{ "uniprot_canonical_ac": "A2CG63-1", "ptm_annotation": [], "sequence": { "header": "sp|A2CG63-1|ARI4B_MOUSE Isoform 1 of AT-rich interactive domain-containing protein 4B OS=Mus musculus OX=10090 GN=Arid4b PE=1 SV=1 CANONICAL=A2CG63-1", "length": 1314, "sequence": "MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDDDEEERKQTDELLGKVVCVDYVSLEKKKAMWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTVPKPDAVLKQAFDQALEFHKSRAIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIDFQMALPEKVLNKPCKDCENKEVKVKEESETEIKEVNVEDSKNVMPKEETPAEDESERKENIKPSLGSKKSLLECIPAQSDEEKEAHITKLEENENLEDKDGGRARTEEAFSTEVDGEEEQARSGDETNKEEDEDDEEIEEEEEEDEEEDEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEALYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDRDEKYSPKNCKLRRLSKSPFQSNPSPEMVSKLDLADAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERCTQDVDNIGKDESKVEHSTHSRNELISKEEQSSPSLLEENKVHTDLVIAKTVSKSPERLRKDMEAISEDTDFEEEDEITKKRKDVKKDTTDKALKPQTKRGKRRYCSADECLQTGSPGKKEDRTKSKEPLCTENSSNSSSDEDEEEKSKAKMTPTKKYNGLEEKRKSLRTTSFYSGFSEVAEKRIKLLNNSDERLQNNRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPDEGAVEESLQTVAEEESCSPIMELEKPLPASVDNKPIEEKPLEVSDRKTEFPSSGSNSVLNTPPTTPESPSSVTITEASQQQSSVTVSVPLPPNQEEVRSIKSETDSTIEVDSVVGELQDLQSEGNSSPAGFDASVSSSSSNQPEPDNPEKACTGQKRVKDTQGVGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESVTKTQTIKSVPTGMKTHNSKSPARVQSPGKGGRNGDKDPDLKEPSNRLPKVYKWSFQTSDLENMTSAERISILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR" }, "uniprot_id": "ARI4B_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23487765", "type": [ "PubMed" ], "id": "23487765" } ], "title": "ARID4A and ARID4B regulate male fertility, a functional link to the AR and RB pathways.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238.1", "id": "NP_919238.1", "database": "RefSeq" } ], "authors": "Beaudet A.L., Jiang M., Wu M.Y., Wu R.C.", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26258622", "type": [ "PubMed" ], "id": "26258622" } ], "title": "Androgen Receptor Coactivator ARID4B Is Required for the Function of Sertoli Cells in Spermatogenesis.", "journal": "Molecular endocrinology (Baltimore, Md.)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238.1", "id": "NP_919238.1", "database": "RefSeq" } ], "authors": "Wu RC, Zeng Y, Pan IW, Wu MY", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28207192", "type": [ "PubMed" ], "id": "28207192" } ], "title": "Temporal-Spatial Establishment of Initial Niche for the Primary Spermatogonial Stem Cell Formation Is Determined by an ARID4B Regulatory Network.", "journal": "Stem cells (Dayton, Ohio)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238.1", "id": "NP_919238.1", "database": "RefSeq" } ], "authors": "Wu RC, Zeng Y, Chen YF, Lanz RB, Wu MY", "date": "2017" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17043311", "type": [ "PubMed" ], "id": "17043311" } ], "title": "Deficiency of Rbbp1/Arid4a and Rbbp1l1/Arid4b alters epigenetic modifications and suppresses an imprinting defect in the PWS/AS domain.", "journal": "Genes Dev.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "authors": "Beaudet A.L., Wu M.Y., Tsai T.F.", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18728284", "type": [ "PubMed" ], "id": "18728284" } ], "title": "Identification of chromatin remodeling genes Arid4a and Arid4b as leukemia suppressor genes.", "journal": "J. Natl. Cancer Inst.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238.1", "id": "NP_919238.1", "database": "RefSeq" } ], "authors": "Beaudet A.L., Wu M.Y., Eldin K.W.", "date": "2008" } ], "uniprot_ac": "A2CG63", "site_annotation": [ { "end_pos": 914, "annotation": "n_glycosylation_sequon", "start_pos": 912 }, { "end_pos": 1090, "annotation": "n_glycosylation_sequon", "start_pos": 1088 }, { "end_pos": 859, "annotation": "n_glycosylation_sequon", "start_pos": 857 }, { "end_pos": 862, "annotation": "n_glycosylation_sequon", "start_pos": 860 }, { "end_pos": 296, "annotation": "n_glycosylation_sequon", "start_pos": 294 }, { "end_pos": 1155, "annotation": "n_glycosylation_sequon", "start_pos": 1153 }, { "end_pos": 1230, "annotation": "n_glycosylation_sequon", "start_pos": 1228 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2CG63#A2CG63-1", "isoform_ac": "A2CG63-1", "locus": { "end_pos": 14064874, "strand": "-", "start_pos": 14197730, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000110534", "id": "ENSMUST00000110534", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000106163", "id": "ENSMUSP00000106163", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2CG63-1|ARI4B_MOUSE Isoform 1 of AT-rich interactive domain-containing protein 4B OS=Mus musculus OX=10090 GN=Arid4b PE=1 SV=1 CANONICAL=A2CG63-1", "length": 