9JE40-1", 
            "protein_name": "Protein PAT1 homolog 2", 
            "sequence": {
                "length": 543, 
                "sequence": "MNCLEGPGKTCGPLASEEELVSACQLEKEEENEGEEEEEEEDEEDLDPDLDPDLEEEENDLGDPAVLGAVHNTQRALLSSPGVKAPGMLGMSLASLHFLWQTLDYLSPIPFWPTFPSTSSPAQHFGPRLPSPDPTLFCSLLTSWPPRFSHLTQLHPRHQRILQQQQHSQTPSPPAKKPWSQQPDPYANLMTRKEKDWVIKVQMVQLQSAKPRLDDYYYQEYYQKLEKKQADEELLGRRNRVESLKLVTPYIPKAEAYESVVRIEGSLGQVAVSTCFSPRRAIDAVPHGTQEQDIEAASSQRLRVLYRIEKMFLQLLEIEEGWKYRPPPPCFSEQQSNQVEKLFQTLKTQEQNNLEEAADGFLQVLSVRKGKALVARLLPFLPQDQAVTILLAITHHLPLLVRRDVADQALQMLFKPLGKCISHLTLHELLQGLQGLTLLPPGSSERPVTVVLQNQFGISLLYALLSHGEQLVSLHSSLEEPNSDHTAWTDMVVLIAWEIAQMPTASLAEPLAFPSNLLPLFCHHVDKQLVQQLEARMEFAWIY"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/12155", 
                    "id": "12155", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "D3Z954-1", 
            "protein_name": "PAT1 homolog 2", 
            "sequence": {
                "length": 526, 
                "sequence": "MKCLEGLHLQHRPSKFSVPLAPEEGLECAFQLEEEEKENEEKFVCSDWAPEGKEEGNDLWDPAIVSAIQNTQVPQQRGLHSSPTVRASGALGMSPASLHFLCQSVFPRTSSPAHHFGPQQPSPDPFLFCSPLTPWPPKLRLPSHLTQLHPQHQKILQQQQGWPKRMFLLARRVPGQKPRSRESDAYANLMTRKEKDWVIRVQMVQLQSENPRLDDYYYQKYYQKLEKRQADQELLGQRNRAQSLKLVTPYIQKSEVYESVVRIEGSLGQVAVSTCFSPRRAIDAVSHGTQEQDTGAASSQRLRVLSQIEKMFLQLLKIEEGQNDGLPQHYHLREQSNQVEKLFQALKTQEQNNLEEAADNLLQVLSVRKGKIFVARLLPFLLQDQAVSLLLYITYHLPLLIQRDMADQSLQMLFKPLRKYIRHLTFPQLLHALQGLMLLSPDSSERPVSVVLQNQFGISLLYALLSHGEQLVSLDSSLQSSSDCVAWTDLVILVAWEIAQLPAASLAEPLAFPRNLPCSTTTWTNN"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A2ARM1/", 
                    "id": "A2ARM1", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Rat", 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }, 
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080527.2", 
        "ac": "NP_080527.2", 
        "name": "protein PAT1 homolog 2", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030371", 
                        "pmid": "20826699", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ARM1", 
                                "id": "A2ARM1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "id": "GO:0030371", 
                        "name": "translation repressor activity"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002151", 
                        "pmid": "20826699", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ARM1", 
                                "id": "A2ARM1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "id": "GO:0002151", 
                        "name": "G-quadruplex RNA binding"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008266", 
                        "pmid": "20826699", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ARM1", 
                                "id": "A2ARM1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "id": "GO:0008266", 
                        "name": "poly(U) RNA binding"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034046", 
                        "pmid": "20826699", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ARM1", 
                                "id": "A2ARM1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "id": "GO:0034046", 
                        "name": "poly(G) binding"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ARM1", 
                                "id": "A2ARM1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "id": "GO:0003723", 
                        "name": "RNA binding"
                    }
                ], 
                "total": 5, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", 
                        "pmid": "20826699", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ARM1", 
                                "id": "A2ARM1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "id": "GO:0005634", 
                        "name": "nucleus"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "pmid": "20826699", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ARM1", 
                                "id": "A2ARM1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "id": "GO:0005737", 
                        "name": "cytoplasm"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000932", 
                        "pmid": "20826699", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ARM1", 
                                "id": "A2ARM1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "id": "GO:0000932", 
                        "name": "P-body"
                    }
                ], 
                "total": 3, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000290", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ARM1", 
                                "id": "A2ARM1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "id": "GO:0000290", 
                        "name": "deadenylation-dependent decapping of nuclear-transcribed mRNA"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033962", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ARM1", 
                                "id": "A2ARM1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "id": "GO:0033962", 
                        "name": "cytoplasmic mRNA processing body assembly"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010607", 
                        "pmid": "20826699", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ARM1", 
                                "id": "A2ARM1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "id": "GO:0010607", 
                        "name": "negative regulation of cytoplasmic mRNA processing body assembly"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017148", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ARM1", 
                                "id": "A2ARM1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "id": "GO:0017148", 
                        "name": "negative regulation of translation"
                    }
                ], 
                "total": 4, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000027233", 
            "id": "ENSMUSG00000027233", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/67578", 
            "id": "67578", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019167", 
            "id": "IPR019167", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR039900", 
            "id": "IPR039900", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:67578", 
            "id": "mmu:67578", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:1914828", 
            "id": "1914828", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/CYSEQQS/", 
            "id": "CYSEQQS", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=950451at2759", 
            "id": "950451at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21551", 
            "id": "PTHR21551", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF09770", 
            "id": "PF09770", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2ARM1", 
            "id": "PR_A2ARM1", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080527.2", 
            "id": "NP_080527.2", 
            "database": "RefSeq"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 59639.0, 
        "chemical_mass": 59639.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2ARM1", 
            "name": "Patl2", 
            "locus": {
                "end_pos": 122120108, 
                "strand": "-", 
                "start_pos": 122186189, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000027233", 
                        "id": "ENSMUSG00000027233", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2ARM1", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "PAT1-like protein 2; protein PAT1 homolog a"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ARM1", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "PAT1-like protein 2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ARM1", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Pat1a"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ARM1", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Protein PAT1 homolog 2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ARM1", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Protein PAT1 homolog a"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2ARM1", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "protein PAT1 homolog 2"
        }
    ]
}