{ "uniprot_canonical_ac": "A6H8H2-1", "ptm_annotation": [ { "annotation": "Phosphorylated in response to insulin.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21454697", "id": "21454697", "database": "PubMed" } ] } ], "sequence": { "header": "sp|A6H8H2-1|DEN4C_MOUSE Isoform 1 of DENN domain-containing protein 4C OS=Mus musculus OX=10090 GN=Dennd4c PE=1 SV=1 CANONICAL=A6H8H2-1", "length": 1906, "sequence": "MIEDKGPRVTDYFVVAGLTDTSTLLDQEINRTDTNSIGPKAPITDIAVIIKSAGETVPEGYTCVEATPSALQANLNYGSLKSPELFLCYRRGRDKPPLTDIGVLYEGKERLMPGCEVIQATPYGRCANVNNSSTTSQRIFITYRRAPPVRSQNSLAVTDICVIITSKGETPPHTFCKVDKNLNCGMWGSNVFLCYKKSVPASNAIAYKAGLIFRYPEEDYESFPLSPSVPLFCLPMGATIECWDPQIKYPLPVFSTFVLTGSSAEKVYGAAIQFYEPYSQERLTEKQLTQLGLLTLVEKRVVSKPINSNKCICLLSHWPFFEAFKNFLMFIYKVSVSGPHPLPIEKHISHFMQNIPFPSPQRPRILIQLSVHDAFILSQPVSTPLPLSGANFSSLLMNLGPENCATLLLLVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAGVLSAPLPFIVGVDSRYFDLHDPPQDVVCIDLDTNTLYVADERKNINWKQLPKRPCKSLLGTLRRLYQQLCSVHRKPQESSAIEMTPIEADYSWQKKMTQLEMEIQETFLRFMASILKGYRSYLRPITEAPSNKATAADSLFDRQGFLKSRDRAYTKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCIEKLFPDKGVERTEKVDLDSAEDTRLIELDDSQRSEHTVFIMPPEPPPDDGNNLSPQYSYTYFPRLDLKLFDSPQKLKLCFNRHPPGSSITNSPALMAKRTKQEIKTAHKLAKRCYTNPPQWAKYLFSHCYSLWFICLPAYVRVSHPKVRALQQAHDVLVKMRKTDVDPLDEVCYRVVMQLCGLWVNPVLAVRVLFEMKTARIKPNAITYGYYNKVVLESPWPSSTRSGIFLWTKVRNVVHGLAQFRQPLKKTGQKSQVFSISGGQSDQGYGSKDELVKEGADGHAPEEHTPPELTTTELHIEEECDISAIVSKHLQPTPEPQSPTEPPAWGSSIVKVPSGLFDTNNRTSTGSTSTVLFSTQAPVEDAVFSEVTNFKKNGDRGEKKQKHFPERSCSFSSESRAGMLLKKSSLDLNSSEMAIMMGADAKILTAALTCPKTSPPHVTRTHSFENVNCHLADSRTRMSEGTRDSEHRSSPVLEMLEESQELLEPVVGDNVAETAAEMTCNSLQSNSHSDQSRDTQAGAQDPVNKRSSSYATRKAIEREDVETGLDPLSLLATECVEKTSDSEDKLFSPVISRNLADEIESYMNLKSPLGSKSCSMELHGEGNQEPGSPAVFAHPLERSSSLPSDRGPPARDSTETEKSSPAVSSSKTLTGRFKPQSPYRAYKDRSTSLSALVRSSPNSSLGSVVNSLSGLKLDNILSGPKIDVLKSSMKQAATVASKMWVAVASAYSYSDDEEETNKDYSFPAGLEDHHIVGETLSPNTSVSGLVPSELTQSNTSLGSSSSSGDVGKLQCPAGEVPFSRNIKGQDFEKSDHGSSQNTSMSSIYQNCAMEVLMSSCSQCRACGALVYDEEIMAGWTADDSNLNTTCPFCKSNFLPLLNVEFKDLRGSASFFLKPSTSGDSLQSGSIPSASEPSEHKPTSSSAEPDLISFMDFSKHSETITEEASYTVESSDEIKKTNGDVQSVKMSSVPNSLSKRNVSLTRSHSVGGPLQNIDFSQRPFHGVSTVSLPSSLQEDVDHLGKRPSPPPVSVPYLSPLVLRKELESLLENEGDQVIHTSSFINQHPIIFWNLVWYFRRLDLPSNLPGLILTSEHCNGGVQLPLSSLSQDSKLVYIQLLWDNINLHQEPGEPLYVSWRNLNSEKKPSLLSEQQQAASALVETIRQSIQQNDVLKPINLLSQQMKPGTKRQRSLYREILFLSLVSLGRENIDIEAFDNEYGLAYRSLPSESLERLQRIDAPPSISVEWCRKCFGAPLI" }, "uniprot_id": "DEN4C_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22472443", "type": [ "PubMed" ], "id": "22472443" } ], "title": "Multivariate proteomic profiling identifies novel accessory proteins of coated vesicles.", "journal": "The Journal of cell biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_908976.1", "id": "NP_908976.1", "database": "RefSeq" } ], "authors": "Borner GH, Antrobus R, Hirst J, Bhumbra GS, Kozik P, Jackson LP, Sahlender DA, Robinson MS", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/29539633", "type": [ "PubMed" ], "id": "29539633" } ], "title": "Placentation defects are highly prevalent in embryonic lethal mouse mutants.", "journal": "Nature", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_908976.1", "id": "NP_908976.1", "database": "RefSeq" } ], "authors": "Perez-Garcia