{ "uniprot_canonical_ac": "A2AIV2-1", "ptm_annotation": [], "sequence": { "header": "sp|A2AIV2-1|VIR_MOUSE Isoform 1 of Protein virilizer homolog OS=Mus musculus OX=10090 GN=Virma PE=1 SV=1 CANONICAL=A2AIV2-1", "length": 1811, "sequence": "MAVDSSMELLFLDTFKHPSAEQSSHIDVVRFPCVVYINEVRVIPPGVRAHSGLPDNRAYGETSPHTFQLDLFFNNVSKPSAPVFDRLGSLEYDENTSIIFRPNSKVNTDGLVLRGWYNCLTLAIYGSVDRVISHDRDSPPPPPPPPPPPQPQPTLKRNLKHADGEKEDQFNGSPPRPQPRGPRTPPGPPPPDDDEDDPMSLPVSGDKEEDVPHREDYFEPISPDRNSVPQEGQYSDEGEVEEEPQEEGEDDEDDVDVEEEEDEDEDDCHTVDSIPDDEEEDEEEEGEEDEEGEGDDGYEQISSDEDGIADLERETFKYPNFDVEYTPEDLASVPPMTYDPYDRELAPLLYFSCPYKTTFEIEISRMKDQGPDKENSGAVEASVKLTELLDLYQEDRGAKWVTALEEIPSLIIKGLSYLQLKNTEQDSLGQLVDWTMQALNLQVAFRQPIALNVRQLKAGTKLVTSLAECGAPGVTELLQAGVINVLFDLLFADHVSSSLKLNAFKALDSVISMTEGMEAFLRSTQNEKSGYQRLLELILLDQTVRVVTAGSAILQKCHFYEILSEIKRLGDHIAEKTSAVPNHSEPDQDTDAVLERANPDYENEVEASMDMDLLESSIISEGEIEKLTNLLEEVFHVMETAPHTMTQPPVKSFPTIARITGPPERDDPYPVLFRYLHSHHFLELVTLLLSIPITSAHQGVLQATKDVLKFLAQSQKGLLFFMSEYEATNLLIRALCHLYDQDEEEGLQSDGADDAFALWLQDSTQTLQCITELFSHFQRCTASEETDHSDLLGTLHNLYLITFNPVGRSAVGHVFSLDKNLQSLITLMEYYSKEALGDSKSKKSVAYNYACVLTLVVAQSSSGVQMLEQHAASLLKLCKADENNAKLQELGKWLEPLKNLRFEINCIPNLIEYVKQNIDNLMTAEGVGLTTALRVLCNVACPPPPVEGQQKDLKWNLAVIQLFSAEGMDTFIRVLQKLNSILTQPWRLHVNMGTTLHRVTTISMARCTLTLLKTMLTELLRGGSFEFKDMRVPSALVTLHMLLCSIPLSGRLDSDEQKIQNDIIDILLTFTQGVNEKLTISEETLANNTWSLMLKEVLSSILKVPEGFFSGLILLSELLPLPLPMQTTQVIEPHDISVALNTRKLWSMHLHVQAKLLQEIVRSFSGTTCQPIQHMLRRICVQLCDLASPTALLIMRTVLDLIVEDLQSTSEDKEKQYTSQTTRLLALLDALASHKACKLAILHLINGTIKGDERYAEIFQDLLALVRSPGDSVTRQQCVEYVTSILQSLCDQDIALILPSPSEGPASELEQLSNSLPSKELMTAICDCLLATLANSESSYNCLLTCVRTMMFLAEHDYGLFHLKSSLRKNSSALHSLLKRVVSTFSKDTGELASASLDFMRQILNADAMGCCGDDSGLMEVEGAHPPRTMSLNAAELKQLLQSKEESPESLFLELEKLVLEHSKDDDSLESLLDNVIGLKQMLESSGEPLPLSDQDVEPVLSAPESLQNLFNNRTAYVLADVMDDQLKSMWFTPFQAEEIDTDLDLVKVDLIELSEKCCSDFDLHSELERSFLSEPSSPGRSKTTKGFKLGKHKHETFITSSGKSEYIEPAKRAHVVPPPRGRGRGGFGQGIRPHDIFRQRKQNTSRPPSMHVDDFVAAESKEVVPQDGIPPPKRPLKVSQKISSRGGFSGNRGGRGAFHSQNRFFTPPASKGNYSRREGTRGSSWSAQNTPRGNYNESRGGQSNFNRGPLPPLRPLSSTGYRPSPRDRASRGRGGLGPSWASTNSGSGGSRGKFVSGGSGRGRHVRSFTR" }, "uniprot_id": "VIR_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2", "id": "A2AIV2", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/29535189", "type": [ "PubMed" ], "id": "29535189" } ], "title": "Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d.", "journal": "Genes Dev.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2", "id": "A2AIV2", "database": "UniProtKB" } ], "authors": "Hess D., Soller M., Andrade-Navarro M.A., Jacob D., Biggiogera M., Buehler M., Carl S.H., Hares T., Haussmann I.U., Helm M., Knuckles P., Kreim N., Lence T., Masiello I., Roignant J.Y., Villasenor R.", "date": "2018" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/29547716", "type": [ "PubMed" ], "id": "29547716" } ], "title": "Zc3h13 regulates nuclear RNA m6A methylation and mouse embryonic stem cell self-renewal.", "journal": "Mol. Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2", "id": "A2AIV2", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333984.1", "id": "NP_001333984.1", "database": "RefSeq" } ], "authors": "Liu H., Shen H., Shi Y., Wang J., Wen J., He C., Ma H., Tan L., Yang P., Diao J., Lan F., Shi Y.G., Jiao F., Lv R., He C.'", "date": "2018" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/29539633", "type": [ "PubMed" ], "id": "29539633" } ], "title": "Placentation defects are highly prevalent in embryonic lethal mouse mutants.", "journal": "Nature", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333984.1", "id": "NP_001333984.1", "database": "RefSeq" } ], "authors": "Perez-Garcia V, Fineberg E, Wilson R, Murray A, Mazzeo CI, Tudor C, Sienerth A, White JK, Tuck E, Ryder EJ, Gleeson D, Siragher E, Wardle-Jones H, Staudt N, Wali N, Collins J, Geyer S, Busch-Nentwich EM, Galli A, Smith JC, Robertson E, Adams DJ, Weninger WJ, Mohun T, Hemberger M", "date": "2018" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24129315", "type": [ "PubMed" ], "id": "24129315" } ], "title": "Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.", "journal": "Mol. Cell. Proteomics", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2", "id": "A2AIV2", "database": "UniProtKB" } ], "authors": "Beausoleil S.A., Wang Y., Zhou J., Comb M.J., Guo A., Lee K.A., Aguiar M., Bedford M.T., Gu H., Jia X., Kornhauser J., Mulhern D., Ren J., Silva J.C., Vemulapalli V., Yang V.", "date": "2014" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17242355", "type": [ "PubMed" ], "id": "17242355" } ], "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2", "id": "A2AIV2", "database": "UniProtKB" } ], "authors": "Beausoleil S.A., Gerber S.A., Gygi S.P., Villen J.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", "type": [ "PubMed" ], "id": "12520002" } ], "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333984.1", "id": "NP_001333984.1", "database": "RefSeq" } ], "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19144319", "type": [ "PubMed" ], "id": "19144319" } ], "title": "The phagosomal proteome in interferon-gamma-activated macrophages.", "journal": "Immunity", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2", "id": "A2AIV2", "database": "UniProtKB" } ], "authors": "Thibault P., Trost M., Desjardins M., Courcelles M., English L., Lemieux S.", "date": "2009" } ], "uniprot_ac": "A2AIV2", "site_annotation": [ { "end_pos": 584, "annotation": "n_glycosylation_sequon", "start_pos": 582 }, { "end_pos": 1089, "annotation": "n_glycosylation_sequon", "start_pos": 1087 }, { "end_pos": 77, "annotation": "n_glycosylation_sequon", "start_pos": 75 }, { "end_pos": 1515, "annotation": "n_glycosylation_sequon", "start_pos": 1513 }, { "end_pos": 1248, "annotation": "n_glycosylation_sequon", "start_pos": 1246 }, { "end_pos": 173, "annotation": "n_glycosylation_sequon", "start_pos": 171 }, { "end_pos": 1739, "annotation": "n_glycosylation_sequon", "start_pos": 