{ "uniprot_canonical_ac": "A2A8R0-1", "ptm_annotation": [], "sequence": { "header": "tr|A2A8R0-1|A2A8R0_MOUSE Isoform 1 of Zinc finger FYVE domain-containing protein OS=Mus musculus OX=10090 GN=Zfyve9 PE=1 SV=1 CANONICAL=A2A8R0-1", "length": 1397, "sequence": "MENYFQAEAYNLDKVLDEFEQNEDETVSPTLLDTKWNKILDPSSHPLSFNPALASVNEPTVSETGPQLKVFSLAGSAPLTKEDKDPCANGQDCSLNPETDTMWIDENAVTEDQLIKRNYNQDDQFSAVEVGEEKCGSLTCLPDEKNVLVVAVMHNCDKRTLQSDLQDCNNYNSQSLMNSFSCSLDNETRQTDQFSFSMNGSTEKGINSEKQMDALNKPKPERDSVNHLCAASSNSATSISSPSQLKDGENVGRDPSTSTVTSLAVNSSQGMDGGPAIKQQGNYMPDEDLSGMNSSSRTDLGISNSFSHSSGELLIKTEPAEERTAEDSLPSDLSLNLKPDTPALSGRDNCEQSSDCLGSSETRADEDEGNDSQMTNWKLTKLNEMSDSQVNEENQMALQSNQPEDTNSGGECVGMADSDLDFKGTCMNESEGYDFSTVNDAPAANSLSNSCDSYGMQSPIVSFVPKTLPSKEDSVTEEKEIEESKSECYSNIYEQRGNENAEGSGLLLNSTGNVMKKNYLHNFCSQIPSVLGQSSPKIANLQSISVPFGGARPKQPSNLKLQIPKPLSDHLQNDLPANNGNNSKNKNDVLGKAKLGENSAVNACSATLGNISVTDTNGEHLETYEAEISSRPCLALAPDSPDNDLRASQFGISARKPFTTLGEVAPVWVPDSQAPNCMKCEARFTFTKRRHHCRACGKVFCASCCSLKCKLLYMDRKEARVCVICHSVLMNAQAWENMMSASSQSPNPNNPAEYCSTIPPLQQAQASGALSSPPPTVMVPVGVLKHPGTEVPQPREQRRVWFADGILPNGEVADAAKLTMNGTSSAGTLAVSHDPVKPVATSPLPTEADTSLFSGSITQVGSPVGSAMNLIPEDGLPPILISTGVKGDYAVEEKPSQISVMQQLEDGGPDPLVFVLNANLLSMVKIVNYVNRKCWCFTTKGMHAVGQSEIVILLQCLPDEKCLPKDIFNHFVQLYRDALAGNVVGSLGHSFFSQSFLGSKEHGGFLYVTSTYQSLQDLVLPTPPYLFGILIQKWETPWAKVFPIRLLLRLGAEYRLYPCPLFSVRFRKPLFGETGHTIMNLLADFRNYQYTLPVVQGLVVDMEVRKTSIKIPSNRYNEMMKAMNKSNEHVLAGGACFNEKADSHLVCVQNDDGNYQTQAISIHNQPRKVTGASFFVFSGALKSSSGYLAKSSIVEDGVMVQITAENMDSLRQALREMKDFTITCGKADAEDPQEQIHIQWVDDDKTVNKGVVSPIDGKSMESITNVKIFHGSEYKANGKVIRWTEVFFLENDDHHNCLSDPADHSRLTEHVAKAFCLALCPHLKLLKEDGMTKLGLRVTLDSDQVGYQAGSNGQPLPSQYMNDLDSALVPVIHGGACQLSEGPVVMELIFYILENIA" }, "uniprot_id": "A2A8R0_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8R0", "id": "A2A8R0", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25170969", "type": [ "PubMed" ], "id": "25170969" } ], "title": "The FYVE domain of Smad Anchor for Receptor Activation (SARA) is required to prevent skin carcinogenesis, but not in mouse development.", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334092.1", "id": "NP_001334092.1", "database": "RefSeq" } ], "authors": "Chang HM, Lin YY, Tsai PC, Liang CT, Yan YT", "date": "2014" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19257813", "type": [ "PubMed" ], "id": "19257813" } ], "title": "Sustained BMP signaling in osteoblasts stimulates bone formation by promoting angiogenesis and osteoblast differentiation.", "journal": "Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334092.1", "id": "NP_001334092.1", "database": "RefSeq" } ], "authors": "Zhang F, Qiu T, Wu X, Wan C, Shi W, Wang Y, Chen JG, Wan M, Clemens TL, Cao X", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25170619", "type": [ "PubMed" ], "id": "25170619" } ], "title": "CCR1 plays a critical role in modulating pain through hematopoietic and non-hematopoietic cells.", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334092.1", "id": "NP_001334092.1", "database": "RefSeq" } ], "authors": "Lewis ND, Muthukumarana A, Fogal SE, Corradini L, Stefanopoulos DE, Adusumalli P, Pelletier J, Panzenbeck M, Berg K, Canfield M, Cook BN, Razavi H, Kuzmich D, Anderson S, Allard D, Harrison P, Grimaldi C, Souza D, Harcken C, Fryer RM, Modis LK, Brown ML", "date": "2014" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15356634", "type": [ "PubMed" ], "id": "15356634" } ], "title": "Cytoplasmic PML function in TGF-beta signalling.", "journal": "Nature", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334092.1", "id": "NP_001334092.1", "database": "RefSeq" } ], "authors": "Lin HK, Bergmann S, Pandolfi PP", "date": "2004" } ], "uniprot_ac": "A2A8R0", "site_annotation": [ { "end_pos": 612, "annotation": "n_glycosylation_sequon", "start_pos": 610 }, { "end_pos": 188, "annotation": "n_glycosylation_sequon", "start_pos": 186 }, { "end_pos": 511, "annotation": "n_glycosylation_sequon", "start_pos": 509 }, { "end_pos": 430, "annotation": "n_glycosylation_sequon", "start_pos": 428 }, { "end_pos": 372, "annotation": "n_glycosylation_sequon", "start_pos": 370 }, { "end_pos": 823, "annotation": "n_glycosylation_sequon", "start_pos": 821 }, { "end_pos": 1126, "annotation": "n_glycosylation_sequon", "start_pos": 1124 }, { "end_pos": 295, "annotation": "n_glycosylation_sequon", "start_pos": 293 }, { "end_pos": 268, "annotation": "n_glycosylation_sequon", "start_pos": 266 }, { "end_pos": 201, "annotation": "n_glycosylation_sequon", "start_pos": 199 }, { "end_pos": 583, "annotation": "n_glycosylation_sequon", "start_pos": 581 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A8R0#A2A8R0-1", "isoform_ac": "A2A8R0-1", "locus": { "end_pos": 108639262, "strand": "+", "start_pos": 108723876, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000106657", "id": "ENSMUST00000106657", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000102268", "id": "ENSMUSP00000102268", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2A8R0-1|A2A8R0_MOUSE Isoform 1 of Zinc finger FYVE domain-containing protein OS=Mus musculus OX=10090 GN=Zfyve9 PE=1 SV=1 CANONICAL=A2A8R0-1", "length": 