1314, "sequence": "MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDDDEEERKQTDELLGKVVCVDYVSLEKKKAMWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTVPKPDAVLKQAFDQALEFHKSRAIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIDFQMALPEKVLNKPCKDCENKEVKVKEESETEIKEVNVEDSKNVMPKEETPAEDESERKENIKPSLGSKKSLLECIPAQSDEEKEAHITKLEENENLEDKDGGRARTEEAFSTEVDGEEEQARSGDETNKEEDEDDEEIEEEEEEDEEEDEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEALYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDRDEKYSPKNCKLRRLSKSPFQSNPSPEMVSKLDLADAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERCTQDVDNIGKDESKVEHSTHSRNELISKEEQSSPSLLEENKVHTDLVIAKTVSKSPERLRKDMEAISEDTDFEEEDEITKKRKDVKKDTTDKALKPQTKRGKRRYCSADECLQTGSPGKKEDRTKSKEPLCTENSSNSSSDEDEEEKSKAKMTPTKKYNGLEEKRKSLRTTSFYSGFSEVAEKRIKLLNNSDERLQNNRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPDEGAVEESLQTVAEEESCSPIMELEKPLPASVDNKPIEEKPLEVSDRKTEFPSSGSNSVLNTPPTTPESPSSVTITEASQQQSSVTVSVPLPPNQEEVRSIKSETDSTIEVDSVVGELQDLQSEGNSSPAGFDASVSSSSSNQPEPDNPEKACTGQKRVKDTQGVGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESVTKTQTIKSVPTGMKTHNSKSPARVQSPGKGGRNGDKDPDLKEPSNRLPKVYKWSFQTSDLENMTSAERISILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR" } }, { "url": "https://www.uniprot.org/uniprot/A2CG63#A2CG63-2", "isoform_ac": "A2CG63-2", "locus": { "end_pos": 14064874, "strand": "-", "start_pos": 14197730, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000039538", "id": "ENSMUST00000039538", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000043889", "id": "ENSMUSP00000043889", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2CG63-2|ARI4B_MOUSE Isoform 2 of AT-rich interactive domain-containing protein 4B OS=Mus musculus OX=10090 GN=Arid4b PE=1 SV=1 CANONICAL=A2CG63-1", "length": 1227, "sequence": "MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDDDEEERKQTDELLGKVVCVDYVSLEKKKAMWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTVPKPDAVLKQAFDQALEFHKSRAIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIDFQMALPEKVLNKPCKDCENKEVKVKEESETEIKEVNVEDSKNVMPKEETPAEDESERKENIKPSLGSKKSLLECIPAQSDEEKEAHITKLEENENLEDKDGGRARTEEAFSTEVDGEEEQARSGYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDRDEKYSPKNCKLRRLSKSPFQSNPSPEMVSKLDLADAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERCTQDVDNIGKDESKVEHSTHSRNELISKEEQSSPSLLEENKVHTDLVIAKTVSKSPERLRKDMEAISEDTDFEEEDEITKKRKDVKKDTTDKALKPQTKRGKRRYCSADECLQTGSPGKKEDRTKSKEPLCTENSSNSSSDEDEEEKSKAKMTPTKKYNGLEEKRKSLRTTSFYSGFSEVAEKRIKLLNNSDERLQNNRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPDEGAVEESLQTVAEEESCSPIMELEKPLPASVDNKPIEEKPLEVSDRKTEFPSSGSNSVLNTPPTTPESPSSVTITEASQQQSSVTVSVPLPPNQEEVRSIKSETDSTIEVDSVVGELQDLQSEGNSSPAGFDASVSSSSSNQPEPDNPEKACTGQKRVKDTQGVGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESVTKTQTIKSVPTGMKTHNSKSPARVQSPGKGGRNGDKDPDLKEPSNRLPKVYKWSFQTSDLENMTSAERISILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR" } }, { "url": "https://www.uniprot.org/uniprot/A2CG63#A0A1Y7VKA9-1", "isoform_ac": "A0A1Y7VKA9-1", "locus": { "end_pos": 14191177, "strand": "-", "start_pos": 14191961, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000151151", "id": "ENSMUST00000151151", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000152798", "id": "ENSMUSP00000152798", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A1Y7VKA9-1|ARI4B_MOUSE Computationally mapped isoform of AT-rich interactive domain-containing protein 4B OS=Mus musculus OX=10090 GN=Arid4b PE=1 SV=1 CANONICAL=A2CG63-1", "length": 31, "sequence": "XGVGSSSKKQKRSHKATVVNNKKKGKGSAPH" } }, { "url": "https://www.uniprot.org/uniprot/A2CG63#Z4YMH1-1", "isoform_ac": "Z4YMH1-1", "locus": { "end_pos": 14064874, "strand": "-", "start_pos": 14169958, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000129488", "id": "ENSMUST00000129488", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000118687", "id": "ENSMUSP00000118687", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Z4YMH1-1|ARI4B_MOUSE Computationally mapped isoform of AT-rich interactive domain-containing protein 4B OS=Mus musculus OX=10090 GN=Arid4b PE=1 SV=1 CANONICAL=A2CG63-1", "length": 540, "sequence": "MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDDDEEERKQTDELLGKVVCVDYVSLEKKKAMWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTVPKPDAVLKQAFDQALEFHKSRAIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIDFQMALPEKVLNKPCKDCENKEVKVKEESETEIKEVNVEDSKNVMPKEETPAEDESERKENIKPSLGSKKSLLECIPAQSDEEKEAHITKLEENENLEDKDGGRARTEEAFSTEVDGEEEQARSGDETNKEEDEDDEE" } }, { "url": "https://www.uniprot.org/uniprot/A2CG63#Z4YL44-1", "isoform_ac": "Z4YL44-1", "locus": { "end_pos": 14064874, "strand": "-", "start_pos": 14164364, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000110533", "id": "ENSMUST00000110533", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000106162", "id": "ENSMUSP00000106162", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Z4YL44-1|ARI4B_MOUSE Computationally mapped isoform of AT-rich interactive domain-containing protein 4B OS=Mus musculus OX=10090 GN=Arid4b PE=1 SV=1 CANONICAL=A2CG63-1", "length": 473, "sequence": "MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDDDEEERKQTDELLGKVVCVDYVSLEKKKAMWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTVPKPDAVLKQAFDQALEFHKSRAIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIDFQMALPEKVLNKPCKDCENKEVKVKEESETEIKEVNVEDSKNVMPKEETPAEDESERKENIKPSLVTSYC" } }, { "url": "https://www.uniprot.org/uniprot/A2CG63#A0A1Y7VIX3-1", "isoform_ac": "A0A1Y7VIX3-1", "locus": { "end_pos": 