V, Fineberg E, Wilson R, Murray A, Mazzeo CI, Tudor C, Sienerth A, White JK, Tuck E, Ryder EJ, Gleeson D, Siragher E, Wardle-Jones H, Staudt N, Wali N, Collins J, Geyer S, Busch-Nentwich EM, Galli A, Smith JC, Robertson E, Adams DJ, Weninger WJ, Mohun T, Hemberger M", "date": "2018" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21454697", "type": [ "PubMed" ], "id": "21454697" } ], "title": "Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C.", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_908976.1", "id": "NP_908976.1", "database": "RefSeq" } ], "authors": "Gerber S.A., Lienhard G.E., Sano H., Kettenbach A.N., Peck G.R.", "date": "2011" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27626380", "type": [ "PubMed" ], "id": "27626380" } ], "title": "High-throughput discovery of novel developmental phenotypes.", "journal": "Nature", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_908976.1", "id": "NP_908976.1", "database": "RefSeq" } ], "authors": "Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M, Murray SA", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17242355", "type": [ "PubMed" ], "id": "17242355" } ], "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "authors": "Beausoleil S.A., Gerber S.A., Gygi S.P., Villen J.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", "type": [ "PubMed" ], "id": "12520002" } ], "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_908976.1", "id": "NP_908976.1", "database": "RefSeq" } ], "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", "date": "2003" } ], "uniprot_ac": "A6H8H2", "site_annotation": [ { "end_pos": 393, "annotation": "n_glycosylation_sequon", "start_pos": 391 }, { "end_pos": 1064, "annotation": "n_glycosylation_sequon", "start_pos": 1062 }, { "end_pos": 1472, "annotation": "n_glycosylation_sequon", "start_pos": 1470 }, { "end_pos": 1518, "annotation": "n_glycosylation_sequon", "start_pos": 1516 }, { "end_pos": 702, "annotation": "n_glycosylation_sequon", "start_pos": 700 }, { "end_pos": 1429, "annotation": "n_glycosylation_sequon", "start_pos": 1427 }, { "end_pos": 133, "annotation": "n_glycosylation_sequon", "start_pos": 131 }, { "end_pos": 996, "annotation": "n_glycosylation_sequon", "start_pos": 994 }, { "end_pos": 1333, "annotation": "n_glycosylation_sequon", "start_pos": 1331 }, { "end_pos": 32, "annotation": "n_glycosylation_sequon", "start_pos": 30 }, { "end_pos": 132, "annotation": "n_glycosylation_sequon", "start_pos": 130 }, { "end_pos": 1631, "annotation": "n_glycosylation_sequon", "start_pos": 1629 }, { "end_pos": 1414, "annotation": "n_glycosylation_sequon", "start_pos": 1412 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2#A6H8H2-1", "isoform_ac": "A6H8H2-1", "locus": { "end_pos": 86774255, "strand": "-", "start_pos": 86848903, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000142837", "id": "ENSMUST00000142837", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000123367", "id": "ENSMUSP00000123367", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A6H8H2-1|DEN4C_MOUSE Isoform 1 of DENN