1737 }, { "end_pos": 1716, "annotation": "n_glycosylation_sequon", "start_pos": 1714 }, { "end_pos": 97, "annotation": "n_glycosylation_sequon", "start_pos": 95 }, { "end_pos": 1646, "annotation": "n_glycosylation_sequon", "start_pos": 1644 }, { "end_pos": 1372, "annotation": "n_glycosylation_sequon", "start_pos": 1370 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2#A2AIV2-2", "isoform_ac": "A2AIV2-2", "locus": { "end_pos": 11486043, "strand": "-", "start_pos": 11527169, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000055372", "id": "ENSMUST00000055372", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000063188", "id": "ENSMUSP00000063188", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AIV2-2|VIR_MOUSE Isoform 2 of Protein virilizer homolog OS=Mus musculus OX=10090 GN=Virma PE=1 SV=1 CANONICAL=A2AIV2-1", "length": 1139, "sequence": "MAVDSSMELLFLDTFKHPSAEQSSHIDVVRFPCVVYINEVRVIPPGVRAHSGLPDNRAYGETSPHTFQLDLFFNNVSKPSAPVFDRLGSLEYDENTSIIFRPNSKVNTDGLVLRGWYNCLTLAIYGSVDRVISHDRDSPPPPPPPPPPPQPQPTLKRNLKHADGEKEDQFNGSPPRPQPRGPRTPPGPPPPDDDEDDPMSLPVSGDKEEDVPHREDYFEPISPDRNSVPQEGQYSDEGEVEEEPQEEGEDDEDDVDVEEEEDEDEDDCHTVDSIPDDEEEDEEEEGEEDEEGEGDDGYEQISSDEDGIADLERETFKYPNFDVEYTPEDLASVPPMTYDPYDRELAPLLYFSCPYKTTFEIEISRMKDQGPDKENSGAVEASVKLTELLDLYQEDRGAKWVTALEEIPSLIIKGLSYLQLKNTEQDSLGQLVDWTMQALNLQVAFRQPIALNVRQLKAGTKLVTSLAECGAPGVTELLQAGVINVLFDLLFADHVSSSLKLNAFKALDSVISMTEGMEAFLRSTQNEKSGYQRLLELILLDQTVRVVTAGSAILQKCHFYEILSEIKRLGDHIAEKTSAVPNHSEPDQDTDAVLERANPDYENEVEASMDMDLLESSIISEGEIEKLTNLLEEVFHVMETAPHTMTQPPVKSFPTIARITGPPERDDPYPVLFRYLHSHHFLELVTLLLSIPITSAHQGVLQATKDVLKFLAQSQKGLLFFMSEYEATNLLIRALCHLYDQDEEEGLQSDGADDAFALWLQDSTQTLQCITELFSHFQRCTASEETDHSDLLGTLHNLYLITFNPVGRSAVGHVFSLDKNLQSLITLMEYYSKEALGDSKSKKSVAYNYACVLTLVVAQSSSGVQMLEQHAASLLKLCKADENNAKLQELGKWLEPLKNLRFEINCIPNLIEYVKQNIDNLMTAEGVGLTTALRVLCNVACPPPPVEGQQKDLKWNLAVIQLFSAEGMDTFIRVLQKLNSILTQPWRLHVNMGTTLHRVTTISMARCTLTLLKTMLTELLRGGSFEFKDMRVPSALVTLHMLLCSIPLSGRLDSDEQKIQNDIIDILLTFTQGVNEKLTISEETLANNTWSLMLKEVLSSILKVPEGFFSGLILLSELLPLPLPMQTTQVPLHITCILS" } }, { "url": "https://www.uniprot.org/uniprot/A2AIV2#A2AIV2-1", "isoform_ac": "A2AIV2-1", "locus": { "end_pos": 11486043, "strand": "-", "start_pos": 11549696, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000059914", "id": "ENSMUST00000059914", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000058078", "id": "ENSMUSP00000058078", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AIV2-1|VIR_MOUSE Isoform 1 of Protein virilizer homolog OS=Mus musculus OX=10090 GN=Virma PE=1 SV=1 CANONICAL=A2AIV2-1", "length": 