{ "uniprot_canonical_ac": "A2SY89-1", "ptm_annotation": [], "sequence": { "header": "tr|A2SY89-1|A2SY89_RAT Isoform 1 of Similar to growth/differentiation factor GDF-3-mouse (Predicted) OS=Rattus norvegicus OX=10116 GN=Gdf3 PE=2 SV=1 CANONICAL=A2SY89-1", "length": 366, "sequence": "MQPSQRLLTLGFLLLTLARGQTSEFQDYDFLQFLGLKKAPSPHRFQPVPRILRKIIRARETAAASGASQDLCYVKELGVRGNLLRLLPDQGFFLNTQKPSQDGSCLQKVLSFNLSAVKEKGKLTMAQLILHLGPRSYHYLQLELVVAVSVVQDRGVWGRSHPKLGRLLVQKSVLGPQGSLQFNLQGVVKDWNRHQLKNLDLYLEILVKEDRYSRVNAQLDNPCNQLMHSLHASLLVVTLNLKHCHPSSRKKRAAIPIPKGLCRNLCHRHQLFVNFQDLGWHKWVIAPKGFMANYCHGDCPFTMTTYLNSSNYAFMQALMHMADPRVPKAVCIPTKLSPISMLYQDNEKNVILRHYEDMVVDECGCG" }, "uniprot_id": "A2SY89_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "id": "A2SY89", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21805089", "type": [ "PubMed" ], "id": "21805089" } ], "title": "The conditioned medium from a stable human GDF3-expressing CHO cell line, induces the differentiation of PC12 cells.", "journal": "Molecular and cellular biochemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103141.1", "id": "NP_001103141.1", "database": "RefSeq" } ], "authors": "Li Q, Liu X, Wu Y, An J, Hexige S, Ling Y, Zhang M, Yang X, Yu L", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23844157", "type": [ "PubMed" ], "id": "23844157" } ], "title": "RNAi screen reveals potentially novel roles of cytokines in myoblast differentiation.", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103141.1", "id": "NP_001103141.1", "database": "RefSeq" } ], "authors": "Ge Y, Waldemer RJ, Nalluri R, Nuzzi PD, Chen J", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22223106", "type": [ "PubMed" ], "id": "22223106" } ], "title": "Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes.", "journal": "Cell death and differentiation", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103141.1", "id": "NP_001103141.1", "database": "RefSeq" } ], "authors": "Ferland-McCollough D, Fernandez-Twinn DS, Cannell IG, David H, Warner M, Vaag AA, Bork-Jensen J, Brons C, Gant TW, Willis AE, Siddle K, Bushell M, Ozanne SE", "date": "2012" } ], "uniprot_ac": "A2SY89", "site_annotation": [ { "end_pos": 310, "annotation": "n_glycosylation_sequon", "start_pos": 308 }, { "end_pos": 115, "annotation": "n_glycosylation_sequon", "start_pos": 113 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2SY89#A2SY89-1", "isoform_ac": "A2SY89-1", "locus": { "end_pos": 155417724, "strand": "+", "start_pos": 155421899, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000041552", "id": "ENSRNOT00000041552", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000050554", "id": "ENSRNOP00000050554", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2SY89-1|A2SY89_RAT Isoform 1 of Similar to growth/differentiation factor GDF-3-mouse (Predicted) OS=Rattus norvegicus OX=10116 GN=Gdf3 PE=2 SV=1 CANONICAL=A2SY89-1", "length": 366, "sequence": "MQPSQRLLTLGFLLLTLARGQTSEFQDYDFLQFLGLKKAPSPHRFQPVPRILRKIIRARETAAASGASQDLCYVKELGVRGNLLRLLPDQGFFLNTQKPSQDGSCLQKVLSFNLSAVKEKGKLTMAQLILHLGPRSYHYLQLELVVAVSVVQDRGVWGRSHPKLGRLLVQKSVLGPQGSLQFNLQGVVKDWNRHQLKNLDLYLEILVKEDRYSRVNAQLDNPCNQLMHSLHASLLVVTLNLKHCHPSSRKKRAAIPIPKGLCRNLCHRHQLFVNFQDLGWHKWVIAPKGFMANYCHGDCPFTMTTYLNSSNYAFMQALMHMADPRVPKAVCIPTKLSPISMLYQDNEKNVILRHYEDMVVDECGCG" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:500311", "resource": "KEGG Pathway", "id": "rno:500311", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103141.1", "annotation": "GDF3 is a potential target of miR-483-3p and is downregulated in low-protein diet rat offspring and low-birth-weight men.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103141.1", "id": "NP_001103141.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q9NR23-1", "protein_name": "Growth/differentiation factor 3", "sequence": { "length": 364, "sequence": "MLRFLPDLAFSFLLILALGQAVQFQEYVFLQFLGLDKAPSPQKFQPVPYILKKIFQDREAAATTGVSRDLCYVKELGVRGNVLRFLPDQGFFLYPKKISQASSCLQKLLYFNLSAIKEREQLTLAQLGLDLGPNSYYNLGPELELALFLVQEPHVWGQTTPKPGKMFVLRSVPWPQGAVHFNLLDVAKDWNDNPRKNFGLFLEILVKEDRDSGVNFQPEDTCARLRCSLHASLLVVTLNPDQCHPSRKRRAAIPVPKLSCKNLCHRHQLFINFRDLGWHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHAVDPEIPQAVCIPTKLSPISMLYQDNNDNVILRHYEDMVVDECGCG" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2SY89/", "id": "A2SY89", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/7336", "id": "7336", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q07104-1", "protein_name": "Growth/differentiation factor 3", "sequence": { "length": 