domain-containing protein 4C OS=Mus musculus OX=10090 GN=Dennd4c PE=1 SV=1 CANONICAL=A6H8H2-1", "length": 1906, "sequence": "MIEDKGPRVTDYFVVAGLTDTSTLLDQEINRTDTNSIGPKAPITDIAVIIKSAGETVPEGYTCVEATPSALQANLNYGSLKSPELFLCYRRGRDKPPLTDIGVLYEGKERLMPGCEVIQATPYGRCANVNNSSTTSQRIFITYRRAPPVRSQNSLAVTDICVIITSKGETPPHTFCKVDKNLNCGMWGSNVFLCYKKSVPASNAIAYKAGLIFRYPEEDYESFPLSPSVPLFCLPMGATIECWDPQIKYPLPVFSTFVLTGSSAEKVYGAAIQFYEPYSQERLTEKQLTQLGLLTLVEKRVVSKPINSNKCICLLSHWPFFEAFKNFLMFIYKVSVSGPHPLPIEKHISHFMQNIPFPSPQRPRILIQLSVHDAFILSQPVSTPLPLSGANFSSLLMNLGPENCATLLLLVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAGVLSAPLPFIVGVDSRYFDLHDPPQDVVCIDLDTNTLYVADERKNINWKQLPKRPCKSLLGTLRRLYQQLCSVHRKPQESSAIEMTPIEADYSWQKKMTQLEMEIQETFLRFMASILKGYRSYLRPITEAPSNKATAADSLFDRQGFLKSRDRAYTKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCIEKLFPDKGVERTEKVDLDSAEDTRLIELDDSQRSEHTVFIMPPEPPPDDGNNLSPQYSYTYFPRLDLKLFDSPQKLKLCFNRHPPGSSITNSPALMAKRTKQEIKTAHKLAKRCYTNPPQWAKYLFSHCYSLWFICLPAYVRVSHPKVRALQQAHDVLVKMRKTDVDPLDEVCYRVVMQLCGLWVNPVLAVRVLFEMKTARIKPNAITYGYYNKVVLESPWPSSTRSGIFLWTKVRNVVHGLAQFRQPLKKTGQKSQVFSISGGQSDQGYGSKDELVKEGADGHAPEEHTPPELTTTELHIEEECDISAIVSKHLQPTPEPQSPTEPPAWGSSIVKVPSGLFDTNNRTSTGSTSTVLFSTQAPVEDAVFSEVTNFKKNGDRGEKKQKHFPERSCSFSSESRAGMLLKKSSLDLNSSEMAIMMGADAKILTAALTCPKTSPPHVTRTHSFENVNCHLADSRTRMSEGTRDSEHRSSPVLEMLEESQELLEPVVGDNVAETAAEMTCNSLQSNSHSDQSRDTQAGAQDPVNKRSSSYATRKAIEREDVETGLDPLSLLATECVEKTSDSEDKLFSPVISRNLADEIESYMNLKSPLGSKSCSMELHGEGNQEPGSPAVFAHPLERSSSLPSDRGPPARDSTETEKSSPAVSSSKTLTGRFKPQSPYRAYKDRSTSLSALVRSSPNSSLGSVVNSLSGLKLDNILSGPKIDVLKSSMKQAATVASKMWVAVASAYSYSDDEEETNKDYSFPAGLEDHHIVGETLSPNTSVSGLVPSELTQSNTSLGSSSSSGDVGKLQCPAGEVPFSRNIKGQDFEKSDHGSSQNTSMSSIYQNCAMEVLMSSCSQCRACGALVYDEEIMAGWTADDSNLNTTCPFCKSNFLPLLNVEFKDLRGSASFFLKPSTSGDSLQSGSIPSASEPSEHKPTSSSAEPDLISFMDFSKHSETITEEASYTVESSDEIKKTNGDVQSVKMSSVPNSLSKRNVSLTRSHSVGGPLQNIDFSQRPFHGVSTVSLPSSLQEDVDHLGKRPSPPPVSVPYLSPLVLRKELESLLENEGDQVIHTSSFINQHPIIFWNLVWYFRRLDLPSNLPGLILTSEHCNGGVQLPLSSLSQDSKLVYIQLLWDNINLHQEPGEPLYVSWRNLNSEKKPSLLSEQQQAASALVETIRQSIQQNDVLKPINLLSQQMKPGTKRQRSLYREILFLSLVSLGRENIDIEAFDNEYGLAYRSLPSESLERLQRIDAPPSISVEWCRKCFGAPLI" } }, { "url": "https://www.uniprot.org/uniprot/A6H8H2#A6H8H2-2", "isoform_ac": "A6H8H2-2", "locus": { "end_pos": 86774255, "strand": "-", "start_pos": 86848903, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000082026", "id": "ENSMUST00000082026", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000080685", "id": "ENSMUSP00000080685", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A6H8H2-2|DEN4C_MOUSE Isoform 2 of DENN domain-containing protein 4C OS=Mus musculus OX=10090 GN=Dennd4c PE=1 SV=1 CANONICAL=A6H8H2-1", "length": 1955, "sequence": "MIEDKGPRVTDYFVVAGLTDTSTLLDQEINRTDTNSIGPKAPITDIAVIIKSAGETVPEGYTCVEATPSALQANLNYGSLKSPELFLCYRRGRDKPPLTDIGVLYEGKERLMPGCEVIQATPYGRCANVNNSSTTSQRIFITYRRAPPVRSQNSLAVTDICVIITSKGETPPHTFCKVDKNLNCGMWGSNVFLCYKKSVPASNAIAYKAGLIFRYPEEDYESFPLSPSVPLFCLPMGATIECWDPQIKYPLPVFSTFVLTGSSAEKVYGAAIQFYEPYSQERLTEKQLTQLGLLTLVEKRVVSKPINSNKCICLLSHWPFFEAFKNFLMFIYKVSVSGPHPLPIEKHISHFMQNIPFPSPQRPRILIQLSVHDAFILSQPVSTPLPLSGANFSSLLMNLGPENCATLLLLVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAGVLSAPLPFIVGVDSRYFDLHDPPQDVVCIDLDTNTLYVADERKNINWKQLPKRPCKSLLGTLRRLYQQLCSVHRKPQESSAIEMTPIEADYSWQKKMTQLEMEIQETFLRFMASILKGYRSYLRPITEAPSNKATAADSLFDRQGFLKSRDRAYTKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCIEKLFPDKGVERTEKVDLDSAEDTRLIELDDSQRSEHTVFIMPPEPPPDDGNNLSPQYSYTYFPRLDLKLFDSPQKLKLCFNRHPPGSSITNSPALMAKRTKQEIKTAHKLAKRCYTNPPQWAKYLFSHCYSLWFICLPAYVRVSHPKVRALQQAHDVLVKMRKTDVDPLDEVCYRVVMQLCGLWVNPVLAVRVLFEMKTARIKPNAITYGYYNKVVLESPWPSSTRSGIFLWTKVRNVVHGLAQFRQPLKKTGQKSQVFSISAPQNAACGSDGDTVSHGSVDSSNDANNGEHTVFVRDLISLDSIDNHSSTGGQSDQGYGSKDELVKEGADGHAPEEHTPPELTTTELHIEEECDISAIVSKHLQPTPEPQSPTEPPAWGSSIVKVPSGLFDTNNRTSTGSTSTVLFSTQAPVEDAVFSEVTNFKKNGDRGEKKQKHFPERSCSFSSESRAGMLLKKSSLDLNSSEMAIMMGADAKILTAALTCPKTSPPHVTRTHSFENVNCHLADSRTRMSEGTRDSEHRSSPVLEMLEESQELLEPVVGDNVAETAAEMTCNSLQSNSHSDQSRDTQAGAQDPVNKRSSSYATRKAIEREDVETGLDPLSLLATECVEKTSDSEDKLFSPVISRNLADEIESYMNLKSPLGSKSCSMELHGEGNQEPGSPAVFAHPLERSSSLPSDRGPPARDSTETEKSSPAVSSSKTLTGRFKPQSPYRAYKDRSTSLSALVRSSPNSSLGSVVNSLSGLKLDNILSGPKIDVLKSSMKQAATVASKMWVAVASAYSYSDDEEETNKDYSFPAGLEDHHIVGETLSPNTSVSGLVPSELTQSNTSLGSSSSSGDVGKLQCPAGEVPFSRNIKGQDFEKSDHGSSQNTSMSSIYQNCAMEVLMSSCSQCRACGALVYDEEIMAGWTADDSNLNTTCPFCKSNFLPLLNVEFKDLRGSASFFLKPSTSGDSLQSGSIPSASEPSEHKPTSSSAEPDLISFMDFSKHSETITEEASYTVESSDEIKKTNGDVQSVKMSSVPNSLSKRNVSLTRSHSVGGPLQNIDFSQRPFHGVSTVSLPSSLQEDVDHLGKRPSPPPVSVPYLSPLVLRKELESLLENEGDQVIHTSSFINQHPIIFWNLVWYFRRLDLPSNLPGLILTSEHCNGGVQLPLSSLSQDSKLVYIQLLWDNINLHQEPGEPLYVSWRNLNSEKKPSLLSEQQQAASALVETIRQSIQQNDVLKPINLLSQQMKPGTKRQRSLYREILFLSLVSLGRENIDIEAFDNEYGLAYRSLPSESLERLQRIDAPPSISVEWCRKCFGAPLI" } }, { "url": "https://www.uniprot.org/uniprot/A6H8H2#E9Q449-1", "isoform_ac": "E9Q449-1", "locus": { "end_pos": 86774255, "strand": "-", "start_pos": 86829739, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000045512", "id": "ENSMUST00000045512", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000039860", "id": "ENSMUSP00000039860", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|E9Q449-1|DEN4C_MOUSE Computationally mapped isoform of DENN domain-containing protein 4C OS=Mus musculus OX=10090 GN=Dennd4c PE=1 SV=1 CANONICAL=A6H8H2-1", "length": 1615, "sequence": "MIEDKGPRVTDYFVVAGLTDTSTLLDQEINRTDTNSIGPKAPITDIAVIIKSAGETVPEGYTCVEATPSALQANLNYGSLKSPELFLCYRRGRDKPPLTDIGVLYEGKERLMPGCEVIQATPYGRCANVNNSSTTSQRIFITYRRAPPVRSQNSLAVTDICVIITSKGETPPHTFCKVDKNLNCGMWGSNVFLCYKKSVPASNAIAYKAGLIFRYPEEDYESFPLSPSVPLFCLPMGATIECWDPQIKYPLPVFSTFVLTGSSAEKVYGAAIQFYEPYSQERLTEKQLTQLGLLTLVEKRVVSKPINSNKCICLLSHWPFFEAFKNFLMFIYKVSVSGPHPLPIEKHISHFMQNIPFPSPQRPRILIQLSVHDAFILSQPVSTPLPLSGANFSSLLMNLGPENCATLLLLVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAGVLSAPLPFIVGVDSRYFDLHDPPQDVVCIDLDTNTLYVADERKNINWKQLPKRPCKSLLGTLRRLYQQLCSVHRKPQESSAIEMTPIEADYSWQKKMTQLEMEIQETFLRFMASILKGYRSYLRPITEAPSNKATAADSLFDRQGFLKSRDRAYTKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCIEKLFPDKGVERTEKVDLDSAEDTRLIELDDSQRSEHTVFIMPPEPPPDDGNNLSPQYSYTYFPRLDLKLFDSPQKLKLCFNRHPPGSSITNSPALMAKRTKQEIKTAHKLAKRCYTNPPQWAKYLFSHCYSLWFICLPAYVRVSHPKVRALQQAHDVLVKMRKTDVDPLDEVCYRVVMQLCGLWVNPVLAVRVLFEMKTARIKPNAITYGYYNKVVLESPWPSSTRSGIFLWTKVRNVVHGLAQFRQPLKKTGQKSQVFSISAPQNAACGSDGDTVSHGSVDSSNDANNGEHTVFVRDLISLDSIDNHSSTGGQSDQGYGSKDELVKEGADGHAPEEHTPPELTTTELHIEEECDISAIVSKHLQPTPEPQSPTEPPAWGSSIVKVPSGLFDTNNRTSTGSTSTVLFSTQAPVEDAVFSEVTNFKKNGDRGEKKQKHFPERSCSFSSESRAGMLLKKSSLDLNSSEMAIMMGADAKILTAALTCPKTSPPHVTRTHSFENVNCHLADSRTRMSEGTRDSEHRSSPVLEMLEESQELLEPVVGDNVAETAAEMTCNSLQSNSHSDQSRDTQAGAQDPVNKRSSSYATRKAIEREDVETGLDPLSLLATECVEKTSDSEDKLFSPVISRNLADEIESYMNLKSPLGSKSCSMELHGEGNQEPGSPAVFAHPLERSSSLPSDRGPPARDSTETEKSSPAVSSSKTLTGRFKPQSPYRAYKDRSTSLSALVRSSPNSSLGSVVNSLSGLKLDNILSGPKIDVLKSSMKQAATVASKMWVAVASAYSYSDDEEETNKDYSFPAGLEDHHIVGETLSPNTSVSGLVPSELTQSNTSLGSSSSSGDVGKLQCPAGEVPFSRNIKGQDFEKSDHGSSQNTSMSSIYQNCAMEVLMSSCSQCRACGALVYDEEIMAGWTADDSNLNTTCPFCKSNFLPLLNVEFKDLRGSARLVLCKLPWEVSALKTWRGWPLLCL" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8876198", "resource": "Reactome", "id": "R-MMU-8876198", "name": "RAB GEFs exchange GTP for GDP on RABs" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:329877", "resource": "KEGG Pathway", "id": "mmu:329877", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_908976.1", "annotation": "Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_908976.1", "id": "NP_908976.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A6H8H2#function", "annotation": "Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2#function", "id": "A6H8H2", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q5VZ89-1", "protein_name": "DENN domain-containing protein 4C", "sequence": { "length": 1909, "sequence": "MIEDKGPRVTDYFVVAGLTDTSTLLDQEINRLDTKSTGPKAPITDIAIIIKSAGETVPEGYTCVEATPSALQANLNYGSLKSPELFLCYKRGRDKPPLTDIGVLYEGKERLIPGCEVILATPYGRCANVNNSSTTSQRIFITYRRAPPVRPQNSLAVTDICVIVTSKGETPPHTFCKVDKNLNCGMWGSSVFLCYKKSVPASNAIAYKAGLIFRYPEEDYESFPLSESDVPLFCLPMGATIECWDPETKYPLPVFSTFVLTGSSAKKVYGAAIQFYEPYSRELLSEKQLMHLGLLTPVERKMVSKSINTNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQNIPFPSPQRPRILVQLSVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVGVDSRYFDLHDPPQDVVCIDLDTNMLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQEGSAIDMTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATAADSLFDRQGFLKSRDRAYAKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCIEKLFPDKGTEKTDKVDFDSAEDTRLIELDDSQKSEHTVFIMPPEPPPDDGKDLSPKYSYKYFPRLDLKLFDRPQELKLCFSRHPTGNSITKSPPLMAKRTKQEIKTAHKLAKRCYTNPPQWAKCLFSHCYSLWFICLPAYVRVSHPKVRALQQAYDVLIKMRKTDVDPLDEVCYRVVMQLCGLWGHPVLAVRVLFEMKTARIKPNAITYGYYNKVVLESPWPSSTRSGIFLWTKVRNVVRGLAQFRQPLKKTVQRSQVSSISGGQSDQGYGSKDELIKDDAEIHVPEEQAARELITKTKMQTEEVCDASAIVAKHSQPSPEPHSPTEPPAWGSSIVKVPSGIFDVNSRKSSTGSISNVLFSTQDPVEDAVFGEATNLKKNGDRGEKRQKHFPERSCSFSSESRAGMLLKKSSLDSNSSEMAIMMGADAKILTAALTCPKTSLLHIARTHSFENVSCHLPDSRTCMSESTWNPEHRSSPVPEMLEESQELLEPVVDDVPKTTATVDTYESLLSDSNSNQSRDLKTVSKDLRNKRSSLYGIAKVVQREDVETGLDPLSLLATECTGGKTPDSEDKLFSPVIARNLADEIESYMNLKSPLGSKSSSMELHREENRESGMTTAFIHALERRSSLPLDHGSPAQENPESEKSSPAVSRSKTFTGRFKQQTPSRTHKERSTSLSALVRSSPHGSLGSVVNSLSGLKLDNILSGPKIDVLKSGMKQAATVASKMWVAVASAYSYSDDEEETNRDYSFPAGLEDHILGENISPNTSISGLVPSELTQSNTSLGSSSSSGDVGKLHYPTGEVPFPRGMKGQDFEKSDHGSSQNTSMSSIYQNCAMEVLMSSCSQCRACGALVYDEEIMAGWTADDSNLNTACPFCKSNFLPLLNIEFKDLRGSASFFLKPSTSGDSLQSGSIPLANESLEHKPVSSLAEPDLINFMDFPKHNQIITEETGSAVEPSDEIKRASGDVQTMKISSVPNSLSKRNVSLTRSHSVGGPLQNIDFTQRPFHGISTVSLPNSLQEVVDPLGKRPNPPPVSVPYLSPLVLRKELESLLENEGDQVIHTSSFINQHPIIFWNLVWYFRRLDLPSNLPGLILTSEHCNEGVQLPLSSLSQDSKLVYIQLLWDNINLHQEPREPLYVSWRNFNSEKKSSLLSEEQQETSTLVETIRQSIQHNNVLKPINLLSQQMKPGMKRQRSLYREILFLSLVSLGRENIDIEAFDNEYGIAYNSLSSEILERLQKIDAPPSASVEWCRKCFGAPLI" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/23057", "id": "23057", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "A0A0G2K089-1", "protein_name": "DENN