{ "uniprot_canonical_ac": "A2A6C4-1", "ptm_annotation": [ { "annotation": "Glycosylated.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A6C4", "id": "A2A6C4", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/P49768", "id": "P49768", "database": "PubMed" } ] } ], "sequence": { "header": "sp|A2A6C4-1|SPP2C_MOUSE Isoform 1 of Signal peptide peptidase-like 2C OS=Mus musculus OX=10090 GN=Sppl2c PE=2 SV=1 CANONICAL=A2A6C4-1", "length": 690, "sequence": "MACLGSLHPLGSLLLLFLLLLLSPEARGEYGLVRVVSKNWSKDYCVLYSSDYVNLPRDLHHAPLLSLHDGTKTPWCPDEDSFHQAQDSSPRQRPLHQTTTMVTRGNCSFYAKGWLAQDQGAQGLLIVSRARNQQCSDTISKPQDPSKPWPALTIPVAVLRYTDMLDIVSHTYGDTDVRVAMFAPLEPVTDYNMAIIFILAVGTVAAGGYWAGLMEANKLQRRQAQRGGGLGGHNQQQTVAAERSQRAWEDDDFEDAPMDFTPAMTGAVVTMSCSIMILLYFFYDCFVYVMIGIFSLGASTGLYSCLAPILCHLPLWRYQWVLPGQRVSVTWPLLLLAGLCAMVTVLWVIHRNEDHWAWLLQDTLGVAYCLFVLRRVRLPTFKNCTLFLLALLAFDVFFVFITPLFTKTGESIMVEVASGPADSSSHERLPMVLKVPRLSFSALTLCNQPFSILGFGDIVVPGFLVAYCHRFDMQVQSRQVYYMACTVAYAVGLLVTFVAMILMQMGQPALLYLVSSTLLTSLAVATCRQEFTLFWTGQGRAKIPAEPVAQPCIASAVGSKMKLEDAKDSRTTNRFEQAVDGESGDLESSTGDDMAEMVTLSEDEATSPEGHSESSEGWSDTNLDPNELPSGSPMALEAMLIPLIQPIPHPSELGHIRTQSRVHDSSLPWMGLHKRKGLKVKKSMSAQAPL" }, "uniprot_id": "SPP2C_MOUSE", "enzyme_annotation": [ { "ec": "3.4.23.-", "activity": "" } ], "glycation": [], "keywords": [ "glycoprotein", "predicted.uniprotkb_gly" ], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A6C4", "id": "A2A6C4", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30733280", "type": [ "PubMed" ], "id": "30733280" } ], "title": "The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban.", "journal": "EMBO reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076004.1", "id": "NP_001076004.1", "database": "RefSeq" } ], "authors": "Niemeyer J, Mentrup T, Heidasch R, Muller SA, Biswas U, Meyer R, Papadopoulou AA, Dederer V, Haug-Kroper M, Adamski V, Lullmann-Rauch R, Bergmann M, Mayerhofer A, Saftig P, Wennemuth G, Jessberger R, Fluhrer R, Lichtenthaler SF, Lemberg MK, Schroder B", "date": "2019" } ], "uniprot_ac": "A2A6C4", "site_annotation": [ { "end_pos": 108, "annotation": "n_glycosylation_sequon", "start_pos": 106 }, { "end_pos": 385, "annotation": "n_glycosylation_sequon", "start_pos": 383 }, { "end_pos": 41, "annotation": "n_glycosylation_sequon", "start_pos": 39 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A6C4#A2A6C4-1", "isoform_ac": "A2A6C4-1", "locus": { "end_pos": 104186376, "strand": "-", "start_pos": 104188445, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000107000", "id": "ENSMUST00000107000", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000102613", "id": "ENSMUSP00000102613", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2A6C4-1|SPP2C_MOUSE Isoform 1 of Signal peptide peptidase-like 2C OS=Mus musculus OX=10090 GN=Sppl2c PE=2 SV=1 CANONICAL=A2A6C4-1", "length": 