{ "uniprot_canonical_ac": "A0PJX4-1", "ptm_annotation": [], "sequence": { "header": "sp|A0PJX4-1|SHSA3_HUMAN Isoform 1 of Protein shisa-3 homolog OS=Homo sapiens OX=9606 GN=SHISA3 PE=1 SV=1 CANONICAL=A0PJX4-1", "length": 238, "sequence": "MRALLALCLLLGWLRWGPAGAQQSGEYCHGWVDVQGNYHEGFQCPEDFDTLDATICCGSCALRYCCAAADARLEQGGCTNDRRELEHPGITAQPVYVPFLIVGSIFIAFIILGSVVAIYCCTCLRPKEPSQQPIRFSLRSYQTETLPMILTSTSPRAPSRQSSTATSSSSTGGSIRRFSFARAEPGCLVPSPPPPYTTSHSIHLAQPSGFLVSPQYFAYPLQQEPPLPGKSCPDFSSS" }, "uniprot_id": "SHSA3_HUMAN", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Human", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0PJX4", "id": "A0PJX4", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17481602", "type": [ "PubMed" ], "id": "17481602" } ], "title": "Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings.", "journal": "Developmental biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "id": "NP_001073974.1", "database": "RefSeq" } ], "authors": "Furushima K, Yamamoto A, Nagano T, Shibata M, Miyachi H, Abe T, Ohshima N, Kiyonari H, Aizawa S", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22120523", "type": [ "PubMed" ], "id": "22120523" } ], "title": "Unexpected diversity in Shisa-like proteins suggests the importance of their roles as transmembrane adaptors.", "journal": "Cellular signalling", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "id": "NP_001073974.1", "database": "RefSeq" } ], "authors": "Pei J, Grishin NV", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25036006", "type": [ "PubMed" ], "id": "25036006" } ], "title": "Shisa3 is associated with prolonged survival through promoting beta-catenin degradation in lung cancer.", "journal": "American journal of respiratory and critical care medicine", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "id": "NP_001073974.1", "database": "RefSeq" } ], "authors": "Chen CC, Chen HY, Su KY, Hong QS, Yan BS, Chen CH, Pan SH, Chang YL, Wang CJ, Hung PF, Yuan S, Chang GC, Chen JJ, Yang PC, Yang YC, Yu SL", "date": "2014" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25968618", "type": [ "PubMed" ], "id": "25968618" } ], "title": "DNA Hypermethylation of SHISA3 in Colorectal Cancer: An Independent Predictor of Poor Prognosis.", "journal": "Annals of surgical oncology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "id": "NP_001073974.1", "database": "RefSeq" } ], "authors": "Tsai MH, Chen WC, Yu SL, Chen CC, Jao TM, Huang CY, Tzeng ST, Yen SJ, Yang YC", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28299336", "type": [ "PubMed" ], "id": "28299336" } ], "title": "SHISA3 Promoter Methylation Is a Potential Diagnostic and Prognostic Biomarker for Laryngeal Squamous Cell Carcinoma.", "journal": "BioMed research international", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "id": "NP_001073974.1", "database": "RefSeq" } ], "authors": "Shen Z, Zhou C, Li J, Ye D, Deng H, Cao B, Hao W, Lin L, Zhang Y", "date": "2017" } ], "uniprot_ac": "A0PJX4", "site_annotation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0PJX4#A0PJX4-1", "isoform_ac": "A0PJX4-1", "locus": { "end_pos": 42398057, "strand": "-", "start_pos": 42401448, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000319234", "id": "ENST00000319234", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000326445", "id": "ENSP00000326445", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A0PJX4-1|SHSA3_HUMAN Isoform 1 of Protein shisa-3 homolog OS=Homo sapiens OX=9606 GN=SHISA3 PE=1 SV=1 CANONICAL=A0PJX4-1", "length": 238, "sequence": "MRALLALCLLLGWLRWGPAGAQQSGEYCHGWVDVQGNYHEGFQCPEDFDTLDATICCGSCALRYCCAAADARLEQGGCTNDRRELEHPGITAQPVYVPFLIVGSIFIAFIILGSVVAIYCCTCLRPKEPSQQPIRFSLRSYQTETLPMILTSTSPRAPSRQSSTATSSSSTGGSIRRFSFARAEPGCLVPSPPPPYTTSHSIHLAQPSGFLVSPQYFAYPLQQEPPLPGKSCPDFSSS" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:152573", "resource": "KEGG Pathway", "id": "hsa:152573", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "annotation": "Down-regulation of SHISA3 expression was associated with colorectal cancer.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "id": "NP_001073974.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "annotation": "For TKI-resistant PC9/ER tumors in nod-scid mice, overexpressed shisa3 had a significant inhibitory effect. In addition, we verified that shisa3 inhibited EGFR-TKI resistance by interacting with FGFR1/3 to regulate AKT/mTOR signaling. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "id": "NP_001073974.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "annotation": "Low Shisa3 expression is associated with Nasopharyngeal Carcinoma Metastasis.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "id": "NP_001073974.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A0PJX4#function", "annotation": "Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0PJX4#function", "id": "A0PJX4", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "annotation": "SHISA3 promoter hypermethylation might increase the risk of LSCC through regulation of gene expression and is a potential diagnostic and prognostic biomarker for laryngeal squamous cell carcinoma", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "id": "NP_001073974.