{ "uniprot_canonical_ac": "A2A432-1", "ptm_annotation": [ { "annotation": "Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A432", "id": "A2A432", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q13620", "id": "Q13620", "database": "PubMed" } ] } ], "sequence": { "header": "sp|A2A432-1|CUL4B_MOUSE Isoform 1 of Cullin-4B OS=Mus musculus OX=10090 GN=Cul4b PE=1 SV=1 CANONICAL=A2A432-1", "length": 970, "sequence": "MSRSTRSKERRENDTDSEDNSSETSNQERRRCRQGPPRPPYPPLLPPVFPPPTPPPQVRRTRGLQDLGAMKSVCPGTSGFSSPNPSAASAAAQEVRSATDGNTSTTPPTSAKKRKLNSSSSSSNSSNEREDFDSTSSSSTPPQPRDSASPSTSSFCLGVPVATSSHVPIQKKLRFEDTLEFVGIDTKMAEESSSSSSSSSPTAATSQQQQQQQLKTKSILISSVASVHHANGLAKSSTAVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSHKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQQFLQETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIASVEKQLLGEHLTAILQKGLNSLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDTCFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTMVLLMFNEGEEFSLEEIKHATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA" }, "uniprot_id": "CUL4B_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A432", "id": "A2A432", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", "type": [ "PubMed" ], "id": "12520002" } ], "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "id": "NP_001103612.1", "database": "RefSeq" } ], "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28604389", "type": [ "PubMed" ], "id": "28604389" } ], "title": "A cullin 4B-RING E3 ligase complex fine-tunes pancreatic delta cell paracrine interactions.", "journal": "The Journal of clinical investigation", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "id": "NP_001103612.1", "database": "RefSeq" } ], "authors": "Li Q, Cui M, Yang F, Li N, Jiang B, Yu Z, Zhang D, Wang Y, Zhu X, Hu H, Li PS, Ning SL, Wang S, Qi H, Song H, He D, Lin A, Zhang J, Liu F, Zhao J, Gao L, Yi F, Xue T, Sun JP, Gong Y, Yu X", "date": "2017" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17242355", "type": [ "PubMed" ], "id": "17242355" } ], "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A432", "id": "A2A432", "database": "UniProtKB" } ], "authors": "Beausoleil S.A., Gerber S.A., Gygi S.P., Villen J.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28178526", "type": [ "PubMed" ], "id": "28178526" } ], "title": "CRL4(DCAF8) Ubiquitin Ligase Targets Histone H3K79 and Promotes H3K9 Methylation in the Liver.", "journal": "Cell reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "id": "NP_001103612.1", "database": "RefSeq" } ], "authors": "Li G, Ji T, Chen J, Fu Y, Hou L, Feng Y, Zhang T, Song T, Zhao J, Endo Y, Lin H, Cai X, Cang Y", "date": "2017" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30992047", "type": [ "PubMed" ], "id": "30992047" } ], "title": "Abnormal level of CUL4B-mediated histone H2A ubiquitination causes disruptive HOX gene expression.", "journal": "Epigenetics & chromatin", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "id": "NP_001103612.1", "database": "RefSeq" } ], "authors": "Lin Y, Yu J, Wu J, Wang S, Zhang T", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17954973", "type": [ "PubMed" ], "id": "17954973" } ], "title": "Cullin4B/E3-ubiquitin ligase negatively regulates beta-catenin.", "journal": "Journal of biosciences", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "id": "NP_001103612.1", "database": "RefSeq" } ], "authors": "Tripathi R, Kota SK, Srinivas UK", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16052071", "type": [ "PubMed" ], "id": "16052071" } ], "title": "Cloning and characterization of mouse cullin4B/E3 ubiquitin ligase.", "journal": "J. Biosci.