{ "uniprot_canonical_ac": "A2AUM9-1", "ptm_annotation": [], "sequence": { "header": "sp|A2AUM9-1|CE152_MOUSE Isoform 1 of Centrosomal protein of 152 kDa OS=Mus musculus OX=10090 GN=Cep152 PE=1 SV=1 CANONICAL=A2AUM9-1", "length": 1736, "sequence": "MSLEFGSVALQTQNEDEEFDKEDFEREKELQQLLTDLPHDMLDDELSSPERHDSDCSMDGRAAEPHPSEHLERKWIERDILPKPHSMNCGNGWEENRSKTEDQHLGYHPGEGGDEGGSGYSPPGKREQADLYRLPEDFRPYTGGSKQAASVITFSDPQRDNFQQFGLSRGPSCGALEPYKAVYKPYRNSSVQKNSSPAQEVAASDMFEGLQQQFLGANETDSAENIHIIQLQVLNKAKERQLDSLVEKLKDSERQVRYLSHQLLIVQDEKDGLALSLRESQQLFQNGKEREMQLEAQIAALEAQVEAFRVSEEKLTKKLRTTEITLESLKQQLVELHHSESLQRAREHHESIVASLTQKHEEQVSSLQKNLDATITALQEQESICTRLKDHVQQLERNQEAVRLEKTELINRLTRSLEDSQKQCAHLLQSGSVQEVAQLQLQLQQAQKAHVLSESMNKALQEELTELKDEISLYESAAELGVLPGDSEGDLSIELTESCVDLGIKKVNWKQSKANRVTQQESPDEDPSKDELILKLKTQVQRLLTSNSVKRHLVSQLQSDLRECRETMEAFQQSKDGDSGMETKTDTSEKTTKQLWLESSEAINREDILQLKNEVQVLQKQNQELKEAEEKLRSTNQDLCNQMRQMVQEFDHDKQEAVARCERTYQQHHEAMKAQIRESLLAKHAVEKQHLLEVYEGTQSQLRSDLDKMNKEMAAVQECYLEVCREKDGLESTLRKTMEKAQEQKRQLLEAREEYVRKLKLELEEKYQETLKTERQSWLQEQAAGATQQAEKESRQKLIQQLEKEWQSKLDDSLAAWRKTTSDRGSQTEQVACPAAVSKAEAAAVLAEEQARQVQQEKELATKEALRKPEVELELKYCEIIAQKVETAVQNARSRWIQELPMLAEYKALLRAQQQEWAKQQELAVAHRLSLALSEAKEKWKSELENMKPNVMSVKELEEKVHSLQKELELKDEEVPVIVRAEVAKARTEWNKEKQEEIHKIQEQNEEDYRQFLEDHRNKINEVLAAAKEDFVKQKAELLLQKETEFQACLDQSRKEWTLQEAQQTQVEIRQYEEDTLTVLAYLLKDTQLEYGGDSQDKQLLEAMSACSSKWISVQYFEKVKACIQKALHDMLSLLTDSVASEQEKRKVVKSSADTVSWTSSEGDSAVPVPLPDSTSVRCAQSSAWLKAEAETDKKICEIKGLRCGHCFQELEKEKQECQDLRRKLEKCRRHLQHLERTHRAAVEKLGEENSRVVEELIEENHDMKNKLEALRALCRTPPRSLSAGAAESAGPSCSRQALEELRGQYIKAVRKIKRDMLRYIQESKERAAEMVKAEVLRERQETARKMRNYYLSCLQQILQDNGKEEGAEKKIMSAASKLATMAELLGTIAESDCRVRCAQAGRSVALPLASEMLTGTERSERSGVNHNIPHYVESKPNSGKTLPRSVCEQLPGRKAAPRSQRRLEESKHREMRPMASTALPSDCRCGDASCRHSGVLAKDVAPEFVPCQGEGGFDLHEKRDALGAGSEPLLYSAAHSFLGGAEKNSSPRCISESRHTTLRSPSEMPRLKALMCGSPTETDSIASEKSQGVGSQDSPVKDGVGPSSSPAWPSDSTLPCGSPAVLFLGDGSQRTQEMLGDSVQWKQFSATSCHPDAQKSNMVCRSSHTLDLPKETLHSQQGKMGATLGHPSPQSTDMLKTDFKRLSGTGPSSLCQKPLIKLTAPMPSQQDSGFDSPLE" }, "uniprot_id": "CE152_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUM9", "id": "A2AUM9", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", "type": [ "PubMed" ], "id": "12520002" } ], "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074560.1", "id": "NP_001074560.1", "database": "RefSeq" } ], "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24240477", "type": [ "PubMed" ], "id": "24240477" } ], "title": "The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis.", "journal": "Nat. Cell Biol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUM9", "id": "A2AUM9", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074560.1", "id": "NP_001074560.1", "database": "RefSeq" } ], "authors": "Cao J., Huang Q., Huang X., Li S., Xu T., Zhao H., Zhu Y., Zhu X., Yan X., Zhu L.", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/10512203", "type": [ "PubMed" ], "id": "10512203" } ], "title": "Exchangeable gene trap using the Cre/mutated lox system.", "journal": "Cellular and molecular biology (Noisy-le-Grand, France)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074560.1", "id": "NP_001074560.1", "database": "RefSeq" } ], "authors": "Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki M, Miura K, Araki M, Yamamura K", "date": "1999" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20360068", "type": [ "PubMed" ], "id": "20360068" } ], "title": "Systematic analysis of human protein complexes identifies chromosome segregation proteins.", "journal": "Science (New York, N.Y.)