690, "sequence": "MACLGSLHPLGSLLLLFLLLLLSPEARGEYGLVRVVSKNWSKDYCVLYSSDYVNLPRDLHHAPLLSLHDGTKTPWCPDEDSFHQAQDSSPRQRPLHQTTTMVTRGNCSFYAKGWLAQDQGAQGLLIVSRARNQQCSDTISKPQDPSKPWPALTIPVAVLRYTDMLDIVSHTYGDTDVRVAMFAPLEPVTDYNMAIIFILAVGTVAAGGYWAGLMEANKLQRRQAQRGGGLGGHNQQQTVAAERSQRAWEDDDFEDAPMDFTPAMTGAVVTMSCSIMILLYFFYDCFVYVMIGIFSLGASTGLYSCLAPILCHLPLWRYQWVLPGQRVSVTWPLLLLAGLCAMVTVLWVIHRNEDHWAWLLQDTLGVAYCLFVLRRVRLPTFKNCTLFLLALLAFDVFFVFITPLFTKTGESIMVEVASGPADSSSHERLPMVLKVPRLSFSALTLCNQPFSILGFGDIVVPGFLVAYCHRFDMQVQSRQVYYMACTVAYAVGLLVTFVAMILMQMGQPALLYLVSSTLLTSLAVATCRQEFTLFWTGQGRAKIPAEPVAQPCIASAVGSKMKLEDAKDSRTTNRFEQAVDGESGDLESSTGDDMAEMVTLSEDEATSPEGHSESSEGWSDTNLDPNELPSGSPMALEAMLIPLIQPIPHPSELGHIRTQSRVHDSSLPWMGLHKRKGLKVKKSMSAQAPL" } }, { "url": "https://www.uniprot.org/uniprot/A2A6C4#A2A6C4-2", "isoform_ac": "A2A6C4-2", "locus": { "end_pos": 104186376, "strand": "-", "start_pos": 104190738, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000059448", "id": "ENSMUST00000059448", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000091453", "id": "ENSMUSP00000091453", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2A6C4-2|SPP2C_MOUSE Isoform 2 of Signal peptide peptidase-like 2C OS=Mus musculus OX=10090 GN=Sppl2c PE=2 SV=1 CANONICAL=A2A6C4-1", "length": 581, "sequence": "MACLGSLHPLGSLLLLFLLLLLSPEARGEYGLVRVVSKNWSKDYCVLYSSDYVNLPRDLHHAPLLSLHDGTKTPWCPDEDSFHQAQDSSPRQRPLHQTTTMVTRGNCSFYAKGWLAQDQGAQGLLIVSRARNQQCSDTISKPQDPSKPWPALTIPVAVLRYTDMLDIVSHTYGDTDVRVAMFAPLEPVTDYNMAIIFILAVGTVAAGGYWAGLMEANKLQRRQAQRGGGLGGHNQQQTVAAERSQRAWEDDDFEDAPMDFTPAMTGAVVTMSCSIMILLYFFYDCFVYVMIGIFSLGASTGLYSCLAPILCHLPLWRYQWVLPGQRVSVTWPLLLLAGLCAMVTVLWVIHRNEDHWAWLLQDTLGVAYCLFVLRRVRLPTFKNCTLFLLALLAFDVFFVFITPLFTKTGESIMVEVASGPADSSSHERLPMVLKVPRLSFSALTLCNQPFSILGFGDIVVPGFLVAYCHRFDMQVQSRQVYYMACTVAYAVGLLVTFVAMILMQMGQPALLYLVSSTLLTSLAVATCRQEFTLFWTGQGRAKIPAEPVAQPCIASAVGSKMKLEDAKDSRTTNRMPEEDFV" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:237958", "resource": "KEGG Pathway", "id": "mmu:237958", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2A6C4#function", "annotation": "Intramembrane-cleaving aspartic protease (I-CLiP) that may be able to cleave type II membrane signal peptides in the hydrophobic plane of the membrane.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A6C4#function", "id": "A2A6C4", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076004.1", "annotation": "The sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA2)-regulating protein phospholamban (PLN) is identified as a physiological SPPL2c substrate.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076004.1", "id": "NP_001076004.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076004.1", "annotation": "These data suggest involvement of SPPL2c in acrosome formation during spermatogenesis. Erratum:[EMBO Rep. 2019 May;20(5):. PMID: 31061204]", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076004.1", "id": "NP_001076004.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "M0R9B3-1", "protein_name": "Signal peptide peptidase-like 2C", "sequence": { "length": 605, "sequence": "MACLGSLLPIGSLLLLLLSPEARGEYGVVRVVSKNWNKDYCVLYSSDYVTLPRDLSHAPLLPLHDGTKTPWCPDEDSFHQAQDSSLSQRPLHQTTTMVVRGNCSFYAKGWLAQDHGAHGLLIVSRASNQQCSDTTSKPQDPSKPRPALTIPVAVLRYTDMLDILSHTYGDTNVHIAMYAPLEPIIDYNMVIIFILAVGTVAAGGYWAGLMEADRLQRHQARRGGGFGGHNQSQTVSAERSPRAWKEEDYEDAAVDFTPAMTGAVVTMSCSIMVLLYFFYDCFVYIMIGIFGLGASTGLYSCLAPIVRYLPLWQHQWVLPGHRASVKLSLLLLAGLCAMVTVLWVIYRNEDRWAWLLQDTLGVAYCLFVLRRVRLPTLKNCTSFLLALLAFDVFFVFITPLFTKTGESIMVEVASGPVDSSSHERLPMVLKVPRMSFSALTLCDQPFSILGFGDIVVPGFLVAYCHRFDVQIQSRQVYYRACTVAYAMGLLVTFVAMVLMQMGQPALLYLVSSTLLTSLVVATCRQELTLFWTGQGRAKIPAEPVVQPCIVSAVACRMKLEGVKDSRVTNRKTPAPGNQEASFKPQLTWLPEPSAQGPDISPCPCP" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/18491", "id": "18491", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q8IUH8-1", "protein_name": "Signal