366, "sequence": "MQPYQRLLALGFLLLTLPWGQTSEFQDSDLLQFLGLEKAPSPHRFQPVPRVLRKIIRAREAAAASGASQDLCYVKELGVRGNLLQLLPDQGFFLNTQKPFQDGSCLQKVLYFNLSAIKEKAKLTMAQLTLDLGPRSYYNLRPELVVALSVVQDRGVWGRSHPKVGRLLFLRSVPGPQGQLQFNLQGALKDWSSNRLKNLDLHLEILVKEDRYSRVTVQPENPCDRLLRSLHASLLVVTLNPKHCHPSSRKRRAAISVPKGFCRNFCHRHQLFINFQDLGWHKWVIAPKGFMANYCHGECPFSMTTYLNSSNYAFMQALMHMADPKVPKAVCVPTKLSPISMLYQDSDKNVILRHYEDMVVDECGCG" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2SY89/", "id": "A2SY89", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/7336", "id": "7336", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103141.1", "ac": "NP_001103141.1", "name": "growth/differentiation factor 3 precursor", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "id": "A2SY89", "database": "UniProtKB" } ], "name": "cytokine activity", "id": "GO:0005125" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005160", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "id": "A2SY89", "database": "UniProtKB" } ], "name": "transforming growth factor beta receptor binding", "id": "GO:0005160" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "id": "A2SY89", "database": "UniProtKB" } ], "name": "protein kinase binding", "id": "GO:0019901" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008083", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "id": "A2SY89", "database": "UniProtKB" } ], "name": "growth factor activity", "id": "GO:0008083" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "id": "A2SY89", "database": "UniProtKB" } ], "name": "extracellular space", "id": "GO:0005615" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "id": "A2SY89", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030509", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "id": "A2SY89", "database": "UniProtKB" } ], "name": "BMP signaling pathway", "id": "GO:0030509" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060395", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "id": "A2SY89", "database": "UniProtKB" } ], "name": "SMAD protein signal transduction", "id": "GO:0060395" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010862", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "id": "A2SY89", "database": "UniProtKB" } ], "name": "positive regulation of pathway-restricted SMAD protein phosphorylation", "id": "GO:0010862" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042981", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "id": "A2SY89", "database": "UniProtKB" } ], "name": "regulation of apoptotic process", "id": "GO:0042981" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048468", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "id": "A2SY89", "database": "UniProtKB" } ], "name": "cell development", "id": "GO:0048468" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043408", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "id": "A2SY89", "database": "UniProtKB" } ], "name": "regulation of MAPK cascade", "id": "GO:0043408" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045605", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "id": "A2SY89", "database": "UniProtKB" } ], "name": "negative regulation of epidermal cell differentiation", "id": "GO:0045605" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001701", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "id": "A2SY89", "database": "UniProtKB" } ], "name": "in utero embryonic development", "id": "GO:0001701" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045600", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "id": "A2SY89", "database": "UniProtKB" } ], "name": "positive regulation of fat cell differentiation", "id": "GO:0045600" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001501", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "id": "A2SY89", "database": "UniProtKB" } ], "name": "skeletal system development", "id": "GO:0001501" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030514", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "id": "A2SY89", "database": "UniProtKB" } ], "name": "negative regulation of BMP signaling pathway", "id": "GO:0030514" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002021", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "id": "A2SY89", "database": "UniProtKB" } ], "name": "response to dietary excess", "id": "GO:0002021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007492", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "id": "A2SY89", "database": "UniProtKB" } ], "name": "endoderm development", "id": "GO:0007492" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045662", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "id": "A2SY89", "database": "UniProtKB" } ], "name": "negative