{
    "uniprot_canonical_ac": "A4Q9E4-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A4Q9E4-1|TTLL2_MOUSE Isoform 1 of Probable tubulin polyglutamylase TTLL2  OS=Mus musculus OX=10090 GN=Ttll2 PE=2 SV=1 CANONICAL=A4Q9E4-1", 
        "length": 540, 
        "sequence": "MDGLQSLGDVTAEIFGLPLEGHSVQESKPLKTEDEPQGAPLKPLVFRVDESTPGLVQSVLLERGWDKFDEQRQDVEDWNLYWRSSSFRRAEYVNVKPWQRLNHHPGMTNLTRKDCLAKHLARMRSRYGESLYEFTPLTFIMPTDYTKFVAKYFKEKQDLGTKPSYWICKPAELSRGRGIIIFSDIRDLMFKGTYVVQKYICNPLLVGRYKCDLRIYVCITGFKPLTIYMYQEGLVRFATEKFDLRNLEDYYSHLTNSSINKLGASYQKIKEVVGQGCKWTLSRFFSYLRNWDVDDLLLRQKISHMVILTVLAMAPSVPVTYNCFELFGFDILIDDNLKPWLLEVNYNPALTLDCSTDESVKRSLVHDVIELLYLNGLRSEEKKCGRTSPGNSVVSLARSHHHEFCATPNSSSYASLIEFTTGSKSDPAVQNICPKHTRTSQLREMMSRRDRLLTKEAAKSKPRHKAWHLPRKMVFPYASQSQPHKMKGPAGDLPEAGSTPNDHAGNFVLIFPFNKATFRASRNGLNVKRIIQELQKLMNK"
    }, 
    "uniprot_id": "TTLL2_MOUSE", 
    "enzyme_annotation": [
        {
            "ec": "6.-.-.-", 
            "activity": ""
        }
    ], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A4Q9E4", 
                    "id": "A4Q9E4", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/17499049", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "17499049"
                }
            ], 
            "title": "A targeted multienzyme mechanism for selective microtubule polyglutamylation.", 
            "journal": "Mol. Cell", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A4Q9E4", 
                    "id": "A4Q9E4", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091737.1", 
                    "id": "NP_001091737.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Janke C., Lacroix B., Rogowski K., van Dijk J., Miro J., Edde B.", 
            "date": "2007"
        }
    ], 
    "uniprot_ac": "A4Q9E4", 
    "site_annotation": [
        {
            "end_pos": 111, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 109
        }, 
        {
            "end_pos": 411, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 409
        }, 
        {
            "end_pos": 258, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 256
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A4Q9E4#A4Q9E4-1", 
            "isoform_ac": "A4Q9E4-1", 
            "locus": {
                "end_pos": 7350907, 
                "strand": "+", 
                "start_pos": 7352696, 
                "chromosome": "17", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000115747", 
                        "id": "ENSMUST00000115747", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000111413", 
                        "id": "ENSMUSP00000111413", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A4Q9E4-1|TTLL2_MOUSE Isoform 1 of Probable tubulin polyglutamylase TTLL2  OS=Mus musculus OX=10090 GN=Ttll2 PE=2 SV=1 CANONICAL=A4Q9E4-1", 
                "length": 540, 
                "sequence": "MDGLQSLGDVTAEIFGLPLEGHSVQESKPLKTEDEPQGAPLKPLVFRVDESTPGLVQSVLLERGWDKFDEQRQDVEDWNLYWRSSSFRRAEYVNVKPWQRLNHHPGMTNLTRKDCLAKHLARMRSRYGESLYEFTPLTFIMPTDYTKFVAKYFKEKQDLGTKPSYWICKPAELSRGRGIIIFSDIRDLMFKGTYVVQKYICNPLLVGRYKCDLRIYVCITGFKPLTIYMYQEGLVRFATEKFDLRNLEDYYSHLTNSSINKLGASYQKIKEVVGQGCKWTLSRFFSYLRNWDVDDLLLRQKISHMVILTVLAMAPSVPVTYNCFELFGFDILIDDNLKPWLLEVNYNPALTLDCSTDESVKRSLVHDVIELLYLNGLRSEEKKCGRTSPGNSVVSLARSHHHEFCATPNSSSYASLIEFTTGSKSDPAVQNICPKHTRTSQLREMMSRRDRLLTKEAAKSKPRHKAWHLPRKMVFPYASQSQPHKMKGPAGDLPEAGSTPNDHAGNFVLIFPFNKATFRASRNGLNVKRIIQELQKLMNK"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:100216474", 
            "resource": "KEGG Pathway", 
            "id": "mmu:100216474", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8955332", 
            "resource": "Reactome", 
            "id": "R-MMU-8955332", 
            "name": "Carboxyterminal post-translational modifications of tubulin"
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A4Q9E4#function", 
            "annotation": "Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A4Q9E4#function", 
                    "id": "A4Q9E4", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "D3ZF82-1", 
            "protein_name": "Tubulin tyrosine ligase-like 2", 
            "sequence": {
                "length": 541, 
                "sequence": "MMNGLQTLGDVTAEIFRLSPEGNTVQKRQRLRMEDEAPGAALKPLVFRVDESTPGVVQSVLLERGWDKFDEQCQDVEDWNLYWRSSSFRMAEYVNIKPWQRLNHHPGTTSLTRKDCLAKHLAHMRRLYGESIYEFTPLTFIMPSDYTKFVAKYFKEKQDLGTKPSYWICKPAKLSQGRGIIIFSDIRDLMFKDAYVVQKYICNPLLVGRYKCDLRIYVCVTGFKPLTIYMYQEGLVRFATEKFDLSNLEDYYSHLTNSSINKLGASYEKIKEVVGQGCKWTLSRFFSYLRNWDVDDLLLRRKINHMVILTVLAMAPSVPVANNCFELFGFDILIDDNLKPWLLEVNYSPALSLECSTDVSVKRSLVHDIIELLYLNGLRSEEKKCGRTSQGNAMVSQARRSQQKLCAAPAPPSYASLIQFATCSKRSPAAQHMCPKHTRTSQLREMLCRQNKLLTREAAKSKPRLKAWHSPRKMLSLCASQSLPRKTKGPTGILPEAGNTPNNHAGNFVLIFPFNKATFSASRNGLNVKRIIQELQKLMNK"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A4Q9E4/", 
                    "id": "A4Q9E4", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/12917", 
                    "id": "12917", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Rat", 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q9BWV7-1", 