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "annotation": "SHISA3, an antagonist of the Wnt/beta-catenin signaling, is epigenetically silenced and its ectopic expression suppresses growth in breast cancer. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "id": "NP_001073974.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "B5DF81-1", "protein_name": "Similar to MGC68837 protein (Predicted)", "sequence": { "length": 238, "sequence": "MGALLALCLLVGLLRWGPAGAQQPGEYCHGWVDAQGNYHEGFQCPEDFDTQDATICCGSCALRYCCAAADARLEQGGCTNDRGELEHPGITAQPVYVPFLIVGSIFIAFIILGSLVAIYCCTCLRPKEPSQQPIRFSLRSYQTETLPMILTSTSLRTASRQSSTATSSSSTGGSVRRFSFARAEPNCLVPSSPPPYTTGHTIHLTQPSGFLVSPQYFAYPLQQEPPLPGKSCPDFSSS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/47831", "id": "47831", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0PJX4/", "id": "A0PJX4", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q3UPR0-1", "protein_name": "Protein shisa-3 homolog", "sequence": { "length": 238, "sequence": "MGALLAFCLLVGLLRWGPAGAQQPGEYCHGWVDAQGNYHEGFQCPEDFDTQDATICCGSCALRYCCAAADARLEQGGCTNDRGELEHPGITAQPVYVPFLIVGSIFIAFIILGSLVAIYCCTCLRPKEPSQQPIRFSLRSYQTETLPMILTSTSLRAASRQSSTATSSSSTGGSVRRFSFARAEPSCLVPSSPPPYTTGHTIHLTQPSGFLVSPQYFAYPLQQEPPLPGKSCPDFSSS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/47831", "id": "47831", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0PJX4/", "id": "A0PJX4", "database": "OMA" } ], "common_name": "Mouse", "organism": "Mus musculus", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [ { "sequence_org": "W", "start_pos": 13, "alt_nt": "T", "chr_id": "4", "ref_nt": "G", "chr_pos": "42400112", "disease": [ { "synonyms": [], "recommended_name": { "id": "DOID:9256", "url": "http://disease-ontology.org/term/DOID:9256", "resource": "Disease Ontology", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." } } ], "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0PJX4", "id": "A0PJX4", "database": "BioMuta" } ], "glycoeffect": [], "frequency": "1.2", "sequence_mut": "C", "subjects_tested": "254", "keywords": [ "biomuta", "somatic", "cancer", "disease" ], "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (1.2%).", "end_pos": 13, "minor_allelic_frequency": "", "subjects_positive": "3" }, { "sequence_org": "R", "start_pos": 160, "alt_nt": "G", "chr_id": "4", "ref_nt": "C", "chr_pos": "42403229", "disease": [ { "synonyms": [], "recommended_name": { "id": "DOID:1324", "url": "http://disease-ontology.org/term/DOID:1324", "resource": "Disease Ontology", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." } } ], "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0PJX4", "id": "A0PJX4", "database": "BioMuta" } ], "glycoeffect": [], "frequency": "1.5", "sequence_mut": "G", "subjects_tested": "66", "keywords": [ "biomuta", "somatic", "cancer", "disease" ], "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (1.5%).", "end_pos": 160, "minor_allelic_frequency": "", "subjects_positive": "1" }, { "sequence_org": "G", "start_pos": 58, "alt_nt": "A", "chr_id": "4", "ref_nt": "G", "chr_pos": "42400245", "disease": [ { "synonyms": [ { "id": "DOID:1781", "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "name": "thyroid neoplasm", "description": "" } ], "recommended_name": { "id": "DOID:1781", "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "name": "thyroid gland cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." } } ], "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0PJX4", "id": "A0PJX4", "database": "BioMuta" } ], "glycoeffect": [], "frequency": "2.0", "sequence_mut": "S", "subjects_tested": "50", "keywords": [ "biomuta", "somatic", "cancer", "disease" ], "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (2.0%).", "end_pos": 58, "minor_allelic_frequency": "", "subjects_positive": "1" }, { "sequence_org": "A", "start_pos": 6, "alt_nt": "A", "chr_id": "4", "ref_nt": "C", "chr_pos": "42400090", "disease": [ { "synonyms": [], "recommended_name": { "id": "DOID:1324", "url": "http://disease-ontology.org/term/DOID:1324", "resource": "Disease Ontology", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." } } ], "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0PJX4", "id": "A0PJX4", "database": "BioMuta" } ], "glycoeffect": [], "frequency": "1.5", "sequence_mut": "E", "subjects_tested": "66", "keywords": [ "biomuta", "somatic", "cancer", "disease" ], "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (1.5%).", "end_pos": 6, "minor_allelic_frequency": "", "subjects_positive": "1" } ], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "ac": "NP_001073974.1", "name": "protein shisa-3 homolog precursor", "summary": "This gene encodes a single-transmembrane protein which is one of nine members of a family of transmembrane adaptors that modulate both WNT and FGF signaling by blocking the maturation and transport of their receptors to the cell surface. Members of this family contain an N-terminal cysteine-rich domain with a distinct cysteine pattern, a single transmembrane domain, and a C-terminal proline-rich, low complexity region. The encoded protein acts as a tumor suppressor by accelerating beta-catenin degradation. [provided