{ "uniprot_canonical_ac": "A2A995-1", "ptm_annotation": [ { "annotation": "Phosphorylation is required for its function in T-cell activation.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A995", "id": "A2A995", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q5VWT5", "id": "Q5VWT5", "database": "PubMed" } ] } ], "sequence": { "header": "sp|A2A995-1|FYB2_MOUSE Isoform 1 of FYN-binding protein 2 OS=Mus musculus OX=10090 GN=Fyb2 PE=1 SV=1 CANONICAL=A2A995-1", "length": 729, "sequence": "MEEEGIRNFKELRAKFQKFNAAPLPGPMRFPAGVSRKHDRGSTQPAQDLANRKCLSSHHHQTPSHSSTGVSQPLKNQTLKSAQGDELQKTSSSSGTPEKSTVCPERDFQKAAVPLDVTKSRAKTSNEEKGMTLSSFRYKLWNWEKVSSQNGEMSPAPLLTNGGIKTFHFEGQKTMGLAQDKPEKSLKATGAQTLPPQSHSMAQRKSPVTSKASSVSLPPHSRKSTKSPATEGSHRSSQCQPVYECELDSLVPEKPQSRHCRLPKTKPLPSIETLGPPPPKPSKPPFVNLYAFHRLPATVTKTPKEETMKEGPLSPDSAELEEAHNYDTTISYLRHSGNSINLCAEGESTEATYEIEIEELQKPWRSFFLPELSPRPKEEENTMEEKESWESEPLEPRKELHPSRPPKVVVYKETPGKTQMAGVHEDRRSVPAGNQEAMTDIMQNRLFPEDVTLTRHSQDKSGYVEALEVTKETPSPSTIRSSSSSEKTYDAVECSREDVRKWDFSSSFTSDSEENCEEMYEDIYKAKNDDPKTEVAGRTALRKLQQIFRKENVVFRMKKTKSKEIVSNGFSVSLPDLGPRSQDDSQDGIIYDDVDTREKESNDEDKVKTWKTKFLIPKGKKWGKGSQGSKSFSPRHFFRTKKQKLEKNRMEKEEKLFRERFQYGKEILVINRAVACASNSRNGMFDLPIIPGEQLEVIDTTEQNLVICRNSKGKYGYVLVEHLDFKHQG" }, "uniprot_id": "FYB2_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A995", "id": "A2A995", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17242355", "type": [ "PubMed" ], "id": "17242355" } ], "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A995", "id": "A2A995", "database": "UniProtKB" } ], "authors": "Beausoleil S.A., Gerber S.A., Gygi S.P., Villen J.", "date": "2007" } ], "uniprot_ac": "A2A995", "site_annotation": [ { "end_pos": 78, "annotation": "n_glycosylation_sequon", "start_pos": 76 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A995#A2A995-1", "isoform_ac": "A2A995-1", "locus": { "end_pos": 104913682, "strand": "-", "start_pos": 105016140, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000106804", "id": "ENSMUST00000106804", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000102416", "id": "ENSMUSP00000102416", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2A995-1|FYB2_MOUSE Isoform 1 of FYN-binding protein 2 OS=Mus musculus OX=10090 GN=Fyb2 PE=1 SV=1 CANONICAL=A2A995-1", "length": 729, "sequence": "MEEEGIRNFKELRAKFQKFNAAPLPGPMRFPAGVSRKHDRGSTQPAQDLANRKCLSSHHHQTPSHSSTGVSQPLKNQTLKSAQGDELQKTSSSSGTPEKSTVCPERDFQKAAVPLDVTKSRAKTSNEEKGMTLSSFRYKLWNWEKVSSQNGEMSPAPLLTNGGIKTFHFEGQKTMGLAQDKPEKSLKATGAQTLPPQSHSMAQRKSPVTSKASSVSLPPHSRKSTKSPATEGSHRSSQCQPVYECELDSLVPEKPQSRHCRLPKTKPLPSIETLGPPPPKPSKPPFVNLYAFHRLPATVTKTPKEETMKEGPLSPDSAELEEAHNYDTTISYLRHSGNSINLCAEGESTEATYEIEIEELQKPWRSFFLPELSPRPKEEENTMEEKESWESEPLEPRKELHPSRPPKVVVYKETPGKTQMAGVHEDRRSVPAGNQEAMTDIMQNRLFPEDVTLTRHSQDKSGYVEALEVTKETPSPSTIRSSSSSEKTYDAVECSREDVRKWDFSSSFTSDSEENCEEMYEDIYKAKNDDPKTEVAGRTALRKLQQIFRKENVVFRMKKTKSKEIVSNGFSVSLPDLGPRSQDDSQDGIIYDDVDTREKESNDEDKVKTWKTKFLIPKGKKWGKGSQGSKSFSPRHFFRTKKQKLEKNRMEKEEKLFRERFQYGKEILVINRAVACASNSRNGMFDLPIIPGEQLEVIDTTEQNLVICRNSKGKYGYVLVEHLDFKHQG" } }, { "url": "https://www.uniprot.org/uniprot/A2A995#E9PZ08-1", "isoform_ac": "E9PZ08-1", "locus": { "end_pos": 104913490, "strand": "-", "start_pos": 105016140, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000106803", "id": "ENSMUST00000106803", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000102415", "id": "ENSMUSP00000102415", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|E9PZ08-1|FYB2_MOUSE