1397, "sequence": "MENYFQAEAYNLDKVLDEFEQNEDETVSPTLLDTKWNKILDPSSHPLSFNPALASVNEPTVSETGPQLKVFSLAGSAPLTKEDKDPCANGQDCSLNPETDTMWIDENAVTEDQLIKRNYNQDDQFSAVEVGEEKCGSLTCLPDEKNVLVVAVMHNCDKRTLQSDLQDCNNYNSQSLMNSFSCSLDNETRQTDQFSFSMNGSTEKGINSEKQMDALNKPKPERDSVNHLCAASSNSATSISSPSQLKDGENVGRDPSTSTVTSLAVNSSQGMDGGPAIKQQGNYMPDEDLSGMNSSSRTDLGISNSFSHSSGELLIKTEPAEERTAEDSLPSDLSLNLKPDTPALSGRDNCEQSSDCLGSSETRADEDEGNDSQMTNWKLTKLNEMSDSQVNEENQMALQSNQPEDTNSGGECVGMADSDLDFKGTCMNESEGYDFSTVNDAPAANSLSNSCDSYGMQSPIVSFVPKTLPSKEDSVTEEKEIEESKSECYSNIYEQRGNENAEGSGLLLNSTGNVMKKNYLHNFCSQIPSVLGQSSPKIANLQSISVPFGGARPKQPSNLKLQIPKPLSDHLQNDLPANNGNNSKNKNDVLGKAKLGENSAVNACSATLGNISVTDTNGEHLETYEAEISSRPCLALAPDSPDNDLRASQFGISARKPFTTLGEVAPVWVPDSQAPNCMKCEARFTFTKRRHHCRACGKVFCASCCSLKCKLLYMDRKEARVCVICHSVLMNAQAWENMMSASSQSPNPNNPAEYCSTIPPLQQAQASGALSSPPPTVMVPVGVLKHPGTEVPQPREQRRVWFADGILPNGEVADAAKLTMNGTSSAGTLAVSHDPVKPVATSPLPTEADTSLFSGSITQVGSPVGSAMNLIPEDGLPPILISTGVKGDYAVEEKPSQISVMQQLEDGGPDPLVFVLNANLLSMVKIVNYVNRKCWCFTTKGMHAVGQSEIVILLQCLPDEKCLPKDIFNHFVQLYRDALAGNVVGSLGHSFFSQSFLGSKEHGGFLYVTSTYQSLQDLVLPTPPYLFGILIQKWETPWAKVFPIRLLLRLGAEYRLYPCPLFSVRFRKPLFGETGHTIMNLLADFRNYQYTLPVVQGLVVDMEVRKTSIKIPSNRYNEMMKAMNKSNEHVLAGGACFNEKADSHLVCVQNDDGNYQTQAISIHNQPRKVTGASFFVFSGALKSSSGYLAKSSIVEDGVMVQITAENMDSLRQALREMKDFTITCGKADAEDPQEQIHIQWVDDDKTVNKGVVSPIDGKSMESITNVKIFHGSEYKANGKVIRWTEVFFLENDDHHNCLSDPADHSRLTEHVAKAFCLALCPHLKLLKEDGMTKLGLRVTLDSDQVGYQAGSNGQPLPSQYMNDLDSALVPVIHGGACQLSEGPVVMELIFYILENIA" } }, { "url": "https://www.uniprot.org/uniprot/A2A8R0#A8Y5G5-1", "isoform_ac": "A8Y5G5-1", "locus": { "end_pos": 108639262, "strand": "+", "start_pos": 108723876, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000106658", "id": "ENSMUST00000106658", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000102269", "id": "ENSMUSP00000102269", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A8Y5G5-1|A2A8R0_MOUSE Computationally mapped isoform of Zinc finger FYVE domain-containing protein OS=Mus musculus OX=10090 GN=Zfyve9 PE=1 SV=1 CANONICAL=A2A8R0-1", "length": 1338, "sequence": "MENYFQAEAYNLDKVLDEFEQNEDETVSPTLLDTKWNKILDPSSHPLSFNPALASVNEPTVSETGPQLKVFSLAGSAPLTKEDKDPCANGQDCSLNPETDTMWIDENAVTEDQLIKRNYNQDDQFSAVEVGEEKCGSLTCLPDEKNVLVVAVMHNCDKRTLQSDLQDCNNYNSQSLMNSFSCSLDNETRQTDQFSFSMNGSTEKGINSEKQMDALNKPKPERDSVNHLCAASSNSATSISSPSQLKDGENVGRDPSTSTVTSLAVNSSQGMDGGPAIKQQGNYMPDEDLSGMNSSSRTDLGISNSFSHSSGELLIKTEPAEERTAEDSLPSDLSLNLKPDTPALSGRDNCEQSSDCLGSSETRADEDEGNDSQMTNWKLTKLNEMSDSQVNEENQMALQSNQPEDTNSGGECVGMADSDLDFKGTCMNESEGYDFSTVNDAPAANSLSNSCDSYGMQSPIVSFVPKTLPSKEDSVTEEKEIEESKSECYSNIYEQRGNENAEGSGLLLNSTGNVMKKNYLHNFCSQIPSVLGQSSPKIANLQSISVPFGGARPKQPSNLKLQIPKPLSDHLQNDLPANNGNNSKNKNDVLGKAKLGENSAVNACSATLGNISVTDTNGEHLETYEAEISSRPCLALAPDSPDNDLRASQFGISARKPFTTLGEVAPVWVPDSQAPNCMKCEARFTFTKRRHHCRACGKVFCASCCSLKCKLLYMDRKEARVCVICHSVLMNVPQPREQRRVWFADGILPNGEVADAAKLTMNGTSSAGTLAVSHDPVKPVATSPLPTEADTSLFSGSITQVGSPVGSAMNLIPEDGLPPILISTGVKGDYAVEEKPSQISVMQQLEDGGPDPLVFVLNANLLSMVKIVNYVNRKCWCFTTKGMHAVGQSEIVILLQCLPDEKCLPKDIFNHFVQLYRDALAGNVVGSLGHSFFSQSFLGSKEHGGFLYVTSTYQSLQDLVLPTPPYLFGILIQKWETPWAKVFPIRLLLRLGAEYRLYPCPLFSVRFRKPLFGETGHTIMNLLADFRNYQYTLPVVQGLVVDMEVRKTSIKIPSNRYNEMMKAMNKSNEHVLAGGACFNEKADSHLVCVQNDDGNYQTQAISIHNQPRKVTGASFFVFSGALKSSSGYLAKSSIVEDGVMVQITAENMDSLRQALREMKDFTITCGKADAEDPQEQIHIQWVDDDKTVNKGVVSPIDGKSMESITNVKIFHGSEYKANGKVIRWTEVFFLENDDHHNCLSDPADHSRLTEHVAKAFCLALCPHLKLLKEDGMTKLGLRVTLDSDQVGYQAGSNGQPLPSQYMNDLDSALVPVIHGGACQLSEGPVVMELIFYILENIA" } }, { "url": "https://www.uniprot.org/uniprot/A2A8R0#A0S860-1", "isoform_ac": "A0S860-1", "locus": { "end_pos": 