14064874, "strand": "-", "start_pos": 14143009, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000222928", "id": "ENSMUST00000222928", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000152177", "id": "ENSMUSP00000152177", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A1Y7VIX3-1|ARI4B_MOUSE Computationally mapped isoform of AT-rich interactive domain-containing protein 4B OS=Mus musculus OX=10090 GN=Arid4b PE=1 SV=1 CANONICAL=A2CG63-1", "length": 128, "sequence": "MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETRGGVFLLIQ" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:94246", "resource": "KEGG Pathway", "id": "mmu:94246", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238.1", "annotation": "These results identified ARID4B as a master regulator of a signaling network that governs the establishment of a niche during the critical gonocyte-to-spermatogonial stem cells (SSC) transition phase to control the fate of gonocytes and SSCs.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238.1", "id": "NP_919238.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238.1", "annotation": "10 of 12 Arid4a(-/-)Arid4b(+/-) mice progressed to acute myeloid leukemia (AML) and had rapid further increases of leukocyte counts.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238.1", "id": "NP_919238.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238.1", "annotation": "ARID4A and ARID4B function as transcriptional coactivators for AR and RB and play an integral part in the AR and RB regulatory pathways involved in the regulation of Sertoli cell function and male fertility.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238.1", "id": "NP_919238.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238.1", "annotation": "The study identified ARID4B to be a key regulator of Sertoli cell function important for male germ cell development.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238.1", "id": "NP_919238.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2CG63#function", "annotation": "Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A (PubMed:17043311). Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (PubMed:23487765). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (PubMed:18728284).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63#function", "id": "A2CG63", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q4LE39-1", "protein_name": "AT-rich interactive domain-containing protein 4B", "sequence": { "length": 1312, "sequence": "MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDEDEDDRKQIDELLGKVVCVDYISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTAPKPDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/12847", "id": "12847", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238.1", "ac": "NP_919238.1", "name": "AT-rich interactive domain-containing protein 4B isoform 1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044212", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "name": "transcription regulatory region DNA binding", "id": "GO:0044212" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "pmid": "23487765", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "name": "spermatogenesis", "id": "GO:0007283" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "pmid": "23487765", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006349", "pmid": "17043311", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "name": "regulation of gene expression by genetic imprinting", "id": "GO:0006349" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034773", "pmid": "17043311", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "name": "histone H4-K20 trimethylation", "id": "GO:0034773" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036124", "pmid": "17043311", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "name": "histone H3-K9 trimethylation", "id": "GO:0036124" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097368", "pmid": "23487765", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "name": "establishment of Sertoli cell barrier", "id": "GO:0097368" } ], "total": 7, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "type": "synonym", "resource": "UniProtKB", "name": "Sap180" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2CG63", "type": "synonym", "resource": "RefSeq", "name": "BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180" }, { "url": "https://www.uniprot.org/uniprot/A2CG63", "type": "recommended", "resource": "UniProtKB", "name": "Arid4b" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2CG63", "type": "synonym", "resource": "RefSeq", "name": "Arid4b" } ], "crossref": [ { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13964:SF24", "id": "PTHR13964:SF24", "database": "PANTHER" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:94246", "id": "mmu:94246", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:2137512", "id": "2137512", "database": "MGI" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000039219", "id": "ENSMUSG00000039219", "database": "Bgee" }, { "url": "https://omabrowser.org/oma/group/CKDCEKE/", "id": "CKDCEKE", "database": "OMA" }, { "url": "http://pfam.xfam.org/family/PF11717", "id": "PF11717", "database": "Pfam" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR025995", "id": "IPR025995", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF01388", "id": "PF01388", "database": "Pfam" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR012603", "id": "IPR012603", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF08169", "id": "PF08169", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/94246", "id": "94246", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2CG63*", "id": "A2CG63", "database": "IntAct" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036431", "id": "IPR036431", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016197", "id": "IPR016197", "database": "InterPro" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238.1", "id": "NP_919238.1", "database": "RefSeq" }, { "url": "http://www.orthodb.org/?query=329541at2759", "id": "329541at2759", "database": "OrthoDB" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002999", "id": "IPR002999", "database": "InterPro" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2CG63", "id": "PR_A2CG63", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001606", "id": "IPR001606", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR028853", "id": "IPR028853", "database": "InterPro" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Ser", "position": "1155", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "1157", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "482", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "1154", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "778", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "668", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b" }, { "residue": "Ser", "position": "1161", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "790", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b" }, { "residue": "Ser", "position": "675", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "1016", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "790", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "295", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "666", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "717", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Thr", "position": "1152", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "276", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Thr", "position": "793", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b" }, { "residue": "Ser", "position": "296", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "1031", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "668", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Thr", "position": "793", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "675", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b" }, { "residue": "Thr", "position": "1028", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" } ], "mass": { "monoisotopic_mass": 147643.0, "chemical_mass": 147643.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "name": "Arid4b", "locus": { "end_pos": 14199603, "strand": "+", "start_pos": 14063232, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000039219", "id": "ENSMUSG00000039219", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2CG63", "type": "synonym", "resource": "UniProtKB", "name": "Sin3-associated polypeptide p180" }, { "url": "https://www.uniprot.org/uniprot/A2CG63", "type": "synonym", "resource": "UniProtKB", "name": "ARID domain-containing protein 4B" }, { "url": "https://www.uniprot.org/uniprot/A2CG63", "type": "synonym", "resource": "UniProtKB", "name": "Histone deacetylase complex subunit SAP180" }, { "url": "https://www.uniprot.org/uniprot/A2CG63", "type": "synonym", "resource": "UniProtKB", "name": "180 kDa Sin3-associated polypeptide" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2CG63", "type": "synonym", "resource": "RefSeq", "name": "AT-rich interactive domain-containing protein 4B isoform 1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2CG63", "type": "synonym", "resource": "RefSeq", "name": "retinoblastoma binding protein 1-like 1; AT-rich interactive domain-containing protein 4B; sin3-associated polypeptide p180; ARID domain-containing protein 4B; 180 kDa Sin3-associated polypeptide; histone deacetylase complex subunit SAP180; breast cancer-associated antigen" }, { "url": "https://www.uniprot.org/uniprot/A2CG63", "type": "recommended", "resource": "UniProtKB", "name": "AT-rich interactive domain-containing protein 4B" } ] }