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074560.1", "id": "NP_001074560.1", "database": "RefSeq" } ], "authors": "Hutchins JR, Toyoda Y, Hegemann B, Poser I, Heriche JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23806337", "type": [ "PubMed" ], "id": "23806337" } ], "title": "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.", "journal": "Mol. Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUM9", "id": "A2AUM9", "database": "UniProtKB" } ], "authors": "Chen Y., Park J., Zhang Y., Zhao Y., Peng C., Tan M., Xie Z., Zwaans B.M., Lombard D.B., Dai L., Tishkoff D.X., Skinner M.E.", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24706806", "type": [ "PubMed" ], "id": "24706806" } ], "title": "Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074560.1", "id": "NP_001074560.1", "database": "RefSeq" } ], "authors": "Bazzi H, Anderson KV", "date": "2014" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23936128", "type": [ "PubMed" ], "id": "23936128" } ], "title": "Cep63 and cep152 cooperate to ensure centriole duplication.", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074560.1", "id": "NP_001074560.1", "database": "RefSeq" } ], "authors": "Brown NJ, Marjanovic M, Luders J, Stracker TH, Costanzo V", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26496610", "type": [ "PubMed" ], "id": "26496610" } ], "title": "A human interactome in three quantitative dimensions organized by stoichiometries and abundances.", "journal": "Cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074560.1", "id": "NP_001074560.1", "database": "RefSeq" } ], "authors": "Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M", "date": "2015" } ], "uniprot_ac": "A2AUM9", "site_annotation": [ { "end_pos": 190, "annotation": "n_glycosylation_sequon", "start_pos": 188 }, { "end_pos": 98, "annotation": "n_glycosylation_sequon", "start_pos": 96 }, { "end_pos": 220, "annotation": "n_glycosylation_sequon", "start_pos": 218 }, { "end_pos": 196, "annotation": "n_glycosylation_sequon", "start_pos": 194 }, { "end_pos": 1547, "annotation": "n_glycosylation_sequon", "start_pos": 1545 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AUM9#A2AUM9-1", "isoform_ac": "A2AUM9-1", "locus": { "end_pos": 125563403, "strand": "+", "start_pos": 125621259, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000089776", "id": "ENSMUST00000089776", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000087208", "id": "ENSMUSP00000087208", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AUM9-1|CE152_MOUSE Isoform 1 of Centrosomal protein of 152 kDa OS=Mus musculus OX=10090 GN=Cep152 PE=1 SV=1 CANONICAL=A2AUM9-1", "length": 1736, "sequence": "MSLEFGSVALQTQNEDEEFDKEDFEREKELQQLLTDLPHDMLDDELSSPERHDSDCSMDGRAAEPHPSEHLERKWIERDILPKPHSMNCGNGWEENRSKTEDQHLGYHPGEGGDEGGSGYSPPGKREQADLYRLPEDFRPYTGGSKQAASVITFSDPQRDNFQQFGLSRGPSCGALEPYKAVYKPYRNSSVQKNSSPAQEVAASDMFEGLQQQFLGANETDSAENIHIIQLQVLNKAKERQLDSLVEKLKDSERQVRYLSHQLLIVQDEKDGLALSLRESQQLFQNGKEREMQLEAQIAALEAQVEAFRVSEEKLTKKLRTTEITLESLKQQLVELHHSESLQRAREHHESIVASLTQKHEEQVSSLQKNLDATITALQEQESICTRLKDHVQQLERNQEAVRLEKTELINRLTRSLEDSQKQCAHLLQSGSVQEVAQLQLQLQQAQKAHVLSESMNKALQEELTELKDEISLYESAAELGVLPGDSEGDLSIELTESCVDLGIKKVNWKQSKANRVTQQESPDEDPSKDELILKLKTQVQRLLTSNSVKRHLVSQLQSDLRECRETMEAFQQSKDGDSGMETKTDTSEKTTKQLWLESSEAINREDILQLKNEVQVLQKQNQELKEAEEKLRSTNQDLCNQMRQMVQEFDHDKQEAVARCERTYQQHHEAMKAQIRESLLAKHAVEKQHLLEVYEGTQSQLRSDLDKMNKEMAAVQECYLEVCREKDGLESTLRKTMEKAQEQKRQLLEAREEYVRKLKLELEEKYQETLKTERQSWLQEQAAGATQQAEKESRQKLIQQLEKEWQSKLDDSLAAWRKTTSDRGSQTEQVACPAAVSKAEAAAVLAEEQARQVQQEKELATKEALRKPEVELELKYCEIIAQKVETAVQNARSRWIQELPMLAEYKALLRAQQQEWAKQQELAVAHRLSLALSEAKEKWKSELENMKPNVMSVKELEEKVHSLQKELELKDEEVPVIVRAEVAKARTEWNKEKQEEIHKIQEQNEEDYRQFLEDHRNKINEVLAAAKEDFVKQKAELLLQKETEFQACLDQSRKEWTLQEAQQTQVEIRQYEEDTLTVLAYLLKDTQLEYGGDSQDKQLLEAMSACSSKWISVQYFEKVKACIQKALHDMLSLLTDSVASEQEKRKVVKSSADTVSWTSSEGDSAVPVPLPDSTSVRCAQSSAWLKAEAETDKKICEIKGLRCGHCFQELEKEKQECQDLRRKLEKCRRHLQHLERTHRAAVEKLGEENSRVVEELIEENHDMKNKLEALRALCRTPPRSLSAGAAESAGPSCSRQALEELRGQYIKAVRKIKRDMLRYIQESKERAAEMVKAEVLRERQETARKMRNYYLSCLQQILQDNGKEEGAEKKIMSAASKLATMAELLGTIAESDCRVRCAQAGRSVALPLASEMLTGTERSERSGVNHNIPHYVESKPNSGKTLPRSVCEQLPGRKAAPRSQRRLEESKHREMRPMASTALPSDCRCGDASCRHSGVLAKDVAPEFVPCQGEGGFDLHEKRDALGAGSEPLLYSAAHSFLGGAEKNSSPRCISESRHTTLRSPSEMPRLKALMCGSPTETDSIASEKSQGVGSQDSPVKDGVGPSSSPAWPSDSTLPCGSPAVLFLGDGSQRTQEMLGDSVQWKQFSATSCHPDAQKSNMVCRSSHTLDLPKETLHSQQGKMGATLGHPSPQSTDMLKTDFKRLSGTGPSSLCQKPLIKLTAPMPSQQDSGFDSPLE" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2565942", "resource": "Reactome", "id": "R-MMU-2565942", "name": "Regulation of PLK1 Activity at G2/M Transition" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5620912", "resource": "Reactome", "id": "R-MMU-5620912", "name": "Anchoring of the basal body to the plasma membrane" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8854518", "resource": "Reactome", "id": "R-MMU-8854518", "name": "AURKA Activation by TPX2" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-380259", "resource": "Reactome", "id": "R-MMU-380259", "name": "Loss of Nlp from mitotic centrosomes" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:99100", "resource": "KEGG Pathway", "id": "mmu:99100", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-380284", "resource": "Reactome", "id": "R-MMU-380284", "name": "Loss of proteins required for interphase microtubule organization from the centrosome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-380270", "resource": "Reactome", "id": "R-MMU-380270", "name": "Recruitment of mitotic centrosome proteins and complexes" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-380320", "resource": "Reactome", "id": "R-MMU-380320", "name": "Recruitment of NuMA to mitotic centrosomes" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074560.1", "annotation": "Both mouse and human Cep63 and Cep152 cooperate to ensure efficient centriole duplication by promoting the accumulation of essential centriole duplication factors upstream of SAS-6 recruitment and procentriole formation. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074560.1", "id": "NP_001074560.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2AUM9#function", "annotation": "Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (By similarity). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation (By similarity). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (By similarity). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (PubMed:24240477). Overexpression of cep152 can drive amplification of centrioles.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUM9#function", "id": "A2AUM9", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "O94986-4", "protein_name": "Centrosomal protein of 152 kDa", "sequence": { "length": 