108639262, "strand": "+", "start_pos": 108723827, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000042185", "id": "ENSMUST00000042185", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000039852", "id": "ENSMUSP00000039852", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0S860-1|A2A8R0_MOUSE Computationally mapped isoform of Zinc finger FYVE domain-containing protein OS=Mus musculus OX=10090 GN=Zfyve9 PE=1 SV=1 CANONICAL=A2A8R0-1", "length": 706, "sequence": "MNLNKMKVFCASCCSLKCKLLYMDRKEARVCVICHSVLMNAQAWENMMSASSQSPNPNNPAEYCSTIPPLQQAQASGALSSPPPTVMVPVGVLKHPGTEVPQPREQRRVWFADGILPNGEVADAAKLTMNGTSSAGTLAVSHDPVKPVATSPLPTEADTSLFSGSITQVGSPVGSAMNLIPEDGLPPILISTGVKGDYAVEEKPSQISVMQQLEDGGPDPLVFVLNANLLSMVKIVNYVNRKCWCFTTKGMHAVGQSEIVILLQCLPDEKCLPKDIFNHFVQLYRDALAGNVVGSLGHSFFSQSFLGSKEHGGFLYVTSTYQSLQDLVLPTPPYLFGILIQKWETPWAKVFPIRLLLRLGAEYRLYPCPLFSVRFRKPLFGETGHTIMNLLADFRNYQYTLPVVQGLVVDMEVRKTSIKIPSNRYNEMMKAMNKSNEHVLAGGACFNEKADSHLVCVQNDDGNYQTQAISIHNQPRKVTGASFFVFSGALKSSSGYLAKSSIVEDGVMVQITAENMDSLRQALREMKDFTITCGKADAEDPQEQIHIQWVDDDKTVNKGVVSPIDGKSMESITNVKIFHGSEYKANGKVIRWTEVFFLENDDHHNCLSDPADHSRLTEHVAKAFCLALCPHLKLLKEDGMTKLGLRVTLDSDQVGYQAGSNGQPLPSQYMNDLDSALVPVIHGGACQLSEGPVVMELIFYILENIA" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:230597", "resource": "KEGG Pathway", "id": "mmu:230597", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2173789", "resource": "Reactome", "id": "R-MMU-2173789", "name": "TGF-beta receptor signaling activates SMADs" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334092.1", "annotation": "Osteoblast targeted expression of a mutant endofin protein lacking the pp1c binding activity results in sustained signaling of the BMP type I receptor, which increases bone formation and skeletal angiogenesis.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334092.1", "id": "NP_001334092.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334092.1", "annotation": "This study describes the expression of two SARA isoforms, SARA1 and SARA2, in mice and reports the generation and characterization of SARA mutant mice with FYVE domain deletion. The loss of SARA promoted skin tumor formation and malignant progression. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334092.1", "id": "NP_001334092.