{ "uniprot_canonical_ac": "A0JPI9-1", "ptm_annotation": [], "sequence": { "header": "sp|A0JPI9-1|LR74A_RAT Isoform 1 of Leucine-rich repeat-containing protein 74A OS=Rattus norvegicus OX=10116 GN=Lrrc74a PE=2 SV=1 CANONICAL=A0JPI9-1", "length": 479, "sequence": "MDDDDIEPLEYETKDETEAALAPQSSEDTLYCEAEAAPSVEKEKPTREDSETDLEIEDTEKFFSIGQKELYLEACKLVGVVPVSYFIRNMEESCMNLNHHGLGPMGIKAIAITLVSNTTVLKLELEDNSIQEEGILSLMEMLHENYYLQELNVSDNNLGLEGARIISDFLQENNSSLWKLKLSGNKFKEECALLLCQALSSNYRIRSLNLSHNEFSDTAGEYLGQMLALNVGLQSLNLSWNHFNVRGAVALCNGLRTNVTLKKLDVSMNGFGNDGALALGDTLKLNSCLVYVDVSRNGITNEGASRISKGLENNECLQVLKLFLNPVSLEGAYSLILAIKRNPKSRMEDLDISNVLVSEQFVKVLDGVCAIHPQLDVVYKGLQGLSTKKTVSLETNPIKLIQNYTDQNKISVVEFFKSLNPSGLMTMPVGDFRKAIIQQTNIPINRYQARELIKKLEEKNGMVNFSGFKSLKVTAAGQL" }, "uniprot_id": "LR74A_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPI9", "id": "A0JPI9", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12477932", "type": [ "PubMed" ], "id": "12477932" } ], "title": "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032872.2", "id": "NP_001032872.2", "database": "RefSeq" } ], "authors": "Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA", "date": "2002" } ], "uniprot_ac": "A0JPI9", "site_annotation": [ { "end_pos": 119, "annotation": "n_glycosylation_sequon", "start_pos": 117 }, { "end_pos": 154, "annotation": "n_glycosylation_sequon", "start_pos": 152 }, { "end_pos": 175, "annotation": "n_glycosylation_sequon", "start_pos": 173 }, { "end_pos": 176, "annotation": "n_glycosylation_sequon", "start_pos": 174 }, { "end_pos": 211, "annotation": "n_glycosylation_sequon", "start_pos": 209 }, { "end_pos": 239, "annotation": "n_glycosylation_sequon", "start_pos": 237 }, { "end_pos": 260, "annotation": "n_glycosylation_sequon", "start_pos": 258 }, { "end_pos": 405, "annotation": "n_glycosylation_sequon", "start_pos": 403 }, { "end_pos": 466, "annotation": "n_glycosylation_sequon", "start_pos": 464 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0JPI9#A0A0G2JWD4-1", "isoform_ac": "A0A0G2JWD4-1", "locus": { "end_pos": 110749705, "strand": "-", "start_pos": 110776772, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000084348", "id": "ENSRNOT00000084348", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000069836", "id": "ENSRNOP00000069836", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JWD4-1|LR74A_RAT Computationally mapped isoform of Leucine-rich repeat-containing protein 74A OS=Rattus norvegicus OX=10116 GN=Lrrc74a PE=2 SV=1 CANONICAL=A0JPI9-1", "length": 464, "sequence": "DETEAALAPQSSEDTLYCEAEAAPSVEKEKPTREDSETDLEIEDTEKFFSIGQKELYLEACKLVGVVPVSYFIRNMEESCMNLNHHGLGPMGIKAIAITLVSNTTVLKLELEDNSIQEEGILSLMEMLHENYYLQELNVSDNNLGLEGARIISDFLQENNSSLWKLKLSGNKFKEECALLLCQALSSNYRIRSLNLSHNEFSDTAGEYLGQMLALNVSSVGLTLHLRSSHLPSVWALAECLRTRVTSKYFDISRYGASQSTHLFMGDHPRSLSIYQNVDVSRNGITNEGASRISKGLENNECLQVLKLFLNPVSLEGAYSLILAIKRNPKSRMEDLDISNVLVSEQFVKVLDGVCAIHPQLDVVYKGLQGLSTKKTVSLETNPIKLIQTITDQNKIVVEFFKSLNPSGLMTMPVGDFRKAIIQQTNIPINRYQARELIKKLEEKNGMVNFSGFKSLKVTAAGQL" } }, { "url": "https://www.uniprot.org/uniprot/A0JPI9#A0JPI9-1", "isoform_ac": "A0JPI9-1", "locus": {}, "sequence": { "header": "sp|A0JPI9-1|LR74A_RAT Isoform 1 of Leucine-rich repeat-containing protein 74A OS=Rattus norvegicus OX=10116 GN=Lrrc74a PE=2 SV=1 CANONICAL=A0JPI9-1", "length": 479, "sequence": "MDDDDIEPLEYETKDETEAALAPQSSEDTLYCEAEAAPSVEKEKPTREDSETDLEIEDTEKFFSIGQKELYLEACKLVGVVPVSYFIRNMEESCMNLNHHGLGPMGIKAIAITLVSNTTVLKLELEDNSIQEEGILSLMEMLHENYYLQELNVSDNNLGLEGARIISDFLQENNSSLWKLKLSGNKFKEECALLLCQALSSNYRIRSLNLSHNEFSDTAGEYLGQMLALNVGLQSLNLSWNHFNVRGAVALCNGLRTNVTLKKLDVSMNGFGNDGALALGDTLKLNSCLVYVDVSRNGITNEGASRISKGLENNECLQVLKLFLNPVSLEGAYSLILAIKRNPKSRMEDLDISNVLVSEQFVKVLDGVCAIHPQLDVVYKGLQGLSTKKTVSLETNPIKLIQNYTDQNKISVVEFFKSLNPSGLMTMPVGDFRKAIIQQTNIPINRYQARELIKKLEEKNGMVNFSGFKSLKVTAAGQL" } }, { "url": "https://www.uniprot.org/uniprot/A0JPI9#A0JPI9-2", "isoform_ac": "A0JPI9-2", "locus": {}, "sequence": { "header": "sp|A0JPI9-2|LR74A_RAT