domain-containing 4C", "sequence": { "length": 1901, "sequence": "MIEDKGPRVTDYFVVAGLTDTSTLLDQEINRIDTNKSIGPKAPITDIAVIIKSAGETVPEGYTCVEATPSALQANLNYGSLKSPELFLCYRRGRDKPPLTDIGVLYEGKERLIPGCEVIQATPYGRCANVNNSSTTSQRIFITYRRAPPVRSQNSLAVTDICVIITSKGETPPHTFCKVDKNLNCGMWGSNVFLCYKKSVPASNAIAYKAGLIFRYPEEDYESFPLSESVPLFCLPMGATIECWDPQTKYPLPVFSTFVLTGSSAEKVYGAAIQFYEPYSRDLLTEKQLSQLGLLTPVERKVVSKPINSNKCICLLSHWPFFEAFKKFLMFIYKVSVSGPHPLPIEKHISHFMQNIPFPSPQRPRILVQLSVHDALILSQPVSTPLPLSGANFSSLLMNLGPENCATLLLLVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAGVLSAPLPFIVGVDSRYFDLHDPPQDVVCIDLDTNTLYVADEKKNTNWKQLPKKPCKSLLGTLRKLYLQLCSVHSRPKQSLQFEMTPMTDFSLQKKMTQERKSKETFCALWPSVFQKDTGSYLRITERFPTNKATADSLVDRQGFLKSRDRAYTKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCIEKLFPDKGVEKTDKVDLDSAEDTKLIELDDSQKSEHTVFITPPEPPPDDGSDLSPQYSYTYFPRLDLKLFDSPQEPKLRFSRHPPGSGITNSPALMAKRTKQEIKTAHKLAKRCYTNPPQWAKYLFSHCYSLWFICLPAYVRVSHPKVRALQQAHDVLVKMRKTDVDPLDEVCYRVVMQLCGLWVHPVLAVRVLFEMKTARIKPNAITYGYYNKVVLESPWPSSTRSGIFLWTKVRNVVHGLAQFRQPLKKTGQKSQVFSISGGQSDQGYGSKDELVKEDADIHASEEHMPQELTATELHIEEESDLSTIVPKHSQPTPEPQSPTEPPAWGSSIVKVPSGLFDTNNRTSSTGSSSNALFSTQAPVEDAVFGEATNFKKSGDRGEKRQKHFPERSCSFSSESRAGMLLKKSSLDLNSSEMAIMMGADAKILTAALTCPKTSPLHVARTHSFENVNCHLADNRTRVSEGIWDSEHRSSPVLEMLEESQELLEPVVGDTVAETAVEMSFNNVQSNSNSNQSRDTKAGSQDTVNKRSSSYTTGKAIEREDVETGLDPLSLLATECVEKTSDSEDKLFSPVISRNLADEIESYMNLKSPLGSKSSSMELHGEGNQEPGSPALFTHPLERRSSLPSAQDSTEIEKSPPAVSRSKTLTGRFKPQTPYRTYKDRSTSLSALVRSSPNSSLGSVVNSLSGLKLDNILSGPKIDVLKSSMKQAATVASKMWVAVASAYSYSDDEEEPNKDYSFPAGLEDHHILGESLSPTTSISGLVPSELTQSSTSLGSSSSSGDVGKSQCPTGEVPFSRNIKGQDFEKSDHGSSQNTSMSSIYQNCAMEVLMSSCSQCRACGALVYDEEIMAGWTADDSNLNTTCPFCKSNFLPLLNVEFKDLRGSASFFLKPSTSGDSLQSGSIPSANEPLEHKPVSSSAEPDLISFMDYSKHSETITEEASYTVESSDEIKKTSDVQSVKMSSVPNSLSKRNVSLTRSHSVGGPLQNIDVSQRPFHGISTVSLPNSLQEDVDHLGKRPNPPPVSVPYLSPLVLRKELESLLENEGDQVIHTSSFINQHPIIFWNLVWYFRRLDLPSNLPGLILTSEHCNEGVQLPLSSLSQDSKLVYIQLLWDNINLHQEPGEPLYVSWRNLNSEKKLSLLSEEQQAASALVETIRQSIQQNDVLKPINLLSQQMKPDTKRQDRSLYREILFLSLVSLGRENIDIEAFDNEYGLAYRSLSSEILEKLQKIDAPPSISVEWCRKCFGAPLI" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A6H8H2/", "id": "A6H8H2", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "tax_id": 10116 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_908976.1", "ac": "NP_908976.1", "name": "DENN domain-containing protein 4C", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017112", "pmid": "21454697", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "name": "Rab guanyl-nucleotide exchange factor activity", "id": "GO:0017112" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "pmid": "21454697", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "pmid": "21454697", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030904", "pmid": "22472443", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "name": "retromer