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A432", "id": "A2A432", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "id": "NP_001103612.1", "database": "RefSeq" } ], "authors": "Kota S.K., Sastry K.S., Srinivas U.K., Tripathi R.", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/29106389", "type": [ "PubMed" ], "id": "29106389" } ], "title": "CUL4B promotes gastric cancer invasion and metastasis-involvement of upregulation of HER2.", "journal": "Oncogene", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "id": "NP_001103612.1", "database": "RefSeq" } ], "authors": "Qi M, Jiao M, Li X, Hu J, Wang L, Zou Y, Zhao M, Zhang R, Liu H, Mi J, Zhang L, Liu L, Gong Y, Han B", "date": "2018" } ], "uniprot_ac": "A2A432", "site_annotation": [ { "end_pos": 104, "annotation": "n_glycosylation_sequon", "start_pos": 102 }, { "end_pos": 15, "annotation": "n_glycosylation_sequon", "start_pos": 13 }, { "end_pos": 22, "annotation": "n_glycosylation_sequon", "start_pos": 20 }, { "end_pos": 119, "annotation": "n_glycosylation_sequon", "start_pos": 117 }, { "end_pos": 126, "annotation": "n_glycosylation_sequon", "start_pos": 124 }, { "end_pos": 288, "annotation": "n_glycosylation_sequon", "start_pos": 286 }, { "end_pos": 270, "annotation": "n_glycosylation_sequon", "start_pos": 268 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A432#A2A432-2", "isoform_ac": "A2A432-2", "locus": {}, "sequence": { "header": "sp|A2A432-2|CUL4B_MOUSE Isoform 2 of Cullin-4B OS=Mus musculus OX=10090 GN=Cul4b PE=1 SV=1 CANONICAL=A2A432-1", "length": 941, "sequence": "MSRSTRSKERRENDTDSEDNSSETSNQERRRCRQGPPRPPYPPLLPPVFPPPTPPPQVRRTRGLQDLGAMKSVCPGTSGFSSPNPSAASAAAQEVRSATDGNTSTTPPTSAKKRKLNSSSSSSNSSNEREDFDSTSSSSTPPQPRDSASPSTSSFCLGVPVATSSHVPIQKKLRFEDTLEFVGIDTKMAEESSSSSSSSSPTAATSQQQQQQQLKTKSILISSVASVHHANGLAKSSTAVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSHKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQQFLQETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIASVEKQLLGEHLTAILQKGLNSLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDTCFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTMVLLMFNEGEEFSLEEIKHATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA" } }, { "url": "https://www.uniprot.org/uniprot/A2A432#E9PXY1-1", "isoform_ac": "E9PXY1-1", "locus": { "end_pos": 38533636, "strand": "+", "start_pos": 38564221, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000016681", "id": "ENSMUST00000016681", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000016681", "id": "ENSMUSP00000016681", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|E9PXY1-1|CUL4B_MOUSE Computationally mapped isoform of Cullin-4B OS=Mus musculus OX=10090 GN=Cul4b PE=1 SV=2 CANONICAL=A2A432-1", "length": 896, "sequence": "MFPTGFSSPNPSAASAAAQEVRSATDGNTSTTPPTSAKKRKLNSSSSSSNSSNEREDFDSTSSSSTPPQPRDSASPSTSSFCLGVPVATSSHVPIQKKLRFEDTLEFVGIDTKMAEESSSSSSSSSPTAATSQQQQQQQLKTKSILISSVASVHHANGLAKSSTAVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSHKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQQFLQETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIASVEKQLLGEHLTAILQKGLNSLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDTCFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTMVLLMFNEGEEFSLEEIKHATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA" } }, { "url": "https://www.uniprot.org/uniprot/A2A432#A2A432-1", "isoform_ac": "A2A432-1", "locus": { "end_pos": 38533636, "strand": "+", "start_pos": 38572464, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000115118", "id": "ENSMUST00000115118", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000110771", "id": "ENSMUSP00000110771", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2A432-1|CUL4B_MOUSE Isoform 1 of Cullin-4B OS=Mus musculus OX=10090 GN=Cul4b PE=1 SV=1 CANONICAL=A2A432-1", "length": 970, "sequence": "MSRSTRSKERRENDTDSEDNSSETSNQERRRCRQGPPRPPYPPLLPPVFPPPTPPPQVRRTRGLQDLGAMKSVCPGTSGFSSPNPSAASAAAQEVRSATDGNTSTTPPTSAKKRKLNSSSSSSNSSNEREDFDSTSSSSTPPQPRDSASPSTSSFCLGVPVATSSHVPIQKKLRFEDTLEFVGIDTKMAEESSSSSSSSSPTAATSQQQQQQQLKTKSILISSVASVHHANGLAKSSTAVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSHKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQQFLQETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIASVEKQLLGEHLTAILQKGLNSLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDTCFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTMVLLMFNEGEEFSLEEIKHATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA" } }, { "url": "https://www.uniprot.org/uniprot/A2A432#J3QJX0-1", "isoform_ac": "J3QJX0-1", "locus": { "end_pos": 38545600, "strand": "+", "start_pos": 38564221, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000147129", "id": "ENSMUST00000147129", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000136083", "id": "ENSMUSP00000136083", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|J3QJX0-1|CUL4B_MOUSE Computationally mapped isoform of Cullin-4B