{ "uniprot_canonical_ac": "A2A5F7-1", "ptm_annotation": [], "sequence": { "header": "tr|A2A5F7-1|A2A5F7_MOUSE Isoform 1 of potassium Voltage-gated channel, subfamily H (Eag-related), member 4 OS=Mus musculus OX=10090 GN=Kcnh4 PE=2 SV=1 CANONICAL=A2A5F7-1", "length": 1018, "sequence": "MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGPRGFPIVYCSDGFCELTGYGRTEVMQKTCSCRFLYGPETSEPALQRLQKALEGHQEHRTEICFYRKDGSAFWCLLDMMPIKNEMGEVVLFLFSFKDISQSGGPGLGSPGIHGDNNHENSLGRRGTSSRLRSTKRQNRTVLHRLTGHFGRRGQSSVKANSNLFEPKPSVPEYKVASVGGSRCLLLHYSIPKAVWDGLILLATFYVAVTVPYNVCFAGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIGLHYLATWFFVDLIAALPFDLLYVFNITVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHWMACVWYVIGRREMEANDPLLWDIGWLHELGKRLEEPYVNGSAGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREILQLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILGKGDLIGADIPELGQEPGSGAGPSCVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYAAAFRAGLPRDLTFNLRQGSENNGLGRFSRSPRLSQARSDTLGSSSDKTLPSITETEGGTEPGAGSKPRRPHLLPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSPTPSPALAGRGQSPSPHGPPRGSAAWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSSNTAEAPTFRFSKRPEPTRTRSQAPPSGPRLSRELATEAAEEVKEKVCRLNQEISRLNQEVSQLSRELRQVMGLLQARLGPPSHTAGPAWLPDLPCPHQRLPCISPHMSGPPPGLQNTTLAVVHCPASVGTVEIGATPSELRPSTIPPYPSEPDPLGPSPAPEAPPLTPSLLKHSFQSGSDTFH" }, "uniprot_id": "A2A5F7_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5F7", "id": "A2A5F7", "database": "UniProtKB" } ], "taxid": 10090, "name": "Mus musculus" } ], "crossref_internal": { "gene": [ "Kcnh4" ], "species": [ 10090 ] }, "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11735219", "type": [ "PubMed" ], "id": "11735219" } ], "title": "The Stat3/5 locus encodes novel endoplasmic reticulum and helicase-like proteins that are preferentially expressed in normal and neoplastic mammary tissue.", "journal": "Genomics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074663.1", "id": "NP_001074663.1", "database": "RefSeq" } ], "authors": "Cui Y, Li M, Walton KD, Sun K, Hanover JA, Furth PA, Hennighausen L", "date": "2001" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26398943", "type": [ "PubMed" ], "id": "26398943" } ], "title": "A gene expression resource generated by genome-wide lacZ profiling in the mouse.", "journal": "Disease models & mechanisms", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074663.1", "id": "NP_001074663.1", "database": "RefSeq" } ], "authors": "Tuck E, Estabel J, Oellrich A, Maguire AK, Adissu HA, Souter L, Siragher E, Lillistone C, Green AL, Wardle-Jones H, Carragher DM, Karp NA, Smedley D, Adams NC, Bussell JN, Adams DJ, Ramirez-Solis R, Steel KP, Galli A, White JK", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27626380", "type": [ "PubMed" ], "id": "27626380" } ], "title": "High-throughput discovery of novel developmental phenotypes.", "journal": "Nature", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074663.1", "id": "NP_001074663.1", "database": "RefSeq" } ], "authors": "Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M, Murray SA", "date": "2016" } ], "uniprot_ac": "A2A5F7", "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A5F7", "type": "synonym", "resource": "RefSeq", "name": "BEC2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A5F7", "type": "synonym", "resource": "RefSeq", "name": "Kcnh4" }, { "url": "https://www.uniprot.org/uniprot/A2A5F7", "type": "recommended", "resource": "UniProtKB", "name": "Kcnh4" } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A5F7#A2A5F7-1", "isoform_ac": "A2A5F7-1", "locus": { "end_pos": 100741606, "strand": "+", "start_pos": 100759605, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000107361", "id": "ENSMUST00000107361", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000102984", "id": "ENSMUSP00000102984", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2A5F7-1|A2A5F7_MOUSE Isoform 1 of potassium Voltage-gated channel, subfamily H (Eag-related), member 4 OS=Mus musculus OX=10090 GN=Kcnh4 PE=2 SV=1 CANONICAL=A2A5F7-1", "length": 