peptide peptidase-like 2C", "sequence": { "length": 684, "sequence": "MACLGFLLPVGFLLLISTVAGGKYGVAHVVSENWSKDYCILFSSDYITLPRDLHHAPLLPLYDGTKAPWCPGEDSPHQAQLRSPSQRPLRQTTAMVMRGNCSFHTKGWLAQGQGAHGLLIVSRVSDQQCSDTTLAPQDPRQPLADLTIPVAMLHYADMLDILSHTRGEAVVRVAMYAPPEPIIDYNMLVIFILAVGTVAAGGYWAGLTEANRLQRRRARRGGGSGGHHQLQEAAAAEGAQKEDNEDIPVDFTPAMTGVVVTLSCSLMLLLYFFYDHFVYVTIGIFGLGAGIGLYSCLSPLVCRLSLRQYQRPPHSLWASLPLPLLLLASLCATVIIFWVAYRNEDRWAWLLQDTLGISYCLFVLHRVRLPTLKNCSSFLLALLAFDVFFVFVTPFFTKTGESIMAQVALGPAESSSHERLPMVLKVPRLRVSALTLCSQPFSILGFGDIVVPGFLVAYCCRFDVQVCSRQIYFVACTVAYAVGLLVTFMAMVLMQMGQPALLYLVSSTLLTSLAVAACRQELSLFWTGQGRAKMCGLGCAPSAGSRQKQEGAADAHTASTLERGTSRGAGDLDSNPGEDTTEIVTISENEATNPEDRSDSSEGWSDAHLDPNELPFIPPGASEELMPLMPMAMLIPLMPLMPPPSELGHVHAQAQAHETGLPWAGLHKRKGLKVRKSMSTQAPL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/18491", "id": "18491", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076004.1", "ac": "NP_001076004.1", "name": "signal peptide peptidase-like 2C isoform b precursor", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042500", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A6C4", "id": "A2A6C4", "database": "UniProtKB" } ], "name": "aspartic endopeptidase activity, intramembrane cleaving", "id": "GO:0042500" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A6C4", "id": "A2A6C4", "database": "UniProtKB" } ], "name": "protein homodimerization activity", "id": "GO:0042803" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A6C4", "id": "A2A6C4", "database": "UniProtKB" } ], "name": "lysosomal membrane", "id": "GO:0005765" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030660", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A6C4", "id": "A2A6C4", "database": "UniProtKB" } ], "name": "Golgi-associated vesicle membrane", "id": "GO:0030660" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071458", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A6C4", "id": "A2A6C4", "database": "UniProtKB" } ], "name": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "id": "GO:0071458" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A6C4", "id": "A2A6C4", "database": "UniProtKB" } ], "name": "endoplasmic reticulum membrane", "id": "GO:0005789" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071556", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A6C4", "id": "A2A6C4", "database": "UniProtKB" } ], "name": "integral component of lumenal side of endoplasmic reticulum membrane", "id": "GO:0071556" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033619", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A6C4", "id": "A2A6C4", "database": "UniProtKB" } ], "name": "membrane protein proteolysis", "id": "GO:0033619" } ], "total": 1, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A6C4", "type": "synonym", "resource": "RefSeq", "name": "4933407P14Rik; IMP5" }, { "url": "https://www.uniprot.org/uniprot/A2A6C4", "type": "synonym", "resource": "UniProtKB", "name": "Imp5" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A6C4", "type": "synonym", "resource": "RefSeq", "name": "Sppl2c" }, { "url": "https://www.uniprot.org/uniprot/A2A6C4", "type": "recommended", "resource": "UniProtKB", "name": "Sppl2c" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000049506", "id": "ENSMUSG00000049506", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/237958", "id": "237958", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR006639", "id": "IPR006639", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR007369", "id": "IPR007369", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR033150", "id": "IPR033150", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:237958", "id": "mmu:237958", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:3045264", "id": "3045264", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/AQGEYGV/", "id": "AQGEYGV", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=535101at2759", "id": "535101at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12174", "id": "PTHR12174", "database": "PANTHER" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12174:SF38", "id": "PTHR12174:SF38", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF04258", "id": "PF04258", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2A6C4", "id": "PR_A2A6C4", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076004.1", "id": "NP_001076004.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2A6C4", "id": "A2A6C4", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [ { "residue": "Asn", "site_category": "predicted", "end_pos": 106, "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A6C4#ptm_processing", "id": "A2A6C4", "database": "UniProtKB" } ], "subtype": "", "relation": "attached", "start_pos": 106, "glytoucan_ac": "", "type": "N-linked" } ], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 76266.0, "chemical_mass": 76266.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2A6C4", "name": "Sppl2c", "locus": { "end_pos": 104191163, "strand": "+", "start_pos": 104186327, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000049506", "id": "ENSMUSG00000049506", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2A6C4", "type": "synonym", "resource": "UniProtKB", "name": "3.4.23.-" }, { "url": "https://www.uniprot.org/uniprot/A2A6C4", "type": "synonym", "resource": "UniProtKB", "name": "IMP-5" }, { "url": "https://www.uniprot.org/uniprot/A2A6C4", "type": "synonym", "resource": "UniProtKB", "name": "Intramembrane protease 5" }, { "url": "https://www.uniprot.org/uniprot/A2A6C4", "type": "synonym", "resource": "UniProtKB", "name": "SPP-like 2C" }, { "url": "https://www.uniprot.org/uniprot/A2A6C4", "type": "synonym", "resource": "UniProtKB", "name": "SPPL2c" }, { "url": "https://www.uniprot.org/uniprot/A2A6C4", "type": "recommended", "resource": "UniProtKB", "name": "Signal peptide peptidase-like 2C" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A6C4", "type": "synonym", "resource": "RefSeq", "name": "signal peptide peptidase-like 2C isoform b precursor" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A6C4", "type": "synonym", "resource": "RefSeq", "name": "signal peptide peptidase-like 2C; ortholog of human intramembrane protease 5 IMP5; IMP-5; protein SPPL2c; protein SPP-like 2C" } ] }