            "protein_name": "Probable tubulin polyglutamylase TTLL2", 
            "sequence": {
                "length": 592, 
                "sequence": "MRGRDLCSSTQSQALGSLRTTTPAFTLNIPSEANHTEQPPAGLGARLQEAGVSIPPRRGRPTPTLEKKKKPHLMAEDEPSGALLKPLVFRVDETTPAVVQSVLLERGWNKFDKQEQNAEDWNLYWRTSSFRMTEHNSVKPWQQLNHHPGTTKLTRKDCLAKHLKHMRRMYGTSLYQFIPLTFVMPNDYTKFVAEYFQERQMLGTKHSYWICKPAELSRGRGILIFSDFKDFIFDDMYIVQKYISNPLLIGRYKCDLRIYVCVTGFKPLTIYVYQEGLVRFATEKFDLSNLQNNYAHLTNSSINKSGASYEKIKEVIGHGCKWTLSRFFSYLRSWDVDDLLLWKKIHRMVILTILAIAPSVPFAANCFELFGFDILIDDNLKPWLLEVNYSPALTLDCSTDVLVKRKLVHDIIDLIYLNGLRNEGREASNATHGNSNIDAAKSDRGGLDAPDCLPYDSLSFTSRMYNEDDSVVEKAVSVRPEAAPASQLEGEMSGQDFHLSTREMPQSKPKLRSRHTPHKTLMPYASLFQSHSCKTKTSPCVLSDRGKAPDPQAGNFVLVFPFNEATLGASRNGLNVKRIIQELQKLMNKQHS"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/12917", 
                    "id": "12917", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }, 
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091737.1", 
        "ac": "NP_001091737.1", 
        "name": "probable tubulin polyglutamylase TTLL2", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4Q9E4", 
                                "id": "A4Q9E4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ATP binding", 
                        "id": "GO:0005524"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016874", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4Q9E4", 
                                "id": "A4Q9E4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ligase activity", 
                        "id": "GO:0016874"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006464", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4Q9E4", 
                                "id": "A4Q9E4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cellular protein modification process", 
                        "id": "GO:0006464"
                    }
                ], 
                "total": 1, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A4Q9E4", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Ttll2"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A4Q9E4", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "EG625850"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4Q9E4", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Ttll2"
        }
    ], 
    "crossref": [
        {
            "url": "http://www.informatics.jax.org/marker/MGI:3644030", 
            "id": "3644030", 
            "database": "MGI"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A4Q9E4", 
            "id": "PR_A4Q9E4", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/100216474", 
            "id": "100216474", 
            "database": "GeneID"
        }, 
        {
            "url": "http://www.orthodb.org/?query=626048at2759", 
            "id": "626048at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/ICKPAEL/", 
            "id": "ICKPAEL", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013815", 
            "id": "IPR013815", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8955332", 
            "id": "R-MMU-8955332", 
            "database": "Reactome"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000079722", 
            "id": "ENSMUSG00000079722", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091737.1", 
            "id": "NP_001091737.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:100216474", 
            "id": "mmu:100216474", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF03133", 
            "id": "PF03133", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR004344", 
            "id": "IPR004344", 
            "database": "InterPro"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 62109.0, 
        "chemical_mass": 62109.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A4Q9E4", 
            "name": "Ttll2", 
            "locus": {
                "end_pos": 7350885, 
                "strand": "-", 
                "start_pos": 7352696, 
                "chromosome": "17", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000079722", 
                        "id": "ENSMUSG00000079722", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A4Q9E4", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "probable tubulin polyglutamylase TTLL2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4Q9E4", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "6.-.-.-"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4Q9E4", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Probable tubulin polyglutamylase TTLL2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4Q9E4", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Tubulin--tyrosine ligase-like protein 2"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A4Q9E4", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "putative polyglutamylase; tubulin--tyrosine ligase-like protein 2; ttll2"
        }
    ]
}