1018, "sequence": "MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGPRGFPIVYCSDGFCELTGYGRTEVMQKTCSCRFLYGPETSEPALQRLQKALEGHQEHRTEICFYRKDGSAFWCLLDMMPIKNEMGEVVLFLFSFKDISQSGGPGLGSPGIHGDNNHENSLGRRGTSSRLRSTKRQNRTVLHRLTGHFGRRGQSSVKANSNLFEPKPSVPEYKVASVGGSRCLLLHYSIPKAVWDGLILLATFYVAVTVPYNVCFAGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIGLHYLATWFFVDLIAALPFDLLYVFNITVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHWMACVWYVIGRREMEANDPLLWDIGWLHELGKRLEEPYVNGSAGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREILQLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILGKGDLIGADIPELGQEPGSGAGPSCVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYAAAFRAGLPRDLTFNLRQGSENNGLGRFSRSPRLSQARSDTLGSSSDKTLPSITETEGGTEPGAGSKPRRPHLLPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSPTPSPALAGRGQSPSPHGPPRGSAAWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSSNTAEAPTFRFSKRPEPTRTRSQAPPSGPRLSRELATEAAEEVKEKVCRLNQEISRLNQEVSQLSRELRQVMGLLQARLGPPSHTAGPAWLPDLPCPHQRLPCISPHMSGPPPGLQNTTLAVVHCPASVGTVEIGATPSELRPSTIPPYPSEPDPLGPSPAPEAPPLTPSLLKHSFQSGSDTFH" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:380728", "resource": "KEGG Pathway", "id": "mmu:380728", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1296072", "resource": "Reactome", "id": "R-MMU-1296072", "name": "Voltage gated Potassium channels" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q9R1T9-1", "protein_name": "Potassium voltage-gated channel subfamily H member 4", "sequence": { "length": 1017, "sequence": "MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGPRGFPIVYCSDGFCELTGYGRTEVMQKTCSCRFLYGPETSEPALQRLQKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNELGEVVLFLFSFKDISQSGGPGLGSPGIHGDNNNHENSLGRRGASSRLRSTRRQNRTVLHRLTGHFGRRDQGSVKANSNVFEPKPSVPEYKVASVGGSRCLLLHYSIPKAVWDGLILLATFYVAVTVPYNVCFAGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVVSAPRSIGLHYLATWFFVDLIAALPFDLLYVFNITVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHWMACVWYVIGRREMEANDPLLWDIGWLHELGKRLEEPYVNGSAGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREILQLPLFGAASRGCLRALSLHIKTSFCAPGEFLLRRGDALQAHYYVCSGSLEVLRDNTVLAILGKGDLIGADIPELGQEPGAGAGCVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYVAAFRAGLPRDLTFNLRQGSENNGLGRFSRSPRLSQARSDTLGSSSDKTLPSITETEGGMEPGAGSKPRRPLLLPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSPTPSPALAGRGSSPSLHGPPRGSAAWKPPQLLTPPLGTFGPPDLSPRIVDGIEDSSNTAEAPTFRFSKRPEPTRTRSQAPLSGPRLSRELATEAAEEVKEKVCRLNQEISRLNQEVSQLSRELRQVMGLLQARLGPPSHPPDSTWLPDLPCPHQRPPCISPHMSGPPPGLQNTTLAVVHCPASVGTVEIGATPSELRSSMVPPFPSEPDPLGPSPVPEASPLTPSLLKHSFQSGSDTFH" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/8180", "id": "8180", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q9UQ05-1", "protein_name": "Potassium voltage-gated channel subfamily H member 4", "sequence": { "length": 1017, "sequence": "MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEVMQKTCSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEMGEVVLFLFSFKDITQSGSPGLGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLHRLTGHFGRRGQGGMKANNNVFEPKPSVPEYKVASVGGSRCLLLHYSVSKAIWDGLILLATFYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIGLHYLATWFFIDLIAALPFDLLYIFNITVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGSVGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREILQLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILGKGDLIGADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAFRAGLPRDLTFNLRQGSDTSGLSRFSRSPRLSQPRSESLGSSSDKTLPSITEAESGAEPGGGPRPRRPLLLPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSPSLSPALAGQGHSASPHGPPRCSAAWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSGSTAEAPSFRFSRRPELPRPRSQAPPTGTRPSPELASEAEEVKEKVCRLNQEISRLNQEVSQLSRELRHIMGLLQARLGPPGHPAGSAWTPDPPCPQLRPPCLSPCASRPPPSLQDTTLAEVHCPASVGTMETGTALLDLRPSILPPYPSEPDPLGPSPVPEASPPTPSLLRHSFQSRSDTFH" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/8180", "id": "8180", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074663.1", "ac": "NP_001074663.1", "name": "potassium voltage-gated channel subfamily H member 4", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005249", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5F7", "id": "A2A5F7", "database": "UniProtKB" } ], "id": "GO:0005249", "name": "voltage-gated