{ "uniprot_canonical_ac": "A2AIV8-1", "ptm_annotation": [ { "annotation": "Phosphorylated at Thr-531 and Thr-531 by CK2 following interaction with VHL, leading to inhibit the ability to activate NF-kappa-B.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ] } ], "sequence": { "header": "sp|A2AIV8-1|CARD9_MOUSE Isoform 1 of Caspase recruitment domain-containing protein 9 OS=Mus musculus OX=10090 GN=Card9 PE=1 SV=1 CANONICAL=A2AIV8-1", "length": 536, "sequence": "MSDYENDDECWSTLESFRVKLISVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLVIRKRKVGVLLDILQRTGHKGYVAFLESLELYYPQLYRKVTGKEPARVFSMIIDASGESGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECELSSAELKRCKDENYELAMCLAHLSEEKGAALMRNRDLQLEVDRLRHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKDLLQARVQELQVSVQEGKLDRNSPYIQVLEEDWRQALQEHQKQVSTIFSLRKDLRQAETLRARCTEEKEMFELQCLALRKDAKMYKDRIEAILLQMEEVSIERDQAMASREELHAQCTQSFQDKDKLRKLVRELGEKADELQLQLFQTESRLLAAEGRLKQQQLDMLILSSDLEDSSPRNSQELSLPQDLEEDAQLSDKGVLADRESPEQPFMALNKEHLSLTHGMGPSSSEPPEKERRRLKESFENYRRKRALRKMQNSWRQGEGDRGNTTGSDNTDTEGS" }, "uniprot_id": "CARD9_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16862125", "type": [ "PubMed" ], "id": "16862125" } ], "title": "Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity.", "journal": "Nature", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" } ], "authors": "Peschel C., Finger K., Gross O., Ruland J., Gewies A., Sparwasser T., Forster I., Schafer M.", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17187069", "type": [ "PubMed" ], "id": "17187069" } ], "title": "The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens.", "journal": "Nat. Immunol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" } ], "authors": "Li H., Zhang Y., Wang D., Dong C., You Y., Lin X., Hsu Y.M., Duramad O., Qin X.F.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17450144", "type": [ "PubMed" ], "id": "17450144" } ], "title": "Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17.", "journal": "Nat. Immunol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" } ], "authors": "Gross O., Ruland J., Brown G.D., Reis e Sousa C., Schweighoffer E., Tybulewicz V., Robinson M.J., LeibundGut-Landmann S., Osorio F., Slack E.C., Tsoni S.V.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17486093", "type": [ "PubMed" ], "id": "17486093" } ], "title": "The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors.", "journal": "Nat. Immunol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" } ], "authors": "Hara H., Saito T., Takeuchi A., Imanishi T., Saijo S., Yoshida H., Shibuya A., Morris S.W., Penninger J.M., Xue L., Koseki H., Takai T., Iwakura Y., Inui M., Ishihara C., Ohno N.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17514206", "type": [ "PubMed" ], "id": "17514206" } ], "title": "All roads lead to CARD9.", "journal": "Nat. Immunol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "authors": "Colonna M.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18192506", "type": [ "PubMed" ], "id": "18192506" } ], "title": "Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-kappaB and MAPK activation to selectively control cytokine production.", "journal": "Blood", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" } ], "authors": "Gross O, Grupp C, Steinberg C, Zimmermann S, Strasser D, Hannesschlager N, Reindl W, Jonsson H, Huo H, Littman DR, Peschel C, Yokoyama WM, Krug A, Ruland J", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20538615", "type": [ "PubMed" ], "id": "20538615" } ], "title": "CARD9 mediates dectin-2-induced IkappaBalpha kinase ubiquitination leading to activation of NF-kappaB in response to stimulation by the hyphal form of Candida albicans.", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "authors": "Wu W., Zhu J., Lin X., Ariizumi K., Bi L., Hsu Y.M., Gojestani S.", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24960071", "type": [ "PubMed" ], "id": "24960071" } ], "title": "Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain.", "journal": "FEBS Lett.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "authors": "Rittinger K., Boyle J.P., Mayle S., Monie T.P., Parkhouse R., Sawmynaden K.", "date": "2014" } ], "uniprot_ac": "A2AIV8", "site_annotation": [ { "end_pos": 526, "annotation": "n_glycosylation_sequon", "start_pos": 524 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8#A2AIV8-1", "isoform_ac": "A2AIV8-1", "locus": { "end_pos": 26352315, "strand": "+", "start_pos": 26359547, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000028294", "id": "ENSMUST00000028294", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000028294", "id": "ENSMUSP00000028294", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AIV8-1|CARD9_MOUSE Isoform 1 of Caspase recruitment domain-containing protein 9 OS=Mus musculus OX=10090 GN=Card9 PE=1 SV=1 CANONICAL=A2AIV8-1", "length": 536, "sequence": "MSDYENDDECWSTLESFRVKLISVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLVIRKRKVGVLLDILQRTGHKGYVAFLESLELYYPQLYRKVTGKEPARVFSMIIDASGESGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECELSSAELKRCKDENYELAMCLAHLSEEKGAALMRNRDLQLEVDRLRHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKDLLQARVQELQVSVQEGKLDRNSPYIQVLEEDWRQALQEHQKQVSTIFSLRKDLRQAETLRARCTEEKEMFELQCLALRKDAKMYKDRIEAILLQMEEVSIERDQAMASREELHAQCTQSFQDKDKLRKLVRELGEKADELQLQLFQTESRLLAAEGRLKQQQLDMLILSSDLEDSSPRNSQELSLPQDLEEDAQLSDKGVLADRESPEQPFMALNKEHLSLTHGMGPSSSEPPEKERRRLKESFENYRRKRALRKMQNSWRQGEGDRGNTTGSDNTDTEGS" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:332579", "resource": "KEGG Pathway", "id": "mmu:332579", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5607764", "resource": "Reactome", "id": "R-MMU-5607764", "name": "CLEC7A (Dectin-1) signaling" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "annotation": "Activation of lymphoid and myeloid cells through Immunoreceptor tyrosine-based activation motifs-associated receptors or Toll-like receptors is regulated by CARMA1-Bcl-10 and CARD9-Bcl-10, respectively", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2AIV8#function", "annotation": "Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM-tyrosine kinase and the Toll-like receptors (TLR) and NOD2 signaling pathways (PubMed:17514206). Probably controls various innate immune response pathways depending on the intracellular pathogen. Controls CLEC7A (dectin-1)-mediated myeloid cell activation induced by the yeast cell wall component zymosan, leading to cytokine production and innate anti-fungal immunity: acts by regulating BCL10-MALT1-mediated NF-kappa-B activation pathway. Activates NF-kappa-B via BCL10 (PubMed:16862125). In response to the hyphal form of C.albicans, mediates CLEC6A (dectin-2)-induced I-kappa-B kinase ubiquitination, leading to NF-kappa-B activation via interaction with BCL10 (PubMed:20538615). In response to L.monocytogenes infection, acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B (PubMed:17187069). In response to fungal infection, may be required for the development and subsequent differentiation of interleukin 17-producing T helper (TH-17) cells (PubMed:17450144). Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (PubMed:17486093).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8#function", "id": "A2AIV8", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "annotation": "CARD9 has a critical function in Nod2-mediated activation of p38 and Jnk in innate immune responses to intracellular pathogens", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "annotation": "CARD9 mediates T cell inflammatory response in Coxsackievirus B3-induced acute myocarditis.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "annotation": "CARD9 mediates dendritic cell-induced development of Lyn deficiency-associated autoimmune and inflammatory diseases. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "annotation": "Card9 is a key transducer of Dectin-1 signalling, where Dectin-1 is the major mammalian pattern recognition receptor for the fungal component zymosan, in antifungal immunity", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "annotation": "Deletion of haematopoietic CARD9 induced minor alterations in plaque composition under hyperglycaemic conditions, without affecting lesion size.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "annotation": "Impairment of Th cell response in Card9 knockout mice with cutaneous mucormycosis caused by Rhizopus arrhizus.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "annotation": "Signaling through Syk and CARD9 can couple innate to adaptive immunity independently of Toll-like receptor signals", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q9EPY0-1", "protein_name": "Caspase recruitment domain-containing protein 9", "sequence": { "length": 536, "sequence": "MSDYENDDECWSALESFRVKLISVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLVIRKRKVGVLLDILQRTGHKGYVAFLESLELYYPQLYRKVTGKEPARVFSMIIDASGESGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECELSSAELKRCKDENYDLAMRLAHLSEEKGAALMRNRDLQLEVDQLRHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWDLQQERDLLQARVQELEVSVQEGKLHRNSPYIQVLEEDWRQALQEHQEQASTIFSLRKDLRQAEALRTRCMEEKEMFELQCLALRKDAKMYKDRIEAILQQMEEVSIERDQAMTSREELHAQCAQSFQDKDKLRKQVRELDEKADELQLQLFQTESRLLAAEGRLKQQQLDMLILSSDLEDSSPRNSQELSLPQDLEEDAQLSDKGVLADRESPEQPFVVLNKKHLSQTHDTVPSSSEPPEKERRRLKESFENYRRKRALRKMQNSWRQGEGDHGNTTGSDNTDTEGS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/14150", "id": "14150", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2AIV8/", "id": "A2AIV8", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q9H257-1", "protein_name": "Caspase recruitment domain-containing protein 9", "sequence": { "length": 536, "sequence": "MSDYENDDECWSVLEGFRVTLTSVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLVIRKRKVGVLLDILQRTGHKGYVAFLESLELYYPQLYKKVTGKEPARVFSMIIDASGESGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPPEKERRRLKESFENYRRKRALRKMQKGWRQGEEDRENTTGSDNTDTEGS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/14150", "id": "14150", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "ac": "NP_001032836.1", "name": "caspase recruitment domain-containing protein 9", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "protein domain specific binding", "id": "GO:0019904" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "identical protein binding", "id": "GO:0042802" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "protein homodimerization activity", "id": "GO:0042803" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050700", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "CARD domain binding", "id": "GO:0050700" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "protein-containing complex", "id": "GO:0032991" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042493", "pmid": "17187069", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "response to drug", "id": "GO:0042493" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046330", "pmid": "17187069", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "positive regulation of JNK cascade", "id": "GO:0046330" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050830", "pmid": "17187069", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "defense response to Gram-positive bacterium", "id": "GO:0050830" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "pmid": "17187069", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "defense response to virus", "id": "GO:0051607" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032755", "pmid": "17187069", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "positive regulation of interleukin-6 production", "id": "GO:0032755" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032675", "pmid": "16862125", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "regulation of interleukin-6 production", "id": "GO:0032675" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043123", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "positive regulation of I-kappaB kinase/NF-kappaB signaling", "id": "GO:0043123" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032760", "pmid": "17187069", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "positive regulation of tumor necrosis factor production", "id": "GO:0032760" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043330", "pmid": "17187069", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "response to exogenous dsRNA", "id": "GO:0043330" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009620", "pmid": "16862125", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "response to