1811, "sequence": "MAVDSSMELLFLDTFKHPSAEQSSHIDVVRFPCVVYINEVRVIPPGVRAHSGLPDNRAYGETSPHTFQLDLFFNNVSKPSAPVFDRLGSLEYDENTSIIFRPNSKVNTDGLVLRGWYNCLTLAIYGSVDRVISHDRDSPPPPPPPPPPPQPQPTLKRNLKHADGEKEDQFNGSPPRPQPRGPRTPPGPPPPDDDEDDPMSLPVSGDKEEDVPHREDYFEPISPDRNSVPQEGQYSDEGEVEEEPQEEGEDDEDDVDVEEEEDEDEDDCHTVDSIPDDEEEDEEEEGEEDEEGEGDDGYEQISSDEDGIADLERETFKYPNFDVEYTPEDLASVPPMTYDPYDRELAPLLYFSCPYKTTFEIEISRMKDQGPDKENSGAVEASVKLTELLDLYQEDRGAKWVTALEEIPSLIIKGLSYLQLKNTEQDSLGQLVDWTMQALNLQVAFRQPIALNVRQLKAGTKLVTSLAECGAPGVTELLQAGVINVLFDLLFADHVSSSLKLNAFKALDSVISMTEGMEAFLRSTQNEKSGYQRLLELILLDQTVRVVTAGSAILQKCHFYEILSEIKRLGDHIAEKTSAVPNHSEPDQDTDAVLERANPDYENEVEASMDMDLLESSIISEGEIEKLTNLLEEVFHVMETAPHTMTQPPVKSFPTIARITGPPERDDPYPVLFRYLHSHHFLELVTLLLSIPITSAHQGVLQATKDVLKFLAQSQKGLLFFMSEYEATNLLIRALCHLYDQDEEEGLQSDGADDAFALWLQDSTQTLQCITELFSHFQRCTASEETDHSDLLGTLHNLYLITFNPVGRSAVGHVFSLDKNLQSLITLMEYYSKEALGDSKSKKSVAYNYACVLTLVVAQSSSGVQMLEQHAASLLKLCKADENNAKLQELGKWLEPLKNLRFEINCIPNLIEYVKQNIDNLMTAEGVGLTTALRVLCNVACPPPPVEGQQKDLKWNLAVIQLFSAEGMDTFIRVLQKLNSILTQPWRLHVNMGTTLHRVTTISMARCTLTLLKTMLTELLRGGSFEFKDMRVPSALVTLHMLLCSIPLSGRLDSDEQKIQNDIIDILLTFTQGVNEKLTISEETLANNTWSLMLKEVLSSILKVPEGFFSGLILLSELLPLPLPMQTTQVIEPHDISVALNTRKLWSMHLHVQAKLLQEIVRSFSGTTCQPIQHMLRRICVQLCDLASPTALLIMRTVLDLIVEDLQSTSEDKEKQYTSQTTRLLALLDALASHKACKLAILHLINGTIKGDERYAEIFQDLLALVRSPGDSVTRQQCVEYVTSILQSLCDQDIALILPSPSEGPASELEQLSNSLPSKELMTAICDCLLATLANSESSYNCLLTCVRTMMFLAEHDYGLFHLKSSLRKNSSALHSLLKRVVSTFSKDTGELASASLDFMRQILNADAMGCCGDDSGLMEVEGAHPPRTMSLNAAELKQLLQSKEESPESLFLELEKLVLEHSKDDDSLESLLDNVIGLKQMLESSGEPLPLSDQDVEPVLSAPESLQNLFNNRTAYVLADVMDDQLKSMWFTPFQAEEIDTDLDLVKVDLIELSEKCCSDFDLHSELERSFLSEPSSPGRSKTTKGFKLGKHKHETFITSSGKSEYIEPAKRAHVVPPPRGRGRGGFGQGIRPHDIFRQRKQNTSRPPSMHVDDFVAAESKEVVPQDGIPPPKRPLKVSQKISSRGGFSGNRGGRGAFHSQNRFFTPPASKGNYSRREGTRGSSWSAQNTPRGNYNESRGGQSNFNRGPLPPLRPLSSTGYRPSPRDRASRGRGGLGPSWASTNSGSGGSRGKFVSGGSGRGRHVRSFTR" } }, { "url": "https://www.uniprot.org/uniprot/A2AIV2#E9PZY8-1", "isoform_ac": "E9PZY8-1", "locus": { "end_pos": 11486043, "strand": "-", "start_pos": 11549696, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000108307", "id": "ENSMUST00000108307", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000103943", "id": "ENSMUSP00000103943", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|E9PZY8-1|VIR_MOUSE Computationally mapped isoform of Protein virilizer homolog OS=Mus musculus OX=10090 GN=Virma PE=1 SV=1 CANONICAL=A2AIV2-1", "length": 1861, "sequence": "MAVDSSMELLFLDTFKHPSAEQSSHIDVVRFPCVVYINEVRVIPPGVRAHSGLPDNRAYGETSPHTFQLDLFFNNVSKPSAPVFDRLGSLEYDENTSIIFRPNSKVNTDGLVLRGWYNCLTLAIYGSVDRVISHDRDSPPPPPPPPPPPQPQPTLKRNLKHADGEKEDQFNGSPPRPQPRGPRTPPGPPPPDDDEDDPMSLPVSGDKEEDVPHREDYFEPISPDRNSVPQEGQYSDEGEVEEEPQEEGEDDEDDVDVEEEEDEDEDDCHTVDSIPDDEEEDEEEEGEEDEEGEGDDGYEQISSDEDGIADLERETFKYPNFDVEYTPEDLASVPPMTYDPYDRELAPLLYFSCPYKTTFEIEISRMKDQGPDKENSGAVEASVKLTELLDLYQEDRGAKWVTALEEIPSLIIKGLSYLQLKNTEQDSLGQLVDWTMQALNLQVAFRQPIALNVRQLKAGTKLVTSLAECGAPGVTELLQAGVINVLFDLLFADHVSSSLKLNAFKALDSVISMTEGMEAFLRSTQNEKSGYQRLLELILLDQTVRVVTAGSAILQKCHFYEILSEIKRLGDHIAEKTSAVPNHSEPDQDTDAVLERANPDYENEVEASMDMDLLESSIISEGEIEKLTNLLEEVFHVMETAPHTMTQPPVKSFPTIARITGPPERDDPYPVLFRGPGFGFQHSIVAHSHQLLQFQRVQCPLLAYVGTVHTWYIDTCKQNTHDIRYLHSHHFLELVTLLLSIPITSAHQGVLQATKDVLKFLAQSQKGLLFFMSEYEATNLLIRALCHLYDQDEEEGLQSDGADDAFALWLQDSTQTLQCITELFSHFQRCTASEETDHSDLLGTLHNLYLITFNPVGRSAVGHVFSLDKNLQSLITLMEYYSKEALGDSKSKKSVAYNYACVLTLVVAQSSSGVQMLEQHAASLLKLCKADENNAKLQELGKWLEPLKNLRFEINCIPNLIEYVKQNIDNLMTAEGVGLTTALRVLCNVACPPPPVEGQQKDLKWNLAVIQLFSAEGMDTFIRVLQKLNSILTQPWRLHVNMGTTLHRVTTISMARCTLTLLKTMLTELLRGGSFEFKDMRVPSALVTLHMLLCSIPLSGRLDSDEQKIQNDIIDILLTFTQGVNEKLTISEETLANNTWSLMLKEVLSSILKVPEGFFSGLILLSELLPLPLPMQTTQVIEPHDISVALNTRKLWSMHLHVQAKLLQEIVRSFSGTTCQPIQHMLRRICVQLCDLASPTALLIMRTVLDLIVEDLQSTSEDKEKQYTSQTTRLLALLDALASHKACKLAILHLINGTIKGDERYAEIFQDLLALVRSPGDSVTRQQCVEYVTSILQSLCDQDIALILPSPSEGPASELEQLSNSLPSKELMTAICDCLLATLANSESSYNCLLTCVRTMMFLAEHDYGLFHLKSSLRKNSSALHSLLKRVVSTFSKDTGELASASLDFMRQILNADAMGCCGDDSGLMEVEGAHPPRTMSLNAAELKQLLQSKEESPESLFLELEKLVLEHSKDDDSLESLLDNVIGLKQMLESSGEPLPLSDQDVEPVLSAPESLQNLFNNRTAYVLADVMDDQLKSMWFTPFQAEEIDTDLDLVKVDLIELSEKCCSDFDLHSELERSFLSEPSSPGRSKTTKGFKLGKHKHETFITSSGKSEYIEPAKRAHVVPPPRGRGRGGFGQGIRPHDIFRQRKQNTSRPPSMHVDDFVAAESKEVVPQDGIPPPKRPLKVSQKISSRGGFSGNRGGRGAFHSQNRFFTPPASKGNYSRREGTRGSSWSAQNTPRGNYNESRGGQSNFNRGPLPPLRPLSSTGYRPSPRDRASRGRGGLGPSWASTNSGSGGSRGKFVSGGSGRGRHVRSFTR" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:66185", "resource": "KEGG Pathway", "id": "mmu:66185", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2#function", "annotation": "Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites. Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2#function", "id": "A2AIV2", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZKC9-1", "protein_name": "Vir-like m6A methyltransferase-associated", "sequence": { "length": 1811, "sequence": "MAVDSSMELLFLDTFKHPSAEQSSHIDVVRFPCVVYINEVRVIPPGVRAHSGLPDNRAYGETSPHTFQLDLFFNNVSKPSAPVFDRLGSLEYDENTSIIFRPNSKVNTDGLVLRGWYNCLTLAIYGSVDRVLSHDRDSPPPPPPPPPPPQPQPTLKRSLKHADGEKEDQFNGSPPRPQPRGPRTPPGPPPPDDDEDDPMSLPVSGDKEEDVPHREDYFEPISPDRNSVPQEGQYSDEGEVEEEQQEEGEDDEDDVDVDEEEDEDEDDCHTVDSIPDDDEEDEEEEGEEDEEGEGDDGYEQISSDEDGIADLERETFKYPNFDVEYTPEDLASVPPMTYDPYDRELVPLLYFSCPYKTTFEIEINRMKDQGPDKENSGAIEASLKLTELLDLYHEDRGAKWVTALEEVPSLIIKGLSYLQLKNTKQDSLGQLVDWTMQALNLQVAFRQPIALNVRQLKAGTKLVTSLAECGAPGVTELLQAGVISVLFDLLFADHVSSSLKLNAFKALDSVISMTEGMEAFLRSTQSEKSGYQKLLELILLDQTVRVVTAGSAILQKCHFYEVLSEIKRLGDHIAEKTSSVPNPSEPDHDTDAVLERANPDYENEVEASMDMDLLESSNISEGEIEKLINLLEEVFHLMETAPHTMIQPPVKSFPTIARITGPPERDDPYPVLFRYLHSHHFLELVTLLLSIPITSAHPGVLQATKDVLKFLAQSQKGLLFFMSEYEATNLLIRALCHLYDQDEEEGLQSDGVDDAFALWLQDSTQTLQCVTELFSHFQRCTASEETDHSDLLGTLHNLYLITFNPVGRSAVGHVFSLDKNLQSLITLMEYYSKEALGDSKSKKSVAYNYACILILVVVQSSSDVQMLEQHAASLLKLCKADENNAKLQELGKWLEPLKNLRFEINCIPNLIEYVKQNIDNLMTAEGVGLTTALRVLCNVACPPPPVEGQQKDLKWNLAVIQLFSAEGMDTFIRVLQKLNSILTQPWRLHVNMGTTLHRVTTISMARCTLTLLKTMLTELLRGGSFEFKDMRVPSALVTLHMLLCSIPLSGRLDSDEQKIQNDIIDILLTFTQGVNEKLTISEETLANNTWSLMLKEVLSSILKVPEGFFSGLILLSELLPLPLPMQTTQVIEPHDISVALNTRKLWSMHLHVQAKLLQEIVRSFSGTTCQPIQHMLRRICVQLCDLASPTALLIMRTVLDLIVEDLQSTSEDKEKQYTSQTTRLLALLDALASHKACKLAILHLINGTIKGDEKYAEIFQDLLALVRSPGDSVIRQQCVEYVTSILQSLCDQDIALILPSPSEGPGSELEQLSNSLPSKELMAAICDCLLATLANSESTYNCLLTCVRTMMFLAEHDYGLFHLKSSLRKNSSALHSLLKRVVSTFSKDTGELTSASLDFMRQILNSDAMGCCGDDSGLMEVESAHPPRTMSINAAELKQLLQSKEESPESLFLELEKLVLEHSKEDDSLESLLDNVIGLKQMLESSGDPLPLSDQDVEPVLSAPESLQNLFNNRTAYVLADVMDDQLKSMWFTPFQAEEIDTDLDLVKVDLIELSEKCCSDFDLHSELERSFLSEPSSPGRAKTTKGFKLGKHKHETFITSSGKSEYIEPAKRAHVVPPPRGRGRGGFGQGIRPHDIFRQRKQNTSRPPSMHVDDFVAAESKEVVPQDGIPPPKRPLKVSQKISSRGGFSGNRGGRGAFHSQNRFFTPPASKGNYSRREGTRGSSWSAQNTPRGNYNESRGGQSNFNRGPLPPLRPLSSTGYRPSPRDRASRGRGGLGPSWASTNSGSGGSRGKFVSGGSGRGRHVRSFTR" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/41043", "id": "41043", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2AIV2/", "id": "A2AIV2", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q69YN4-1", "protein_name": "Protein virilizer homolog", "sequence": { "length": 1812, "sequence": "MAVDSAMELLFLDTFKHPSAEQSSHIDVVRFPCVVYINEVRVIPPGVRAHSSLPDNRAYGETSPHTFQLDLFFNNVSKPSAPVFDRLGSLEYDENTSIIFRPNSKVNTDGLVLRGWYNCLTLAIYGSVDRVISHDRDSPPPPPPPPPPPQPQPSLKRNPKHADGEKEDQFNGSPPRPQPRGPRTPPGPPPPDDDEDDPVPLPVSGDKEEDAPHREDYFEPISPDRNSVPQEGQYSDEGEVEEEQQEEGEEDEDDVDVEEEEDEDEDDRRTVDSIPEEEEEDEEEEGEEDEEGEGDDGYEQISSDEDGIADLERETFKYPNFDVEYTAEDLASVPPMTYDPYDRELVPLLYFSCPYKTTFEIEISRMKDQGPDKENSGAIEASVKLTELLDLYREDRGAKWVTALEEIPSLIIKGLSYLQLKNTKQDSLGQLVDWTMQALNLQVALRQPIALNVRQLKAGTKLVSSLAECGAQGVTGLLQAGVISGLFELLFADHVSSSLKLNAFKALDSVISMTEGMEAFLRGRQNEKSGYQKLLELILLDQTVRVVTAGSAILQKCHFYEVLSEIKRLGDHLAEKTSSLPNHSEPDHDTDAGLERTNPEYENEVEASMDMDLLESSNISEGEIERLINLLEEVFHLMETAPHTMIQQPVKSFPTMARITGPPERDDPYPVLFRYLHSHHFLELVTLLLSIPVTSAHPGVLQATKDVLKFLAQSQKGLLFFMSEYEATNLLIRALCHFYDQDEEEGLQSDGVIDDAFALWLQDSTQTLQCITELFSHFQRCTASEETDHSDLLGTLHNLYLITFNPVGRSAVGHVFSLEKNLQSLITLMEYYSKEALGDSKSKKSVAYNYACILILVVVQSSSDVQMLEQHAASLLKLCKADENNAKLQELGKWLEPLKNLRFEINCIPNLIEYVKQNIDNLMTPEGVGLTTALRVLCNVACPPPPVEGQQKDLKWNLAVIQLFSAEGMDTFIRVLQKLNSILTQPWRLHVNMGTTLHRVTTISMARCTLTLLKTMLTELLRGGSFEFKDMRVPSALVTLHMLLCSIPLSGRLDSDEQKIQNDIIDILLTFTQGVNEKLTISEETLANNTWSLMLKEVLSSILKVPEGFFSGLILLSELLPLPLPMQTTQVIEPHDISVALNTRKLWSMHLHVQAKLLQEIVRSFSGTTCQPIQHMLRRICVQLCDLASPTALLIMRTVLDLIVEDLQSTSEDKEKQYTSQTTRLLALLDALASHKACKLAILHLINGTIKGDERYAEIFQDLLALVRSPGDSVIRQQCVEYVTSILQSLCDQDIALILPSSSEGSISELEQLSNSLPNKELMTSICDCLLATLANSESSYNCLLTCVRTMMFLAEHDYGLFHLKSSLRKNSSALHSLLKRVVSTFSKDTGELASSFLEFMRQILNSDTIGCCGDDNGLMEVEGAHTSRTMSINAAELKQLLQSKEESPENLFLELEKLVLEHSKDDDNLDSLLDSVVGLKQMLESSGDPLPLSDQDVEPVLSAPESLQNLFNNRTAYVLADVMDDQLKSMWFTPFQAEEIDTDLDLVKVDLIELSEKCCSDFDLHSELERSFLSEPSSPGRTKTTKGFKLGKHKHETFITSSGKSEYIEPAKRAHVVPPPRGRGRGGFGQGIRPHDIFRQRKQNTSRPPSMHVDDFVAAESKEVVPQDGIPPPKRPLKVSQKISSRGGFSGNRGGRGAFHSQNRFFTPPASKGNYSRREGTRGSSWSAQNTPRGNYNESRGGQSNFNRGPLPPLRPLSSTGYRPSPRDRASRGRGGLGPSWASANSGSGGSRGKFVSGGSGRGRHVRSFTR" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/41043", "id": "41043", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2AIV2/", "id": "A2AIV2", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333984.1", "ac": "NP_001333984.1", "name": "protein virilizer homolog isoform 2", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036396", "pmid": "29547716", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2", "id": "A2AIV2", "database": "UniProtKB" } ], "name": "RNA N6-methyladenosine methyltransferase