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "O95405-1", "protein_name": "Zinc finger FYVE domain-containing protein 9", "sequence": { "length": 1425, "sequence": "MENYFQAEAYNLDKVLDEFEQNEDETVSSTLLDTKWNKILDPPSHRLSFNPTLASVNESAVSNESQPQLKVFSLAHSAPLTTEEEDHCANGQDCNLNPEIATMWIDENAVAEDQLIKRNYSWDDQCSAVEVGEKKCGNLACLPDEKNVLVVAVMHNCDKRTLQNDLQDCNNYNSQSLMDAFSCSLDNENRQTDQFSFSINESTEKDMNSEKQMDPLNRPKTEGRSVNHLCPTSSDSLASVCSPSQLKDDGSIGRDPSMSAITSLTVDSVISSQGTDGCPAVKKQENYIPDEDLTGKISSPRTDLGSPNSFSHMSEGILMKKEPAEESTTEESLRSGLPLLLKPDMPNGSGRNNDCERCSDCLVPNEVRADENEGYEHEETLGTTEFLNMTEHFSESQDMTNWKLTKLNEMNDSQVNEEKEKFLQISQPEDTNGDSGGQCVGLADAGLDLKGTCISESEECDFSTVIDTPAANYLSNGCDSYGMQDPGVSFVPKTLPSKEDSVTEEKEIEESKSECYSNIYEQRGNEATEGSGLLLNSTGDLMKKNYLHNFCSQVPSVLGQSSPKVVASLPSISVPFGGARPKQPSNLKLQIPKPLSDHLQNDFPANSGNNTKNKNDILGKAKLGENSATNVCSPSLGNISNVDTNGEHLESYEAEISTRPCLALAPDSPDNDLRAGQFGISARKPFTTLGEVAPVWVPDSQAPNCMKCEARFTFTKRRHHCRACGKVFCASCCSLKCKLLYMDRKEARVCVICHSVLMNAQAWENMMSASSQSPNPNNPAEYCSTIPPLQQAQASGALSSPPPTVMVPVGVLKHPGAEVAQPREQRRVWFADGILPNGEVADAAKLTMNGTSSAGTLAVSHDPVKPVTTSPLPAETDICLFSGSITQVGSPVGSAMNLIPEDGLPPILISTGVKGDYAVEEKPSQISVMQQLEDGGPDPLVFVLNANLLSMVKIVNYVNRKCWCFTTKGMHAVGQSEIVILLQCLPDEKCLPKDIFNHFVQLYRDALAGNVVSNLGHSFFSQSFLGSKEHGGFLYVTSTYQSLQDLVLPTPPYLFGILIQKWETPWAKVFPIRLMLRLGAEYRLYPCPLFSVRFRKPLFGETGHTIMNLLADFRNYQYTLPVVQGLVVDMEVRKTSIKIPSNRYNEMMKAMNKSNEHVLAGGACFNEKADSHLVCVQNDDGNYQTQAISIHNQPRKVTGASFFVFSGALKSSSGYLAKSSIVEDGVMVQITAENMDSLRQALREMKDFTITCGKADAEEPQEHIHIQWVDDDKNVSKGVVSPIDGKSMETITNVKIFHGSEYKANGKVIRWTEVFFLENDDQHNCLSDPADHSRLTEHVAKAFCLALCPHLKLLKEDGMTKLGLRVTLDSDQVGYQAGSNGQPLPSQYMNDLDSALVPVIHGGACQLSEGPVVMELIFYILENIV" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/3527", "id": "3527", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2A8R0/", "id": "A2A8R0", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "D3ZDC7-1", "protein_name": "Zinc finger FYVE domain-containing protein", "sequence": { "length": 1398, "sequence": "MENYFQAEAYNLDKVLDEFEQNEDETVSPTLLDTKWNKILDSSSHPLSFNPALANVNEPTISNETGPQRKIFSLAGSAPLTREGKGPCANGQDGSLNPEIDTMWIDENAVAEDQLIKRNYNQDDQFSAVEVGEEKRGSLTCLPDEKNVLVVAVMHNCDKRTLQSDLQDCNNYNSQSLMDSFSCSLDNETRQTDQFSFSMNGSAEKGINSEKQMDALNKPKSERDSLNHLCAASANSATSISSSSQLKDNENVGRDPSTSTATSLAINTSQGMDGGPAIKKQEDYMPDEDLSGANSSSRTDLGSSNSFSHSREELLTKTEPAEERTAEDPLPSGLSLNLKPDTPALCGRDNCEPSSDCLVSSETRTDGDGGKDSQTTHWDSAKLNEVDDRQGSEENQVVLQISQPEDPQSAGECVRMADSDLDFKGTCLNESEGYDFSTVSDAPAANSLSNSCDSYGMQSPIVSFVPKTLPSKEDSVTEEKEIEESKSECYSNLYEQRGNENTEGNGLLLNSTGTIMKKNYLHNFCSQIPSVLGQSSPKIANLQSISVPFGGARPKQPSNLKLQIPKPLSDHLQNDLPANNGNNSKNKNDILGKAKLGENSAVSACSATLGNISVTDTNGEHLESFEADISSRPCLALSPDSPDNDLRAGQFGISARKPFTTLGEVAPVWVPDSQAPNCMKCEARFTFTKRRHHCRACGKVFCASCCSLKCKLLYMDRKEARVCVICHSVLMNAQAWENMMSASSQSPNPNNPAEYCSTIPPLQQAQASGALSSPPPTVMVPVGVLKHPGTEVPQPREQRRVWFADGILPNGEVADAAKLTMNGTSSAGTLAVSHDPVKPVATSPLPAEADVSLFSGSITQVGSPVGSAMNLIPEDGLPPILISTGVKGDYAVEEKPSQISVMQQLEDGGPDPLVFVLNANLLSMVKIVNYVNRKCWCFTTKGMHAVGQSEIVILLQCLPDEKCLPKDIFNHFVQLYRDALAGSVVGSLGHSFFSQSFLGSKEHGGFLYMTSTHQSLQDLLLPTPPYLFGILIQKWETPWAKVFPIRLMLRLGAEYRRKSRPAFSTEFRKLQFGETGHTIMNLLADFRNYQYTLPGVQGLVVDMEVRKTSIKIPSNRYNEMMKAMNKSNEHVLAGGACFNEKADSHLVCVQNDDGNYQTQAISIHNQPRKVTGASFFVFSGALKSSSGYLAKSSIVEDGVMVQITAENMDSLRQALREMKDFTITCGKADAEDPQEQIHIQWVDDDKTVNKGVVSPIDGKSMESITNVKIFHGSEYKANGKVIRWTEVFFLENDDHRTCLSDPADHSRLTEHVAKAFCLALCPHLKLLKEDGMTKLGLRVTLDSDQVGYQAGSNGQPLPSQYMKDLDSALVPVIHGGACQLSEGPVGIELIFYILENIA" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2A8R0/", "id": "A2A8R0", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "tax_id": 10116 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334092.1", "ac": "NP_001334092.1", "name": "zinc finger FYVE domain-containing protein 9 isoform 1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8R0", "id": "A2A8R0", "database": "UniProtKB" } ], "name": "protein domain specific binding", "id": "GO:0019904" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8R0", "id": "A2A8R0", "database": "UniProtKB" } ], "name": "metal ion binding", "id": "GO:0046872" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005545", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8R0", "id": "A2A8R0", "database": "UniProtKB" } ], "name": "1-phosphatidylinositol binding", "id": "GO:0005545" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046332", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8R0", "id": "A2A8R0", "database": "UniProtKB" } ], "name": "SMAD binding", "id": "GO:0046332" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8R0", "id": "A2A8R0", "database": "UniProtKB" } ], "name": "early endosome", "id": "GO:0005769" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8R0", "id": "A2A8R0", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8R0", "id": "A2A8R0", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8R0", "id": "A2A8R0", "database": "UniProtKB" } ], "name": "intracellular membrane-bounded organelle", "id": "GO:0043231" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8R0", "id": "A2A8R0", "database": "UniProtKB" } ], "name": "early endosome membrane", "id": "GO:0031901" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8R0", "id": "A2A8R0", "database": "UniProtKB" } ], "name": "protein-containing complex", "id": "GO:0032991" } ], "total": 6, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016197", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8R0", "id": "A2A8R0", "database": "UniProtKB" } ], "name": "endosomal transport", "id": "GO:0016197" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017015", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8R0", "id": "A2A8R0", "database": "UniProtKB" } ], "name": "regulation of transforming growth factor beta receptor signaling