regulation of myoblast differentiation", "id": "GO:0045662" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030903", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "id": "A2SY89", "database": "UniProtKB" } ], "name": "notochord development", "id": "GO:0030903" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048859", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "id": "A2SY89", "database": "UniProtKB" } ], "name": "formation of anatomical boundary", "id": "GO:0048859" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001654", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "id": "A2SY89", "database": "UniProtKB" } ], "name": "eye development", "id": "GO:0001654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007498", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "id": "A2SY89", "database": "UniProtKB" } ], "name": "mesoderm development", "id": "GO:0007498" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010453", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "id": "A2SY89", "database": "UniProtKB" } ], "name": "regulation of cell fate commitment", "id": "GO:0010453" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032525", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "id": "A2SY89", "database": "UniProtKB" } ], "name": "somite rostral/caudal axis specification", "id": "GO:0032525" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090009", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "id": "A2SY89", "database": "UniProtKB" } ], "name": "primitive streak formation", "id": "GO:0090009" } ], "total": 21, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2SY89", "type": "synonym", "resource": "RefSeq", "name": "RGD1564178" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2SY89", "type": "synonym", "resource": "RefSeq", "name": "Gdf3" }, { "url": "https://www.uniprot.org/uniprot/A2SY89", "type": "synonym", "resource": "UniProtKB", "name": "RGD1564178_predicted" }, { "url": "https://www.uniprot.org/uniprot/A2SY89", "type": "synonym", "resource": "UniProtKB", "name": "rCG_29801" }, { "url": "https://www.uniprot.org/uniprot/A2SY89", "type": "recommended", "resource": "UniProtKB", "name": "Gdf3" } ], "crossref": [ { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015615", "id": "IPR015615", "database": "InterPro" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/500311", "id": "500311", "database": "GeneID" }, { "url": "http://pfam.xfam.org/family/PF00688", "id": "PF00688", "database": "Pfam" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001839", "id": "IPR001839", "database": "InterPro" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103141.1", "id": "NP_001103141.1", "database": "RefSeq" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001111", "id": "IPR001111", "database": "InterPro" }, { "url": "https://omabrowser.org/oma/group/QKFQPVP/", "id": "QKFQPVP", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=919690at2759", "id": "919690at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11848", "id": "PTHR11848", "database": "PANTHER" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000015331", "id": "ENSRNOG00000015331", "database": "Bgee" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029034", "id": "IPR029034", "database": "InterPro" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1564178", "id": "1564178", "database": "RGD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017948", "id": "IPR017948", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:500311", "id": "rno:500311", "database": "KEGG Pathway" }, { "url": "http://pfam.xfam.org/family/PF00019", "id": "PF00019", "database": "Pfam" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 41562.0, "chemical_mass": 41562.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "name": "Gdf3", "locus": { "end_pos": 155417004, "strand": "-", "start_pos": 155421998, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000015331", "id": "ENSRNOG00000015331", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2SY89", "type": "synonym", "resource": "UniProtKB", "name": "Similar to growth/differentiation factor GDF-3-mouse (Predicted)" }, { "url": "https://www.uniprot.org/uniprot/A2SY89", "type": "synonym", "resource": "UniProtKB", "name": "Growth differentiation factor 3" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2SY89", "type": "synonym", "resource": "RefSeq", "name": "growth/differentiation factor 3 precursor" } ] }