Isoform 2 of Leucine-rich repeat-containing protein 74A OS=Rattus norvegicus OX=10116 GN=Lrrc74a PE=2 SV=1 CANONICAL=A0JPI9-1", "length": 262, "sequence": "MDDDDIEPLEYETKDETEAALAPQSSEDTLYCEAEAAPSVEKEKPTREDSETDLEIEDTEKFFSIGQKELYLEACKLVGVVPVSYFIRNMEESCMNLNHHGLGPMGIKAIAITLVSNTTVLKLELEDNSIQEEGILSLMEMLHENYYLQELNVSDNNLGLEGARIISDFLQENNSSLWKLKLSGNKFKEECALLLCQALSSNYRIRSLNLSHNEFSDTAGEYLGQMLALNVGLQSLNLSWNHFNVRGAVALCNGLRLPSPGD" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:314328", "resource": "KEGG Pathway", "id": "rno:314328", "name": "" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q0VAA2-1", "protein_name": "Leucine-rich repeat-containing protein 74A", "sequence": { "length": 488, "sequence": "MHIQFPSKPTLPRACWEGRITAGSPGMPPDEIEIEPVRQSSDKMLYCEAESPPTVEKVKPARENSETDLEIEDDEKFFTTGQKELYLEACKLMGVVPVSYFIRNMEESYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAILLILAIKRNPKSRMEELDISNVLVSEQFMKTLDGVYAVHPQLDVVFKAVQGLSPKKTIFLLTNPMKLIQSYADQHKITIVDFFKSLNPTGTMKMSVDEFQKVMIEQNKVPLNQYQVREVIKKLDEKTGMVNFSFLNTMKP" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/19331", "id": "19331", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032872.2", "ac": "NP_001032872.2", "name": "leucine-rich repeat-containing protein 74A", "summary": "" }, "go_annotation": {}, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0JPI9", "type": "synonym", "resource": "RefSeq", "name": "Lrrc74a" }, { "url": "https://www.uniprot.org/uniprot/A0JPI9", "type": "recommended", "resource": "UniProtKB", "name": "Lrrc74a" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0JPI9", "type": "synonym", "resource": "RefSeq", "name": "Lrrc74" }, { "url": "https://www.uniprot.org/uniprot/A0JPI9", "type": "synonym", "resource": "UniProtKB", "name": "Lrrc74" } ], "pro_annotation": [], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/gene/314328", "id": "314328", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "id": "IPR001611", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "id": "IPR032675", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:314328", "id": "rno:314328", "database": "KEGG Pathway" }, { "url": "http://www.orthodb.org/?query=1463268at2759", "id": "1463268at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF13516", "id": "PF13516", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A0JPI9", "id": "PR_A0JPI9", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032872.2", "id": "NP_001032872.2", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1564488", "id": "1564488", "database": "RGD" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 53227.0, "chemical_mass": 53227.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0JPI9", "name": "Lrrc74a", "locus": { "end_pos": 110776775, "strand": "+", "start_pos": 110749705, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000052456", "id": "ENSRNOG00000052456", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0JPI9", "type": "recommended", "resource": "UniProtKB", "name": "Leucine-rich repeat-containing protein 74A" }, { "url": "https://www.uniprot.org/uniprot/A0JPI9", "type": "synonym", "resource": "UniProtKB", "name": "Leucine-rich repeat-containing protein 74" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0JPI9", "type": "synonym", "resource": "RefSeq", "name": "leucine-rich repeat-containing protein 74; leucine rich repeat containing 74" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0JPI9", "type": "synonym", "resource": "RefSeq", "name": "leucine-rich repeat-containing protein 74A" } ] }