complex", "id": "GO:0036396" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "29547716", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2", "id": "A2AIV2", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "29547716", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2", "id": "A2AIV2", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2", "id": "A2AIV2", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2", "id": "A2AIV2", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2", "id": "A2AIV2", "database": "UniProtKB" } ], "name": "nuclear speck", "id": "GO:0016607" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2", "id": "A2AIV2", "database": "UniProtKB" } ], "name": "nuclear body", "id": "GO:0016604" } ], "total": 7, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080009", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2", "id": "A2AIV2", "database": "UniProtKB" } ], "name": "mRNA methylation", "id": "GO:0080009" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007275", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2", "id": "A2AIV2", "database": "UniProtKB" } ], "name": "multicellular organism development", "id": "GO:0007275" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2", "id": "A2AIV2", "database": "UniProtKB" } ], "name": "mRNA processing", "id": "GO:0006397" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2", "id": "A2AIV2", "database": "UniProtKB" } ], "name": "RNA splicing", "id": "GO:0008380" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0110104", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2", "id": "A2AIV2", "database": "UniProtKB" } ], "name": "mRNA alternative polyadenylation", "id": "GO:0110104" } ], "total": 5, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2", "type": "recommended", "resource": "UniProtKB", "name": "Virma" }, { "url": "https://www.uniprot.org/uniprot/A2AIV2", "type": "synonym", "resource": "UniProtKB", "name": "Kiaa1429" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AIV2", "type": "synonym", "resource": "RefSeq", "name": "1110037F02Rik; 4930422M05Rik; Kiaa1429; mKIAA1429" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AIV2", "type": "synonym", "resource": "RefSeq", "name": "Virma" } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/gene/66185", "id": "66185", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR031801", "id": "IPR031801", "database": "InterPro" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333984.1", "id": "NP_001333984.