fungus", "id": "GO:0009620" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045089", "pmid": "17187069", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "positive regulation of innate immune response", "id": "GO:0045089" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032494", "pmid": "17187069", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "response to peptidoglycan", "id": "GO:0032494" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032495", "pmid": "17187069", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "response to muramyl dipeptide", "id": "GO:0032495" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032874", "pmid": "17187069", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "positive regulation of stress-activated MAPK cascade", "id": "GO:0032874" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042534", "pmid": "16862125", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "regulation of tumor necrosis factor biosynthetic process", "id": "GO:0042534" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032663", "pmid": "16862125", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "regulation of interleukin-2 production", "id": "GO:0032663" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043280", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "positive regulation of cysteine-type endopeptidase activity involved in apoptotic process", "id": "GO:0043280" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "innate immune response", "id": "GO:0045087" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007249", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "name": "I-kappaB kinase/NF-kappaB signaling", "id": "GO:0007249" } ], "total": 19, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AIV8", "type": "synonym", "resource": "RefSeq", "name": "Card9" }, { "url": "https://www.uniprot.org/uniprot/A2AIV8", "type": "recommended", "resource": "UniProtKB", "name": "Card9" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AIV8", "type": "synonym", "resource": "RefSeq", "name": "Gm782" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000026928", "id": "ENSMUSG00000026928", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08809", "id": "cd08809", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/332579", "id": "332579", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AIV8*", "id": "A2AIV8", "database": "IntAct" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001315", "id": "IPR001315", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011029", "id": "IPR011029", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR042142", "id": "IPR042142", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:332579", "id": "mmu:332579", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:2685628", "id": "2685628", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/QTAKKDC/", "id": "QTAKKDC", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=115953at2759", "id": "115953at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00619", "id": "PF00619", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AIV8", "id": "PR_A2AIV8", "database": "PRO" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5607764", "id": "R-MMU-5607764", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032836.1", "id": "NP_001032836.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Thr", "kinase_gene_name": "Atxn7l3b", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22265677", "id": "22265677", "database": "PubMed" } ], "start_pos": "231", "end_pos": "231", "kinase_uniprot_canonical_ac": "Q3UD01-1" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "start_pos": "277", "end_pos": "277", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "start_pos": "2", "end_pos": "2", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "Atxn7l3b", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22265677", "id": "22265677", "database": "PubMed" } ], "start_pos": "303", "end_pos": "303", "kinase_uniprot_canonical_ac": "Q3UD01-1" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "start_pos": "424", "end_pos": "424", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "start_pos": "425", "end_pos": "425", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "Atxn7l3b", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "start_pos": "431", "end_pos": "431", "kinase_uniprot_canonical_ac": "Q3UD01-1" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "start_pos": "431", "end_pos": "431", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "start_pos": "451", "end_pos": "451", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "Atxn7l3b", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "start_pos": "461", "end_pos": "461", "kinase_uniprot_canonical_ac": "Q3UD01-1" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "start_pos": "461", "end_pos": "461", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "start_pos": "483", "end_pos": "483", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "start_pos": "498", "end_pos": "498", "kinase_uniprot_canonical_ac": "" }, { "residue": "Thr", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "start_pos": "531", "end_pos": "531", "kinase_uniprot_canonical_ac": "" }, { "residue": "Thr", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "id": "A2AIV8", "database": "UniProtKB" } ], "start_pos": "533", "end_pos": "533", "kinase_uniprot_canonical_ac": "" }, { "residue": "Thr", "kinase_gene_name": "Atxn7l3b", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22265677", "id": "22265677", "database": "PubMed" } ], "start_pos": "95", "end_pos": "95", "kinase_uniprot_canonical_ac": "Q3UD01-1" } ], "mass": { "monoisotopic_mass": 62462.0, "chemical_mass": 62462.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "name": "Card9", "locus": { "end_pos": 26352176, "strand": "-", "start_pos": 26360918, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000026928", "id": "ENSMUSG00000026928", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2AIV8", "type": "recommended", "resource": "UniProtKB", "name": "Caspase recruitment domain-containing protein 9" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AIV8", "type": "synonym", "resource": "RefSeq", "name": "caspase recruitment domain-containing protein 9" } ] }