1710, "sequence": "MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDGTDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYHPEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQGPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQTIKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCLDQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAGHHAQPLALQATEAEADKKKVLEIKDLCCGHCFQELEKAKQECQDLKGKLEKCCRHLQHLERKHKAVVEKIGEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSGGALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQQILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVKKSKRNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGSKETHLEFQFGDGSCKHLNSLPRNVSPEFVPCEGEGGFGLHKKKDLLSDNGSESLPHSAAYPFLGTLGNKPSPRCTPGPSESGCMHITFRDSNERLGLKVYKCNPLMESENAASEKSQGLDVQEPPVKDGGDLSDCLGWPSSSATLSFDSREASFVHGRPQGTLEIPSESVKSKQFSPSGYLSDTEESNMICQTMKCQRYQTPYLSEETTYLEPGKISVNCGHPSRHKADRLKSDFKKLSSTLPSSVCQQPSRKLIVPLSSQQDSGFDSPFVNLD" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/37159", "id": "37159", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2AUM9/", "id": "A2AUM9", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074560.1", "ac": "NP_001074560.1", "name": "centrosomal protein of 152 kDa", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUM9", "id": "A2AUM9", "database": "UniProtKB" } ], "name": "protein kinase binding", "id": "GO:0019901" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "pmid": "26158450", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUM9", "id": "A2AUM9", "database": "UniProtKB" } ], "name": "centrosome", "id": "GO:0005813" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098536", "pmid": "24240477", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUM9", "id": "A2AUM9", "database": "UniProtKB" } ], "name": "deuterosome", "id": "GO:0098536" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUM9", "id": "A2AUM9", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUM9", "id": "A2AUM9", "database": "UniProtKB" } ], "name": "centriole", "id": "GO:0005814" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000242", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUM9", "id": "A2AUM9", "database": "UniProtKB" } ], "name": "pericentriolar material", "id": "GO:0000242" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007099", "pmid": "24240477", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUM9", "id": "A2AUM9", "database": "UniProtKB" } ], "name": "centriole replication", "id": "GO:0007099" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098535", "pmid": "24240477", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUM9", "id": "A2AUM9", "database": "UniProtKB" } ], "name": "de novo centriole assembly involved in multi-ciliated epithelial cell differentiation", "id": "GO:0098535" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030030", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUM9", "id": "A2AUM9", "database": "UniProtKB" } ], "name": "cell projection organization", "id": "GO:0030030" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051298", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUM9", "id": "A2AUM9", "database": "UniProtKB" } ], "name": "centrosome duplication", "id": "GO:0051298" } ], "total": 4, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AUM9", "type": "synonym", "resource": "RefSeq", "name": "Cep152" }, { "url": "https://www.uniprot.org/uniprot/A2AUM9", "type": "synonym", "resource": "UniProtKB", "name": "Kiaa0912" }, { "url": "https://www.uniprot.org/uniprot/A2AUM9", "type": "recommended", "resource": "UniProtKB", "name": "Cep152" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AUM9", "type": "synonym", "resource": "RefSeq", "name": "AI851464; mKIAA0912" } ], "crossref": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-380259", "id": "R-MMU-380259", "database": "Reactome" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029598", "id": "IPR029598", 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