Computationally mapped isoform of FYN-binding protein 2 OS=Mus musculus OX=10090 GN=Fyb2 PE=1 SV=1 CANONICAL=A2A995-1", "length": 793, "sequence": "MEARPPERGRSHSPGGAGEEPRLQLLRDRRSDCKLAGGGESIVGPRIQLWEAGIVSQSLPRRTTMEEEGIRNFKELRAKFQKFNAAPLPGPMRFPAGVSRKHDRGSTQPAQDLANRKCLSSHHHQTPSHSSTGVSQPLKNQTLKSAQGDELQKTSSSSGTPEKSTVCPERDFQKAAVPLDVTKSRAKTSNEEKGMTLSSFRYKLWNWEKVSSQNGEMSPAPLLTNGGIKTFHFEGQKTMGLAQDKPEKSLKATGAQTLPPQSHSMAQRKSPVTSKASSVSLPPHSRKSTKSPATEGSHRSSQCQPVYECELDSLVPEKPQSRHCRLPKTKPLPSIETLGPPPPKPSKPPFVNLYAFHRLPATVTKTPKEETMKEGPLSPDSAELEEAHNYDTTISYLRHSGNSINLCAEGESTEATYEIEIEELQKPWRSFFLPELSPRPKEEENTMEEKESWESEPLEPRKELHPSRPPKVVVYKETPGKTQMAGVHEDRRSVPAGNQEAMTDIMQNRLFPEDVTLTRHSQDKSGYVEALEVTKETPSPSTIRSSSSSEKTYDAVECSREDVRKWDFSSSFTSDSEENCEEMYEDIYKAKNDDPKTEVAGRTALRKLQQIFRKENVVFRMKKTKSKEIVSNGFSVSLPDLGPRSQDDSQDGIIYDDVDTREKESNDEDKVKTWKTKFLIPKGKKWGKGSQGSKSFSPRHFFRTKKQKLEKNRMEKEEKLFRERFQYGKEILVINRAVACASNSRNGMFDLPIIPGEQLEVIDTTEQNLVICRNSKGKYGYVLVEHLDFKHQG" } } ], "pathway": [], "function": [ { "url": "https://www.uniprot.org/uniprot/A2A995#function", "annotation": "Adapter protein that plays a role in T-cell receptor (TCR)-mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A995#function", "id": "A2A995", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q5VWT5-1", "protein_name": "FYN-binding protein 2", "sequence": { "length": 728, "sequence": "MEGEGVRNFKELRAKFQNLDAPPLPGPIKFPAGVSPKGDIGGTQSTQILANGKPLSSNHKQRTPYCSSSESQPLQPQKIKLAQKSEIPKCSNSPGPLGKSTVCSATSSQKASLLLEVTQSNVEIITKEKVMVANSFRNKLWNWEKVSSQKSEMSSALLLANYGSKAIHLEGQKGMGLTPEEPRKKLETKGAQTLPSQKHVVAPKILHNVSEDPSFVISQHIRKSWENPPPERSPASSPCQPIYECELASQAPEKQPDVRHHHLPKTKPLPSIDSLGPPPPKPSRPPIVNLQAFQRQPAAVPKTQGEVTVEEGSLSPERLFNAEFEEPHNYEATISYLRHSGNSINLCTAKEIADPTYEVGIEELQKPGKNFPYPEPSAKHEDKKMKEKQPCELKPKNTEKEPYSNHVFKVDACEGTPEKIQMTNVHTGRRNMLAGKQEAMIDIIQTNPCPEGPKLARHSQGHCGHLEVLESTKETPDLGVSKTSSISEEIYDDVEYSRKEVPKLNYSSSLASSSEENRELYEDVYKTKNNYPKIDLDGKEALKRLQQFFKKEKDRFKIKKTKSKENLSAFSILLPDLELKSQEVIIYDDVDLSEKESKDEDKLKMWKPKFLTPKEKKEKNGAEESESFSPRNFFKTKKQNLEKNRMKREEKLFRERFKYDKEIIVINTAVACSNNSRNGIFDLPISPGEELEVIDTTEQNLVICRNSKGKYGYVLIEHLDFKHQSWSP" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2A995/", "id": "A2A995", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "F1LYH4-1", "protein_name": "Uncharacterized protein", "sequence": { "length": 653, "sequence": "PEGGRSHCPGGAGGESRFQPVPDRGSDCTLAGGGGSVVGPKIQLWEAGIVSQSEPRRTTMEEEGIRNFKELRAKFQKLNAVPLSGPIKLPAGVSRKDGRGYTQPSQDPANRKHLSSHHYRTPSNSSAGLSHPLKTQKIKSAQRDDVQKSSLGTPENSTVYPERNFQKAAMPLDVNKSRSETSNEERGMTLSSFRCKLWNWEKVSSQKSEMSPTALLTNGRLKTFHLEGHKTMGLAQEKPEKNLKTTEAQPLPPQNHLMAQGKSPIASKASKGSLPRYSRKQTESPGTEGSHESSPCQPVYECELVSLVPEKPESQHCQLPKTKPLPSIETLGPPPPKPSKPPFVNIYAFPRQPAVVSKSLKEGKKMHRAHPHCAELEEAHNYDTTISYLRHSGNSINLCAAGESAEATYEIEIEELQKPYFSLVSSYYSPRPKDGENTTREKEPCASEPPKPGKVSYPKHPSKIAVCEGTPGKTQMSGVQENRRSMPAGNQQAIIDIIQSRHFQEDAMLTRHSQGKSGYVEALGVTKETPSPSTVRSSSSSEKTYDDVECSREDIQKWDFSSSFTSDSEENSEETYEDIYRAKTSDPKTDAAGRAALRRLQQLFSRENGVFRMKKTKSKEIVSNGFSMSLPDLGPRSHDGIIYDDVDAREKES" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2A995/", "id": "A2A995", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "tax_id": 10116 