{ "uniprot_canonical_ac": "A2AEV7-1", "ptm_annotation": [ { "annotation": "Ubiquitinated; interaction with CYTH2 may prevent ubiquitination.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7", "id": "A2AEV7", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q96HB5", "id": "Q96HB5", "database": "PubMed" } ] } ], "sequence": { "header": "sp|A2AEV7-1|CC120_MOUSE Isoform 1 of Coiled-coil domain-containing protein 120 OS=Mus musculus OX=10090 GN=Ccdc120 PE=1 SV=1 CANONICAL=A2AEV7-1", "length": 629, "sequence": "MEVKGQLISSPTFTAPAALFGEAAPLVKSDRLRGLLDRQRALQEALSVKLQELRKVCLQEAELTGQLPPECPLEPGERPQLVRRRPPAARAYPPPHPNPAHHSLCPAEELALEALEREVSVQQQIAAAARRLALAPDLNGEQRRRRRQVQVDALRRLHELEEQLRDFRARLGLPVLQPLPLSAGALVNAQGVCLGTRLAQLSQEDVVLHSESSSLSESGASHDNEEPHSCFPLTERPSPPKAWDQFRAVSGGSPERRAPWKPPPSDIYGDLKSRRNSVASPTSPTRSLPRSASSFEGRSVPATPVLTRGSGPRLCKPEGLHSRQWSGSQDSQMGFPRPDPASDRASLFAARTRRSNSSEALLVDRAAAGGAGSPPAPLAPPAAGPPVCKSSEVLYERPQPVPSFSSRTTGPPDPPRAARPSSAAPASRGAPRLPTVCGDFLLDYPLDRGLPRGSGGAGWGELLPAPEVPGPLSRRDGLLAMLPGPPPIYAADGSSPLLRSKDPNTRAIRSKPSGLPPEAVEGLEVHPNPLLWMPPPTRIPPAGERGGHKNLALEGLRDWYIRNSGLAVGPQRRPMLPHVGPTHTPFLHARCYEVGQSLYGPPSQAPLPHSRSFTAPPVSGRYGGAFTDG" }, "uniprot_id": "CC120_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7", "id": "A2AEV7", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28422092", "type": [ "PubMed" ], "id": "28422092" } ], "title": "Hierarchical assembly of centriole subdistal appendages via centrosome binding proteins CCDC120 and CCDC68.", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7", "id": "A2AEV7", "database": "UniProtKB" } ], "authors": "Chen J., Wang S., Zhang D., Xia Y., He R., Huang N., Teng J., Bao Y.", "date": "2017" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24129315", "type": [ "PubMed" ], "id": "24129315" } ], "title": "Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.", "journal": "Mol. Cell. Proteomics", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7", "id": "A2AEV7", "database": "UniProtKB" } ], "authors": "Beausoleil S.A., Wang Y., Zhou J., Comb M.J., Guo A., Lee K.A., Aguiar M., Bedford M.T., Gu H., Jia X., Kornhauser J., Mulhern D., Ren J., Silva J.C., Vemulapalli V., Yang V.", "date": "2014" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24194600", "type": [ "PubMed" ], "id": "24194600" } ], "title": "The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997085.2", "id": "NP_997085.2", "database": "RefSeq" } ], "authors": "Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H", "date": "2014" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27626380", "type": [ "PubMed" ], "id": "27626380" } ], "title": "High-throughput discovery of novel developmental phenotypes.", "journal": "Nature", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997085.2", "id": "NP_997085.2", "database": "RefSeq" } ], "authors": "Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M, Murray SA", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17242355", "type": [ "PubMed" ], "id": "17242355" } ], "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7", "id": "A2AEV7", "database": "UniProtKB" } ], "authors": "Beausoleil S.A., Gerber S.A., Gygi S.P., Villen J.", "date": "2007" } ], "uniprot_ac": "A2AEV7", "site_annotation": [ { "end_pos": 358, "annotation": "n_glycosylation_sequon", "start_pos": 356 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7#A0A286YDD1-1", "isoform_ac": "A0A286YDD1-1", "locus": { "end_pos": 7732621, "strand": "+", "start_pos": 7733904, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000224502", "id": "ENSMUST00000224502", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000153379", "id": "ENSMUSP00000153379", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A286YDD1-1|CC120_MOUSE Computationally mapped isoform of Coiled-coil domain-containing protein 120 OS=Mus musculus OX=10090 GN=Ccdc120 PE=1 SV=1 CANONICAL=A2AEV7-1", "length": 