complex", "id": "GO:0030904" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032593", "pmid": "21454697", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "name": "insulin-responsive compartment", "id": "GO:0032593" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "name": "cytoplasmic vesicle membrane", "id": "GO:0030659" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032869", "pmid": "21454697", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "name": "cellular response to insulin stimulus", "id": "GO:0032869" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659", "pmid": "21454697", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "name": "protein localization to plasma membrane", "id": "GO:0072659" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "name": "protein transport", "id": "GO:0015031" } ], "total": 3, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A6H8H2", "type": "synonym", "resource": "RefSeq", "name": "Dennd4c" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A6H8H2", "type": "synonym", "resource": "RefSeq", "name": "1700065A05Rik; AA420392" }, { "url": "https://www.uniprot.org/uniprot/A6H8H2", "type": "recommended", "resource": "UniProtKB", "name": "Dennd4c" } ], "crossref": [ { "url": "https://omabrowser.org/oma/group/SQWPSDS/", "id": "SQWPSDS", "database": "OMA" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000038024", "id": "ENSMUSG00000038024", "database": "Bgee" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR005113", "id": "IPR005113", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR005112", "id": "IPR005112", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF03455", "id": "PF03455", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A6H8H2", "id": "PR_A6H8H2", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "id": "IPR011990", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF02141", "id": "PF02141", "database": "Pfam" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8876198", "id": "R-MMU-8876198", "database": "Reactome" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR037516", "id": "IPR037516", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR023341", "id": "IPR023341", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF03456", "id": "PF03456", "database": "Pfam" }, { "url": "http://www.informatics.jax.org/marker/MGI:1914769", "id": "1914769", "database": "MGI" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_908976.1", "id": "NP_908976.1", "database": "RefSeq" }, { "url": "http://www.orthodb.org/?query=75304at2759", "id": "75304at2759", "database": "OrthoDB" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/329877", "id": "329877", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001194", "id": "IPR001194", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:329877", "id": "mmu:329877", "database": "KEGG Pathway" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Ser", "position": "1624", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "740", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "740", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", 