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": {}, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A995", "id": "A2A995", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045121", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A995", "id": "A2A995", "database": "UniProtKB" } ], "name": "membrane raft", "id": "GO:0045121" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001772", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A995", "id": "A2A995", "database": "UniProtKB" } ], "name": "immunological synapse", "id": "GO:0001772" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007229", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A995", "id": "A2A995", "database": "UniProtKB" } ], "name": "integrin-mediated signaling pathway", "id": "GO:0007229" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A995", "id": "A2A995", "database": "UniProtKB" } ], "name": "protein localization to plasma membrane", "id": "GO:0072659" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050852", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A995", "id": "A2A995", "database": "UniProtKB" } ], "name": "T cell receptor signaling pathway", "id": "GO:0050852" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033627", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A995", "id": "A2A995", "database": "UniProtKB" } ], "name": "cell adhesion mediated by integrin", "id": "GO:0033627" } ], "total": 4, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A2A995", "type": "recommended", "resource": "UniProtKB", "name": "Fyb2" }, { "url": "https://www.uniprot.org/uniprot/A2A995", "type": "synonym", "resource": "UniProtKB", "name": "ARAP" } ], "crossref": [ { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "id": "IPR036028", "database": "InterPro" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2A995", "id": "PR_A2A995", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "id": "IPR001452", "database": "InterPro" }, { "url": "https://omabrowser.org/oma/group/KPWKSFL/", "id": "KPWKSFL", "database": "OMA" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000078612", "id": "ENSMUSG00000078612", "database": "Bgee" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029294", "id": "IPR029294", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF14603", "id": "PF14603", "database": "Pfam" }, { "url": "http://www.informatics.jax.org/marker/MGI:2685466", "id": "2685466", "database": "MGI" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Tyr", "position": "489", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A995", "id": "A2A995", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Tyr", "position": "591", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A995", "id": "A2A995", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" } ], "mass": { "monoisotopic_mass": 82296.0, "chemical_mass": 82296.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2A995", "name": "Fyb2", "locus": { "end_pos": 105016863, "strand": "+", "start_pos": 104913456, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000078612", "id": "ENSMUSG00000078612", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2A995", "type": "synonym", "resource": "UniProtKB", "name": "Activation-dependent, raft-recruited ADAP-like phosphoprotein" }, { "url": "https://www.uniprot.org/uniprot/A2A995", "type": "recommended", "resource": "UniProtKB", "name": "FYN-binding protein 2" } ] }