278, "sequence": "XAAGPPVCKSSEVLYERPQPVPSFSSRTTGPPDPPRAARPSSAAPASRGAPRLPTVCGDFLLDYPLDRGLPRGSGGAGWGELLPAPEVPGPLSRRDGLLAMLPGPPPIYAADGSSPLLRSKDPNTRAIRSKPSGLPPEAVEGLEVHPNPLLWMPPPTRIPPAGERGGHKNLALEGLRDWYIRNSGLAVGPQRRPMLPHVGPTHTPFLHARCYEVGQSLYGPPSQAPLPHSRSFTAPPVSGRYYTDFLYPPELSARLSDLTLEGEPSSSSDTQTPGTLV" } }, { "url": "https://www.uniprot.org/uniprot/A2AEV7#A2AEV7-1", "isoform_ac": "A2AEV7-1", "locus": { "end_pos": 7733159, "strand": "+", "start_pos": 7738210, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000033490", "id": "ENSMUST00000033490", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000033490", "id": "ENSMUSP00000033490", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AEV7-1|CC120_MOUSE Isoform 1 of Coiled-coil domain-containing protein 120 OS=Mus musculus OX=10090 GN=Ccdc120 PE=1 SV=1 CANONICAL=A2AEV7-1", "length": 629, "sequence": "MEVKGQLISSPTFTAPAALFGEAAPLVKSDRLRGLLDRQRALQEALSVKLQELRKVCLQEAELTGQLPPECPLEPGERPQLVRRRPPAARAYPPPHPNPAHHSLCPAEELALEALEREVSVQQQIAAAARRLALAPDLNGEQRRRRRQVQVDALRRLHELEEQLRDFRARLGLPVLQPLPLSAGALVNAQGVCLGTRLAQLSQEDVVLHSESSSLSESGASHDNEEPHSCFPLTERPSPPKAWDQFRAVSGGSPERRAPWKPPPSDIYGDLKSRRNSVASPTSPTRSLPRSASSFEGRSVPATPVLTRGSGPRLCKPEGLHSRQWSGSQDSQMGFPRPDPASDRASLFAARTRRSNSSEALLVDRAAAGGAGSPPAPLAPPAAGPPVCKSSEVLYERPQPVPSFSSRTTGPPDPPRAARPSSAAPASRGAPRLPTVCGDFLLDYPLDRGLPRGSGGAGWGELLPAPEVPGPLSRRDGLLAMLPGPPPIYAADGSSPLLRSKDPNTRAIRSKPSGLPPEAVEGLEVHPNPLLWMPPPTRIPPAGERGGHKNLALEGLRDWYIRNSGLAVGPQRRPMLPHVGPTHTPFLHARCYEVGQSLYGPPSQAPLPHSRSFTAPPVSGRYGGAFTDG" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:54648", "resource": "KEGG Pathway", "id": "mmu:54648", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7#function", "annotation": "Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth (By similarity). Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7#function", "id": "A2AEV7", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZAB5-1", "protein_name": "Coiled-coil domain-containing 120", "sequence": { "length": 658, "sequence": "MEVKGQLINSPTFNAPAALFGEAAPQVKSDRLRGLLDRQQALQETLRLKLQELRKVCLQEAELTGQLPPECPLEPGERPQLVRRRPPAARAYPPPHSNPAHHSLCPAEELALEALEREVSVQQQIAAAARRLALAPDLNGEQRRRRRQVQVDALRRLHELEEQLRDFRARLGLPVLQPLPLSSGAPVNAQGVCLGTRLAQLSQEDVVLHSESSSLSESGASHDNEEPHSCFPLTERPSPPKAWDQFRAVSGGSPERRAPWKPPPSDIYGDLKSRRNSVASPTSPTRSLPRSASSFEGRSVPATPVLTRGSGPRLCKPEGLHPRQWSGSQDSQMGFPRPDPASDRASLFAARTRRSNSSEALLVDRAAAGGAGSPPAPLAPPAAGPPVCKSSEVLYERPQPVPSFSSRTTGPPDPPRAARPSSAAPASRGPPRLPPVCGDFLLDYSLDRGLPRGSGGAGWGDLLPAPEVPGPLSRRDGLLAMLPGPPPIYAADGSSPLLRSKDPNSRAIRSKPCGLPPEAVEGLEVHPNPLLWMPPPTRIPPAGERGGHKNLALEGLRDWYIRNSGLAVGPQRRPMLPHVGPTHTPFLHARCYEVGQSLYGPPSQAPLPHSRSFTAPPVSGRYYTDFLYPPELSARLSDLTLEGEQSSSSDTQTPGTLV" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2AEV7/", "id": "A2AEV7", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/14146", "id": "14146", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q96HB5-1", "protein_name": "Coiled-coil domain-containing protein 120", "sequence": { "length": 630, "sequence": "MEVKGQLISSPTFNAPAALFGEAAPQVKSERLRGLLDRQRTLQEALSLKLQELRKVCLQEAELTGQLPPECPLEPGERPQLVRRRPPTARAYPPPHPNQAHHSLCPAEELALEALEREVSVQQQIAAAARRLALAPDLSTEQRRRRRQVQADALRRLHELEEQLRDVRARLGLPVLPLPQPLPLSTGSVITTQGVCLGMRLAQLSQEDVVLHSESSSLSESGASHDNEEPHGCFSLAERPSPPKAWDQLRAVSGGSPERRTPWKPPPSDLYGDLKSRRNSVASPTSPTRSLPRSASSFEGRSVPATPVLTRGAGPQLCKPEGLHSRQWSGSQDSQMGFPRADPASDRASLFVARTRRSNSSEALLVDRAAGGGAGSPPAPLAPSASGPPVCKSSEVLYERPQPTPAFSSRTAGPPDPPRAARPSSAAPASRGAPRLPPVCGDFLLDYSLDRGLPRSGGGTGWGELPPAAEVPGPLSRRDGLLTMLPGPPPVYAADSNSPLLRTKDPHTRATRTKPCGLPPEAAEGPEVHPNPLLWMPPPTRIPSAGERSGHKNLALEGLRDWYIRNSGLAAGPQRRPVLPSVGPPHPPFLHARCYEVGQALYGAPSQAPLPHSRSFTAPPVSGRYGGCFY" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/14146", "id": "14146", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997085.2", "ac": "NP_997085.2", "name": "coiled-coil domain-containing protein 120", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7", "id": "A2AEV7", "database": "UniProtKB" } ], "name": "endosome", "id": "GO:0005768" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030426", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7", "id": "A2AEV7", "database": "UniProtKB" } ], "name": "growth cone", "id": "GO:0030426" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7", "id": "A2AEV7", "database": "UniProtKB" } ], "name": "centriole", "id": "GO:0005814" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120103", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7", "id": "A2AEV7", "database": "UniProtKB" } ], "name": "centriolar subdistal appendage", "id": "GO:0120103" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007275", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7", "id": "A2AEV7", "database": "UniProtKB" } ], "name": "multicellular organism development", "id": "GO:0007275" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008104", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7", "id": "A2AEV7", "database": "UniProtKB" } ], "name": "protein localization", "id": "GO:0008104" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034454", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7", "id": "A2AEV7", "database": "UniProtKB" } ], "name": "microtubule anchoring at centrosome", "id": "GO:0034454" } ], "total": 3, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AEV7", "type": "synonym", "resource": "RefSeq", "name": "Ccdc120" }, { "url": "https://www.uniprot.org/uniprot/A2AEV7", "type": "recommended", "resource": "UniProtKB", "name": "Ccdc120" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AEV7", "type": "synonym", "resource": "RefSeq", "name": "AA030924; DXImx50e; Jm11; Sfc25" } ], "crossref": [ { "url": "https://www.ebi.ac.uk/interpro/entry/IPR021774", "id": "IPR021774", "database": "InterPro" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AEV7", "id": "PR_A2AEV7", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997085.2", "id": "NP_997085.2", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:54648", "id": "mmu:54648", "database": "KEGG Pathway" }, { "url": "http://pfam.xfam.org/family/PF11819", "id": "PF11819", "database": "Pfam" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR039108", "id": "IPR039108", "database": "InterPro" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/54648", "id": "54648", "database": "GeneID" }, { "url": "http://www.informatics.jax.org/marker/MGI:1859619", "id": "1859619", "database": "MGI" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000031150", "id": "ENSMUSG00000031150", "database": "Bgee" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16093:SF5", "id": "PTHR16093:SF5", "database": "PANTHER" }, { "url": "https://omabrowser.org/oma/group/WGKQQRM/", "id": "WGKQQRM", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=595503at2759", "id": "595503at2759", "database": "OrthoDB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Ser", "position": "357", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b" }, { "residue": "Ser", "position": "357", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7", "id": "A2AEV7", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "355", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7", "id": "A2AEV7", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" } ], "mass": { "monoisotopic_mass": 67407.0, "chemical_mass": 67407.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7", "name": "Ccdc120", "locus": { "end_pos": 7731714, "strand": "-", "start_pos": 7750905, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000031150", "id": "ENSMUSG00000031150", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2AEV7", "type": "recommended", "resource": "UniProtKB", "name": "Coiled-coil domain-containing protein 120" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AEV7", "type": "synonym", "resource": "RefSeq", "name": "coiled-coil domain-containing protein 120" } ] }