by RefSeq, Jul 2017]." }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0PJX4", "id": "A0PJX4", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0PJX4", "id": "A0PJX4", "database": "UniProtKB" } ], "name": "endoplasmic reticulum membrane", "id": "GO:0005789" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007275", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0PJX4", "id": "A0PJX4", "database": "UniProtKB" } ], "name": "multicellular organism development", "id": "GO:0007275" } ], "total": 1, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0PJX4", "type": "synonym", "resource": "RefSeq", "name": "SHISA3" }, { "url": "https://www.uniprot.org/uniprot/A0PJX4", "type": "recommended", "resource": "UniProtKB", "name": "SHISA3" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0PJX4", "type": "synonym", "resource": "RefSeq", "name": "hShisa3" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000178343", "id": "ENSG00000178343", "database": "Bgee" }, { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0PJX4", "id": "A0PJX4", "database": "BioMuta" }, { "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=SHISA3", "id": "SHISA3", "database": "GeneCards" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/152573", "id": "152573", "database": "GeneID" }, { "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=25159", "id": "25159", "database": "HGNC" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A0PJX4*", "id": "A0PJX4", "database": "IntAct" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR026910", "id": "IPR026910", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:152573", "id": "hsa:152573", "database": "KEGG Pathway" }, { "url": "http://www.omim.org/entry/617325", "id": "617325", "database": "MIM" }, { "url": "https://www.nextprot.org/entry/NX_A0PJX4", "id": "NX_A0PJX4", "database": "neXtProt" }, { "url": "https://omabrowser.org/oma/group/PYFGYPL/", "id": "PYFGYPL", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=1325567at2759", "id": "1325567at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31395", "id": "PTHR31395", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF13908", "id": "PF13908", "database": "Pfam" }, { "url": "https://pharos.nih.gov/targets/A0PJX4", "id": "A0PJX4", "database": "PHAROS" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A0PJX4", "id": "PR_A0PJX4", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "id": "NP_001073974.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A0PJX4", "id": "A0PJX4", "database": "UniProtKB" } ], "expression_disease": [ { "name": "Prostate cancer [DO disease name]", "trend": "Up", "disease": [ { "synonyms": [ { "id": "DOID:10283", "url": "http://disease-ontology.org/term/DOID:10283", "resource": "Disease Ontology", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "url": "http://disease-ontology.org/term/DOID:10283", "resource": "Disease Ontology", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "url": "http://disease-ontology.org/term/DOID:10283", "resource": "Disease Ontology", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "url": "http://disease-ontology.org/term/DOID:10283", "resource": "Disease Ontology", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "url": "http://disease-ontology.org/term/DOID:10283", "resource": "Disease Ontology", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "url": "http://disease-ontology.org/term/DOID:10283", "resource": "Disease Ontology", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "url": "http://disease-ontology.org/term/DOID:10283", "resource": "Disease Ontology", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "url": "http://disease-ontology.org/term/DOID:10283", "resource": "Disease Ontology", "name": "tumor of the prostate", "description": "" } ], "recommended_name": { "id": "DOID:10283", "url": "http://disease-ontology.org/term/DOID:10283", "resource": "Disease Ontology", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." } } ], "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0PJX4", "id": "A0PJX4", "database": "BioXpress" } ], "url": "http://disease-ontology.org/term/DOID:10283", "significant": "No" }, { "name": "Urinary bladder cancer [DO disease name]", "trend": "Down", "disease": [ { "synonyms": [ { "id": "DOID:11054", "url": "http://disease-ontology.org/term/DOID:11054", "resource": "Disease Ontology", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "url": "http://disease-ontology.org/term/DOID:11054", "resource": "Disease Ontology", "name": "tumor of the bladder", "description": "" } ], "recommended_name": { "id": "DOID:11054", "url": "http://disease-ontology.org/term/DOID:11054", "resource": "Disease Ontology", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." } } ], "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0PJX4", "id": "A0PJX4", "database": "BioXpress" } ], "url": "http://disease-ontology.org/term/DOID:11054", "significant": "Yes" }, { "name": "Thyroid gland cancer [DO disease name]", "trend": "Down", "disease": [ { "synonyms": [ { "id": "DOID:1781", "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "url": 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