potassium channel activity" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005887", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5F7", "id": "A2A5F7", "database": "UniProtKB" } ], "id": "GO:0005887", "name": "integral component of plasma membrane" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042391", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5F7", "id": "A2A5F7", "database": "UniProtKB" } ], "id": "GO:0042391", "name": "regulation of membrane potential" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071805", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5F7", "id": "A2A5F7", "database": "UniProtKB" } ], "id": "GO:0071805", "name": "potassium ion transmembrane transport" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034765", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5F7", "id": "A2A5F7", "database": "UniProtKB" } ], "id": "GO:0034765", "name": "regulation of ion transmembrane transport" } ], "total": 3, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 174, "annotation": "n_glycosylation_sequon", "start_pos": 172 }, { "end_pos": 328, "annotation": "n_glycosylation_sequon", "start_pos": 326 }, { "end_pos": 416, "annotation": "n_glycosylation_sequon", "start_pos": 414 }, { "end_pos": 475, "annotation": "n_glycosylation_sequon", "start_pos": 473 }, { "end_pos": 750, "annotation": "n_glycosylation_sequon", "start_pos": 748 }, { "end_pos": 953, "annotation": "n_glycosylation_sequon", "start_pos": 951 } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000035355", "id": "ENSMUSG00000035355", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00038", "id": "cd00038", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00130", "id": "cd00130", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/380728", "id": "380728", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000014", "id": "IPR000014", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000595", "id": "IPR000595", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000700", "id": "IPR000700", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001610", "id": "IPR001610", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003938", "id": "IPR003938", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003950", "id": "IPR003950", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "id": "IPR005821", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR014710", "id": "IPR014710", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018490", "id": "IPR018490", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035965", "id": "IPR035965", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:380728", "id": "mmu:380728", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:2156184", "id": "2156184", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/NVCFLGD/", "id": "NVCFLGD", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=247304at2759", "id": "247304at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00520", "id": "PF00520", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF13426", "id": "PF13426", "database": "Pfam" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1296072", "id": "R-MMU-1296072", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074663.1", "id": "NP_001074663.1", "database": "RefSeq" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 111481.0, "chemical_mass": 111481.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2A5F7", "name": "Kcnh4", "locus": { "end_pos": 100740376, "strand": "-", "start_pos": 100759942, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000035355", "id": "ENSMUSG00000035355", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2A5F7", "type": "synonym", "resource": "UniProtKB", "name": "potassium Voltage-gated channel, subfamily H (Eag-related), member 4" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A5F7", "type": "synonym", "resource": "RefSeq", "name": "potassium voltage-gated channel subfamily H member 4" } ] }