OS=Mus musculus OX=10090 GN=Cul4b PE=1 SV=1 CANONICAL=A2A432-1", "length": 552, "sequence": "MFPTGFSSPNPSAASAAAQEVRSATDGNTSTTPPTSAKKRKLNSSSSSSNSSNEREDFDSTSSSSTPPQPRDSASPSTSSFCLGVPVATSSHVPIQKKLRFEDTLEFVGIDTKMAEESSSSSSSSSPTAATSQQQQQQQLKTKSILISSVASVHHANGLAKSSTAVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSHKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQQFLQETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIASVEKQLLGEHLTAILQKGLNSLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDTCFLKNEKFINAMKEAFETFINKRPNKPAELIVFLHFS" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6782135", "resource": "Reactome", "id": "R-MMU-6782135", "name": "Dual incision in TC-NER" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5696400", "resource": "Reactome", "id": "R-MMU-5696400", "name": "Dual Incision in GG-NER" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5696394", "resource": "Reactome", "id": "R-MMU-5696394", "name": "DNA Damage Recognition in GG-NER" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5696395", "resource": "Reactome", "id": "R-MMU-5696395", "name": "Formation of Incision Complex in GG-NER" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-110314", "resource": "Reactome", "id": "R-MMU-110314", "name": "Recognition of DNA damage by PCNA-containing replication complex" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:72584", "resource": "KEGG Pathway", "id": "mmu:72584", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6781823", "resource": "Reactome", "id": "R-MMU-6781823", "name": "Formation of TC-NER Pre-Incision Complex" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8951664", "resource": "Reactome", "id": "R-MMU-8951664", "name": "Neddylation" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6782210", "resource": "Reactome", "id": "R-MMU-6782210", "name": "Gap-filling DNA repair synthesis and ligation in TC-NER" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "annotation": "A cullin 4B-RING E3 ligase complex fine-tunes pancreatic delta cell paracrine interactions", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "id": "NP_001103612.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "annotation": "High CUL4B expression promotes gastric cancer invasion and metastasis.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "id": "NP_001103612.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "annotation": "The cloning and expression of amino and carboxy-terminal halves of cullin4B in mouse PCC4 cells is reported.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "id": "NP_001103612.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "annotation": "Plays a conserved role in the regulation of beta-catenin levels.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "id": "NP_001103612.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2A432#function", "annotation": "Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8 (By similarity). With CUL4A, contributes to ribosome biogenesis (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A432#function", "id": "A2A432", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "annotation": "CUL4B level mediates HOX gene expression via histone H2A ubiquitination. Aberrant CUL4B-mediated H2AK119ub1 level may be a risk factor for neural tube defects. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "id": "NP_001103612.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZK73-1", "protein_name": "Cullin 4B (Predicted)", "sequence": { "length": 971, "sequence": "MSRSTKSRERRENDANSEDNSSETSNQERRRCLQGPPRPPYPPLLPPVFPPPTPPPQVRRTRGLQDLGAMKSVCPGTSGFSSPNPSAASAAAQEVRSATDGNTSTTPPTSAKKRKLNSSSSSSSSNSSNEREDFDSTSSSSTPPQPRDSASPSTSSFCLGVPVATSSHVPIQKKLRFEDTLEFVGFDTKMAEESSSSSSSSSPTAATSQQQQQQLKNKSILISSVASVHHANGLAKSSTTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSLLRSLLNMLSDLQIYQDSFEQRFLQETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIASVEKQLLGEHLTAILQKGLNSLLDENRIQDLSLLYQLFSRVRGGVQVLLQHWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDTCFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/2660", "id": "2660", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q13620-2", "protein_name": "Cullin-4B", "sequence": { "length": 913, "sequence": 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