pathway", "id": "GO:0017015" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007179", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8R0", "id": "A2A8R0", "database": "UniProtKB" } ], "name": "transforming growth factor beta receptor signaling pathway", "id": "GO:0007179" } ], "total": 3, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A8R0", "type": "synonym", "resource": "RefSeq", "name": "Madhip; NSP; SARA; SMADIP" }, { "url": "https://www.uniprot.org/uniprot/A2A8R0", "type": "synonym", "resource": "UniProtKB", "name": "mCG_17975" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A8R0", "type": "synonym", "resource": "RefSeq", "name": "Zfyve9" }, { "url": "https://www.uniprot.org/uniprot/A2A8R0", "type": "recommended", "resource": "UniProtKB", "name": "Zfyve9" } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334092.1", "id": "NP_001334092.1", "database": "RefSeq" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035438", "id": "IPR035438", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "id": "IPR011011", "database": "InterPro" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/230597", "id": "230597", "database": "GeneID" }, { "url": "http://pfam.xfam.org/family/PF11409", "id": "PF11409", "database": "Pfam" }, { "url": "https://omabrowser.org/oma/group/VHIQWVE/", "id": "VHIQWVE", "database": "OMA" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:230597", "id": "mmu:230597", "database": "KEGG Pathway" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR037145", "id": "IPR037145", "database": "InterPro" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000034557", "id": "ENSMUSG00000034557", "database": "Bgee" }, { "url": "http://www.informatics.jax.org/marker/MGI:2652838", "id": "2652838", "database": "MGI" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017455", "id": "IPR017455", "database": "InterPro" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2173789", "id": "R-MMU-2173789", "database": "Reactome" }, { "url": "http://www.orthodb.org/?query=278124at2759", "id": "278124at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF01363", "id": "PF01363", "database": "Pfam" }, { "url": 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], "protein_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A8R0", "type": "synonym", "resource": "RefSeq", "name": "zinc finger FYVE domain-containing protein 9 isoform 1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A8R0", "type": "synonym", "resource": "RefSeq", "name": "MAD, mothers against decapentaplegic homolog interacting protein, receptor activation anchor" }, { "url": "https://www.uniprot.org/uniprot/A2A8R0", "type": "recommended", "resource": "UniProtKB", "name": "Zinc finger FYVE domain-containing protein" } ] }