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    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A2NJV5-1|KV229_HUMAN Isoform 1 of Immunoglobulin kappa variable 2-29  OS=Homo sapiens OX=9606 GN=IGKV2-29 PE=3 SV=2 CANONICAL=A2NJV5-1", 
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    "uniprot_id": "KV229_HUMAN", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
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            "common_name": "Human", 
            "evidence": [
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                    "url": "https://www.uniprot.org/uniprot/A2NJV5", 
                    "id": "A2NJV5", 
                    "database": "UniProtKB"
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            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
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        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/24600447", 
                    "type": [
                        "PubMed"
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                    "id": "24600447"
                }
            ], 
            "title": "Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise of Immunoinformatics.", 
            "journal": "Front. Immunol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2NJV5", 
                    "id": "A2NJV5", 
                    "database": "UniProtKB"
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            "authors": "Lefranc M.P.", 
            "date": "2014"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/11549845", 
                    "type": [
                        "PubMed"
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                    "id": "11549845"
                }
            ], 
            "title": "Nomenclature of the human immunoglobulin kappa (IGK) genes.", 
            "journal": "Exp. Clin. Immunogenet.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2NJV5", 
                    "id": "A2NJV5", 
                    "database": "UniProtKB"
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            "authors": "Lefranc M.P.", 
            "date": "2001"
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        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/8662073", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "8662073"
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            ], 
            "title": "New alleles of IGKV genes A2 and A18 suggest significant human IGKV locus polymorphism.", 
            "journal": "Immunogenetics", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2NJV5", 
                    "id": "A2NJV5", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Cowan M.J., Atkinson M.J., Feeney A.J.", 
            "date": "1996"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/17576170", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "17576170"
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            ], 
            "title": "Immunoglobulin somatic hypermutation.", 
            "journal": "Annu. Rev. Genet.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2NJV5", 
                    "id": "A2NJV5", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Teng G., Papavasiliou F.N.", 
            "date": "2007"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/22158414", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "22158414"
                }
            ], 
            "title": "Molecular programming of B cell memory.", 
            "journal": "Nat. Rev. Immunol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2NJV5", 
                    "id": "A2NJV5", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Wang N., McHeyzer-Williams L., McHeyzer-Williams M., Okitsu S.", 
            "date": "2012"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/20176268", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "20176268"
                }
            ], 
            "title": "Structure and function of immunoglobulins.", 
            "journal": "J. Allergy Clin. Immunol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2NJV5", 
                    "id": "A2NJV5", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Cavacini L., Schroeder H.W. Jr.", 
            "date": "2010"
        }
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            "url": "https://www.uniprot.org/uniprot/A2NJV5#A2NJV5-1", 
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            "locus": {}, 
            "sequence": {
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            "name": "Role of LAT2/NTAL/LAB on calcium mobilization"
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            "resource": "Reactome", 
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            "name": "FCGR activation"
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            "resource": "Reactome", 
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            "name": "FCERI mediated MAPK activation"
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            "resource": "Reactome", 
            "id": "R-HSA-2871809", 
            "name": "FCERI mediated Ca+2 mobilization"
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            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977606", 
            "resource": "Reactome", 
            "id": "R-HSA-977606", 
            "name": "Regulation of Complement cascade"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202733", 
            "resource": "Reactome", 
            "id": "R-HSA-202733", 
            "name": "Cell surface interactions at the vascular wall"
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            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-173623", 
            "resource": "Reactome", 
            "id": "R-HSA-173623", 
            "name": "Classical antibody-mediated complement activation"
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            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166663", 
            "resource": "Reactome", 
            "id": "R-HSA-166663", 
            "name": "Initial triggering of complement"
        }, 
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            "resource": "Reactome", 
            "id": "R-HSA-983695", 
            "name": "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"
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            "resource": "Reactome", 
            "id": "R-HSA-2168880", 
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            "resource": "Reactome", 
            "id": "R-HSA-2454202", 
            "name": "Fc epsilon receptor (FCERI) signaling"
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            "resource": "Reactome", 
            "id": "R-HSA-5690714", 
            "name": "CD22 mediated BCR regulation"
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            "resource": "Reactome", 
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            "name": "Regulation of actin dynamics for phagocytic cup formation"
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            "resource": "Reactome", 
            "id": "R-HSA-2029485", 
            "name": "Role of phospholipids in phagocytosis"
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        {
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            "resource": "Reactome", 
            "id": "R-HSA-198933", 
            "name": "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"
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                    "database": "UniProtKB"
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                        "pmid": "21873635", 
                        "evidence": [
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                    {
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                    {
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                        "pmid": "", 
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                                "url": "https://www.uniprot.org/uniprot/A2NJV5", 
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                                "id": "A2NJV5", 
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                        "id": "GO:0038096"
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                        "pmid": "", 
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                        "pmid": "", 
                        "evidence": [
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                                "url": "https://www.uniprot.org/uniprot/A2NJV5", 
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                        "id": "GO:0006898"
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                    {
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                        "pmid": "", 
                        "evidence": [
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                        "evidence": [
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                                "url": "https://www.uniprot.org/uniprot/A2NJV5", 
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                        "id": "GO:0006956"
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}