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:66185", "id": "mmu:66185", "database": "KEGG Pathway" }, { "url": "https://omabrowser.org/oma/group/ETSPHAF/", "id": "ETSPHAF", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=210051at2759", "id": "210051at2759", "database": "OrthoDB" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AIV2", "id": "PR_A2AIV2", "database": "PRO" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000040720", "id": "ENSMUSG00000040720", "database": "Bgee" }, { "url": "http://www.informatics.jax.org/marker/MGI:1913435", "id": "1913435", "database": "MGI" }, { "url": "http://pfam.xfam.org/family/PF15912", "id": "PF15912", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23185", "id": "PTHR23185", "database": "PANTHER" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR026736", "id": "IPR026736", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AIV2*", "id": "A2AIV2", "database": "IntAct" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Ser", "position": "222", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2", "id": "A2AIV2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "1578", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17242355", "id": "17242355", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b" }, { "residue": "Ser", "position": "138", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2", "id": "A2AIV2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Tyr", "position": "913", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2", "id": "A2AIV2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "173", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2", "id": "A2AIV2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Thr", "position": "1707", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2", "id": "A2AIV2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "133", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2", "id": "A2AIV2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Thr", "position": "184", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2", "id": "A2AIV2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "138", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19144319", "id": "19144319", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b" }, { "residue": "Ser", "position": "1578", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2", "id": "A2AIV2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "173", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19144319", "id": "19144319", "database": "PubMed" } ], "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b" } ], "mass": { "monoisotopic_mass": 201439.0, "chemical_mass": 201439.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AIV2", "name": "Virma", "locus": { "end_pos": 11550684, "strand": "+", "start_pos": 11485958, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000040720", "id": "ENSMUSG00000040720", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AIV2", "type": "synonym", "resource": "RefSeq", "name": "protein virilizer homolog" }, { "url": "https://www.uniprot.org/uniprot/A2AIV2", "type": "recommended", "resource": "UniProtKB", "name": "Protein virilizer homolog" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AIV2", "type": "synonym", "resource": "RefSeq", "name": "protein virilizer homolog isoform 2" } ] }