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"Atxn7l3b" }, { "residue": "Ser", "position": "971", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "987", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17242355", "id": "17242355", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b" }, { "residue": "Ser", "position": "1043", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21454697", "id": "21454697", "database": "PubMed" } ], "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b" }, { "residue": "Ser", "position": "1637", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b" }, { "residue": "Thr", "position": "966", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "1626", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Thr", "position": "973", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "1000", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "1796", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "1240", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "1058", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "1342", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "1637", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "1274", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "1321", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "1043", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "736", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "971", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19131326", "id": "19131326", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b" }, { "residue": "Ser", "position": "1248", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Thr", "position": "966", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b" }, { "residue": "Ser", "position": "1123", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "987", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "702", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "1096", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21454697", "id": "21454697", "database": "PubMed" } ], "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b" }, { "residue": "Ser", "position": "1333", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "1096", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "1181", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "id": "A6H8H2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" } ], "mass": { "monoisotopic_mass": 211458.0, "chemical_mass": 211458.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "name": "Dennd4c", "locus": { "end_pos": 86850603, "strand": "+", "start_pos": 86748555, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000038024", "id": "ENSMUSG00000038024", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A6H8H2", "type": "recommended", "resource": "UniProtKB", "name": "DENN domain-containing protein 4C" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A6H8H2", "type": "synonym", "resource": "RefSeq", "name": "likely ortholog of H. sapiens chromosome 9 open reading frame 55 (C9orf55)" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A6H8H2", "type": "synonym", "resource": "RefSeq", "name": "DENN domain-containing protein 4C" } ] }